(Q38155902)

29 August 2017

title

H2AX a promising biomarker for lung cancer: a review (English)

1 reference

29 August 2017

0 references

1 reference

4

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:24164298%20AND%20SRC:MED&resulttype=core&format=json

3 June 2020

author name string

D Matthaios

1

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:24164298%20AND%20SRC:MED&resulttype=core&format=json

3 June 2020

P Hountis

2

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:24164298%20AND%20SRC:MED&resulttype=core&format=json

3 June 2020

P Karakitsos

3

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:24164298%20AND%20SRC:MED&resulttype=core&format=json

3 June 2020

S Kakolyris

5

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:24164298%20AND%20SRC:MED&resulttype=core&format=json

3 June 2020

publication date

1 November 2013

1 reference

29 August 2017

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:24164298%20AND%20SRC:MED&resulttype=core&format=json

3 June 2020

volume

31

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:24164298%20AND%20SRC:MED&resulttype=core&format=json

3 June 2020

issue

9

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:24164298%20AND%20SRC:MED&resulttype=core&format=json

3 June 2020

page(s)

582-599

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:24164298%20AND%20SRC:MED&resulttype=core&format=json

Global cancer statistics, 2002

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MDC1 directly binds phosphorylated histone H2AX to regulate cellular responses to DNA double-strand breaks

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Phospho-dependent interactions between NBS1 and MDC1 mediate chromatin retention of the MRN complex at sites of DNA damage

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Protein phosphatase 6 interacts with the DNA-dependent protein kinase catalytic subunit and dephosphorylates gamma-H2AX.

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MDC1 regulates intra-S-phase checkpoint by targeting NBS1 to DNA double-strand breaks

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RNF8 transduces the DNA-damage signal via histone ubiquitylation and checkpoint protein assembly

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gammaH2AX and MDC1: anchoring the DNA-damage-response machinery to broken chromosomes

21 January 2018

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MCPH1 functions in an H2AX-dependent but MDC1-independent pathway in response to DNA damage

21 January 2018

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Phosphorylation of H2AX at short telomeres in T cells and fibroblasts

21 January 2018

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Heterochromatin is refractory to gamma-H2AX modification in yeast and mammals

21 January 2018

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Telomere maintenance and DNA damage responses during lung carcinogenesis.

21 January 2018

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Telomere length, telomeric proteins and DNA damage repair proteins are differentially expressed between primary lung tumors and their adrenal metastases

21 January 2018

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Involvement of the TIP60 histone acetylase complex in DNA repair and apoptosis

21 January 2018

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Histone acetylation by Trrap-Tip60 modulates loading of repair proteins and repair of DNA double-strand breaks

21 January 2018

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DNA damage-dependent acetylation and ubiquitination of H2AX enhances chromatin dynamics

21 January 2018

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The INO80 chromatin remodeling complex in transcription, replication and repair

21 January 2018

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ATM and DNA-PK function redundantly to phosphorylate H2AX after exposure to ionizing radiation

21 January 2018

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Histone H2AX stabilizes broken DNA strands to suppress chromosome breaks and translocations during V(D)J recombination

21 January 2018

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MRE11-RAD50-NBS1 complex dictates DNA repair independent of H2AX.

21 January 2018

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Control of sister chromatid recombination by histone H2AX.

21 January 2018

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Conditional gene targeted deletion by Cre recombinase demonstrates the requirement for the double-strand break repair Mre11 protein in murine embryonic stem cells

21 January 2018

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Targeted mutations of breast cancer susceptibility gene homologs in mice: lethal phenotypes of Brca1, Brca2, Brca1/Brca2, Brca1/p53, and Brca2/p53 nullizygous embryos

21 January 2018

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Embryonic lethality and radiation hypersensitivity mediated by Rad51 in mice lacking Brca2

21 January 2018

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Inactivation of CtIP leads to early embryonic lethality mediated by G1 restraint and to tumorigenesis by haploid insufficiency

21 January 2018

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Targeted disruption of the Rad51 gene leads to lethality in embryonic mice

21 January 2018

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Pleiotropic defects in ataxia-telangiectasia protein-deficient mice

21 January 2018

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MDC1 is a mediator of the mammalian DNA damage checkpoint

21 January 2018

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Counterbalance between RB inactivation and miR-17-92 overexpression in reactive oxygen species and DNA damage induction in lung cancers

21 January 2018

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Replication stress, defective S-phase checkpoint and increased death in Plk2-deficient human cancer cells

21 January 2018

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Microelectrophoretic study of radiation-induced DNA damages in individual mammalian cells

21 January 2018

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Modelling the comet assay.

21 January 2018

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Cytometric assessment of DNA damage in relation to cell cycle phase and apoptosis

21 January 2018

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Detection of DNA strand breaks by flow and laser scanning cytometry in studies of apoptosis and cell proliferation (DNA replication).

21 January 2018

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An optimized method for detecting gamma-H2AX in blood cells reveals a significant interindividual variation in the gamma-H2AX response among humans

21 January 2018

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High throughput evaluation of gamma-H2AX.

21 January 2018

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The RABiT: a rapid automated biodosimetry tool for radiological triage. II. Technological developments

21 January 2018

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Monitoring drug-induced gammaH2AX as a pharmacodynamic biomarker in individual circulating tumor cells

21 January 2018

1 reference

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Adduct-specific monoclonal antibodies for the measurement of cisplatin-induced DNA lesions in individual cell nuclei

21 January 2018

1 reference

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Repair capacity for platinum-DNA adducts determines the severity of cisplatin-induced peripheral neuropathy

21 January 2018

1 reference

https://api.crossref.org/works/10.3109%2F07357907.2013.849721

ATR-Chk2 signaling in p53 activation and DNA damage response during cisplatin-induced apoptosis

21 January 2018

1 reference

https://api.crossref.org/works/10.3109%2F07357907.2013.849721

Chronic cisplatin treatment promotes enhanced damage repair and tumor progression in a mouse model of lung cancer

21 January 2018

1 reference

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Platinum resistance: the role of DNA repair pathways

21 January 2018

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Cellular processing of platinum anticancer drugs

21 January 2018

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Enhancement of cisplatin [cis-diammine dichloroplatinum (II)] cytotoxicity by O6-benzylguanine involves endoplasmic reticulum stress

21 January 2018

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Downregulation of XPF-ERCC1 enhances cisplatin efficacy in cancer cells.

21 January 2018

1 reference

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Insulin-like growth factor-1 attenuates cisplatin-induced gammaH2AX formation and DNA double-strand breaks repair pathway in non-small cell lung cancer

21 January 2018

1 reference

https://api.crossref.org/works/10.3109%2F07357907.2013.849721

Marked anti-tumour activity of the combination of YM155, a novel survivin suppressant, and platinum-based drugs

21 January 2018

1 reference

https://api.crossref.org/works/10.3109%2F07357907.2013.849721

Spectrum of cellular responses to pyriplatin, a monofunctional cationic antineoplastic platinum(II) compound, in human cancer cells

21 January 2018

1 reference

https://api.crossref.org/works/10.3109%2F07357907.2013.849721

NPRL2 sensitizes human non-small cell lung cancer (NSCLC) cells to cisplatin treatment by regulating key components in the DNA repair pathway

21 January 2018

1 reference

https://api.crossref.org/works/10.3109%2F07357907.2013.849721

Obtusilactone A and (-)-sesamin induce apoptosis in human lung cancer cells by inhibiting mitochondrial Lon protease and activating DNA damage checkpoints.

21 January 2018

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Inhibition of inflammation and carcinogenesis in the lung and colon by tocopherols

21 January 2018

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A gamma-tocopherol-rich mixture of tocopherols inhibits chemically induced lung tumorigenesis in A/J mice and xenograft tumor growth

21 January 2018

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Pro-oxidative activities and dose-response relationship of (-)-epigallocatechin-3-gallate in the inhibition of lung cancer cell growth: a comparative study in vivo and in vitro

21 January 2018

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Resveratrol induces senescence-like growth inhibition of U-2 OS cells associated with the instability of telomeric DNA and upregulation of BRCA1.

21 January 2018

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Activation of the DNA damage checkpoint and genomic instability in human precancerous lesions

21 January 2018

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DNA damage response as a candidate anti-cancer barrier in early human tumorigenesis

21 January 2018

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Depletion of CHK1, but not CHK2, induces chromosomal instability and breaks at common fragile sites.

21 January 2018

1 reference

https://api.crossref.org/works/10.3109%2F07357907.2013.849721

Fhit loss in lung preneoplasia: relation to DNA damage response checkpoint activation

21 January 2018

1 reference

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Molecular analysis of a multistep lung cancer model induced by chronic inflammation reveals epigenetic regulation of p16 and activation of the DNA damage response pathway

21 January 2018

1 reference

https://api.crossref.org/works/10.3109%2F07357907.2013.849721

Novel genotoxicity assays identify norethindrone to activate p53 and phosphorylate H2AX.

21 January 2018

1 reference

https://api.crossref.org/works/10.3109%2F07357907.2013.849721

Water soluble fraction of solar-simulated light-exposed crude oil generates phosphorylation of histone H2AX in human skin cells under UVA exposure.

21 January 2018

1 reference

https://api.crossref.org/works/10.3109%2F07357907.2013.849721

Cigarette sidestream smoke induces phosphorylated histone H2AX.

21 January 2018

1 reference

https://api.crossref.org/works/10.3109%2F07357907.2013.849721

DNA damage response induced by exposure of human lung adenocarcinoma cells to smoke from tobacco- and nicotine-free cigarettes

21 January 2018

1 reference

https://api.crossref.org/works/10.3109%2F07357907.2013.849721

DNA damage response induced by tobacco smoke in normal human bronchial epithelial and A549 pulmonary adenocarcinoma cells assessed by laser scanning cytometry

21 January 2018

1 reference

https://api.crossref.org/works/10.3109%2F07357907.2013.849721

DNA double-strand breaks by asbestos, silica, and titanium dioxide

21 January 2018

1 reference

https://api.crossref.org/works/10.3109%2F07357907.2013.849721

Diminished carcinogen detoxification is a novel mechanism for hypoxia-inducible factor 1-mediated genetic instability

21 January 2018

1 reference

https://api.crossref.org/works/10.3109%2F07357907.2013.849721

Expression of glutathione S-transferase M2 in stage I/II non-small cell lung cancer and alleviation of DNA damage exposure to benzo[a]pyrene

21 January 2018

1 reference

https://api.crossref.org/works/10.3109%2F07357907.2013.849721

Kinetics of the UV-induced DNA damage response in relation to cell cycle phase. Correlation with DNA replication

21 January 2018

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H2AX phosphorylation after UV irradiation is triggered by DNA repair intermediates and is mediated by the ATR kinase.

21 January 2018

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Radiation-induced gamma-H2AX in mammalian cells irradiated with a synchrotron X-ray microbeam.

21 January 2018

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Phosphorylation of histone H2AX and activation of Mre11, Rad50, and Nbs1 in response to replication-dependent DNA double-strand breaks induced by mammalian DNA topoisomerase I cleavage complexes.

21 January 2018

1 reference

https://api.crossref.org/works/10.3109%2F07357907.2013.849721

Comparison of checkpoint responses triggered by DNA polymerase inhibition versus DNA damaging agents

21 January 2018

1 reference

https://api.crossref.org/works/10.3109%2F07357907.2013.849721

Short-term culture and gammaH2AX flow cytometry determine differences in individual radiosensitivity in human peripheral T lymphocytes.

21 January 2018

1 reference

https://api.crossref.org/works/10.3109%2F07357907.2013.849721

Candidate protein biodosimeters of human exposure to ionizing radiation.

21 January 2018

1 reference

https://api.crossref.org/works/10.3109%2F07357907.2013.849721

Kinetics of H2AX phosphorylation after exposure to cisplatin

21 January 2018

1 reference

https://api.crossref.org/works/10.3109%2F07357907.2013.849721

Kinetics of histone H2AX phosphorylation and Chk2 activation in A549 cells treated with topotecan and mitoxantrone in relation to the cell cycle phase

21 January 2018

1 reference

https://api.crossref.org/works/10.3109%2F07357907.2013.849721

Inhibition of REV3 expression induces persistent DNA damage and growth arrest in cancer cells

21 January 2018

1 reference

https://api.crossref.org/works/10.3109%2F07357907.2013.849721

Downregulation of peroxiredoxin V stimulates formation of etoposide-induced double-strand DNA breaks

21 January 2018

1 reference

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Gefitinib radiosensitizes non-small cell lung cancer cells by suppressing cellular DNA repair capacity

21 January 2018

1 reference

https://api.crossref.org/works/10.3109%2F07357907.2013.849721

Preclinical evidence for a beneficial impact of valproate on the response of small cell lung cancer to first-line chemotherapy

21 January 2018

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https://api.crossref.org/works/10.3109%2F07357907.2013.849721

Opposite expression of securin and γ-H2AX regulates baicalein-induced cancer cell death

21 January 2018

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https://api.crossref.org/works/10.3109%2F07357907.2013.849721

Evidence for the involvement of double-strand breaks in heat-induced cell killing.

21 January 2018

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https://api.crossref.org/works/10.3109%2F07357907.2013.849721

Chromatin-associated proteins HMGB1/2 and PDIA3 trigger cellular response to chemotherapy-induced DNA damage

21 January 2018

1 reference

https://api.crossref.org/works/10.3109%2F07357907.2013.849721

Synthesis and biological evaluation of 4β-acrylamidopodophyllotoxin congeners as DNA damaging agents

21 January 2018

1 reference

https://api.crossref.org/works/10.3109%2F07357907.2013.849721

Vorinostat increases carboplatin and paclitaxel activity in non-small-cell lung cancer cells

21 January 2018

1 reference

https://api.crossref.org/works/10.3109%2F07357907.2013.849721

miR-181a and miR-630 regulate cisplatin-induced cancer cell death

21 January 2018

1 reference

https://api.crossref.org/works/10.3109%2F07357907.2013.849721

Activation of DNA damage response signaling in lung adenocarcinoma A549 cells following oxygen beam irradiation

21 January 2018

1 reference

https://api.crossref.org/works/10.3109%2F07357907.2013.849721

DNA damage response signaling in lung adenocarcinoma A549 cells following gamma and carbon beam irradiation.

21 January 2018

1 reference

https://api.crossref.org/works/10.3109%2F07357907.2013.849721

DNA damage intensity in fibroblasts in a 3-dimensional collagen matrix correlates with the Bragg curve energy distribution of a high LET particle

21 January 2018

1 reference

https://api.crossref.org/works/10.3109%2F07357907.2013.849721

Sustained metaphase arrest in response to ionizing radiation in a non-small cell lung cancer cell line

21 January 2018

1 reference

https://api.crossref.org/works/10.3109%2F07357907.2013.849721

Targeting of Rad51-dependent homologous recombination: implications for the radiation sensitivity of human lung cancer cell lines

21 January 2018

1 reference

https://api.crossref.org/works/10.3109%2F07357907.2013.849721

Adenoviral-mediated PTEN expression radiosensitizes non-small cell lung cancer cells by suppressing DNA repair capacity

21 January 2018

1 reference

https://api.crossref.org/works/10.3109%2F07357907.2013.849721

Comparison of RBE values of high-LET α-particles for the induction of DNA-DSBs, chromosome aberrations and cell reproductive death.

21 January 2018

1 reference

https://api.crossref.org/works/10.3109%2F07357907.2013.849721

Albendazole sensitizes cancer cells to ionizing radiation.

21 January 2018

1 reference

https://api.crossref.org/works/10.3109%2F07357907.2013.849721

Intranuclear delivery of a novel antibody-derived radiosensitizer targeting the DNA-dependent protein kinase catalytic subunit

21 January 2018

1 reference

https://api.crossref.org/works/10.3109%2F07357907.2013.849721

Histone deacetylase (HDAC) inhibitor LBH589 increases duration of gamma-H2AX foci and confines HDAC4 to the cytoplasm in irradiated non-small cell lung cancer

21 January 2018

1 reference

https://api.crossref.org/works/10.3109%2F07357907.2013.849721

Histone deacetylase inhibitor NVP-LAQ824 sensitizes human nonsmall cell lung cancer to the cytotoxic effects of ionizing radiation

21 January 2018

1 reference

https://api.crossref.org/works/10.3109%2F07357907.2013.849721

Histone deacetylase inhibitors enhance phosphorylation of histone H2AX after ionizing radiation

21 January 2018

1 reference

https://api.crossref.org/works/10.3109%2F07357907.2013.849721

Identification and biological evaluation of a novel and potent small molecule radiation sensitizer via an unbiased screen of a chemical library

21 January 2018

1 reference

https://api.crossref.org/works/10.3109%2F07357907.2013.849721

Downregulation of peroxiredoxin I by a novel fully human phage display recombinant antibody induces apoptosis and enhances radiation sensitization in A549 lung carcinoma cells

21 January 2018

1 reference

https://api.crossref.org/works/10.3109%2F07357907.2013.849721

gamma-H2AX in bystander cells: not just a radiation-triggered event, a cellular response to stress mediated by intercellular communication

21 January 2018

1 reference

https://api.crossref.org/works/10.3109%2F07357907.2013.849721

Evidence of an Adaptive Response Targeting DNA Nonhomologous End Joining and Its Transmission to Bystander Cells

21 January 2018

1 reference

https://api.crossref.org/works/10.3109%2F07357907.2013.849721

Targeting the DNA repair defect in BRCA mutant cells as a therapeutic strategy

21 January 2018

1 reference

https://api.crossref.org/works/10.3109%2F07357907.2013.849721

Interaction between ATM and PARP-1 in response to DNA damage and sensitization of ATM deficient cells through PARP inhibition

21 January 2018

1 reference

https://api.crossref.org/works/10.3109%2F07357907.2013.849721

Inhibition of poly(ADP-ribose) polymerase enhances cell death and improves tumor growth delay in irradiated lung cancer models

21 January 2018

1 reference

https://api.crossref.org/works/10.3109%2F07357907.2013.849721

Development of a functional assay for homologous recombination status in primary cultures of epithelial ovarian tumor and correlation with sensitivity to poly(ADP-ribose) polymerase inhibitors.

21 January 2018

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Histone γH2AX and Poly(ADP-Ribose) as Clinical Pharmacodynamic Biomarkers

21 January 2018

1 reference

https://api.crossref.org/works/10.3109%2F07357907.2013.849721

Inhibition of poly(ADP-ribose) polymerase in tumors from BRCA mutation carriers

21 January 2018

1 reference

https://api.crossref.org/works/10.3109%2F07357907.2013.849721

Preclinical modeling of a phase 0 clinical trial: qualification of a pharmacodynamic assay of poly (ADP-ribose) polymerase in tumor biopsies of mouse xenografts

21 January 2018

1 reference

https://api.crossref.org/works/10.3109%2F07357907.2013.849721

Phase I study of the poly(ADP-ribose) polymerase inhibitor, AG014699, in combination with temozolomide in patients with advanced solid tumors.

21 January 2018

1 reference

https://api.crossref.org/works/10.3109%2F07357907.2013.849721

Identification and characterization of a novel and specific inhibitor of the ataxia-telangiectasia mutated kinase ATM

21 January 2018

1 reference

https://api.crossref.org/works/10.3109%2F07357907.2013.849721

gamma-H2AX as a therapeutic target for improving the efficacy of radiation therapy.

21 January 2018

1 reference

https://api.crossref.org/works/10.3109%2F07357907.2013.849721

Endogenous expression of phosphorylated histone H2AX in tumors in relation to DNA double-strand breaks and genomic instability.

21 January 2018

1 reference

https://api.crossref.org/works/10.3109%2F07357907.2013.849721

γ-H2AX expression detected by immunohistochemistry correlates with prognosis in early operable non-small cell lung cancer.

21 January 2018

1 reference

https://api.crossref.org/works/10.3109%2F07357907.2013.849721

Immunofluorescence Detection of Clustered γ-H2AX Foci Induced by HZE-Particle Radiation

21 January 2018

1 reference

https://api.crossref.org/works/10.3109%2F07357907.2013.849721