(Q43278795)

English

Potent and selective agonism of the melanocortin receptor 4 with MK-0493 does not induce weight loss in obese human subjects: energy intake predicts lack of weight loss efficacy

scientific article published on 9 September 2009

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Europe PubMed Central

PubMed publication ID

18 November 2017

Potent and selective agonism of the melanocortin receptor 4 with MK-0493 does not induce weight loss in obese human subjects: energy intake predicts lack of weight loss efficacy (English)

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18 November 2017

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human subject research project

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John Edward Blundell

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J Blundell

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R Krishna

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18 November 2017

B Gumbiner

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C Stevens

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B Musser

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M Mallick

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S Suryawanshi

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L Maganti

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H Zhu

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T H Han

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L Scherer

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B Simpson

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D Cosgrove

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K Gottesdiener

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J Amatruda

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B J Rolls

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G A Bray

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K Fujioka

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S B Heymsfield

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J A Wagner

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G A Herman

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18 November 2017

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9 September 2009

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18 November 2017

Clinical Pharmacology & Therapeutics

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18 November 2017

86

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6

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18 November 2017

659-666

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18 November 2017

Targeting melanocortin receptors: an approach to treat weight disorders and sexual dysfunction

1 reference

https://api.crossref.org/works/10.1038%2FCLPT.2009.167

21 January 2018

Melanocortin-4 receptor (MC4R) agonists for the treatment of obesity

1 reference

https://api.crossref.org/works/10.1038%2FCLPT.2009.167

21 January 2018

Obesity-associated mutations in the melanocortin 4 receptor provide novel insights into its function

1 reference

https://api.crossref.org/works/10.1038%2FCLPT.2009.167

21 January 2018

A missense mutation disrupting a dibasic prohormone processing site in pro-opiomelanocortin (POMC) increases susceptibility to early-onset obesity through a novel molecular mechanism

1 reference

https://api.crossref.org/works/10.1038%2FCLPT.2009.167

21 January 2018

Targeted disruption of the melanocortin-4 receptor results in obesity in mice

1 reference

https://api.crossref.org/works/10.1038%2FCLPT.2009.167

21 January 2018

Clinical spectrum of obesity and mutations in the melanocortin 4 receptor gene

1 reference

https://api.crossref.org/works/10.1038%2FCLPT.2009.167

21 January 2018

Association between an agouti-related protein gene polymorphism and anorexia nervosa

1 reference

https://api.crossref.org/works/10.1038%2FCLPT.2009.167

21 January 2018

Agouti-related protein promoter variant associated with leanness and decreased risk for diabetes in West Africans

1 reference

https://api.crossref.org/works/10.1038%2FCLPT.2009.167

21 January 2018

Long-term weight loss with sibutramine: a randomized controlled trial

1 reference

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21 January 2018

Sibutramine pharmacokinetics in young and elderly healthy subjects.

1 reference

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21 January 2018

The acyclic CB1R inverse agonist taranabant mediates weight loss by increasing energy expenditure and decreasing caloric intake

1 reference

https://api.crossref.org/works/10.1038%2FCLPT.2009.167

21 January 2018

Modulation of blood pressure by central melanocortinergic pathways

1 reference

https://api.crossref.org/works/10.1038%2FCLPT.2009.167

21 January 2018

The ultimate model organism: progress in experimental medicine

1 reference

https://api.crossref.org/works/10.1038%2FCLPT.2009.167

21 January 2018

Ala67Thr polymorphism in the Agouti-related peptide gene is associated with inherited leanness in humans

1 reference

https://api.crossref.org/works/10.1038%2FCLPT.2009.167

21 January 2018

Two ethnic-specific polymorphisms in the human Agouti-related protein gene are associated with macronutrient intake

1 reference

https://api.crossref.org/works/10.1038%2FCLPT.2009.167

7 January 2021

based on heuristic

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The role of melanocortins in body weight regulation: opportunities for the treatment of obesity

1 reference

https://api.crossref.org/works/10.1038%2FCLPT.2009.167

7 January 2021

based on heuristic

inferred from DOI database lookup

Sibutramine reduces food intake in non-dieting women with obesity

1 reference

https://api.crossref.org/works/10.1038%2FCLPT.2009.167

7 January 2021

based on heuristic

inferred from DOI database lookup

Exendin-4 reduces fasting and postprandial glucose and decreases energy intake in healthy volunteers

1 reference

https://api.crossref.org/works/10.1038%2FCLPT.2009.167

7 January 2021

based on heuristic

inferred from DOI database lookup

Thermogenic effects of sibutramine in humans

1 reference

https://api.crossref.org/works/10.1038%2FCLPT.2009.167

7 January 2021

based on heuristic

inferred from DOI database lookup

Modalities of the food intake-reducing effect of sibutramine in humans

1 reference

https://api.crossref.org/works/10.1038%2FCLPT.2009.167

7 January 2021

based on heuristic

inferred from DOI database lookup

Identifiers

10.1038/CLPT.2009.167

1 reference

Europe PubMed Central

PubMed publication ID

18 November 2017

PubMed publication ID

1 reference

Europe PubMed Central

PubMed publication ID

18 November 2017

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