(Q38155817)

29 August 2017

title

Pathogenesis of pulmonary hypertension: a case for caveolin-1 and cell membrane integrity (English)

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29 August 2017

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arterial hypertension

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pulmonary hypertension

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Rajamma Mathew

1

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29 August 2017

publication date

25 October 2013

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American Journal of Physiology Heart and Circulatory Physiology

29 August 2017

published in

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29 August 2017

volume

306

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29 August 2017

issue

1

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29 August 2017

page(s)

H15-25

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Loss of caveolin and heme oxygenase expression in severe pulmonary hypertension.

29 August 2017

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Vascular smooth muscle modulates endothelial control of vasoreactivity via reactive oxygen species production through myoendothelial communications.

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Oxidative stress in severe pulmonary hypertension

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Sustained hypoxia promotes the development of a pulmonary artery-specific chronic inflammatory microenvironment

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Phosphorylation of endothelial nitric-oxide synthase regulates superoxide generation from the enzyme

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Caveolin-1 inhibits matrix metalloproteinase-2 activity in the heart

21 January 2018

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Signal transduction of a G protein-coupled receptor in caveolae: colocalization of endothelin and its receptor with caveolin

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Pulmonary hypertension and human immunodeficiency virus infection: epidemiology, pathogenesis, and clinical approach

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Identification of peptide and protein ligands for the caveolin-scaffolding domain. Implications for the interaction of caveolin with caveolae-associated proteins

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Survival in patients with primary pulmonary hypertension. Results from a national prospective registry.

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Caveolin-1, transforming growth factor-beta receptor internalization, and the pathogenesis of systemic sclerosis

21 January 2018

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Associated inflammation or increased flow-mediated shear stress, but not pressure alone, disrupts endothelial caveolin-1 in infants with pulmonary hypertension

21 January 2018

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Loss of caveolae, vascular dysfunction, and pulmonary defects in caveolin-1 gene-disrupted mice

21 January 2018

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Cholesterol depletion disrupts caveolae and differentially impairs agonist-induced arterial contraction

21 January 2018

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p42/44 MAP kinase-dependent and -independent signaling pathways regulate caveolin-1 gene expression. Activation of Ras-MAP kinase and protein kinase a signaling cascades transcriptionally down-regulates caveolin-1 promoter activity

21 January 2018

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Primary pulmonary arterial hypertension: a look back

21 January 2018

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Caveolin, caveolae, and endothelial cell function

21 January 2018

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Calcium pump of the plasma membrane is localized in caveolae

21 January 2018

1 reference

https://api.crossref.org/works/10.1152%2FAJPHEART.00266.2013

Targeted downregulation of caveolin-1 is sufficient to drive cell transformation and hyperactivate the p42/44 MAP kinase cascade

21 January 2018

1 reference

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Caveolin-1 expression negatively regulates cell cycle progression by inducing G(0)/G(1) arrest via a p53/p21(WAF1/Cip1)-dependent mechanism.

21 January 2018

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Knockdown of Stat3 expression using RNAi inhibits growth of laryngeal tumors in vivo

21 January 2018

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Composition of the endothelial glycocalyx and its relation to its thickness and diffusion of small solutes

21 January 2018

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Enhanced expression of vascular endothelial growth factor in pulmonary plexogenic arteriopathy due to congenital heart disease

21 January 2018

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https://api.crossref.org/works/10.1152%2FAJPHEART.00266.2013

Gene expression patterns in the lungs of patients with primary pulmonary hypertension: a gene microarray analysis

21 January 2018

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Reconstitution of an endothelial nitric-oxide synthase (eNOS), hsp90, and caveolin-1 complex in vitro. Evidence that hsp90 facilitates calmodulin stimulated displacement of eNOS from caveolin-1.

21 January 2018

1 reference

https://api.crossref.org/works/10.1152%2FAJPHEART.00266.2013

Caveolin-1-deficient aortic smooth muscle cells show cell autonomous abnormalities in proliferation, migration, and endothelin-based signal transduction

21 January 2018

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https://api.crossref.org/works/10.1152%2FAJPHEART.00266.2013

Caveolin-1 deficiency stimulates neointima formation during vascular injury

21 January 2018

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https://api.crossref.org/works/10.1152%2FAJPHEART.00266.2013

PDGF receptor tyrosine kinase inhibitor suppresses mesangial cell proliferation involving STAT3 activation

21 January 2018

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https://api.crossref.org/works/10.1152%2FAJPHEART.00266.2013

Rapamycin reverses pulmonary artery smooth muscle cell proliferation in pulmonary hypertension

21 January 2018

1 reference

https://api.crossref.org/works/10.1152%2FAJPHEART.00266.2013

Pyrrolidine dithiocarbamate restores endothelial cell membrane integrity and attenuates monocrotaline-induced pulmonary artery hypertension

21 January 2018

1 reference

https://api.crossref.org/works/10.1152%2FAJPHEART.00266.2013

Progressive endothelial cell damage in an inflammatory model of pulmonary hypertension

21 January 2018

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https://api.crossref.org/works/10.1152%2FAJPHEART.00266.2013

Caveolin-1 Expression and Hemodynamics in COPD Patients.

21 January 2018

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Increased interleukin-1 and interleukin-6 serum concentrations in severe primary pulmonary hypertension.

21 January 2018

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Survival in patients with idiopathic, familial, and anorexigen-associated pulmonary arterial hypertension in the modern management era.

21 January 2018

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Ca2+ and inositol 1,4,5-trisphosphate-mediated signaling across the myoendothelial junction

21 January 2018

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https://api.crossref.org/works/10.1152%2FAJPHEART.00266.2013

A Molecular Sensor Detects Signal Transduction from Caveolae in Living Cells

21 January 2018

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https://api.crossref.org/works/10.1152%2FAJPHEART.00266.2013

Function of Caveolae in Ca2+ Entry and Ca2+‐Dependent Signal Transduction

21 January 2018

1 reference

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Increased plasma monocyte chemoattractant protein-1 level in idiopathic pulmonary arterial hypertension.

21 January 2018

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Lung remodeling and pulmonary hypertension after myocardial infarction: pathogenic role of reduced caveolin expression.

21 January 2018

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Short-Term Administration of a Cell-Permeable Caveolin-1 Peptide Prevents the Development of Monocrotaline-Induced Pulmonary Hypertension and Right Ventricular Hypertrophy

21 January 2018

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SOCS proteins and caveolin-1 as negative regulators of endocrine signaling

21 January 2018

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Suppression of eNOS-derived superoxide by caveolin-1: a biopterin-dependent mechanism

21 January 2018

1 reference

https://api.crossref.org/works/10.1152%2FAJPHEART.00266.2013

Translocation of caveolin regulates stretch-induced ERK activity in vascular smooth muscle cells.

21 January 2018

1 reference

https://api.crossref.org/works/10.1152%2FAJPHEART.00266.2013

von Willebrand factor independently predicts long-term survival in patients with pulmonary arterial hypertension

21 January 2018

1 reference

https://api.crossref.org/works/10.1152%2FAJPHEART.00266.2013

Pulmonary vascular disease associated with parasitic infection--the role of schistosomiasis

21 January 2018

1 reference

https://api.crossref.org/works/10.1152%2FAJPHEART.00266.2013

Circulating angiopoietins in idiopathic pulmonary arterial hypertension

21 January 2018

1 reference

https://api.crossref.org/works/10.1152%2FAJPHEART.00266.2013

VIP21, a 21-kD membrane protein is an integral component of trans-Golgi-network-derived transport vesicles

21 January 2018

1 reference

https://api.crossref.org/works/10.1152%2FAJPHEART.00266.2013

Regulation of vascular endothelial growth factor receptor-2 activity by caveolin-1 and plasma membrane cholesterol.

21 January 2018

1 reference

https://api.crossref.org/works/10.1152%2FAJPHEART.00266.2013

Pulmonary hypertension in POEMS syndrome: a new feature mediated by cytokines.

21 January 2018

1 reference

https://api.crossref.org/works/10.1152%2FAJPHEART.00266.2013

Angiogenesis activators and inhibitors differentially regulate caveolin-1 expression and caveolae formation in vascular endothelial cells. Angiogenesis inhibitors block vascular endothelial growth factor-induced down-regulation of caveolin-1.

21 January 2018

1 reference

https://api.crossref.org/works/10.1152%2FAJPHEART.00266.2013

High expression of endothelial nitric oxide synthase in plexiform lesions of pulmonary hypertension

21 January 2018

1 reference

https://api.crossref.org/works/10.1152%2FAJPHEART.00266.2013

Pulmonary arterial hypertension associated with systemic sclerosis

21 January 2018

1 reference

https://api.crossref.org/works/10.1152%2FAJPHEART.00266.2013

Effects of monocrotaline on endothelial nitric oxide synthase expression and sulfhydryl levels in rat lungs

21 January 2018

1 reference

https://api.crossref.org/works/10.1152%2FAJPHEART.00266.2013

Disruption of endothelial-cell caveolin-1alpha/raft scaffolding during development of monocrotaline-induced pulmonary hypertension

21 January 2018

1 reference

https://api.crossref.org/works/10.1152%2FAJPHEART.00266.2013

Pulmonary artery hypertension: caveolin-1 and eNOS interrelationship: a new perspective

21 January 2018

1 reference

https://api.crossref.org/works/10.1152%2FAJPHEART.00266.2013

Cell-specific dual role of caveolin-1 in pulmonary hypertension

21 January 2018

1 reference

https://api.crossref.org/works/10.1152%2FAJPHEART.00266.2013

Caveolin regulation of endothelial function

21 January 2018

1 reference

https://api.crossref.org/works/10.1152%2FAJPHEART.00266.2013

Smurf1 ubiquitin ligase causes downregulation of BMP receptors and is induced in monocrotaline and hypoxia models of pulmonary arterial hypertension

21 January 2018

1 reference

https://api.crossref.org/works/10.1152%2FAJPHEART.00266.2013

Hypoxia impairs endothelium-dependent relaxation in organ cultured pulmonary artery

21 January 2018

1 reference

https://api.crossref.org/works/10.1152%2FAJPHEART.00266.2013

Decreased endothelial nitric-oxide synthase (eNOS) activity resulting from abnormal interaction between eNOS and its regulatory proteins in hypoxia-induced pulmonary hypertension

21 January 2018

1 reference

https://api.crossref.org/works/10.1152%2FAJPHEART.00266.2013

Statin protects endothelial nitric oxide synthase activity in hypoxia-induced pulmonary hypertension

21 January 2018

1 reference

https://api.crossref.org/works/10.1152%2FAJPHEART.00266.2013

Reexpression of caveolin-1 in endothelium rescues the vascular, cardiac, and pulmonary defects in global caveolin-1 knockout mice

21 January 2018

1 reference

https://api.crossref.org/works/10.1152%2FAJPHEART.00266.2013

Genetic evidence supporting caveolae microdomain regulation of calcium entry in endothelial cells

21 January 2018

1 reference

https://api.crossref.org/works/10.1152%2FAJPHEART.00266.2013

Matrix metalloproteinases regulate migration, proliferation, and death of vascular smooth muscle cells by degrading matrix and non-matrix substrates

21 January 2018

1 reference

https://api.crossref.org/works/10.1152%2FAJPHEART.00266.2013

Tyrosine-phosphorylated caveolin-1: immunolocalization and molecular characterization

21 January 2018

1 reference

https://api.crossref.org/works/10.1152%2FAJPHEART.00266.2013

Pulmonary hypertension associated with sarcoidosis: mechanisms, haemodynamics and prognosis

21 January 2018

1 reference

https://api.crossref.org/works/10.1152%2FAJPHEART.00266.2013

Caveolins, a family of scaffolding proteins for organizing "preassembled signaling complexes" at the plasma membrane

21 January 2018

1 reference

https://api.crossref.org/works/10.1152%2FAJPHEART.00266.2013

Altered membrane lipid domains limit pulmonary endothelial calcium entry following chronic hypoxia

21 January 2018

1 reference

https://api.crossref.org/works/10.1152%2FAJPHEART.00266.2013

Increased smooth muscle cell expression of caveolin-1 and caveolae contribute to the pathophysiology of idiopathic pulmonary arterial hypertension.

21 January 2018

1 reference

https://api.crossref.org/works/10.1152%2FAJPHEART.00266.2013

Caveolae as organizers of pharmacologically relevant signal transduction molecules

21 January 2018

1 reference

https://api.crossref.org/works/10.1152%2FAJPHEART.00266.2013

Platelet-derived growth factor expression and function in idiopathic pulmonary arterial hypertension

21 January 2018

1 reference

https://api.crossref.org/works/10.1152%2FAJPHEART.00266.2013

Caveolin-1 can regulate vascular smooth muscle cell fate by switching platelet-derived growth factor signaling from a proliferative to an apoptotic pathway

21 January 2018

1 reference

https://api.crossref.org/works/10.1152%2FAJPHEART.00266.2013

Persistence of complex vascular lesions despite prolonged prostacyclin therapy of pulmonary arterial hypertension

21 January 2018

1 reference

https://api.crossref.org/works/10.1152%2FAJPHEART.00266.2013

Heat shock protein 90 mediates the balance of nitric oxide and superoxide anion from endothelial nitric-oxide synthase

21 January 2018

1 reference

https://api.crossref.org/works/10.1152%2FAJPHEART.00266.2013

The BMP type II receptor is located in lipid rafts, including caveolae, of pulmonary endothelium in vivo and in vitro

21 January 2018

1 reference

https://api.crossref.org/works/10.1152%2FAJPHEART.00266.2013

Caveolin-1 regulates transforming growth factor (TGF)-beta/SMAD signaling through an interaction with the TGF-beta type I receptor

21 January 2018

1 reference

https://api.crossref.org/works/10.1152%2FAJPHEART.00266.2013

Bone morphogenetic protein type 2 receptor gene therapy attenuates hypoxic pulmonary hypertension

21 January 2018

1 reference

https://api.crossref.org/works/10.1152%2FAJPHEART.00266.2013

BMPR2 mutations in pulmonary arterial hypertension with congenital heart disease.

21 January 2018

1 reference

https://api.crossref.org/works/10.1152%2FAJPHEART.00266.2013

Smooth muscle cell phenotype alters cocultured endothelial cell response to biomaterial-pretreated leukocytes.

21 January 2018

1 reference

https://api.crossref.org/works/10.1152%2FAJPHEART.00266.2013

Caveolin, a protein component of caveolae membrane coats

21 January 2018

1 reference

https://api.crossref.org/works/10.1152%2FAJPHEART.00266.2013

Apoptosis of pulmonary microvascular endothelial cells stimulates vascular smooth muscle cell growth

21 January 2018

1 reference

https://api.crossref.org/works/10.1152%2FAJPHEART.00266.2013

Reversal of experimental pulmonary hypertension by PDGF inhibition

21 January 2018

1 reference

https://api.crossref.org/works/10.1152%2FAJPHEART.00266.2013

Caveolin-1: dual role for proliferation of vascular smooth muscle cells

21 January 2018

1 reference

https://api.crossref.org/works/10.1152%2FAJPHEART.00266.2013

Updated clinical classification of pulmonary hypertension.

21 January 2018

1 reference

https://api.crossref.org/works/10.1152%2FAJPHEART.00266.2013

Electron microscopy of the plexiform lesion

21 January 2018

1 reference

https://api.crossref.org/works/10.1152%2FAJPHEART.00266.2013

Caveolin-1 scaffold domain interacts with TRPC1 and IP3R3 to regulate Ca2+ store release-induced Ca2+ entry in endothelial cells

21 January 2018

1 reference

https://api.crossref.org/works/10.1152%2FAJPHEART.00266.2013

Shear stress and the endothelial transport barrier

21 January 2018

1 reference

https://api.crossref.org/works/10.1152%2FAJPHEART.00266.2013

Hypoxia enhances platelet-derived growth factor signaling in the pulmonary vasculature by down-regulation of protein tyrosine phosphatases.

21 January 2018

1 reference

https://api.crossref.org/works/10.1152%2FAJPHEART.00266.2013

Sporadic primary pulmonary hypertension is associated with germline mutations of the gene encoding BMPR-II, a receptor member of the TGF-beta family

21 January 2018

1 reference

https://api.crossref.org/works/10.1152%2FAJPHEART.00266.2013

Differences in Caveolae Dynamics in Vascular Smooth Muscle Cells of Different Phenotypes

21 January 2018

1 reference

https://api.crossref.org/works/10.1152%2FAJPHEART.00266.2013

Caveolin-1 controls cell proliferation and cell death by suppressing expression of the inhibitor of apoptosis protein survivin.

21 January 2018

1 reference

https://api.crossref.org/works/10.1152%2FAJPHEART.00266.2013

21 January 2018

Plexogenic arteriopathy

1 reference

https://api.crossref.org/works/10.1152%2FAJPHEART.00266.2013

Caveolin is an inhibitor of platelet-derived growth factor receptor signaling

21 January 2018

1 reference

https://api.crossref.org/works/10.1152%2FAJPHEART.00266.2013

Interleukin-6 regulation of transforming growth factor (TGF)-beta receptor compartmentalization and turnover enhances TGF-beta1 signaling.

21 January 2018

1 reference

https://api.crossref.org/works/10.1152%2FAJPHEART.00266.2013

Defects in caveolin-1 cause dilated cardiomyopathy and pulmonary hypertension in knockout mice

21 January 2018

1 reference

https://api.crossref.org/works/10.1152%2FAJPHEART.00266.2013

Persistent eNOS activation secondary to caveolin-1 deficiency induces pulmonary hypertension in mice and humans through PKG nitration

21 January 2018

1 reference

https://api.crossref.org/works/10.1152%2FAJPHEART.00266.2013

Circulating Endothelial Cells

21 January 2018

1 reference

https://api.crossref.org/works/10.1152%2FAJPHEART.00266.2013

CX3C Chemokine Fractalkine in Pulmonary Arterial Hypertension

21 January 2018

1 reference

https://api.crossref.org/works/10.1152%2FAJPHEART.00266.2013

10.1152/AJPHEART.00266.2013

21 January 2018

Identifiers

DOI

1 reference

29 August 2017

1 reference