(Q38166683)

30 August 2017

title

Acetaldehyde and the genome: beyond nuclear DNA adducts and carcinogenesis (English)

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30 August 2017

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ChEBI release 2020-05-28

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Philip J Brooks

1

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30 August 2017

Samir Zakhari

series ordinal

2

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30 August 2017

language of work or name

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27 November 2013

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Environmental and Molecular Mutagenesis

30 August 2017

published in

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30 August 2017

volume

55

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30 August 2017

issue

2

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30 August 2017

page(s)

77-91

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Alcohol metabolism in human cells causes DNA damage and activates the Fanconi anemia-breast cancer susceptibility (FA-BRCA) DNA damage response network

30 August 2017

cites work

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Deciphering signatures of mutational processes operative in human cancer

21 January 2018

1 reference

Fanconi anemia and its diagnosis

21 January 2018

1 reference

N2-ethyldeoxyguanosine as a potential biomarker for assessing effects of alcohol consumption on DNA.

21 January 2018

1 reference

Kinetics of DNA adduct formation in the oral cavity after drinking alcohol.

21 January 2018

1 reference

Towards systematic functional characterization of cancer genomes

21 January 2018

1 reference

The alcohol flushing response: an unrecognized risk factor for esophageal cancer from alcohol consumption

21 January 2018

1 reference

DNA adducts from acetaldehyde: implications for alcohol-related carcinogenesis

21 January 2018

1 reference

Identification of somatically acquired rearrangements in cancer using genome-wide massively parallel paired-end sequencing

21 January 2018

1 reference

Activation of aldehyde dehydrogenase-2 reduces ischemic damage to the heart

21 January 2018

1 reference

Volatile flavor compounds in yogurt: a review

21 January 2018

1 reference

Differential blocking effects of the acetaldehyde-derived DNA lesion N2-ethyl-2'-deoxyguanosine on transcription by multisubunit and single subunit RNA polymerases

21 January 2018

1 reference

Stereospecific formation of interstrand carbinolamine DNA cross-links by crotonaldehyde- and acetaldehyde-derived alpha-CH3-gamma-OH-1,N2-propano-2'-deoxyguanosine adducts in the 5'-CpG-3' sequence

21 January 2018

1 reference

Translesion synthesis across bulky N2-alkyl guanine DNA adducts by human DNA polymerase kappa

21 January 2018

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Adduct size limits efficient and error-free bypass across bulky N2-guanine DNA lesions by human DNA polymerase eta.

21 January 2018

1 reference

Kinetic analysis of translesion synthesis opposite bulky N2- and O6-alkylguanine DNA adducts by human DNA polymerase REV1.

21 January 2018

1 reference

Translesion synthesis across 1,N2-ethenoguanine by human DNA polymerases

21 January 2018

1 reference

Repair kinetics of trans-4-hydroxynonenal-induced cyclic 1,N2-propanodeoxyguanine DNA adducts by human cell nuclear extracts

21 January 2018

1 reference

Cancer in xeroderma pigmentosum and related disorders of DNA repair

21 January 2018

1 reference

Overview of the role of alcohol dehydrogenase and aldehyde dehydrogenase and their variants in the genesis of alcohol-related pathology

21 January 2018

2 references

21 January 2018

7 January 2021

Conserved structural motifs governing the stoichiometric repair of alkylated DNA by O(6)-alkylguanine-DNA alkyltransferase

1 reference

AlkB reverses etheno DNA lesions caused by lipid oxidation in vitro and in vivo

21 January 2018

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Exome and whole-genome sequencing of esophageal adenocarcinoma identifies recurrent driver events and mutational complexity

21 January 2018

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In vitro and in vivo inhibitory effect of ethanol and acetaldehyde on O6-methylguanine transferase

21 January 2018

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Mammalian cell mutagenesis of the DNA adducts of vinyl chloride and crotonaldehyde

21 January 2018

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Genotoxic consequences of endogenous aldehydes on mouse haematopoietic stem cell function

21 January 2018

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[13C2]-Acetaldehyde promotes unequivocal formation of 1,N2-propano-2'-deoxyguanosine in human cells

21 January 2018

1 reference

Ethanol consumption inhibits fetal DNA methylation in mice: implications for the fetal alcohol syndrome

21 January 2018

1 reference

EUKARYOTIC CYTOSINE METHYLTRANSFERASES

21 January 2018

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Aristolochic acid and the etiology of endemic (Balkan) nephropathy

21 January 2018

1 reference

Specific recognition of O6-methylguanine in DNA by active site mutants of human O6-methylguanine-DNA methyltransferase

21 January 2018

1 reference

Purification of all forms of HeLa cell mitochondrial DNA and assessment of damage to it caused by hydrogen peroxide treatment of mitochondria or cells.

21 January 2018

1 reference

Mutational signature of aristolochic acid exposure as revealed by whole-exome sequencing

21 January 2018

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Role of mismatch-specific uracil-DNA glycosylase in repair of 3,N4-ethenocytosine in vivo.

21 January 2018

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A spectrum of mutations induced by crotonaldehyde in shuttle vector plasmids propagated in human cells

21 January 2018

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Demethylation of 3-methylthymine in DNA by bacterial and human DNA dioxygenases

21 January 2018

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Genotoxicity of alcohol is linked to DNA replication-associated damage and homologous recombination repair.

21 January 2018

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Cytotoxicity, thiol depletion and inhibition of O6-methylguanine-DNA methyltransferase by various aldehydes in cultured human bronchial fibroblasts

21 January 2018

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Mutations induced in the hypoxanthine phosphoribosyl transferase gene by three urban air pollutants: acetaldehyde, benzo[a]pyrene diolepoxide, and ethylene oxide

21 January 2018

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Fancd2 counteracts the toxic effects of naturally produced aldehydes in mice

21 January 2018

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The mutation spectrum revealed by paired genome sequences from a lung cancer patient

21 January 2018

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Histone H3 phosphorylation at serine 10 and serine 28 is mediated by p38 MAPK in rat hepatocytes exposed to ethanol and acetaldehyde

21 January 2018

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Enzymatic breakdown of threonine by threonine aldolase

21 January 2018

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Instability and decay of the primary structure of DNA

21 January 2018

1 reference

Toll-like receptor 4 mediates synergism between alcohol and HCV in hepatic oncogenesis involving stem cell marker Nanog

21 January 2018

1 reference

Chloroacetaldehyde-induced mutagenesis in Escherichia coli: the role of AlkB protein in repair of 3,N(4)-ethenocytosine and 3,N(4)-alpha-hydroxyethanocytosine

21 January 2018

1 reference

Duplex DNA catalyzes the chemical rearrangement of a malondialdehyde deoxyguanosine adduct

21 January 2018

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Acetaldehyde stimulates FANCD2 monoubiquitination, H2AX phosphorylation, and BRCA1 phosphorylation in human cells in vitro: implications for alcohol-related carcinogenesis

21 January 2018

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Specific tandem GG to TT base substitutions induced by acetaldehyde are due to intra-strand crosslinks between adjacent guanine bases

21 January 2018

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Increased DNA damage in ALDH2-deficient alcoholics.

21 January 2018

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Ethanol-mediated carcinogenesis in the human esophagus implicates CYP2E1 induction and the generation of carcinogenic DNA-lesions

21 January 2018

1 reference

Chemistry and biology of DNA containing 1,N(2)-deoxyguanosine adducts of the alpha,beta-unsaturated aldehydes acrolein, crotonaldehyde, and 4-hydroxynonenal

21 January 2018

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Mutagenic potency of exocyclic DNA adducts: marked differences between Escherichia coli and simian kidney cells

21 January 2018

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Dosimetry, toxicity and carcinogenicity of inspired acetaldehyde in the rat.

21 January 2018

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Impairment of histone H1 DNA binding by adduct formation with acetaldehyde

21 January 2018

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Mutational spectrum induced by acetaldehyde in the HPRT gene of human T lymphocytes resembles that in the p53 gene of esophageal cancers

21 January 2018

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Acetaldehyde-induced mutational pattern in the tumour suppressor gene TP53 analysed by use of a functional assay, the FASAY (functional analysis of separated alleles in yeast).

21 January 2018

1 reference

Bypass of N²-ethylguanine by human DNA polymerase κ.

21 January 2018

1 reference

Lesion Bypass of N2-Ethylguanine by Human DNA Polymerase ι

21 January 2018

1 reference

Alda-1 is an agonist and chemical chaperone for the common human aldehyde dehydrogenase 2 variant

21 January 2018

1 reference

Next-generation sequencing: emerging lessons on the origins of human cancer

21 January 2018

1 reference

A comprehensive catalogue of somatic mutations from a human cancer genome

21 January 2018

1 reference

A small-cell lung cancer genome with complex signatures of tobacco exposure

21 January 2018

1 reference

Genome-wide mutational signatures of aristolochic acid and its application as a screening tool

21 January 2018

1 reference

Histones accelerate the cyclic 1, N 2 -propanoguanine adduct-formation of DNA by the primary metabolite of alcohol and carcinogenic crotonaldehyde

21 January 2018

1 reference

A review of human carcinogens--Part E: tobacco, areca nut, alcohol, coal smoke, and salted fish

21 January 2018

1 reference

Molecular mechanisms of alcohol-mediated carcinogenesis

21 January 2018

1 reference

Alcohol-induced alterations in hepatic microtubule dynamics can be explained by impaired histone deacetylase 6 function

21 January 2018

1 reference

Genotoxicity of acetaldehyde- and crotonaldehyde-induced 1,N2-propanodeoxyguanosine DNA adducts in human cells

21 January 2018

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Identification of 67 histone marks and histone lysine crotonylation as a new type of histone modification

21 January 2018

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Polyamines stimulate the formation of mutagenic 1,N2-propanodeoxyguanosine adducts from acetaldehyde

21 January 2018

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Cellular and molecular consequences of defective Fanconi anemia proteins in replication-coupled DNA repair: mechanistic insights

21 January 2018

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Application of LC-TOF MS to analysis of hemoglobin acetaldehyde adducts in alcohol detoxification patients

21 January 2018

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Replication of N2-ethyldeoxyguanosine DNA adducts in the human embryonic kidney cell line 293.

21 January 2018

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Time- and concentration-dependent increases in cell proliferation in rats and mice administered vinyl acetate in drinking water

21 January 2018

1 reference

Xeroderma pigmentosum and the role of UV-induced DNA damage in skin cancer.

21 January 2018

1 reference

Identification of DNA adducts of acetaldehyde.

21 January 2018

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Identification of an acetaldehyde adduct in human liver DNA and quantitation as N2-ethyldeoxyguanosine

21 January 2018

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Ethanol-induced cytochrome P4502E1 causes carcinogenic etheno-DNA lesions in alcoholic liver disease

21 January 2018

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Acute ethanol exposure suppresses the repair of O6-methylguanine DNA lesions in castrated adult male rats.

21 January 2018

1 reference

Molecular mechanisms of sister-chromatid exchange

21 January 2018

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Environmental and chemical carcinogenesis

21 January 2018

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The mutation in the mitochondrial aldehyde dehydrogenase (ALDH2) gene responsible for alcohol-induced flushing increases turnover of the enzyme tetramers in a dominant fashion

21 January 2018

1 reference

Genetic polymorphisms of alcohol and aldehyde dehydrogenases and risk for esophageal and head and neck cancers

21 January 2018

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Molecular abnormality of an inactive aldehyde dehydrogenase variant commonly found in Orientals

21 January 2018

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Mutagenicity of site-specifically located 1,N2-ethenoguanine in Chinese hamster ovary cell chromosomal DNA

21 January 2018

1 reference

7 January 2021

Aldehyde dehydrogenase deficiency as cause of facial flushing reaction to alcohol in Japanese

1 reference

7 January 2021

Screening patients for heterozygous p53 mutations using a functional assay in yeast

1 reference

7 January 2021

trans,trans-2,4-decadienal-induced 1,N(2)-etheno-2'-deoxyguanosine adduct formation

1 reference

7 January 2021

Increased formation of hepatic N2-ethylidene-2'-deoxyguanosine DNA adducts in aldehyde dehydrogenase 2-knockout mice treated with ethanol

1 reference

7 January 2021

Induction of chromosomal aberrations in peripheral lymphocytes of human blood in vitro, and of SCEs in bone-marrow cells of mice in vivo by ethanol and its metabolite acetaldehyde

1 reference

7 January 2021

Possible role of acetaldehyde in ethanol-related rectal cocarcinogenesis in the rat

1 reference

7 January 2021

Studies of the reaction of acetaldehyde with deoxynucleosides

1 reference

7 January 2021

Identifiers

DOI

10.1002/EM.21824

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30 August 2017

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