(Q30650758)

25 June 2017

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title

Improving enzymes for cancer gene therapy (English)

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25 June 2017

0 references

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Encell LP

1

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25 June 2017

Landis DM

series ordinal

2

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25 June 2017

Loeb LA

series ordinal

3

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25 June 2017

publication date

1 February 1999

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25 June 2017

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25 June 2017

volume

17

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25 June 2017

issue

2

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25 June 2017

page(s)

143-147

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Creating novel enzymes by applied molecular evolution

25 June 2017

cites work

1 reference

Lymphoma regression induced by ganciclovir in mice bearing a herpes thymidine kinase transgene.

21 January 2018

1 reference

Gene transfer and the treatment of childhood cancer

21 January 2018

1 reference

Gene therapy utilizing drug resistance genes: a review

21 January 2018

1 reference

Chemoprotection of normal tissues by transfer of drug resistance genes

21 January 2018

1 reference

The chemotherapeutic exploitation of virus-specified enzymes

21 January 2018

1 reference

In Vivo Gene Transfer with Retroviral Vector-Producer Cells for Treatment of Experimental Brain Tumors

21 January 2018

1 reference

Identification of important residues within the putative nucleoside binding site of HSV-1 thymidine kinase by random sequence selection: analysis of selected mutants in vitro

21 January 2018

1 reference

Creation of drug-specific herpes simplex virus type 1 thymidine kinase mutants for gene therapy

21 January 2018

1 reference

The role of the bystander effect in suicide gene therapy

21 January 2018

1 reference

In vitro evidence that metabolic cooperation is responsible for the bystander effect observed with HSV tk retroviral gene therapy

21 January 2018

1 reference

Increasing DNA repair methyltransferase levels via bone marrow stem cell transduction rescues mice from the toxic effects of 1,3-bis(2-chloroethyl)-1-nitrosourea, a chemotherapeutic alkylating agent

21 January 2018

1 reference

Novel human DNA alkyltransferases obtained by random substitution and genetic selection in bacteria

21 January 2018

1 reference

Chemoprotective gene transfer II: multilineage in vivo protection of haemopoiesis against the effects of an antitumour agent by expression of a mutant human O6-alkylguanine-DNA alkyltransferase.

21 January 2018

1 reference

Isolation and characterization of thymitaq (AG337) and 5-fluoro-2-deoxyuridylate-resistant mutants of human thymidylate synthase from ethyl methanesulfonate-exposed human sarcoma HT1080 cells

21 January 2018

1 reference

Random sequence mutagenesis and resistance to 5-fluorouridine in human thymidylate synthases

21 January 2018

1 reference

Probing the folate-binding site of human thymidylate synthase by site-directed mutagenesis. Generation of mutants that confer resistance to raltitrexed, Thymitaq, and BW1843U89.

21 January 2018

1 reference

Isolation and characterization of a variant dihydrofolate reductase cDNA from methotrexate-resistant murine L5178Y cells

21 January 2018

1 reference

Protection of bone marrow transplant recipients from lethal doses of methotrexate by the generation of methotrexate-resistant bone marrow

21 January 2018

1 reference

Co-expression of the herpes simplex virus thymidine kinase gene potentiates methotrexate resistance conferred by transfer of a mutated dihydrofolate reductase gene

21 January 2018

1 reference

Forced evolution of glutathione S-transferase to create a more efficient drug detoxication enzyme.

21 January 2018

1 reference

Promoters selected from random DNA sequences

21 January 2018

1 reference

Detection and characterization of mammalian DNA polymerase beta mutants by functional complementation in Escherichia coli

21 January 2018

1 reference

Rapid evolution of a protein in vitro by DNA shuffling

21 January 2018

1 reference

Functional and nonfunctional mutations distinguished by random recombination of homologous genes

21 January 2018

1 reference

The role of human cytochrome P450 enzymes in the metabolism of anticancer agents: implications for drug interactions

21 January 2018

1 reference

Interaction of anticancer drugs with hepatic monooxygenase enzymes

21 January 2018

1 reference

Thymidylate synthase: a target for anticancer drug design

21 January 2018

1 reference

inferred from DOI database lookup

7 January 2021

based on heuristic

Post-transplant methotrexate administration leads to improved curability of mice bearing a mammary tumor transplanted with marrow transduced with a mutant human dihydrofolate reductase cDNA

1 reference

inferred from DOI database lookup

7 January 2021

based on heuristic

1 reference

inferred from DOI database lookup

7 January 2021

based on heuristic

Identifiers

DOI

10.1038/6142

1 reference

25 June 2017

1 reference