(Q38172774)

30 August 2017

Sensory neurons and circuits mediating itch (English)

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30 August 2017

2

Xinzhong Dong

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author name string

Robert H LaMotte

series ordinal

1

1 reference

30 August 2017

Matthias Ringkamp

series ordinal

3

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30 August 2017

language of work or name

English

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publication date

1 January 2014

1 reference

Nature Reviews Neuroscience

30 August 2017

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30 August 2017

15

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30 August 2017

1

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30 August 2017

19-31

1 reference

https://scigraph.springernature.com/pub.10.1038/nrn3641

30 August 2017

0 references

cites work

Roles of glutamate, substance P, and gastrin-releasing peptide as spinal neurotransmitters of histaminergic and nonhistaminergic itch

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Ontogeny of excitatory spinal neurons processing distinct somatic sensory modalities

6 September 2017

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Potential new therapeutic targets for pathological pruritus

6 September 2017

1 reference

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Neural processing of itch

6 September 2017

1 reference

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The ion channel TRPA1 is required for chronic itch.

6 September 2017

1 reference

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The cells and circuitry for itch responses in mice

6 September 2017

1 reference

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Activity-dependent silencing reveals functionally distinct itch-generating sensory neurons

6 September 2017

1 reference

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Excitatory superficial dorsal horn interneurons are functionally heterogeneous and required for the full behavioral expression of pain and itch

6 September 2017

1 reference

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Itch and analgesia resulting from intrathecal application of morphine: contrasting effects on different populations of trigeminothalamic tract neurons

6 September 2017

1 reference

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A subpopulation of nociceptors specifically linked to itch

6 September 2017

1 reference

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Mechanisms of itch evoked by β-alanine

6 September 2017

1 reference

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TRPA1: A gatekeeper for inflammation

6 September 2017

1 reference

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Pruriceptive spinothalamic tract neurons: physiological properties and projection targets in the primate

6 September 2017

1 reference

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Population coding of somatic sensations

6 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4096293

Pain and itch: insights into the neural circuits of aversive somatosensation in health and disease

6 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4096293

A role for nociceptive, myelinated nerve fibers in itch sensation

6 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4096293

Unidirectional cross-activation of GRPR by MOR1D uncouples itch and analgesia induced by opioids

6 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4096293

In vivo responses of cutaneous C-mechanosensitive neurons in mouse to punctate chemical stimuli that elicit itch and nociceptive sensations in humans

6 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4096293

Mouse models of acute, chemical itch and pain in humans

6 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4096293

Itch signaling in the nervous system

6 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4096293

Transmitters and pathways mediating inhibition of spinal itch-signaling neurons by scratching and other counterstimuli

6 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4096293

Sensory responses to injection and punctate application of capsaicin and histamine to the skin

6 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4096293

The distinct roles of two GPCRs, MrgprC11 and PAR2, in itch and hyperalgesia

6 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4096293

Pruritus: management algorithms and experimental therapies.

6 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4096293

BAM8-22 peptide produces itch and nociceptive sensations in humans independent of histamine release

6 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4096293

TRPA1 is required for histamine-independent, Mas-related G protein-coupled receptor-mediated itch

6 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4096293

Neuronal circuitry for pain processing in the dorsal horn

6 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4096293

VGLUT2-dependent sensory neurons in the TRPV1 population regulate pain and itch.

6 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4096293

Cellular basis of itch sensation

6 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4096293

Mrgprd enhances excitability in specific populations of cutaneous murine polymodal nociceptors

6 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4096293

TRPV1-expressing primary afferents generate behavioral responses to pruritogens via multiple mechanisms

6 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4096293

Distinct subsets of unmyelinated primary sensory fibers mediate behavioral responses to noxious thermal and mechanical stimuli

6 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4096293

6 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4096293

Relief of itch by scratching: state-dependent inhibition of primate spinothalamic tract neurons

6 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4096293

Models and mechanisms of hyperalgesia and allodynia

6 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4096293

Pruritic and nociceptive sensations and dysesthesias from a spicule of cowhage

6 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4096293

A role for polymodal C-fiber afferents in nonhistaminergic itch

6 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4096293

Separate peripheral pathways for pruritus in man

6 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4096293

Cowhage-evoked itch is mediated by a novel cysteine protease: a ligand of protease-activated receptors

6 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4096293

TRPV1 unlike TRPV2 is restricted to a subset of mechanically insensitive cutaneous nociceptors responding to heat

6 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4096293

The itch-producing agents histamine and cowhage activate separate populations of primate spinothalamic tract neurons

6 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4096293

Psychophysical and physiological evidence for parallel afferent pathways mediating the sensation of itch.

6 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4096293

Noxious heat and scratching decrease histamine-induced itch and skin blood flow

6 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4096293

Electrically evoked itch in humans

6 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4096293

Mustard oils and cannabinoids excite sensory nerve fibres through the TRP channel ANKTM1

6 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4096293

ANKTM1, a TRP-like channel expressed in nociceptive neurons, is activated by cold temperatures

6 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4096293

An experimental itch model in monkeys: characterization of intrathecal morphine-induced scratching and antinociception.

6 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4096293

Encoding of burning pain from capsaicin-treated human skin in two categories of unmyelinated nerve fibres

6 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4096293

An evidence-based review of the efficacy of antihistamines in relieving pruritus in atopic dermatitis

6 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4096293

Specific C-receptors for itch in human skin.

6 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4096293

Itching for an explanation

6 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4096293

Pruritus--itching for a cause and relief?

6 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4096293

Effects of histamine receptor antagonists on histamine-induced responses in human skin

6 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4096293

The epithelial cell-derived atopic dermatitis cytokine TSLP activates neurons to induce itch

14 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4096293

Loss of inhibitory interneurons in the dorsal spinal cord and elevated itch in Bhlhb5 mutant mice.

14 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4096293

Differential itch- and pain-related behavioral responses and µ-opoid modulation in mice.

14 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4096293

VGLUT2-dependent glutamate release from nociceptors is required to sense pain and suppress itch

23 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4096293

Enhancement of experimental pruritus and mechanically evoked dysesthesiae with local anesthesia.

23 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4096293

Neurogenic hyperalgesia: central neural correlates in responses of spinothalamic tract neurons.

23 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4096293

Neurogenic hyperalgesia: psychophysical studies of underlying mechanisms

23 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4096293

Mechanically insensitive afferents (MIAs) in cutaneous nerves of monkey.

23 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4096293

Mechano-insensitive nociceptors are sufficient to induce histamine-induced itch

23 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4096293

Inhibition of inflammatory pain by activating B-type natriuretic peptide signal pathway in nociceptive sensory neurons.

31 August 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4096293

Sensory neuron-specific GPCR Mrgprs are itch receptors mediating chloroquine-induced pruritus

31 August 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4096293

Behavioral differentiation between itch and pain in mouse

31 August 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4096293

Topographically distinct epidermal nociceptive circuits revealed by axonal tracers targeted to Mrgprd

31 August 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4096293

Painful stimuli evoke itch in patients with chronic pruritus: central sensitization for itch

31 August 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4096293

Comparison of responses of primate spinothalamic tract neurons to pruritic and algogenic stimuli

31 August 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4096293

Chemical response pattern of different classes of C-nociceptors to pruritogens and algogens

31 August 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4096293

Histamine-induced itch converts into pain in neuropathic hyperalgesia

31 August 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4096293

Capsaicin responses in heat-sensitive and heat-insensitive A-fiber nociceptors.

31 August 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4096293

A gastrin-releasing peptide receptor mediates the itch sensation in the spinal cord

31 August 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4096293

3 December 2018

1 reference

Discharge patterns of human C-fibers induced by itching and burning stimuli

31 March 2020

1 reference

Novel classes of responsive and unresponsive C nociceptors in human skin

31 March 2020

1 reference

TRPV1 mediates histamine-induced itching via the activation of phospholipase A2 and 12-lipoxygenase

31 March 2020

1 reference

Mapping cell fate and function using recombinase-based intersectional strategies

31 March 2020

1 reference

Attenuation of experimental pruritus and mechanically evoked dysesthesiae in an area of cutaneous allodynia

31 March 2020

1 reference

Itch evoked by electrical stimulation of the skin

31 March 2020

1 reference

31 March 2020

1 reference

Conditioning of histamine by bradykinin alters responses of rat nociceptor and human itch sensation

31 March 2020

1 reference

The neuroscience of Helmholtz and the theories of Johannes Müller. Part 2: Sensation and perception.

31 March 2020

1 reference

31 March 2020

Identifiers

DOI

10.1038/NRN3641

1 reference

Dimensions Publication ID

30 August 2017

0 references

1 reference

30 August 2017

1 reference