(Q38169718)

30 August 2017

title

Immunological functions of the neuropilins and plexins as receptors for semaphorins (English)

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30 August 2017

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Atsushi Kumanogoh

1

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30 August 2017

Hitoshi Kikutani

series ordinal

2

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30 August 2017

publication date

1 November 2013

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Nature Reviews Immunology

30 August 2017

published in

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30 August 2017

volume

13

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30 August 2017

issue

11

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30 August 2017

page(s)

802-814

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The semaphorin genes encode a family of transmembrane and secreted growth cone guidance molecules

30 August 2017

cites work

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Unified nomenclature for the semaphorins/collapsins. Semaphorin Nomenclature Committee

31 March 2020

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Getting neural circuits into shape with semaphorins

31 March 2020

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Diverse roles for semaphorin-plexin signaling in the immune system

31 March 2020

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Emerging role of semaphorins as major regulatory signals and potential therapeutic targets in cancer.

31 March 2020

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Neuropilin-1: a surface marker of regulatory T cells

31 March 2020

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Neuropilin 1 deficiency on CD4+Foxp3+ regulatory T cells impairs mouse melanoma growth

31 March 2020

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Neuropilin 1 is expressed on thymus-derived natural regulatory T cells, but not mucosa-generated induced Foxp3+ T reg cells

31 March 2020

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Neuropilin-1 distinguishes natural and inducible regulatory T cells among regulatory T cell subsets in vivo

31 March 2020

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Suppression of bone formation by osteoclastic expression of semaphorin 4D

31 March 2020

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Osteoprotection by semaphorin 3A.

31 March 2020

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Guidance of myocardial patterning in cardiac development by Sema6D reverse signalling

31 March 2020

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Semaphorin 3E and plexin-D1 control vascular pattern independently of neuropilins

31 March 2020

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Sema3E-Plexin D1 signaling drives human cancer cell invasiveness and metastatic spreading in mice

31 March 2020

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Semaphorin 3A overcomes cancer hypoxia and metastatic dissemination induced by antiangiogenic treatment in mice

31 March 2020

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Plexin-A1 and its interaction with DAP12 in immune responses and bone homeostasis.

31 March 2020

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Endosomal sorting by Semaphorin 4A in retinal pigment epithelium supports photoreceptor survival

31 March 2020

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Identification of CD72 as a Lymphocyte Receptor for the Class IV Semaphorin CD100

31 March 2020

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The class IV semaphorin CD100 plays nonredundant roles in the immune system: defective B and T cell activation in CD100-deficient mice.

31 March 2020

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Class IV semaphorin Sema4A enhances T-cell activation and interacts with Tim-2.

31 March 2020

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Nonredundant roles of Sema4A in the immune system: defective T cell priming and Th1/Th2 regulation in Sema4A-deficient mice

31 March 2020

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Semaphorin 7A initiates T-cell-mediated inflammatory responses through alpha1beta1 integrin

31 March 2020

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Semaphorins guide the entry of dendritic cells into the lymphatics by activating myosin II

31 March 2020

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Semaphorins and their receptors in immune cell interactions.

31 March 2020

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Semaphorin signaling in cancer cells and in cells of the tumor microenvironment--two sides of a coin

31 March 2020

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A point mutation in Semaphorin 4A associates with defective endosomal sorting and causes retinal degeneration.

31 March 2020

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The role of immune semaphorins in multiple sclerosis

31 March 2020

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The A5 antigen, a candidate for the neuronal recognition molecule, has homologies to complement components and coagulation factors.

31 March 2020

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Neuropilin is a receptor for the axonal chemorepellent Semaphorin III

31 March 2020

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Neuropilin is a semaphorin III receptor

31 March 2020

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Plexin-neuropilin-1 complexes form functional semaphorin-3A receptors

31 March 2020

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Plexins are a large family of receptors for transmembrane, secreted, and GPI-anchored semaphorins in vertebrates

31 March 2020

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Neuropilins are multifunctional coreceptors involved in tumor initiation, growth, metastasis and immunity

31 March 2020

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Neuropilin-1 is expressed by endothelial and tumor cells as an isoform-specific receptor for vascular endothelial growth factor

31 March 2020

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Neuropilin-1 is a receptor for transforming growth factor beta-1, activates its latent form, and promotes regulatory T cell activity

31 March 2020

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Alphav beta3 integrin limits the contribution of neuropilin-1 to vascular endothelial growth factor-induced angiogenesis

31 March 2020

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Neuropilin-1/GIPC1 signaling regulates alpha5beta1 integrin traffic and function in endothelial cells.

31 March 2020

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The neuropilin 1 cytoplasmic domain is required for VEGF-A-dependent arteriogenesis

31 March 2020

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BDCA-2, BDCA-3, and BDCA-4: three markers for distinct subsets of dendritic cells in human peripheral blood

31 March 2020

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Plasmacytoid dendritic cells: recent progress and open questions

31 March 2020

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Anti-BDCA-4 (neuropilin-1) antibody can suppress virus-induced IFN-alpha production of plasmacytoid dendritic cells

31 March 2020

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Control of human thymocyte migration by Neuropilin-1/Semaphorin-3A-mediated interactions

31 March 2020

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A neuronal receptor, neuropilin-1, is essential for the initiation of the primary immune response

31 March 2020

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Neuropilin-1 expression on regulatory T cells enhances their interactions with dendritic cells during antigen recognition

31 March 2020

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Neuropilin-1 attenuates autoreactivity in experimental autoimmune encephalomyelitis

31 March 2020

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Neuropilin-1 expression identifies a subset of regulatory T cells in human lymph nodes that is modulated by preoperative chemoradiation therapy in cervical cancer

31 March 2020

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Stability and function of regulatory T cells is maintained by a neuropilin-1-semaphorin-4a axis.

31 March 2020

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Class 3 semaphorins control vascular morphogenesis by inhibiting integrin function

31 March 2020

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Involvement of Sema4A in the progression of experimental autoimmune myocarditis

31 March 2020

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The Semaphorin 4D receptor Plexin-B1 is a GTPase activating protein for R-Ras

31 March 2020

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Semaphorin signals on the road of endothelial tip cells

31 March 2020

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p190 Rho-GTPase activating protein associates with plexins and it is required for semaphorin signalling

31 March 2020

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Plexin B regulates Rho through the guanine nucleotide exchange factors leukemia-associated Rho GEF (LARG) and PDZ-RhoGEF

31 March 2020

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Plexin-B1 directly interacts with PDZ-RhoGEF/LARG to regulate RhoA and growth cone morphology

31 March 2020

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MICALs, a family of conserved flavoprotein oxidoreductases, function in plexin-mediated axonal repulsion

31 March 2020

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FARP2 triggers signals for Sema3A-mediated axonal repulsion

31 March 2020

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Integral roles of a guanine nucleotide exchange factor, FARP2, in osteoclast podosome rearrangements

31 March 2020

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Plexin-B1 is a GTPase activating protein for M-Ras, remodelling dendrite morphology.

31 March 2020

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The semaphorin 4D receptor controls invasive growth by coupling with Met

31 March 2020

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Dual roles of Sema6D in cardiac morphogenesis through region-specific association of its receptor, Plexin-A1, with off-track and vascular endothelial growth factor receptor type 2

31 March 2020

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CIITA-regulated plexin-A1 affects T-cell-dendritic cell interactions.

31 March 2020

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The role of semaphorins and their receptors in vascular development and cancer.

31 March 2020

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Interactions between plexin-A2, plexin-A4, and semaphorin 6A control lamina-restricted projection of hippocampal mossy fibers

31 March 2020

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Plexin-A4 promotes tumor progression and tumor angiogenesis by enhancement of VEGF and bFGF signaling

31 March 2020

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Immune plexins and semaphorins: old proteins, new immune functions

31 March 2020

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Plexin-A4 negatively regulates T lymphocyte responses.

31 March 2020

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Plexin-A4-semaphorin 3A signaling is required for Toll-like receptor- and sepsis-induced cytokine storm

31 March 2020

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Signalling by semaphorin receptors: cell guidance and beyond.

31 March 2020

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Plexin-B2, but not Plexin-B1, critically modulates neuronal migration and patterning of the developing nervous system in vivo

31 March 2020

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Functional regulation of semaphorin receptors by proprotein convertases

31 March 2020

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Soluble CD100 functions on human monocytes and immature dendritic cells require plexin C1 and plexin B1, respectively

31 March 2020

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CD100/Plexin-B1 interactions sustain proliferation and survival of normal and leukemic CD5+ B lymphocytes

31 March 2020

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Expression of neuroimmune semaphorins 4A and 4D and their receptors in the lung is enhanced by allergen and vascular endothelial growth factor

31 March 2020

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Endogenous CD100 promotes glomerular injury and macrophage recruitment in experimental crescentic glomerulonephritis.

31 March 2020

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Semaphorin CD100 from activated T lymphocytes induces process extension collapse in oligodendrocytes and death of immature neural cells

31 March 2020

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Roles of Sema4D-plexin-B1 interactions in the central nervous system for pathogenesis of experimental autoimmune encephalomyelitis

31 March 2020

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Direct interaction of Rnd1 with Plexin-B1 regulates PDZ-RhoGEF-mediated Rho activation by Plexin-B1 and induces cell contraction in COS-7 cells

31 March 2020

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Class IV semaphorins promote angiogenesis by stimulating Rho-initiated pathways through plexin-B.

31 March 2020

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The plexin-B1/Rac interaction inhibits PAK activation and enhances Sema4D ligand binding

31 March 2020

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Plexin-B2 and Plexin-D1 in dendritic cells: expression and IL-12/IL-23p40 production

31 March 2020

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The CD100 Receptor Interacts with Its Plexin B2 Ligand to Regulate Epidermal γδ T Cell Function

31 March 2020

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Semaphorin 7A promotes axon outgrowth through integrins and MAPKs

31 March 2020

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Intestinal epithelial cell-derived semaphorin 7A negatively regulates development of colitis via αvβ1 integrin

31 March 2020

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A poxvirus-encoded semaphorin induces cytokine production from monocytes and binds to a novel cellular semaphorin receptor, VESPR

31 March 2020

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Semaphorin 7A plays a critical role in TGF-beta1-induced pulmonary fibrosis

31 March 2020

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PlexinD1 and semaphorin signaling are required in endothelial cells for cardiovascular development

31 March 2020

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Semaphorin-4A, an activator for T-cell-mediated immunity, suppresses angiogenesis via Plexin-D1

31 March 2020

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PlexinD1 glycoprotein controls migration of positively selected thymocytes into the medulla

31 March 2020

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Plexin-D1 is a novel regulator of germinal centers and humoral immune responses

31 March 2020

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Semaphorin 4A exerts a proangiogenic effect by enhancing vascular endothelial growth factor-A expression in macrophages.

31 March 2020

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Class 3 semaphorins as a therapeutic target

31 March 2020

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Requirement for the lymphocyte semaphorin, CD100, in the induction of antigen-specific T cells and the maturation of dendritic cells

31 March 2020

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Elevation of Sema4A implicates Th cell skewing and the efficacy of IFN-β therapy in multiple sclerosis

31 March 2020

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Expression of vascular endothelial growth factor isoforms and their receptors Flt-1, KDR, and neuropilin-1 in synovial tissues of rheumatoid arthritis

31 March 2020

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Anti-neuropilin-1 peptide inhibition of synoviocyte survival, angiogenesis, and experimental arthritis

31 March 2020

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The neuroimmune semaphorin-3A reduces inflammation and progression of experimental autoimmune arthritis.

31 March 2020

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Semaphorin 3A is a marker for disease activity and a potential immunoregulator in systemic lupus erythematosus

31 March 2020

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Semaphorin 3A - a marker for disease activity and a potential putative disease-modifying treatment in systemic lupus erythematosus

31 March 2020

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Semaphorin3A alleviates skin lesions and scratching behavior in NC/Nga mice, an atopic dermatitis model

31 March 2020

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Decreased expression of semaphorin-3A, a neurite-collapsing factor, is associated with itch in psoriatic skin

31 March 2020

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Intranasal administration of semaphorin-3A alleviates sneezing and nasal rubbing in a murine model of allergic rhinitis

31 March 2020

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Neuroimmune semaphorin 4A downregulates the severity of allergic response

31 March 2020

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An inhibitory role for Sema4A in antigen-specific allergic asthma

31 March 2020

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The chemorepulsive activity of secreted semaphorins is regulated by furin-dependent proteolytic processing

31 March 2020

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Axon guidance mechanisms: semaphorins as simultaneous repellents and anti-repellents

31 March 2020

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Neuropilin-1 extracellular domains mediate semaphorin D/III-induced growth cone collapse

31 March 2020

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Mechanism of selective VEGF-A binding by neuropilin-1 reveals a basis for specific ligand inhibition

31 March 2020

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Site-directed mutagenesis in the B-neuropilin-2 domain selectively enhances its affinity to VEGF165, but not to semaphorin 3F

31 March 2020

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Function of members of the neuropilin family as essential pleiotropic cell surface receptors.

31 March 2020

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Neuropilins lock secreted semaphorins onto plexins in a ternary signaling complex

31 March 2020

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Structural insights into semaphorins and their receptors

31 March 2020

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The involvement of immune semaphorins and neuropilin-1 in lupus nephritis.

31 March 2020

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Human CD72 splicing isoform responsible for resistance to systemic lupus erythematosus regulates serum immunoglobulin level and is localized in endoplasmic reticulum

31 March 2020

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Decreased semaphorin3A expression correlates with disease activity and histological features of rheumatoid arthritis

31 March 2020

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Semaphorin 3A and 3F: key players in myelin repair in multiple sclerosis?

31 March 2020

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Sema3a maintains normal heart rhythm through sympathetic innervation patterning

31 March 2020

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Semaphorin-3A is expressed by tumor cells and alters T-cell signal transduction and function

31 March 2020

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Identification of semaphorin 4B as a negative regulator of basophil-mediated immune responses.

31 March 2020

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The class 6 semaphorin SEMA6A is induced by interferon-gamma and defines an activation status of langerhans cells observed in pathological situations

31 March 2020

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Association of granulomatosis with polyangiitis (Wegener's) with HLA-DPB1*04 and SEMA6A gene variants: evidence from genome-wide analysis

31 March 2020

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Biological activity of soluble CD100. II. Soluble CD100, similarly to H-SemaIII, inhibits immune cell migration

31 March 2020

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Disruption of SEMA4D ameliorates platelet hypersensitivity in dyslipidemia and confers protection against the development of atherosclerosis

31 March 2020

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Semaphorin 7A is a negative regulator of T cell responses.

31 March 2020

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Plexin C1 engagement on mouse dendritic cells by viral semaphorin A39R induces actin cytoskeleton rearrangement and inhibits integrin-mediated adhesion and chemokine-induced migration

31 March 2020

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Plexins Are GTPase-Activating Proteins for Rap and Are Activated by Induced Dimerization

31 March 2020

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12 December 2020

A novel role for the semaphorin Sema4D in the induction of allo-responses

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12 December 2020

Semaphorin 3A is an endogenous angiogenesis inhibitor that blocks tumor growth and normalizes tumor vasculature in transgenic mouse models

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12 December 2020

Increased surface expression of a newly identified 150-kDa dimer early after human T lymphocyte activation

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12 December 2020

Neuropilin-1 mediates collapsin-1/semaphorin III inhibition of endothelial cell motility: functional competition of collapsin-1 and vascular endothelial growth factor-165.

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12 December 2020

Identification of CD72 as a lymphocyte receptor for the class IV semaphorin CD100: a novel mechanism for regulating B cell signaling

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12 December 2020

Identifiers

DOI

10.1038/NRI3545

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30 August 2017

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