(Q38131512)

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:23977698%20AND%20SRC:MED&resulttype=core&format=json

8 March 2020

title

New anti-inflammatory targets for chronic obstructive pulmonary disease (English)

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:23977698%20AND%20SRC:MED&resulttype=core&format=json

chronic obstructive pulmonary disease

8 March 2020

main subject

inflammation

0 references

1 reference

1

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:23977698%20AND%20SRC:MED&resulttype=core&format=json

8 March 2020

author name string

Peter J Barnes

series ordinal

1

1 reference

29 August 2017

publication date

1 July 2013

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:23977698%20AND%20SRC:MED&resulttype=core&format=json

Nature Reviews Drug Discovery

8 March 2020

published in

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:23977698%20AND%20SRC:MED&resulttype=core&format=json

8 March 2020

volume

12

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:23977698%20AND%20SRC:MED&resulttype=core&format=json

8 March 2020

issue

7

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:23977698%20AND%20SRC:MED&resulttype=core&format=json

8 March 2020

page(s)

543-559

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:23977698%20AND%20SRC:MED&resulttype=core&format=json

Chronic obstructive pulmonary disease: a growing but neglected global epidemic

8 March 2020

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1 reference

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Novel bronchodilators for the treatment of chronic obstructive pulmonary disease

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Decreased histone deacetylase activity in chronic obstructive pulmonary disease.

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The nature of small-airway obstruction in chronic obstructive pulmonary disease

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Small-airway obstruction and emphysema in chronic obstructive pulmonary disease

21 January 2018

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Lung CD8+ T cells in COPD have increased expression of bacterial TLRs

21 January 2018

1 reference

Cigarette smoke increases TLR4 and TLR9 expression and induces cytokine production from CD8(+) T cells in chronic obstructive pulmonary disease

21 January 2018

1 reference

Cigarette smoke promotes dendritic cell accumulation in COPD; a Lung Tissue Research Consortium study

21 January 2018

1 reference

T helper type 17-related cytokine expression is increased in the bronchial mucosa of stable chronic obstructive pulmonary disease patients.

21 January 2018

1 reference

Defective macrophage phagocytosis of bacteria in COPD.

21 January 2018

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Antiendothelial Cell Antibodies in Patients With COPD.

21 January 2018

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Oxidative stress-induced antibodies to carbonyl-modified protein correlate with severity of chronic obstructive pulmonary disease

21 January 2018

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A protein deacetylase SIRT1 is a negative regulator of metalloproteinase-9.

21 January 2018

1 reference

The safety and efficacy of infliximab in moderate to severe chronic obstructive pulmonary disease

21 January 2018

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The cytokine network in chronic obstructive pulmonary disease

21 January 2018

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Profiling of sputum inflammatory mediators in asthma and chronic obstructive pulmonary disease

21 January 2018

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Interleukin-18 in induced sputum: association with lung function in chronic obstructive pulmonary disease.

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Extracellular adenosine triphosphate and chronic obstructive pulmonary disease.

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SCH527123, a novel CXCR2 antagonist, inhibits ozone-induced neutrophilia in healthy subjects.

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SB-656933, a novel CXCR2 selective antagonist, inhibits ex vivo neutrophil activation and ozone-induced airway inflammation in humans

21 January 2018

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A novel proteolytic cascade generates an extracellular matrix-derived chemoattractant in chronic neutrophilic inflammation

21 January 2018

1 reference

A self-propagating matrix metalloprotease-9 (MMP-9) dependent cycle of chronic neutrophilic inflammation

21 January 2018

1 reference

Increased levels of the chemokines GROalpha and MCP-1 in sputum samples from patients with COPD.

21 January 2018

1 reference

Neutrophil elastase inhibitors

21 January 2018

1 reference

AZD9668: pharmacological characterization of a novel oral inhibitor of neutrophil elastase

21 January 2018

1 reference

AZD9668, a neutrophil elastase inhibitor, plus ongoing budesonide/formoterol in patients with COPD.

21 January 2018

1 reference

A randomised, placebo-controlled, dose-finding study of AZD9668, an oral inhibitor of neutrophil elastase, in patients with chronic obstructive pulmonary disease treated with tiotropium

21 January 2018

1 reference

Effect of an MMP-9/MMP-12 inhibitor on smoke-induced emphysema and airway remodelling in guinea pigs

21 January 2018

1 reference

4-Hydroxy-2-nonenal, a specific lipid peroxidation product, is elevated in lungs of patients with chronic obstructive pulmonary disease

21 January 2018

1 reference

Unbalanced oxidant-induced DNA damage and repair in COPD: a link towards lung cancer.

21 January 2018

1 reference

The effect of oxidative stress on histone acetylation and IL-8 release

21 January 2018

1 reference

Decline in NRF2-regulated antioxidants in chronic obstructive pulmonary disease lungs due to loss of its positive regulator, DJ-1

21 January 2018

1 reference

Decreased histone deacetylase 2 impairs Nrf2 activation by oxidative stress

21 January 2018

1 reference

Denitrosylation of HDAC2 by targeting Nrf2 restores glucocorticosteroid sensitivity in macrophages from COPD patients

21 January 2018

1 reference

Targeting Nrf2 with the triterpenoid CDDO-imidazolide attenuates cigarette smoke-induced emphysema and cardiac dysfunction in mice

21 January 2018

1 reference

Diabetic nephropathy: Could problems with bardoxolone methyl have been predicted?

21 January 2018

1 reference

Placebo-controlled phase 3 study of oral BG-12 for relapsing multiple sclerosis

21 January 2018

1 reference

In patients with chronic bronchitis a four week trial with inhaled steroids does not attenuate airway inflammation

21 January 2018

1 reference

The preclinical pharmacology of roflumilast--a selective, oral phosphodiesterase 4 inhibitor in development for chronic obstructive pulmonary disease

21 January 2018

1 reference

A controlled trial of 6-weeks' treatment with a novel inhaled phosphodiesterase type-4 inhibitor in COPD.

21 January 2018

1 reference

Discovery of selective PDE4B inhibitors

21 January 2018

1 reference

Discovery of BRL 50481 [3-(N,N-dimethylsulfonamido)-4-methyl-nitrobenzene], a selective inhibitor of phosphodiesterase 7: in vitro studies in human monocytes, lung macrophages, and CD8+ T-lymphocytes.

21 January 2018

1 reference

A multi-target antisense approach against PDE4 and PDE7 reduces smoke-induced lung inflammation in mice

21 January 2018

1 reference

The pharmacology of two novel long-acting phosphodiesterase 3/4 inhibitors, RPL554 [9,10-dimethoxy-2(2,4,6-trimethylphenylimino)-3-(n-carbamoyl-2-aminoethyl)-3,4,6,7-tetrahydro-2H-pyrimido[6,1-a]isoquinolin-4-one] and RPL565 [6,7-dihydro-2-(2,6-diis

21 January 2018

1 reference

BET protein function is required for inflammation: Brd2 genetic disruption and BET inhibitor JQ1 impair mouse macrophage inflammatory responses.

21 January 2018

1 reference

A selective jumonji H3K27 demethylase inhibitor modulates the proinflammatory macrophage response

21 January 2018

1 reference

Inhibitory effect of p38 mitogen-activated protein kinase inhibitors on cytokine release from human macrophages

21 January 2018

1 reference

p38alpha-selective mitogen-activated protein kinase inhibitor SD-282 reduces inflammation in a subchronic model of tobacco smoke-induced airway inflammation

21 January 2018

1 reference

"Go upstream, young man": lessons learned from the p38 saga

21 January 2018

1 reference

An oral inhibitor of p38 MAP kinase reduces plasma fibrinogen in patients with chronic obstructive pulmonary disease.

21 January 2018

1 reference

Inhaled p38alpha mitogen-activated protein kinase antisense oligonucleotide attenuates asthma in mice.

21 January 2018

1 reference

Design and synthesis of inhaled p38 inhibitors for the treatment of chronic obstructive pulmonary disease

21 January 2018

1 reference

TRX-ASK1-JNK signaling regulation of cell density-dependent cytotoxicity in cigarette smoke-exposed human bronchial epithelial cells

21 January 2018

1 reference

Phosphatidylinositol 3-kinase isoforms as targets in respiratory disease.

21 January 2018

1 reference

Targeting phosphoinositide-3-kinase-delta with theophylline reverses corticosteroid insensitivity in chronic obstructive pulmonary disease.

21 January 2018

1 reference

Airway PI3K pathway activation is an early and reversible event in lung cancer development

21 January 2018

1 reference

Phosphoinositide 3-kinase signalling in lung disease: leucocytes and beyond.

21 January 2018

1 reference

Aerosolized phosphoinositide 3-kinase gamma/delta inhibitor TG100-115 [3-[2,4-diamino-6-(3-hydroxyphenyl)pteridin-7-yl]phenol] as a therapeutic candidate for asthma and chronic obstructive pulmonary disease

21 January 2018

1 reference

Inhibition of PI3Kdelta restores glucocorticoid function in smoking-induced airway inflammation in mice

21 January 2018

1 reference

Impaired inhibition by dexamethasone of cytokine release by alveolar macrophages from patients with chronic obstructive pulmonary disease

21 January 2018

1 reference

Histone deacetylase 2-mediated deacetylation of the glucocorticoid receptor enables NF-kappaB suppression

21 January 2018

1 reference

Theophylline restores histone deacetylase activity and steroid responses in COPD macrophages.

21 January 2018

1 reference

Treatment effects of low-dose theophylline combined with an inhaled corticosteroid in COPD.

21 January 2018

1 reference

Nortriptyline reverses corticosteroid insensitivity by inhibition of phosphoinositide-3-kinase-δ

21 January 2018

1 reference

Curcumin restores corticosteroid function in monocytes exposed to oxidants by maintaining HDAC2

21 January 2018

1 reference

Changes in prevalence and load of airway bacteria using quantitative PCR in stable and exacerbated COPD.

21 January 2018

1 reference

Pulsed moxifloxacin for the prevention of exacerbations of chronic obstructive pulmonary disease: a randomized controlled trial

21 January 2018

1 reference

Ciprofloxacin dry powder for inhalation in non-cystic fibrosis bronchiectasis: a phase II randomised study

21 January 2018

1 reference

Liposomal nanoparticles control the uptake of ciprofloxacin across respiratory epithelia

21 January 2018

1 reference

Azithromycin for prevention of exacerbations of COPD.

21 January 2018

1 reference

A novel macrolide solithromycin exerts superior anti-inflammatory effect via NF-κB inhibition.

21 January 2018

1 reference

Cigarette smoke impairs clearance of apoptotic cells through oxidant-dependent activation of RhoA

21 January 2018

1 reference

Low-dose azithromycin improves phagocytosis of bacteria by both alveolar and monocyte-derived macrophages in chronic obstructive pulmonary disease subjects.

21 January 2018

1 reference

Novel lipid mediators and resolution mechanisms in acute inflammation: to resolve or not?

21 January 2018

1 reference

Macrophage proresolving mediator maresin 1 stimulates tissue regeneration and controls pain

21 January 2018

1 reference

Retinoid induction of alveolar regeneration: from mice to man?

21 January 2018

1 reference

Feasibility of retinoids for the treatment of emphysema study.

21 January 2018

1 reference

Randomised controlled trial for emphysema with a selective agonist of the γ-type retinoic acid receptor

21 January 2018

1 reference

Intranasal HGF administration ameliorates the physiologic and morphologic changes in lung emphysema.

21 January 2018

1 reference

Rapamycin slows aging in mice

21 January 2018

1 reference

Metformin slows down aging and extends life span of female SHR mice.

21 January 2018

1 reference

Anti-inflammatory effects of resveratrol in lung epithelial cells: molecular mechanisms.

21 January 2018

1 reference

The antifibrogenic potential of PPARgamma ligands in pulmonary fibrosis

21 January 2018

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Endothelin in pulmonary fibrosis

21 January 2018

1 reference

Dissecting direct and indirect genetic effects on chronic obstructive pulmonary disease (COPD) susceptibility.

21 January 2018

1 reference

New drugs for exacerbations of chronic obstructive pulmonary disease

21 January 2018

1 reference

Computed tomography-based biomarker provides unique signature for diagnosis of COPD phenotypes and disease progression

21 January 2018

1 reference

Persistent systemic inflammation is associated with poor clinical outcomes in COPD: a novel phenotype

21 January 2018

1 reference

Simvastatin inhibits cigarette smoking-induced emphysema and pulmonary hypertension in rat lungs

21 January 2018

1 reference

Two distinct chronic obstructive pulmonary disease (COPD) phenotypes are associated with high risk of mortality

21 January 2018

1 reference

Eosinophilic airway inflammation and exacerbations of COPD: a randomised controlled trial.

21 January 2018

1 reference

Reduction of morbidity and mortality by statins, angiotensin-converting enzyme inhibitors, and angiotensin receptor blockers in patients with chronic obstructive pulmonary disease

21 January 2018

1 reference

Treating viral exacerbations of chronic obstructive pulmonary disease: insights from a mouse model of cigarette smoke and H1N1 influenza infection

21 January 2018

1 reference

Leukotriene B4 receptor antagonists as therapeutics for inflammatory disease: preclinical and clinical developments

21 January 2018

1 reference

Pulmonary biomarkers in chronic obstructive pulmonary disease.

21 January 2018

1 reference

Randomized trial of zileuton for treatment of COPD exacerbations requiring hospitalization

21 January 2018

1 reference

Effect of the oral leukotriene B4 receptor antagonist LTB019 on inflammatory sputum markers in patients with chronic obstructive pulmonary disease

21 January 2018

1 reference

MK-0633, a potent 5-lipoxygenase inhibitor, in chronic obstructive pulmonary disease

21 January 2018

1 reference

21 January 2018

1 reference

Improvements in health-related quality of life after treatment with tocilizumab in patients with rheumatoid arthritis refractory to tumour necrosis factor inhibitors: results from the 24-week randomized controlled RADIATE study

21 January 2018

1 reference

Efficacy and safety of a monoclonal antibody recognizing interleukin-8 in COPD: a pilot study

21 January 2018

1 reference

Expression of the T helper 17-associated cytokines IL-17A and IL-17F in asthma and COPD.

21 January 2018

1 reference

Therapeutic targeting of the IL-12/23 pathways: generation and characterization of ustekinumab

21 January 2018

1 reference

Transforming growth factor-beta activation in the lung: focus on fibrosis and reactive oxygen species

21 January 2018

1 reference

Vessel-associated transforming growth factor-beta1 (TGF-β1) is increased in the bronchial reticular basement membrane in COPD and normal smokers

21 January 2018

1 reference

Safety and efficacy of an inhaled epidermal growth factor receptor inhibitor (BIBW 2948 BS) in chronic obstructive pulmonary disease

21 January 2018

1 reference

A catalytic antioxidant attenuates alveolar structural remodeling in bronchopulmonary dysplasia

21 January 2018

1 reference

Pharmacokinetics of 8-hour intravenous infusion of NXY-059: a phase I, randomized, double-blind (within dose panels), placebo-controlled study in healthy Chinese volunteers

21 January 2018

1 reference

Small-Molecule Inhibitors of NADPH Oxidase 4

21 January 2018

1 reference

Late intervention with a myeloperoxidase inhibitor stops progression of experimental chronic obstructive pulmonary disease

21 January 2018

1 reference

Bardoxolone methyl and kidney function in CKD with type 2 diabetes

21 January 2018

1 reference

Efficacy and safety of oral fumarate in patients with relapsing-remitting multiple sclerosis: a multicentre, randomised, double-blind, placebo-controlled phase IIb study

21 January 2018

1 reference

Different mitogen-activated protein kinase-dependent cytokine responses in cells of the monocyte lineage

21 January 2018

1 reference

STAT4 activation in smokers and patients with chronic obstructive pulmonary disease

21 January 2018

1 reference

Stat3 downstream genes serve as biomarkers in human lung carcinomas and chronic obstructive pulmonary disease

21 January 2018

1 reference

A double-blind, placebo-controlled trial of ruxolitinib for myelofibrosis

21 January 2018

1 reference

Tofacitinib, an oral Janus kinase inhibitor, in active ulcerative colitis.

21 January 2018

1 reference

Nuclear localisation of p65 in sputum macrophages but not in sputum neutrophils during COPD exacerbations.

21 January 2018

1 reference

An Oral Spleen Tyrosine Kinase (Syk) Inhibitor for Rheumatoid Arthritis

21 January 2018

1 reference

The clinically active BTK inhibitor PCI-32765 targets B-cell receptor- and chemokine-controlled adhesion and migration in chronic lymphocytic leukemia

21 January 2018

1 reference

Tolerability and efficacy of inhaled AZD4818, a CCR1 antagonist, in moderate to severe COPD patients

21 January 2018

1 reference

Inflammatory Biomarkers Improve Clinical Prediction of Mortality in Chronic Obstructive Pulmonary Disease

21 January 2018

1 reference

Anti–Interleukin-17 Monoclonal Antibody Ixekizumab in Chronic Plaque Psoriasis

21 January 2018

1 reference

Infections and Airway Inflammation in Chronic Obstructive Pulmonary Disease Severe Exacerbations

21 January 2018

1 reference

Increased activation of p38 MAPK in COPD

21 January 2018

1 reference

Brodalumab, an Anti–Interleukin-17–Receptor Antibody for Psoriasis

21 January 2018

1 reference

Tofacitinib or Adalimumab versus Placebo in Rheumatoid Arthritis

21 January 2018

1 reference

Lymphocyte population and apoptosis in the lungs of smokers and their relation to emphysema

21 January 2018

1 reference

Regulation of IL-17 in chronic inflammation in the human lung

31 March 2020

1 reference

P2X7 receptor signaling in the pathogenesis of smoke-induced lung inflammation and emphysema

31 March 2020

1 reference

CXCR3 and CCR5 Chemokines in Induced Sputum From Patients With COPD

31 March 2020

1 reference

Exhaled 8-isoprostane as an in vivo biomarker of lung oxidative stress in patients with COPD and healthy smokers

31 March 2020

1 reference

Effects of inhaled and oral glucocorticoids on inflammatory indices in asthma and COPD

31 March 2020

1 reference

Effect of High Dose Inhaled Steroid on Cells, Cytokines, and Proteases in Induced Sputum in Chronic Obstructive Pulmonary Disease

31 March 2020

1 reference

In vivo characterization of GSK256066, a high-affinity inhaled phosphodiesterase 4 inhibitor

31 March 2020

1 reference

A novel macrolide/fluoroketolide, solithromycin (CEM-101), reverses corticosteroid insensitivity via phosphoinositide 3-kinase pathway inhibition

31 March 2020

1 reference

Long-term erythromycin therapy is associated with decreased chronic obstructive pulmonary disease exacerbations

31 March 2020

1 reference

Novel 12-membered non-antibiotic macrolides from erythromycin A; EM900 series as novel leads for anti-inflammatory and/or immunomodulatory agents

31 March 2020

1 reference

Transforming growth factor beta1 and recruitment of macrophages and mast cells in airways in chronic obstructive pulmonary disease

31 March 2020

1 reference

Development and preclinical efficacy of novel transforming growth factor-β1 short interfering RNAs for pulmonary fibrosis

31 March 2020

1 reference

Effect of infliximab on local and systemic inflammation in chronic obstructive pulmonary disease: a pilot study

31 March 2020

1 reference

Neutralizing Granulocyte/Macrophage Colony–Stimulating Factor Inhibits Cigarette Smoke–induced Lung Inflammation

31 March 2020

1 reference

Effect of transforming growth factor-beta receptor I kinase inhibitor 2,4-disubstituted pteridine (SD-208) in chronic allergic airway inflammation and remodeling

31 March 2020

1 reference

Phosphodiesterase inhibitors: factors that influence potency, selectivity, and action

31 March 2020

1 reference

PubMed

https://pubmed.ncbi.nlm.nih.gov/23977698

inferred from PubMed ID database lookup

12 December 2020

based on heuristic

Identifiers

DOI

10.1038/NRD4025

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:23977698%20AND%20SRC:MED&resulttype=core&format=json

8 March 2020

1 reference