(Q38174792)

30 August 2017

title

Therapeutic opportunities of the IL-22-IL-22R1 system (English)

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30 August 2017

2

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30 August 2017

Robert Sabat

1

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30 August 2017

Kerstin Wolk

series ordinal

3

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30 August 2017

publication date

1 January 2014

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Nature Reviews Drug Discovery

30 August 2017

published in

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30 August 2017

volume

13

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30 August 2017

issue

1

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30 August 2017

page(s)

21-38

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Cloning and characterization of IL-10-related T cell-derived inducible factor (IL-TIF), a novel cytokine structurally related to IL-10 and inducible by IL-9.

30 August 2017

cites work

1 reference

Human interleukin-10-related T cell-derived inducible factor: molecular cloning and functional characterization as an hepatocyte-stimulating factor

21 January 2018

1 reference

Interleukin (IL)-22, a novel human cytokine that signals through the interferon receptor-related proteins CRF2-4 and IL-22R

21 January 2018

1 reference

Regulation and functions of the IL-10 family of cytokines in inflammation and disease

21 January 2018

1 reference

IL-10 family of cytokines

21 January 2018

1 reference

IL-22 increases the innate immunity of tissues

21 January 2018

1 reference

Crystal structure of recombinant human interleukin-22

21 January 2018

1 reference

Structure of insect-cell-derived IL-22.

21 January 2018

1 reference

Interleukin-22 forms dimers that are recognized by two interleukin-22R1 receptor chains

21 January 2018

1 reference

Comparison of interleukin-22 and interleukin-10 soluble receptor complexes

21 January 2018

1 reference

Cutting edge: immune cells as sources and targets of the IL-10 family members?

21 January 2018

1 reference

Interleukin (IL)-22 and IL-17 are coexpressed by Th17 cells and cooperatively enhance expression of antimicrobial peptides

21 January 2018

1 reference

Expression and regulation of IL-22 in the IL-17-producing CD4+ T lymphocytes

21 January 2018

1 reference

Interleukin-22, a T(H)17 cytokine, mediates IL-23-induced dermal inflammation and acanthosis

21 January 2018

1 reference

Transcription factor c-Maf mediates the TGF-β-dependent suppression of IL-22 production in T(H)17 cells.

21 January 2018

1 reference

Production of interleukin 22 but not interleukin 17 by a subset of human skin-homing memory T cells.

21 January 2018

1 reference

Identification of a human helper T cell population that has abundant production of interleukin 22 and is distinct from T(H)-17, T(H)1 and T(H)2 cells

21 January 2018

1 reference

Interleukin-22: A cytokine produced by T, NK and NKT cell subsets, with importance in the innate immune defense and tissue protection

21 January 2018

1 reference

Microbial flora drives interleukin 22 production in intestinal NKp46+ cells that provide innate mucosal immune defense

21 January 2018

1 reference

CD4(+) lymphoid tissue-inducer cells promote innate immunity in the gut.

21 January 2018

1 reference

IL-7 and IL-15 independently program the differentiation of intestinal CD3-NKp46+ cell subsets from Id2-dependent precursors

21 January 2018

1 reference

Human fetal lymphoid tissue-inducer cells are interleukin 17-producing precursors to RORC+ CD127+ natural killer-like cells

21 January 2018

1 reference

Distinct requirements for T-bet in gut innate lymphoid cells

21 January 2018

1 reference

AHR drives the development of gut ILC22 cells and postnatal lymphoid tissues via pathways dependent on and independent of Notch

21 January 2018

1 reference

The aryl hydrocarbon receptor regulates gut immunity through modulation of innate lymphoid cells

21 January 2018

1 reference

The transcription factor T-bet is essential for the development of NKp46+ innate lymphocytes via the Notch pathway

21 January 2018

1 reference

Innate lymphoid cells--a proposal for uniform nomenclature

21 January 2018

1 reference

Interleukin-22 mediates early host defense against attaching and effacing bacterial pathogens

21 January 2018

1 reference

Th22 cells are an important source of IL-22 for host protection against enteropathogenic bacteria

21 January 2018

1 reference

Maturing dendritic cells are an important source of IL-29 and IL-20 that may cooperatively increase the innate immunity of keratinocytes

21 January 2018

1 reference

Aryl hydrocarbon receptor-induced signals up-regulate IL-22 production and inhibit inflammation in the gastrointestinal tract

21 January 2018

1 reference

Identification of the functional interleukin-22 (IL-22) receptor complex: the IL-10R2 chain (IL-10Rbeta ) is a common chain of both the IL-10 and IL-22 (IL-10-related T cell-derived inducible factor, IL-TIF) receptor complexes

21 January 2018

1 reference

Structure of IL-22 bound to its high-affinity IL-22R1 chain

21 January 2018

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Crystal structure of the IL-22/IL-22R1 complex and its implications for the IL-22 signaling mechanism

21 January 2018

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Structure and Mechanism of Receptor Sharing by the IL-10R2 Common Chain

21 January 2018

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The IL-10R2 binding hot spot on IL-22 is located on the N-terminal helix and is dependent on N-linked glycosylation

21 January 2018

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The expression of legumain, an asparaginyl endopeptidase that controls antigen processing, is reduced in endotoxin-tolerant monocytes

21 January 2018

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IL-22R, IL-10R2, and IL-22BP binding sites are topologically juxtaposed on adjacent and overlapping surfaces of IL-22.

21 January 2018

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Cutting edge: STAT activation by IL-19, IL-20 and mda-7 through IL-20 receptor complexes of two types

21 January 2018

1 reference

Interleukin 24 (MDA-7/MOB-5) signals through two heterodimeric receptors, IL-22R1/IL-20R2 and IL-20R1/IL-20R2.

21 January 2018

1 reference

Interleukin-22 (IL-22) activates the JAK/STAT, ERK, JNK, and p38 MAP kinase pathways in a rat hepatoma cell line. Pathways that are shared with and distinct from IL-10.

21 January 2018

1 reference

New activation modus of STAT3: a tyrosine-less region of the interleukin-22 receptor recruits STAT3 by interacting with its coiled-coil domain

21 January 2018

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Stat3 dimerization regulated by reversible acetylation of a single lysine residue

21 January 2018

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STAT3 inhibition of gluconeogenesis is downregulated by SirT1

21 January 2018

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STAT3-dependent effects of IL-22 in human keratinocytes are counterregulated by sirtuin 1 through a direct inhibition of STAT3 acetylation

21 January 2018

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Expression of interleukin-22 in rheumatoid arthritis: potential role as a proinflammatory cytokine.

21 January 2018

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Participation of Gab1 and Gab2 in IL-22-mediated keratinocyte proliferation, migration, and differentiation

21 January 2018

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IL-22 induced cell proliferation is regulated by PI3K/Akt/mTOR signaling cascade.

21 January 2018

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Interleukin-22: a potential immunomodulatory molecule in the lung

21 January 2018

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IL-22 mediates mucosal host defense against Gram-negative bacterial pneumonia

21 January 2018

1 reference

IL-22 and IL-20 are key mediators of the epidermal alterations in psoriasis while IL-17 and IFN-gamma are not.

21 January 2018

1 reference

Acinar cells of the pancreas are a target of interleukin-22.

21 January 2018

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Interleukin 22 receptor 1 expression in pancreas islets

21 January 2018

1 reference

Interleukin-22 drives endogenous thymic regeneration in mice

21 January 2018

1 reference

Interleukin-22 protects intestinal stem cells from immune-mediated tissue damage and regulates sensitivity to graft versus host disease

21 January 2018

1 reference

Interleukin-22 promotes proliferation of liver stem/progenitor cells in mice and patients with chronic hepatitis B virus infection

21 January 2018

1 reference

Cloning and characterization of IL-22 binding protein, a natural antagonist of IL-10-related T cell-derived inducible factor/IL-22

21 January 2018

1 reference

Identification, cloning, and characterization of a novel soluble receptor that binds IL-22 and neutralizes its activity

21 January 2018

1 reference

A soluble class II cytokine receptor, IL-22RA2, is a naturally occurring IL-22 antagonist

21 January 2018

1 reference

Cloning and characterization of mouse IL-22 binding protein

21 January 2018

1 reference

Cloning of murine IL-22 receptor alpha 2 and comparison with its human counterpart

21 January 2018

1 reference

IL-22 induces lipopolysaccharide-binding protein in hepatocytes: a potential systemic role of IL-22 in Crohn's disease.

21 January 2018

1 reference

Crystal structure of a soluble decoy receptor IL-22BP bound to interleukin-22

21 January 2018

1 reference

IL-22BP is regulated by the inflammasome and modulates tumorigenesis in the intestine

21 January 2018

1 reference

Hydrodynamic-based delivery of an interleukin-22-Ig fusion gene ameliorates experimental autoimmune myocarditis in rats

21 January 2018

1 reference

Redundant and pathogenic roles for IL-22 in mycobacterial, protozoan, and helminth infections

21 January 2018

1 reference

Epithelial antimicrobial defence of the skin and intestine

21 January 2018

1 reference

Involvement of the IL-22/REG Ialpha axis in ulcerative colitis

21 January 2018

1 reference

Interleukin-28 and interleukin-29: novel regulators of skin biology.

21 January 2018

1 reference

IL-22 inhibits epidermal differentiation and induces proinflammatory gene expression and migration of human keratinocytes

21 January 2018

1 reference

IL-22 from conventional NK cells is epithelial regenerative and inflammation protective during influenza infection

21 January 2018

1 reference

IL-22 is produced by innate lymphoid cells and limits inflammation in allergic airway disease

21 January 2018

1 reference

The Th17 cytokine IL-22 induces IL-20 production in keratinocytes: a novel immunological cascade with potential relevance in psoriasis

21 January 2018

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Aryl hydrocarbon receptor regulates pancreatic IL-22 production and protects mice from acute pancreatitis

21 January 2018

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Interleukin-22 ameliorates cerulein-induced pancreatitis in mice by inhibiting the autophagic pathway

21 January 2018

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The involvement of interleukin-22 in the expression of pancreatic beta cell regenerative Reg genes

21 January 2018

1 reference

A proinflammatory role for interleukin-22 in the immune response to hepatitis B virus

21 January 2018

1 reference

Interleukin 22 (IL-22) plays a protective role in T cell-mediated murine hepatitis: IL-22 is a survival factor for hepatocytes via STAT3 activation

21 January 2018

1 reference

In vivo consequences of liver-specific interleukin-22 expression in mice: Implications for human liver disease progression

21 January 2018

1 reference

IL-17A but not IL-22 suppresses the replication of hepatitis B virus mediated by over-expression of MxA and OAS mRNA in the HepG2.2.15 cell line

21 January 2018

1 reference

Interleukin-22 treatment ameliorates alcoholic liver injury in a murine model of chronic-binge ethanol feeding: Role of signal transducer and activator of transcription 3

21 January 2018

1 reference

IL-17A-producing gammadelta T and Th17 lymphocytes mediate lung inflammation but not fibrosis in experimental silicosis

21 January 2018

1 reference

IL-22 promotes fibroblast-mediated wound repair in the skin

21 January 2018

1 reference

Three decades of psoriasis research: where has it led us?

21 January 2018

1 reference

IL-29 is produced by T(H)17 cells and mediates the cutaneous antiviral competence in psoriasis.

21 January 2018

1 reference

IL-22-producing "T22" T cells account for upregulated IL-22 in atopic dermatitis despite reduced IL-17-producing TH17 T cells

21 January 2018

1 reference

Deficiency of IL-22 contributes to a chronic inflammatory disease: pathogenetic mechanisms in acne inversa.

21 January 2018

1 reference

Epidermal overexpression of interleukin-19 and -20 mRNA in psoriatic skin disappears after short-term treatment with cyclosporine a or calcipotriol.

21 January 2018

1 reference

IL-22 is required for imiquimod-induced psoriasiform skin inflammation in mice

21 January 2018

1 reference

The psoriasis-associated D10N variant of the adaptor Act1 with impaired regulation by the molecular chaperone hsp90.

21 January 2018

1 reference

Amelioration of epidermal hyperplasia by TNF inhibition is associated with reduced Th17 responses

21 January 2018

1 reference

Interleukin 20: discovery, receptor identification, and role in epidermal function

21 January 2018

1 reference

IL-24 transgenic mice: in vivo evidence of overlapping functions for IL-20, IL-22, and IL-24 in the epidermis

21 January 2018

1 reference

Endogenous antimicrobial peptides and skin infections in atopic dermatitis

21 January 2018

1 reference

Clinical practice. Hidradenitis suppurativa.

21 January 2018

1 reference

IL-23-responsive innate lymphoid cells are increased in inflammatory bowel disease

21 January 2018

1 reference

Expression of IL-24, an activator of the JAK1/STAT3/SOCS3 cascade, is enhanced in inflammatory bowel disease

21 January 2018

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IL-10-- and IL-20--expressing epithelial and inflammatory cells are increased in patients with ulcerative colitis.

21 January 2018

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Increased levels of circulating Th17 cells in quiescent versus active Crohn's disease.

21 January 2018

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Innate and adaptive interleukin-22 protects mice from inflammatory bowel disease

21 January 2018

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IL-22 deficiency alters colonic microbiota to be transmissible and colitogenic.

21 January 2018

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STAT3 links IL-22 signaling in intestinal epithelial cells to mucosal wound healing

21 January 2018

1 reference

Interleukin (IL)-23 mediates Toxoplasma gondii-induced immunopathology in the gut via matrixmetalloproteinase-2 and IL-22 but independent of IL-17.

21 January 2018

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Memory/effector (CD45RB(lo)) CD4 T cells are controlled directly by IL-10 and cause IL-22-dependent intestinal pathology

21 January 2018

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IL-22+ CD4+ T cells are associated with therapeutic trichuris trichiura infection in an ulcerative colitis patient.

21 January 2018

1 reference

Dual Role of IL-22 in Allergic Airway Inflammation and its Cross-talk with IL-17A

21 January 2018

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IL-22 attenuates IL-25 production by lung epithelial cells and inhibits antigen-induced eosinophilic airway inflammation

21 January 2018

1 reference

Interleukin-22 is produced by invariant natural killer T lymphocytes during influenza A virus infection: potential role in protection against lung epithelial damages

21 January 2018

1 reference

IL-17A produced by αβ T cells drives airway hyper-responsiveness in mice and enhances mouse and human airway smooth muscle contraction

21 January 2018

1 reference

γδ T cells protect against lung fibrosis via IL-22

21 January 2018

1 reference

Protective properties of inhaled IL-22 in a model of ventilator-induced lung injury.

21 January 2018

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Pathological versus protective functions of IL-22 in airway inflammation are regulated by IL-17A

21 January 2018

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IL-22 production is regulated by IL-23 during Listeria monocytogenes infection but is not required for bacterial clearance or tissue protection

21 January 2018

1 reference

Protective immunity to systemic infection with attenuated Salmonella enterica serovar enteritidis in the absence of IL-12 is associated with IL-23-dependent IL-22, but not IL-17.

21 January 2018

1 reference

Interleukin-17 is required for T helper 1 cell immunity and host resistance to the intracellular pathogen Francisella tularensis

21 January 2018

1 reference

Innate lymphoid cells promote anatomical containment of lymphoid-resident commensal bacteria.

21 January 2018

1 reference

Commensal microbiota and myelin autoantigen cooperate to trigger autoimmune demyelination.

21 January 2018

1 reference

Sex differences in the gut microbiome drive hormone-dependent regulation of autoimmunity.

21 January 2018

1 reference

Dectin-1-dependent interleukin-22 contributes to early innate lung defense against Aspergillus fumigatus.

21 January 2018

1 reference

IL-22 defines a novel immune pathway of antifungal resistance.

21 January 2018

1 reference

IL-23 and IL-17A, but not IL-12 and IL-22, are required for optimal skin host defense against Candida albicans

21 January 2018

1 reference

Chronic mucocutaneous candidiasis in APECED or thymoma patients correlates with autoimmunity to Th17-associated cytokines

21 January 2018

1 reference

IL-22 is essential for lung epithelial repair following influenza infection

21 January 2018

1 reference

Interleukin-22 reduces lung inflammation during influenza A virus infection and protects against secondary bacterial infection.

21 January 2018

1 reference

Loss of mucosal CD103+ DCs and IL-17+ and IL-22+ lymphocytes is associated with mucosal damage in SIV infection

21 January 2018

1 reference

A role for mucosal IL-22 production and Th22 cells in HIV-associated mucosal immunopathogenesis.

21 January 2018

1 reference

The role of interleukin-22 in hepatitis C virus infection

21 January 2018

1 reference

Interleukin-22 but not interleukin-17 provides protection to hepatocytes during acute liver inflammation

21 January 2018

1 reference

Interleukin-22: implications for liver ischemia-reperfusion injury

21 January 2018

1 reference

IL-22 Protects Against Liver Pathology and Lethality of an Experimental Blood-Stage Malaria Infection

21 January 2018

1 reference

IL-22 is involved in liver regeneration after hepatectomy

21 January 2018

1 reference

Frequency and phenotype of peripheral blood Th17 cells in ankylosing spondylitis and rheumatoid arthritis

21 January 2018

1 reference

Identification of a cytokine network sustaining neutrophil and Th17 activation in untreated early rheumatoid arthritis.

21 January 2018

1 reference

Proinflammatory role of the Th17 cytokine interleukin-22 in collagen-induced arthritis in C57BL/6 mice

21 January 2018

1 reference

Interleukin-22 reduces the severity of collagen-induced arthritis in association with increased levels of interleukin-10.

21 January 2018

1 reference

The expression of IL-20 and IL-24 and their shared receptors are increased in rheumatoid arthritis and spondyloarthropathy

21 January 2018

1 reference

Interleukin-20 antibody is a potential therapeutic agent for experimental arthritis

21 January 2018

1 reference

Anti-IL-20 monoclonal antibody inhibits the differentiation of osteoclasts and protects against osteoporotic bone loss

21 January 2018

1 reference

IL-23 induces spondyloarthropathy by acting on ROR-γt+ CD3+CD4-CD8- entheseal resident T cells

21 January 2018

1 reference

21 January 2018

1 reference

Increased intratumoral IL-22-producing CD4(+) T cells and Th22 cells correlate with gastric cancer progression and predict poor patient survival

21 January 2018

1 reference

Interleukin-22 is frequently expressed in small- and large-cell lung cancer and promotes growth in chemotherapy-resistant cancer cells

21 January 2018

1 reference

High fat diet induces formation of spontaneous liposarcoma in mouse adipose tissue with overexpression of interleukin 22

21 January 2018

1 reference

Innate lymphoid cells sustain colon cancer through production of interleukin-22 in a mouse model

21 January 2018

1 reference

Clinical targeting of the TNF and TNFR superfamilies

21 January 2018

1 reference

Efficacy and safety of ustekinumab, a human interleukin-12/23 monoclonal antibody, in patients with psoriasis: 52-week results from a randomised, double-blind, placebo-controlled trial (PHOENIX 2)

21 January 2018

1 reference

Efficacy and safety of ustekinumab, a human interleukin-12/23 monoclonal antibody, in patients with psoriasis: 76-week results from a randomised, double-blind, placebo-controlled trial (PHOENIX 1)

21 January 2018

1 reference

Targeting IL-17 and TH17 cells in chronic inflammation

21 January 2018

1 reference

Lymph node homing of T cells and dendritic cells via afferent lymphatics

21 January 2018

1 reference

Anti–Interleukin-17 Monoclonal Antibody Ixekizumab in Chronic Plaque Psoriasis

21 January 2018

1 reference

Increased expression of interleukin-22 by synovial Th17 cells during late stages of murine experimental arthritis is controlled by interleukin-1 and enhances bone degradation

21 January 2018

1 reference

Is there an interaction between interleukin-10 and interleukin-22?

21 January 2018

1 reference

Interleukin-22, a member of the IL-10 subfamily, induces inflammatory responses in colonic subepithelial myofibroblasts

31 March 2020

1 reference

IL-22 regulates the expression of genes responsible for antimicrobial defense, cellular differentiation, and mobility in keratinocytes: a potential role in psoriasis

31 March 2020

1 reference

A novel, soluble homologue of the human IL-10 receptor with preferential expression in placenta

31 March 2020

1 reference

Interleukin-22 binding protein (IL-22BP) is constitutively expressed by a subset of conventional dendritic cells and is strongly induced by retinoic acid

31 March 2020

1 reference

IL-22 is increased in active Crohn's disease and promotes proinflammatory gene expression and intestinal epithelial cell migration

31 March 2020

1 reference

The Effects of IL-20 Subfamily Cytokines on Reconstituted Human Epidermis Suggest Potential Roles in Cutaneous Innate Defense and Pathogenic Adaptive Immunity in Psoriasis

31 March 2020

1 reference

IL-22 Induces an Acute-Phase Response

31 March 2020

1 reference

Interleukin-22 promotes osteoclastogenesis in rheumatoid arthritis through induction of RANKL in human synovial fibroblasts

31 March 2020

1 reference

Interleukin (IL)-19, IL-20 and IL-24 are produced by and act on keratinocytes and are distinct from classical ILs

31 March 2020

1 reference

Interleukin-20 plays a critical role in maintenance and development of psoriasis in the human xenograft transplantation model

31 March 2020

1 reference

IL-13/IL-22-coproducing T cells, a novel subset, are increased in atopic dermatitis

31 March 2020

1 reference

IL-22 mRNA in peripheral blood mononuclear cells from allergic rhinitic and asthmatic pediatric patients

31 March 2020

1 reference

High expression of IL-22 suppresses antigen-induced immune responses and eosinophilic airway inflammation via an IL-10-associated mechanism

31 March 2020

1 reference

Interleukin-22 protects against acute alcohol-induced hepatotoxicity in mice

31 March 2020

1 reference

Interleukin 22 serum levels are associated with radiographic progression in rheumatoid arthritis

31 March 2020

1 reference

Elevated Th22 cells correlated with Th17 cells in patients with rheumatoid arthritis

31 March 2020

1 reference

Increased serum interleukin 22 in patients with rheumatoid arthritis and correlation with disease activity

31 March 2020

1 reference

IL-17/Th17 mediated synovial inflammation is IL-22 independent

31 March 2020

1 reference

Interleukin-22 promotes human hepatocellular carcinoma by activation of STAT3

31 March 2020

1 reference

IL-22 is required for Th17 cell-mediated pathology in a mouse model of psoriasis-like skin inflammation

31 March 2020

1 reference

PubMed

https://pubmed.ncbi.nlm.nih.gov/24378801

inferred from PubMed ID database lookup

12 December 2020

based on heuristic

IL-22 ameliorates intestinal inflammation in a mouse model of ulcerative colitis

1 reference

PubMed

https://pubmed.ncbi.nlm.nih.gov/24378801

inferred from PubMed ID database lookup

12 December 2020

based on heuristic

Hydrodynamic gene delivery of interleukin-22 protects the mouse liver from concanavalin A-, carbon tetrachloride-, and Fas ligand-induced injury via activation of STAT3.

1 reference

PubMed

https://pubmed.ncbi.nlm.nih.gov/24378801

inferred from PubMed ID database lookup

12 December 2020

based on heuristic

Identifiers

DOI

10.1038/NRD4176

1 reference

30 August 2017

1 reference