(Q34006340)

30 July 2017

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title

Conserved structural motifs governing the stoichiometric repair of alkylated DNA by O(6)-alkylguanine-DNA alkyltransferase (English)

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DNA dealkylation involved in DNA repair

30 July 2017

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Gene Ontology release 2020-05-02

D S Daniels

1

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30 July 2017

J A Tainer

series ordinal

2

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30 July 2017

language of work or name

English

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publication date

1 August 2000

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30 July 2017

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30 July 2017

volume

460

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30 July 2017

issue

3-4

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30 July 2017

page(s)

151-163

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Nonenzymatic methylation of DNA by the intracellular methyl group donor S-adenosyl-L-methionine is a potentially mutagenic reaction

30 July 2017

cites work

1 reference

https://api.crossref.org/works/10.1016%2FS0921-8777%2800%2900024-0

7 January 2021

Distribution of methyl and ethyl adducts following alkylation with monofunctional alkylating agents

1 reference

https://api.crossref.org/works/10.1016%2FS0921-8777%2800%2900024-0

7 January 2021

Increased killing of prostate, breast, colon, and lung tumor cells by the combination of inactivators of O6-alkylguanine-DNA alkyltransferase and N,N'-bis(2-chloroethyl)-N-nitrosourea

1 reference

https://api.crossref.org/works/10.1016%2FS0921-8777%2800%2900024-0

7 January 2021

Isolation and purification of O6-alkylguanine-DNA alkyltransferase from human leukemic cells. Prevention of chloroethylnitrosourea-induced cross-links by purified enzyme

1 reference

https://api.crossref.org/works/10.1016%2FS0921-8777%2800%2900024-0

7 January 2021

O6-methylguanine-DNA methyltransferase activity and sensitivity to cyclophosphamide and cisplatin in human lung tumor xenografts

1 reference

https://api.crossref.org/works/10.1016%2FS0921-8777%2800%2900024-0

7 January 2021

Transfection and expression of human O6-methylguanine-DNA methyltransferase (MGMT) cDNA in Chinese hamster cells: the role of MGMT in protection against the genotoxic effects of alkylating agents

1 reference

https://api.crossref.org/works/10.1016%2FS0921-8777%2800%2900024-0

7 January 2021

Structural features of substituted purine derivatives compatible with depletion of human O6-alkylguanine-DNA alkyltransferase

1 reference

https://api.crossref.org/works/10.1016%2FS0921-8777%2800%2900024-0

7 January 2021

Substituted O6-benzylguanine derivatives and their inactivation of human O6-alkylguanine-DNA alkyltransferase

1 reference

https://api.crossref.org/works/10.1016%2FS0921-8777%2800%2900024-0

7 January 2021

8-Substituted O6-benzylguanine, substituted 6(4)-(benzyloxy)pyrimidine, and related derivatives as inactivators of human O6-alkylguanine-DNA alkyltransferase.

1 reference

https://api.crossref.org/works/10.1016%2FS0921-8777%2800%2900024-0

7 January 2021

Mechanism of inactivation of human O6-alkylguanine-DNA alkyltransferase by O6-benzylguanine

1 reference

https://api.crossref.org/works/10.1016%2FS0921-8777%2800%2900024-0

7 January 2021

Phase I trial of O6-benzylguanine for patients undergoing surgery for malignant glioma

1 reference

https://api.crossref.org/works/10.1016%2FS0921-8777%2800%2900024-0

7 January 2021

Activation of human O6-methylguanine-DNA methyltransferase gene by glucocorticoid hormone

1 reference

https://api.crossref.org/works/10.1016%2FS0921-8777%2800%2900024-0

7 January 2021

Quantitation of O6-methylguanine-DNA methyltransferase in HeLa cells

1 reference

https://api.crossref.org/works/10.1016%2FS0921-8777%2800%2900024-0

7 January 2021

Positive and negative regulation of transcription by a cleavage product of Ada protein

1 reference

https://api.crossref.org/works/10.1016%2FS0921-8777%2800%2900024-0

7 January 2021

The Ada protein acts as both a positive and a negative modulator of Escherichia coli's response to methylating agents.

1 reference

https://api.crossref.org/works/10.1016%2FS0921-8777%2800%2900024-0

7 January 2021

Hyperthermostable protein structure maintained by intra and inter-helix ion-pairs in archaeal O6-methylguanine-DNA methyltransferase

1 reference

https://api.crossref.org/works/10.1016%2FS0921-8777%2800%2900024-0

7 January 2021

Active and alkylated human AGT structures: a novel zinc site, inhibitor and extrahelical base binding

1 reference

https://api.crossref.org/works/10.1016%2FS0921-8777%2800%2900024-0

7 January 2021

Crystal structure of the human O(6)-alkylguanine-DNA alkyltransferase

1 reference

https://api.crossref.org/works/10.1016%2FS0921-8777%2800%2900024-0

7 January 2021

Investigation of the role of tyrosine-114 in the activity of human O6-alkylguanine-DNA alkyltranferase

1 reference

https://api.crossref.org/works/10.1016%2FS0921-8777%2800%2900024-0

7 January 2021

Structural classification of HTH DNA-binding domains and protein-DNA interaction modes

1 reference

https://api.crossref.org/works/10.1016%2FS0921-8777%2800%2900024-0

7 January 2021

The winged-helix DNA-binding motif: another helix-turn-helix takeoff

1 reference

https://api.crossref.org/works/10.1016%2FS0921-8777%2800%2900024-0

7 January 2021

Crystal structure of a CAP-DNA complex: the DNA is bent by 90 degrees

1 reference

https://api.crossref.org/works/10.1016%2FS0921-8777%2800%2900024-0

7 January 2021

Alteration of arginine-128 to alanine abolishes the ability of human O6-alkylguanine-DNA alkyltransferase to repair methylated DNA but has no effect on its reaction with O6-benzylguanine

1 reference

https://api.crossref.org/works/10.1016%2FS0921-8777%2800%2900024-0

7 January 2021

O6-ethylguanine carcinogenic lesions in DNA: an NMR study of O6etG.C pairing in dodecanucleotide duplexes.

1 reference

https://api.crossref.org/works/10.1016%2FS0921-8777%2800%2900024-0

7 January 2021

Crystal structure of a human alkylbase-DNA repair enzyme complexed to DNA: mechanisms for nucleotide flipping and base excision

1 reference

https://api.crossref.org/works/10.1016%2FS0921-8777%2800%2900024-0

7 January 2021

A nucleotide-flipping mechanism from the structure of human uracil-DNA glycosylase bound to DNA

1 reference

https://api.crossref.org/works/10.1016%2FS0921-8777%2800%2900024-0

7 January 2021

Base excision repair initiation revealed by crystal structures and binding kinetics of human uracil-DNA glycosylase with DNA.

1 reference

https://api.crossref.org/works/10.1016%2FS0921-8777%2800%2900024-0

7 January 2021

Reaction and binding of oligodeoxynucleotides containing analogues of O6-methylguanine with wild-type and mutant human O6-alkylguanine-DNA alkyltransferase

1 reference

https://api.crossref.org/works/10.1016%2FS0921-8777%2800%2900024-0

7 January 2021

Differential inactivation of O6-methylguanine-DNA methyltransferase activity by O6-arylmethylguanines.

1 reference

https://api.crossref.org/works/10.1016%2FS0921-8777%2800%2900024-0

7 January 2021

Differential inactivation of mammalian and Escherichia coli O6-alkylguanine-DNA alkyltransferases by O6-benzylguanine

1 reference

https://api.crossref.org/works/10.1016%2FS0921-8777%2800%2900024-0

7 January 2021

Mutations in the Ada O6-alkylguanine-DNA alkyltransferase conferring sensitivity to inactivation by O6-benzylguanine and 2,4-diamino-6-benzyloxy-5-nitrosopyrimidine

1 reference

https://api.crossref.org/works/10.1016%2FS0921-8777%2800%2900024-0

7 January 2021

Role of codon 160 in the sensitivity of human O6-alkylguanine-DNA alkyltransferase to O6-benzylguanine.

1 reference

https://api.crossref.org/works/10.1016%2FS0921-8777%2800%2900024-0

7 January 2021

Point mutations at multiple sites including highly conserved amino acids maintain activity, but render O6-alkylguanine-DNA alkyltransferase insensitive to O6-benzylguanine

1 reference

https://api.crossref.org/works/10.1016%2FS0921-8777%2800%2900024-0

7 January 2021

Conserved residue lysine165 is essential for the ability of O6-alkylguanine-DNA alkyltransferase to react with O6-benzylguanine

1 reference

https://api.crossref.org/works/10.1016%2FS0921-8777%2800%2900024-0

7 January 2021

Improving enzymes for cancer gene therapy

1 reference

https://api.crossref.org/works/10.1016%2FS0921-8777%2800%2900024-0

7 January 2021

Amino acid residues affecting the activity and stability of human O6-alkylguanine-DNA alkyltransferase.

1 reference

https://api.crossref.org/works/10.1016%2FS0921-8777%2800%2900024-0

7 January 2021

Catalytic triads and their relatives

1 reference

https://api.crossref.org/works/10.1016%2FS0921-8777%2800%2900024-0

7 January 2021

Use of antibodies to human O6-alkylguanine-DNA alkyltransferase to study the content of this protein in cells treated with O6-benzylguanine or N-methyl-N'-nitro-N-nitrosoguanidine

1 reference

https://api.crossref.org/works/10.1016%2FS0921-8777%2800%2900024-0

7 January 2021

Ubiquitination-dependent proteolysis of O6-methylguanine-DNA methyltransferase in human and murine tumor cells following inactivation with O6-benzylguanine or 1,3-bis(2-chloroethyl)-1-nitrosourea

1 reference

https://api.crossref.org/works/10.1016%2FS0921-8777%2800%2900024-0

7 January 2021

O6-methylguanine methyltransferase in rat liver

1 reference

https://api.crossref.org/works/10.1016%2FS0921-8777%2800%2900024-0

7 January 2021

Probing of conformational changes in human O6-alkylguanine-DNA alkyl transferase protein in its alkylated and DNA-bound states by limited proteolysis

1 reference

https://api.crossref.org/works/10.1016%2FS0921-8777%2800%2900024-0

7 January 2021

10.1016/S0921-8777(00)00024-0

Identifiers

DOI

1 reference

30 July 2017

1 reference