(Q38116071)

29 August 2017

title

Targeting the sphingosine kinase/sphingosine 1-phosphate pathway to treat chronic inflammatory kidney diseases (English)

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29 August 2017

Stephanie Schwalm

1

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29 August 2017

Josef Pfeilschifter

series ordinal

2

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29 August 2017

Andrea Huwiler

series ordinal

3

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29 August 2017

publication date

15 July 2013

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Basic and Clinical Pharmacology and Toxicology

29 August 2017

published in

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29 August 2017

volume

114

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29 August 2017

issue

1

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29 August 2017

page(s)

44-49

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Glomerulonephritis: approaches to classification

29 August 2017

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Sphingosine-1-phosphate is a missing cofactor for the E3 ubiquitin ligase TRAF2

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Regulation and functional roles of sphingosine kinases

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Sphingosine kinase 1 and 2 regulate the capacity of mesangial cells to resist apoptotic stimuli in an opposing manner

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Sphingosine-1-phosphate, a novel lipid, involved in cellular proliferation

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Sphingosine 1-phosphate stimulates rat mesangial cell proliferation from outside the cells

21 January 2018

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Extracellular nucleotides induce migration of renal mesangial cells by upregulating sphingosine kinase-1 expression and activity

21 January 2018

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Signalling mechanisms in sphingosine 1-phosphate-promoted mesangial cell proliferation

21 January 2018

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Heterologous desensitization of the sphingosine-1-phosphate receptors by purinoceptor activation in renal mesangial cells

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Selective lymphocyte inhibition by FTY720 slows the progressive course of chronic anti-thy 1 glomerulosclerosis

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Chronic sphingosine 1-phosphate 1 receptor activation attenuates early-stage diabetic nephropathy independent of lymphocytes

21 January 2018

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Divergent roles of sphingosine kinases in kidney ischemia-reperfusion injury

21 January 2018

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Inhibition of sphingosine 1-phosphate receptor 2 protects against renal ischemia-reperfusion injury

21 January 2018

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Transforming growth factor-beta2 upregulates sphingosine kinase-1 activity, which in turn attenuates the fibrotic response to TGF-beta2 by impeding CTGF expression.

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21 January 2018

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21 January 2018

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Sphingosine 1-phosphate cross-activates the Smad signaling cascade and mimics transforming growth factor-beta-induced cell responses

21 January 2018

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Common and unique mechanisms regulate fibrosis in various fibroproliferative diseases

21 January 2018

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Renal fibrosis: new insights into the pathogenesis and therapeutics

21 January 2018

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Low-density lipoprotein induced expression of connective tissue growth factor via transactivation of sphingosine 1-phosphate receptors in mesangial cells.

21 January 2018

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21 January 2018

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The immunomodulator FTY720 and its phosphorylated derivative activate the Smad signalling cascade and upregulate connective tissue growth factor and collagen type IV expression in renal mesangial cells

21 January 2018

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21 January 2018

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21 January 2018

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Transforming growth factor-beta1 induces transdifferentiation of myoblasts into myofibroblasts via up-regulation of sphingosine kinase-1/S1P3 axis.

21 January 2018

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Glomerular proliferation during early stages of diabetic nephropathy is associated with local increase of sphingosine-1-phosphate levels

21 January 2018

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Sphingosine kinase-1 pathway mediates high glucose-induced fibronectin expression in glomerular mesangial cells

21 January 2018

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Thiazolidinedione-dependent activation of sphingosine kinase 1 causes an anti-fibrotic effect in renal mesangial cells

21 January 2018

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21 January 2018

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Treatment of glomerulonephritis: will we ever have options other than steroids and cytotoxics?

21 January 2018

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Sphingosine-1-phosphate: a Janus-faced mediator of fibrotic diseases

21 January 2018

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New players on the center stage: sphingosine 1-phosphate and its receptors as drug targets

21 January 2018

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Unbalanced expression of sphingosine 1-phosphate receptors in diabetic nephropathy.

21 January 2018

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Sphingosine-1-phosphate antibodies as potential agents in the treatment of cancer and age-related macular degeneration

21 January 2018

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A prokaryotic S1P lyase degrades extracellular S1P in vitro and in vivo: implication for treating hyperproliferative disorders

21 January 2018

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21 January 2018

Identifiers

DOI

10.1111/BCPT.12103

1 reference

29 August 2017

1 reference