(Q54625083)

1 June 2018

title

Hypoxia enhances platelet-derived growth factor signaling in the pulmonary vasculature by down-regulation of protein tyrosine phosphatases. (English)

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1 June 2018

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2

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Norbert Weissmann

7

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Ralph T Schermuly

9

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author name string

Henrik ten Freyhaus

1

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Maike Leuchs

3

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Marius Vantler

4

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Eva M Berghausen

5

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Evren Caglayan

6

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Bhola K Dahal

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Arne Ostman

10

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Kai Kappert

11

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Stephan Rosenkranz

12

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language of work or name

English

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publication date

22 December 2010

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1 June 2018

American Journal of Respiratory and Critical Care Medicine

published in

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volume

183

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issue

8

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page(s)

1092-1102

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1 June 2018

Platelet-derived growth factor expression and function in idiopathic pulmonary arterial hypertension

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Activation of phosphatidylinositol 3-kinase, Akt, and mammalian target of rapamycin is necessary for hypoxia-induced pulmonary artery adventitial fibroblast proliferation

21 January 2018

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Identification of the receptor-associated signaling enzymes that are required for platelet-derived growth factor-AA-dependent chemotaxis and DNA synthesis

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Novel Nox inhibitor VAS2870 attenuates PDGF-dependent smooth muscle cell chemotaxis, but not proliferation.

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Phosphatidylinositol 3-kinase-dependent membrane recruitment of Rac-1 and p47phox is critical for alpha-platelet-derived growth factor receptor-induced production of reactive oxygen species

21 January 2018

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Functional blockade of platelet-derived growth factor receptor-beta but not of receptor-alpha prevents vascular smooth muscle cell accumulation in fibrous cap lesions in apolipoprotein E-deficient mice

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Cardiotoxicity of the cancer therapeutic agent imatinib mesylate.

21 January 2018

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Tyrosine phosphatases in vessel wall signaling

21 January 2018

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Increased insulin sensitivity and obesity resistance in mice lacking the protein tyrosine phosphatase-1B gene

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Site-selective regulation of platelet-derived growth factor beta receptor tyrosine phosphorylation by T-cell protein tyrosine phosphatase

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The protein-tyrosine phosphatase DEP-1 modulates growth factor-stimulated cell migration and cell-matrix adhesion

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Regulation of platelet-derived growth factor receptor activation by afadin through SHP-2: implications for cellular morphology.

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An extracellular ligand increases the specific activity of the receptor-like protein tyrosine phosphatase DEP-1.

21 January 2018

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Systematic evaluation of anti-apoptotic growth factor signaling in vascular smooth muscle cells. Only phosphatidylinositol 3'-kinase is important

21 January 2018

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Dynamic changes in the expression of DEP-1 and other PDGF receptor-antagonizing PTPs during onset and termination of neointima formation

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21 January 2018

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Heterotrimeric G proteins and the platelet-derived growth factor receptor-beta contribute to hypoxic proliferation of smooth muscle cells

21 January 2018

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The 5-HT transporter transactivates the PDGFbeta receptor in pulmonary artery smooth muscle cells.

21 January 2018

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Smooth muscle cells isolated from discrete compartments of the mature vascular media exhibit unique phenotypes and distinct growth capabilities.

21 January 2018

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Addition of nitric oxide to oxygen improves cardiopulmonary function in patients with severe COPD.

21 January 2018

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Protein-tyrosine phosphatases and cancer

21 January 2018

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A brake becomes an accelerator: PTP1B--a new therapeutic target for breast cancer.

21 January 2018

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21 January 2018

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21 January 2018

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21 January 2018

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A phase II multicenter, randomized, double-blind, safety trial assessing the pharmacokinetics, pharmacodynamics, and efficacy of oral 2-methoxyestradiol capsules in hormone-refractory prostate cancer

21 January 2018

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2-Methoxyestradiol mediates the protective effects of estradiol in monocrotaline-induced pulmonary hypertension.

21 January 2018

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Imatinib for the treatment of pulmonary arterial hypertension

21 January 2018

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Counter-regulatory function of protein tyrosine phosphatase 1B in platelet-derived growth factor- or fibroblast growth factor-induced motility and proliferation of cultured smooth muscle cells and in neointima formation

21 January 2018

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10.1164/RCCM.200911-1663OC

21 January 2018

Identifiers

DOI

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1 June 2018

PubMed ID

21177885

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1 June 2018