(Q39974242)

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Inhibition of integrin alphavbeta6 on cholangiocytes blocks transforming growth factor-beta activation and retards biliary fibrosis progression

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Europe PubMed Central

PMC publication ID

16 September 2017

Inhibition of integrin alphavbeta6 on cholangiocytes blocks transforming growth factor-beta activation and retards biliary fibrosis progression (English)

1 reference

Europe PubMed Central

PMC publication ID

16 September 2017

Detlef Schuppan

6

object named as

Detlef Schuppan

1 reference

Europe PubMed Central

PMC publication ID

16 September 2017

author name string

Eleonora Patsenker

1

1 reference

Europe PubMed Central

PMC publication ID

16 September 2017

Yury Popov

2

1 reference

Europe PubMed Central

PMC publication ID

16 September 2017

Felix Stickel

3

1 reference

Europe PubMed Central

PMC publication ID

16 September 2017

Alfred Jonczyk

4

1 reference

Europe PubMed Central

PMC publication ID

16 September 2017

Simon L Goodman

5

1 reference

Europe PubMed Central

PMC publication ID

16 September 2017

language of work or name

0 references

publication date

16 April 2008

1 reference

Europe PubMed Central

PMC publication ID

16 September 2017

Gastroenterology

1 reference

Europe PubMed Central

PMC publication ID

16 September 2017

135

1 reference

Europe PubMed Central

PMC publication ID

16 September 2017

2

1 reference

Europe PubMed Central

PMC publication ID

16 September 2017

660-670

1 reference

Europe PubMed Central

PMC publication ID

16 September 2017

Role of alphavbeta6 integrin in acute biliary fibrosis

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3505071

22 September 2017

Integrin structures and conformational signaling

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3505071

22 September 2017

Halofuginone induces matrix metalloproteinases in rat hepatic stellate cells via activation of p38 and NFkappaB.

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3505071

22 September 2017

Mechanisms of disease: Mechanisms of hepatic fibrosis and therapeutic implications

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3505071

22 September 2017

Alpha v beta 6 integrin down-regulates the MMP-13 expression in oral squamous cell carcinoma cells

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3505071

22 September 2017

Hepatitis C virus-replicating hepatocytes induce fibrogenic activation of hepatic stellate cells.

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3505071

22 September 2017

Pathophysiology of cholangiopathies

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3505071

22 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3505071

22 September 2017

Immunohistochemical screening for beta6-integrin subunit expression in adenocarcinomas using a novel monoclonal antibody reveals strong up-regulation in pancreatic ductal adenocarcinomas in vivo and in vitro.

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3505071

22 September 2017

Integrin alphaVbeta6-mediated activation of latent TGF-beta requires the latent TGF-beta binding protein-1.

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3505071

22 September 2017

Establishment of a highly differentiated immortalized human cholangiocyte cell line with SV40T and hTERT.

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3505071

22 September 2017

Increased expression of beta6-integrin in skin leads to spontaneous development of chronic wounds

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3505071

22 September 2017

Transforming Growth Factor-β-Dependent and -Independent Pathways of Induction of Tubulointerstitial Fibrosis in β6−/− Mice

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3505071

22 September 2017

Nanomolar small molecule inhibitors for alphav(beta)6, alphav(beta)5, and alphav(beta)3 integrins

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3505071

22 September 2017

Pentoxifylline downregulates profibrogenic cytokines and procollagen I expression in rat secondary biliary fibrosis

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3505071

22 September 2017

Hepatic stellate cell behavior during resolution of liver injury

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3505071

22 September 2017

Matrix as a modulator of hepatic fibrogenesis

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3505071

22 September 2017

Proliferating bile duct epithelial cells are a major source of connective tissue growth factor in rat biliary fibrosis

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3505071

22 September 2017

Matrix metalloproteinases

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3505071

22 September 2017

The integrin alpha v beta 6 binds and activates latent TGF beta 1: a mechanism for regulating pulmonary inflammation and fibrosis

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3505071

22 September 2017

Contribution of hepatic parenchymal and nonparenchymal cells to hepatic fibrogenesis in biliary atresia.

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3505071

22 September 2017

Tissue inhibitor of metalloproteinase-1 and -2 RNA expression in rat and human liver fibrosis

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3505071

22 September 2017

Modulation of cell migration by integrin-mediated cytoskeletal linkages and ligand-binding affinity

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3505071

22 September 2017

Inactivation of the integrin beta 6 subunit gene reveals a role of epithelial integrins in regulating inflammation in the lung and skin

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3505071

22 September 2017

Role of the integrin alpha v beta 6 in cell attachment to fibronectin. Heterologous expression of intact and secreted forms of the receptor

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3505071

22 September 2017

Homozygous disruption of the murine mdr2 P-glycoprotein gene leads to a complete absence of phospholipid from bile and to liver disease

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3505071

22 September 2017

Requirement for transglutaminase in the activation of latent transforming growth factor-beta in bovine endothelial cells

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3505071

22 September 2017

Multiple integrins mediate cell attachment to cytotactin/tenascin

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3505071

22 September 2017

A point mutation in the integrin beta 6 subunit abolishes both alpha v beta 6 binding to fibronectin and receptor localization to focal contacts

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3505071

22 September 2017

Cellular localization of type I III and IV procollagen gene transcripts in normal and fibrotic human liver

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3505071

22 September 2017

Transforming growth factors beta 1 and beta 2 are differentially expressed in fibrotic liver disease

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3505071

22 September 2017

Characterization of the integrin alpha v beta 6 as a fibronectin-binding protein

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3505071

22 September 2017

Establishment of a new extrahepatic bile duct carcinoma cell line, TFK-1.

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3505071

25 September 2017

Loss of integrin alpha(v)beta6-mediated TGF-beta activation causes Mmp12-dependent emphysema

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3505071

15 June 2018

Silymarin retards collagen accumulation in early and advanced biliary fibrosis secondary to complete bile duct obliteration in rats

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3505071

15 June 2018

Keratinocytes in human wounds express alpha v beta 6 integrin

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3505071

15 June 2018

Transforming growth factor beta differentially regulates expression of integrin subunits in guinea pig airway epithelial cells

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3505071

15 June 2018

A quantitative assessment of the structural changes the rat's liver following obstruction of the common bile duct

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3505071

15 June 2018

Integrin alphavbeta6 is a marker of the progression of biliary and portal liver fibrosis and a novel target for antifibrotic therapies

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3505071

20 August 2018

Tumor necrosis factor-alpha and interferon-gamma directly impair epithelial barrier function in cultured mouse cholangiocytes

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3505071

20 August 2018

Expression of the beta 6 integrin subunit in development, neoplasia and tissue repair suggests a role in epithelial remodeling.

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3505071

20 August 2018

Latent transforming growth factor-beta from human platelets. A high molecular weight complex containing precursor sequences.

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3505071

20 August 2018

Epidermal integrin expression is upregulated rapidly in human fetal wound repair

1 reference

https://pubmed.ncbi.nlm.nih.gov/18538673

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

M6P/IGFII-receptor complexes urokinase receptor and plasminogen for activation of transforming growth factor-beta1

1 reference

https://pubmed.ncbi.nlm.nih.gov/18538673

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

The activation sequence of thrombospondin-1 interacts with the latency-associated peptide to regulate activation of latent transforming growth factor-beta

1 reference

https://pubmed.ncbi.nlm.nih.gov/18538673

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Mdr2 (Abcb4)-/- mice spontaneously develop severe biliary fibrosis via massive dysregulation of pro- and antifibrogenic genes

1 reference

https://pubmed.ncbi.nlm.nih.gov/18538673

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Pharmacological inhibition of the vitronectin receptor abrogates PDGF-BB-induced hepatic stellate cell migration and activation in vitro

1 reference

https://pubmed.ncbi.nlm.nih.gov/18538673

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Immunohistochemical analysis of cell-matrix adhesion molecules and their ligands in the portal tracts of primary biliary cirrhosis

1 reference

https://pubmed.ncbi.nlm.nih.gov/18538673

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Significance of coexpression of urokinase-type plasminogen activator, and matrix metalloproteinase 3 (stromelysin) and 9 (gelatinase B) in colorectal carcinoma

1 reference

https://pubmed.ncbi.nlm.nih.gov/18538673

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Direct integrin alphavbeta6-ERK binding: implications for tumour growth

1 reference

https://pubmed.ncbi.nlm.nih.gov/18538673

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Matrix metalloproteinases 1, 2, and 3 from rheumatoid synovial cells are sufficient to destroy joints

1 reference

https://pubmed.ncbi.nlm.nih.gov/18538673

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Identifiers

10.1053/J.GASTRO.2008.04.009

1 reference

Europe PubMed Central

PMC publication ID

16 September 2017

PMC publication ID

1 reference

Europe PubMed Central

PMC publication ID

16 September 2017

PubMed publication ID

1 reference

Europe PubMed Central

PMC publication ID

16 September 2017

ResearchGate publication ID

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