(Q38171270)

30 August 2017

title

Natural product synthesis in the age of scalability (English)

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30 August 2017

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Christian A Kuttruff

1

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30 August 2017

Martin D Eastgate

series ordinal

2

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30 August 2017

Phil S Baran

series ordinal

3

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30 August 2017

language of work or name

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16 December 2013

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30 August 2017

published in

Natural Product Reports

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30 August 2017

volume

31

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30 August 2017

issue

4

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30 August 2017

page(s)

419-432

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The economies of synthesis

30 August 2017

cites work

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Atom Economy—A Challenge for Organic Synthesis: Homogeneous Catalysis Leads the Way

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Function-oriented synthesis, step economy, and drug design

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Synthesis at the molecular frontier

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Aiming for the ideal synthesis

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Protecting-group-free synthesis as an opportunity for invention

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Innate and Guided C–H Functionalization Logic

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If C-H bonds could talk: selective C-H bond oxidation

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C-H functionalization logic in total synthesis

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Solid C60: a new form of carbon

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The story of making fullerenes

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The halichondrins and E7389.

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From micrograms to grams: scale-up synthesis of eribulin mesylate

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A convergent enantioselective route to structurally diverse 6-deoxytetracycline antibiotics

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A practical, enantioselective synthetic route to a key precursor to the tetracycline antibiotics

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A robust platform for the synthesis of new tetracycline antibiotics

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8-Azatetracyclines: synthesis and evaluation of a novel class of tetracycline antibacterial agents

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Synthesis and antibacterial activity of pentacyclines: a novel class of tetracycline analogs

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A practical, convergent route to the key precursor to the tetracycline antibiotics

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Total Synthesis of Spongistatin 1: A Synthetic Strategy Exploiting Its Latent Pseudo-Symmetry

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New Type of Asymmetric Cyclization to Optically Active Steroid CD Partial Structures

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Asymmetric synthesis of bicyclic intermediates of natural product chemistry

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Proline-catalyzed asymmetric reactions

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Two-step synthesis of carbohydrates by selective aldol reactions

21 January 2018

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Enantioselective organocatalytic direct aldol reactions of alpha-oxyaldehydes: step one in a two-step synthesis of carbohydrates

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Synthesis of (±)-actinophyllic acid and analogs: applications of cascade reactions and diverted total synthesis.

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Enantioselective total synthesis of avrainvillamide and the stephacidins

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Intermolecular enolate heterocoupling: scope, mechanism, and application

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A robust and scalable synthesis of the potent neuroprotective agent (−)-huperzine A

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Development of a Large-Scale Synthetic Route to Manufacture (−)-Huperzine A

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Nature-inspired total synthesis of (-)-fusarisetin A.

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Total synthesis of (-)-fusarisetin A and reassignment of the absolute configuration of its natural counterpart

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Engineering Escherichia coli for production of functionalized terpenoids using plant P450s

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Continuous-Flow Synthesis of the Anti-Malaria Drug Artemisinin

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Sceptrin, a marine natural compound, inhibits cell motility in a variety of cancer cell lines

21 January 2018

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Total synthesis of (+/-)-psychotrimine

21 January 2018

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Scalable total syntheses of N-linked tryptamine dimers by direct indole-aniline coupling: psychotrimine and kapakahines B and F.

21 January 2018

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The psychotrimine natural products have antibacterial activity against Gram-positive bacteria and act via membrane disruption

21 January 2018

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Kapakahine B, a cyclic hexapeptide with an .alpha.-carboline ring system from the marine sponge Cribrochalina olemda

21 January 2018

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Enantiospecific Total Syntheses of Kapakahines B and F

21 January 2018

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Cortistatins A, B, C, and D, anti-angiogenic steroidal alkaloids, from the marine sponge Corticium simplex

21 January 2018

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Synthesis of (+)-cortistatin A.

21 January 2018

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Stereodivergent synthesis of 17-alpha and 17-beta-alpharyl steroids: application and biological evaluation of D-ring cortistatin analogues

21 January 2018

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Scalable synthesis of cortistatin A and related structures

21 January 2018

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On the structure of endogenous ouabain

21 January 2018

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Strategic redox relay enables a scalable synthesis of ouabagenin, a bioactive cardenolide.

21 January 2018

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3EZ,20Ac-ingenol, a catalytic inhibitor of topoisomerases, downregulates p-Akt and induces DSBs and apoptosis of DT40 cells

21 January 2018

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Ingenol mebutate gel for actinic keratosis

21 January 2018

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Tobacco smoking and dermatologic surgery

21 January 2018

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Effective treatment of squamous cell carcinomas with ingenol mebutate gel in immunologically intact SKH1 mice

21 January 2018

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Clinical findings using ingenol mebutate gel to treat actinic keratoses

21 January 2018

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The first total synthesis of (+/-)-ingenol

21 January 2018

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Total Synthesis of Ingenol

21 January 2018

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Total synthesis of ingenol.

21 January 2018

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14-step synthesis of (+)-ingenol from (+)-3-carene

21 January 2018

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An efficient approach to Aspidosperma alkaloids via [4 + 2] cycloadditions of aminosiloxydienes: stereocontrolled total synthesis of (+/-)-tabersonine. Gram-scale catalytic asymmetric syntheses of (+)-tabersonine and (+)-16-methoxytabersonine. Asymm

21 January 2018

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An Enantioselective Synthesis of FR182877 Provides a Chemical Rationalization of Its Structure and Affords Multigram Quantities of Its Direct Precursor

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Enantioselective total syntheses of welwitindolinone A and fischerindoles I and G.

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A synthesis of (+)-saxitoxin

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(+)-saxitoxin: a first and second generation stereoselective synthesis

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Total Synthesis of (±)-Haouamine A

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Scalable total synthesis and biological evaluation of haouamine A and its atropisomer

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Total synthesis of all (-)-Agelastatin alkaloids

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A short total synthesis of the marine sponge pyrrole-2-aminoimidazole alkaloid (±)-agelastatin A.

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Gram-scale synthesis of iejimalide B.

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Scalable enantioselective total synthesis of taxanes

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Scalable, stereocontrolled total syntheses of (±)-axinellamines A and B.

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Scalable total synthesis of (-)-berkelic acid by using a protecting-group-free strategy.

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Halichondrins - antitumor polyether macrolides from a marine sponge

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20 August 2023

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The structures of huperzine A and B, two new alkaloids exhibiting marked anticholinesterase activity

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Identifiers

DOI

10.1039/C3NP70090A

1 reference

30 August 2017

1 reference