(Q38151636)

29 August 2017

title

Macrophage plasticity and polarization in liver homeostasis and pathology (English)

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29 August 2017

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29 August 2017

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29 August 2017

Antonio Sica

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29 August 2017

language of work or name

English

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publication date

1 April 2014

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29 August 2017

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29 August 2017

volume

59

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29 August 2017

issue

5

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29 August 2017

page(s)

2034-2042

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The liver as a lymphoid organ

29 August 2017

cites work

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Macrophage plasticity and polarization: in vivo veritas

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The immunology of fibrosis

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Macrophage plasticity and polarization in tissue repair and remodelling

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Orchestration of metabolism by macrophages

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Selective depletion of macrophages reveals distinct, opposing roles during liver injury and repair

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Monocyte subsets in human liver disease show distinct phenotypic and functional characteristics

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A lineage of myeloid cells independent of Myb and hematopoietic stem cells

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Local macrophage proliferation, rather than recruitment from the blood, is a signature of TH2 inflammation

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Macrophage heterogeneity and acute inflammation

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Kupffer cell heterogeneity: functional properties of bone marrow derived and sessile hepatic macrophages

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IL-34 is a tissue-restricted ligand of CSF1R required for the development of Langerhans cells and microglia

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Short-term memory of danger signals and environmental stimuli in immune cells

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Macrophage activation and polarization as an adaptive component of innate immunity

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Shaping gene expression in activated and resting primary macrophages by IL-10.

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Alternative activation of macrophages

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Macrophage polarization: tumor-associated macrophages as a paradigm for polarized M2 mononuclear phagocytes

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IRF5 promotes inflammatory macrophage polarization and TH1-TH17 responses

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Notch-RBP-J signaling regulates the transcription factor IRF8 to promote inflammatory macrophage polarization

21 January 2018

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Suppressor of cytokine signaling (SOCS)1 is a key determinant of differential macrophage activation and function.

21 January 2018

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Unique expression of suppressor of cytokine signaling 3 is essential for classical macrophage activation in rodents in vitro and in vivo

21 January 2018

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Notch signaling determines the M1 versus M2 polarization of macrophages in antitumor immune responses

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Suppressors of cytokine signaling 2 and 3 diametrically control macrophage polarization.

21 January 2018

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Tolerance and M2 (alternative) macrophage polarization are related processes orchestrated by p50 nuclear factor kappaB.

21 January 2018

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JNK expression by macrophages promotes obesity-induced insulin resistance and inflammation

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Critical role of Trib1 in differentiation of tissue-resident M2-like macrophages

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Epigenetic regulation of the alternatively activated macrophage phenotype

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The Jmjd3-Irf4 axis regulates M2 macrophage polarization and host responses against helminth infection

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MicroRNA let-7c regulates macrophage polarization.

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Macrophage-derived Wnt opposes Notch signaling to specify hepatic progenitor cell fate in chronic liver disease.

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MSCs, Macrophages, and Cancer: A Dangerous Ménage-à-Trois

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Loss of NF-kappaB activation in Kupffer cell-depleted mice impairs liver regeneration after partial hepatectomy.

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IL-1 receptor antagonist ameliorates inflammasome-dependent alcoholic steatohepatitis in mice

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Inhibition of Kupffer cell-mediated early proinflammatory response with carbon monoxide in transplant-induced hepatic ischemia/reperfusion injury in rats

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Programmed death-1/B7-H1 negative costimulation protects mouse liver against ischemia and reperfusion injury

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Kupffer cell suppression of CD8+ T cells in human hepatocellular carcinoma is mediated by B7-H1/programmed death-1 interactions

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Innate immune cells in liver inflammation

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Molecular mechanism for adiponectin-dependent M2 macrophage polarization: link between the metabolic and innate immune activity of full-length adiponectin

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Adiponectin prevents progression of steatohepatitis in mice by regulating oxidative stress and Kupffer cell phenotype polarization

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Adipocyte-derived Th2 cytokines and myeloid PPARdelta regulate macrophage polarization and insulin sensitivity.

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Depletion of liver Kupffer cells prevents the development of diet-induced hepatic steatosis and insulin resistance

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Macrophages that have ingested apoptotic cells in vitro inhibit proinflammatory cytokine production through autocrine/paracrine mechanisms involving TGF-beta, PGE2, and PAF

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Hepatocyte-specific disruption of Bcl-xL leads to continuous hepatocyte apoptosis and liver fibrotic responses.

21 January 2018

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Erythrophagocytosis by liver macrophages (Kupffer cells) promotes oxidative stress, inflammation, and fibrosis in a rabbit model of steatohepatitis: implications for the pathogenesis of human nonalcoholic steatohepatitis.

21 January 2018

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Evidence of hepatocyte apoptosis in rat liver after the administration of carbon tetrachloride

21 January 2018

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Inhibition of integrin alphavbeta6 on cholangiocytes blocks transforming growth factor-beta activation and retards biliary fibrosis progression

21 January 2018

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Mfge8 diminishes the severity of tissue fibrosis in mice by binding and targeting collagen for uptake by macrophages

21 January 2018

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Differential Ly-6C expression identifies the recruited macrophage phenotype, which orchestrates the regression of murine liver fibrosis

21 January 2018

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Interleukin-13 induces tissue fibrosis by selectively stimulating and activating transforming growth factor beta(1).

21 January 2018

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Osteopontin expression in normal and fibrotic liver. altered liver healing in osteopontin-deficient mice

21 January 2018

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CCR2 promotes hepatic fibrosis in mice

21 January 2018

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An IL-13 inhibitor blocks the development of hepatic fibrosis during a T-helper type 2-dominated inflammatory response

21 January 2018

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Hyper-responsiveness of IPF/UIP fibroblasts: interplay between TGFbeta1, IL-13 and CCL2.

21 January 2018

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NF-κB and STAT3 - key players in liver inflammation and cancer

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NF-kappaB functions as a tumour promoter in inflammation-associated cancer

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Oncogenic β-catenin triggers an inflammatory response that determines the aggressiveness of hepatocellular carcinoma in mice

21 January 2018

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A lymphotoxin-driven pathway to hepatocellular carcinoma

21 January 2018

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Cancer-related inflammation

21 January 2018

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Tim-3/galectin-9 signaling pathway mediates T-cell dysfunction and predicts poor prognosis in patients with hepatitis B virus-associated hepatocellular carcinoma.

21 January 2018

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Activated CD69+ T cells foster immune privilege by regulating IDO expression in tumor-associated macrophages.

21 January 2018

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Tumor-infiltrating macrophages can predict favorable prognosis in hepatocellular carcinoma after resection.

21 January 2018

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Significance of alternatively activated macrophages in patients with intrahepatic cholangiocarcinoma.

21 January 2018

1 reference

Prediction of venous metastases, recurrence, and prognosis in hepatocellular carcinoma based on a unique immune response signature of the liver microenvironment.

21 January 2018

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The proinflammatory myeloid cell receptor TREM-1 controls Kupffer cell activation and development of hepatocellular carcinoma

21 January 2018

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Distinct role of macrophages in different tumor microenvironments

21 January 2018

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Tumor-associated macrophages express lymphatic endothelial growth factors and are related to peritumoral lymphangiogenesis

21 January 2018

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Direct transformation of lung microenvironment by interferon-α treatment counteracts growth of lung metastasis of hepatocellular carcinoma

21 January 2018

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Depletion of tumor-associated macrophages enhances the effect of sorafenib in metastatic liver cancer models by antimetastatic and antiangiogenic effects.

21 January 2018

1 reference

Role of Macrophage Targeting in the Antitumor Activity of Trabectedin

21 January 2018

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Kupffer cell depletion by CI2MDP-liposomes alters hepatic cytokine expression and delays liver regeneration after partial hepatectomy

21 January 2018

1 reference

7 January 2021

Cannabinoid CB2 receptors protect against alcoholic liver disease by regulating Kupffer cell polarization in mice

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7 January 2021

Hypoadiponectinemia accelerates hepatic tumor formation in a nonalcoholic steatohepatitis mouse model

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7 January 2021

Hepatic recruitment of the inflammatory Gr1+monocyte subset upon liver injury promotes hepatic fibrosis

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7 January 2021

Enhanced interstitial collagenase (matrix metalloproteinase-13) production of Kupffer cell by gadolinium chloride prevents pig serum-induced rat liver fibrosis

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7 January 2021

High expression of macrophage colony-stimulating factor in peritumoral liver tissue is associated with poor survival after curative resection of hepatocellular carcinoma

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7 January 2021

Interleukin-22 promotes human hepatocellular carcinoma by activation of STAT3

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7 January 2021

Identifiers

DOI

10.1002/HEP.26754

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29 August 2017

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