(Q38115094)

29 August 2017

The melanocortin-4 receptor as target for obesity treatment: a systematic review of emerging pharmacological therapeutic options (English)

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29 August 2017

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L Fani

1

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29 August 2017

S Bak

2

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29 August 2017

P Delhanty

3

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29 August 2017

E F C van Rossum

4

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29 August 2017

E L T van den Akker

5

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29 August 2017

language of work or name

English

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publication date

18 June 2013

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International Journal of Obesity

29 August 2017

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29 August 2017

38

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29 August 2017

2

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29 August 2017

163-169

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https://scigraph.springernature.com/pub.10.1038/ijo.2013.80

29 August 2017

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cites work

The economic burden of obesity worldwide: a systematic review of the direct costs of obesity

1 reference

https://api.crossref.org/works/10.1038%2FIJO.2013.80

The obesity epidemic: prospects for prevention

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FIJO.2013.80

Gene-environment interaction and obesity

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FIJO.2013.80

Social position, psychological stress, and obesity: a systematic review

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FIJO.2013.80

Interacting appetite-regulating pathways in the hypothalamic regulation of body weight

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FIJO.2013.80

Backbone cyclic peptidomimetic melanocortin-4 receptor agonist as a novel orally administrated drug lead for treating obesity

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FIJO.2013.80

Pharmacological Chaperones Restore Function to MC4R Mutants Responsible for Severe Early-Onset Obesity

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FIJO.2013.80

21 January 2018

Monogenic human obesity

1 reference

https://api.crossref.org/works/10.1038%2FIJO.2013.80

Feeding responses to a melanocortin agonist and antagonist in obesity induced by a palatable high-fat diet.

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FIJO.2013.80

Targeting melanocortin receptors as potential novel therapeutics

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FIJO.2013.80

Structure-activity relationship of linear tetrapeptides Tic-DPhe-Arg-Trp-NH2 at the human melanocortin-4 receptor and effects on feeding behaviors in rat.

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FIJO.2013.80

Potent and selective agonism of the melanocortin receptor 4 with MK-0493 does not induce weight loss in obese human subjects: energy intake predicts lack of weight loss efficacy

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FIJO.2013.80

Serendipitous discovery of a new class of agonists for the melanocortin 1 and 4 receptors and a new class of cyclophanes.

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FIJO.2013.80

C-terminal fragments of ACTH stimulate feeding in fasted rats

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FIJO.2013.80

Assessment of a small molecule melanocortin-4 receptor-specific agonist on energy homeostasis

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FIJO.2013.80

Identification and characterization of pyrrolidine diastereoisomers as potent functional agonists and antagonists of the human melanocortin-4 receptor

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FIJO.2013.80

Analysis of the therapeutic functions of novel melanocortin receptor agonists in MC3R- and MC4R-deficient C57BL/6J mice.

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FIJO.2013.80

A novel and selective beta-melanocyte-stimulating hormone-derived peptide agonist for melanocortin 4 receptor potently decreased food intake and body weight gain in diet-induced obese rats

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FIJO.2013.80

Potent peptide agonists for human melanocortin 3 and 4 receptors derived from enzymatic cleavages of human beta-MSH(5-22) by dipeptidyl peptidase I and dipeptidyl peptidase IV.

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FIJO.2013.80

MT-II induces penile erection via brain and spinal mechanisms.

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FIJO.2013.80

Chronic treatment with a melanocortin-4 receptor agonist causes weight loss, reduces insulin resistance, and improves cardiovascular function in diet-induced obese rhesus macaques

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FIJO.2013.80

Structure-activity relationship and metabolic stability studies of backbone cyclization and N-methylation of melanocortin peptides

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FIJO.2013.80

Obesity-linked variants of melanocortin-4 receptor are misfolded in the endoplasmic reticulum and can be rescued to the cell surface by a chemical chaperone

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FIJO.2013.80

Sympathetic response to insulin is mediated by melanocortin 3/4 receptors in the hypothalamic paraventricular nucleus

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FIJO.2013.80

Novel pharmacological MC4R agonists can efficiently activate mutated MC4R from obese patient with impaired endogenous agonist response

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FIJO.2013.80

Pericardial fat and atrial conduction abnormalities in the Multiethnic Study of Atherosclerosis (MESA).

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FIJO.2013.80

The FDA's assessment of two drugs for chronic weight management

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FIJO.2013.80

Multicenter, placebo-controlled trial of lorcaserin for weight management

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FIJO.2013.80

[Obesity caused by melanocortin-4 receptor mutations]

21 January 2018

1 reference

12 December 2020

Discovery of a piperazine urea based compound as a potent, selective, orally bioavailable melanocortin subtype-4 receptor partial agonist

1 reference

12 December 2020

Spiroindane based amides as potent and selective MC4R agonists for the treatment of obesity

1 reference

12 December 2020

A novel selective melanocortin-4 receptor agonist reduces food intake in rats and mice without producing aversive consequences.

1 reference

12 December 2020

Discovery of highly potent and efficacious MC4R agonists with spiroindane N-Me-1,2,4-triazole privileged structures for the treatment of obesity

1 reference

12 December 2020

Identifiers

DOI

10.1038/IJO.2013.80

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Dimensions Publication ID

29 August 2017

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