(Q38047820)

27 August 2017

title

Targeting IL-17 and TH17 cells in chronic inflammation (English)

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27 August 2017

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1

Pierre Miossec

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author name string

Jay K Kolls

series ordinal

2

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27 August 2017

language of work or name

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1 October 2012

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Nature Reviews Drug Discovery

27 August 2017

published in

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27 August 2017

volume

11

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27 August 2017

issue

10

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27 August 2017

page(s)

763-776

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https://scigraph.springernature.com/pub.10.1038/nrd3794

27 August 2017

exact match

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cites work

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IL-17 enhances chemokine gene expression through mRNA stabilization

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Ozone exposure in a mouse model induces airway hyperreactivity that requires the presence of natural killer T cells and IL-17

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Mast cells produce interleukin-25 upon Fc epsilon RI-mediated activation

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Murine mast cells secrete a unique profile of cytokines and prostaglandins in response to distinct TLR2 ligands

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Mast cells and neutrophils release IL-17 through extracellular trap formation in psoriasis

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Mast cells express IL-17A in rheumatoid arthritis synovium

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IL-17A expression is localised to both mononuclear and polymorphonuclear synovial cell infiltrates

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Interleukin-17-positive mast cells contribute to synovial inflammation in spondylarthritis

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31 March 2020

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31 March 2020

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31 March 2020

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31 March 2020

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Increased granulopoiesis through interleukin-17 and granulocyte colony-stimulating factor in leukocyte adhesion molecule-deficient mice

31 March 2020

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Phagocytosis of apoptotic neutrophils regulates granulopoiesis via IL-23 and IL-17.

31 March 2020

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Cytokine-mediated regulation of antimicrobial proteins

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Th17 cells and IL-17 receptor signaling are essential for mucosal host defense against oral candidiasis

31 March 2020

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31 March 2020

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IL-17 is essential for host defense against cutaneous Staphylococcus aureus infection in mice

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31 March 2020

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Vaccine-induced protection against 3 systemic mycoses endemic to North America requires Th17 cells in mice.

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31 March 2020

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31 March 2020

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IL-23 and IL-17 in the establishment of protective pulmonary CD4+ T cell responses after vaccination and during Mycobacterium tuberculosis challenge

31 March 2020

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Overexpression of IL-17 in the knee joint of collagen type II immunized mice promotes collagen arthritis and aggravates joint destruction

31 March 2020

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Treatment with a neutralizing anti-murine interleukin-17 antibody after the onset of collagen-induced arthritis reduces joint inflammation, cartilage destruction, and bone erosion

31 March 2020

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Interleukin-17 receptor deficiency results in impaired synovial expression of interleukin-1 and matrix metalloproteinases 3, 9, and 13 and prevents cartilage destruction during chronic reactivated streptococcal cell wall-induced arthritis.

31 March 2020

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31 March 2020

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31 March 2020

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Interleukin-22, a T(H)17 cytokine, mediates IL-23-induced dermal inflammation and acanthosis

31 March 2020

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Amelioration of epidermal hyperplasia by TNF inhibition is associated with reduced Th17 responses

31 March 2020

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Induction of IL-17+ T cell trafficking and development by IFN-gamma: mechanism and pathological relevance in psoriasis

31 March 2020

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Psoriasis Vulgaris Lesions Contain Discrete Populations of Th1 and Th17 T Cells

31 March 2020

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Chronically inflamed human tissues are infiltrated by highly differentiated Th17 lymphocytes

31 March 2020

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Th17 cytokines stimulate CCL20 expression in keratinocytes in vitro and in vivo: implications for psoriasis pathogenesis

31 March 2020

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Analysis of IL-17(+) cells in facet joints of patients with spondyloarthritis suggests that the innate immune pathway might be of greater relevance than the Th17-mediated adaptive immune response

31 March 2020

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Genetic determinants of ulcerative colitis include the ECM1 locus and five loci implicated in Crohn's disease

31 March 2020

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IL-23 receptor (IL-23R) gene protects against pediatric Crohn's disease

31 March 2020

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IL23 differentially regulates the Th1/Th17 balance in ulcerative colitis and Crohn's disease

31 March 2020

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IL-23 is essential for T cell-mediated colitis and promotes inflammation via IL-17 and IL-6

31 March 2020

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Monoclonal Anti–Interleukin 23 Reverses Active Colitis in a T Cell–Mediated Model in Mice

31 March 2020

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A protective function for interleukin 17A in T cell-mediated intestinal inflammation

31 March 2020

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31 March 2020

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31 March 2020

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31 March 2020

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31 March 2020

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31 March 2020

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31 March 2020

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31 March 2020

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31 March 2020

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Role of interleukin-17 and interleukin-17-induced cytokines interleukin-6 and interleukin-8 in unstable coronary artery disease

31 March 2020

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Interleukin-17 and interferon-gamma are produced concomitantly by human coronary artery-infiltrating T cells and act synergistically on vascular smooth muscle cells

31 March 2020

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Attenuated atherosclerosis upon IL-17R signaling disruption in LDLr deficient mice.

31 March 2020

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Blockade of interleukin-17A results in reduced atherosclerosis in apolipoprotein E-deficient mice

31 March 2020

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IL-17A is proatherogenic in high-fat diet-induced and Chlamydia pneumoniae infection-accelerated atherosclerosis in mice

31 March 2020

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Role of IL-17A, IL-17F, and the IL-17 receptor in regulating growth-related oncogene-alpha and granulocyte colony-stimulating factor in bronchial epithelium: implications for airway inflammation in cystic fibrosis

31 March 2020

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Interleukin-17A mRNA and protein expression within cells from the human bronchoalveolar space after exposure to organic dust

31 March 2020

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31 March 2020

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31 March 2020

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31 March 2020

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31 March 2020

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31 March 2020

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31 March 2020

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T helper type 17-related cytokine expression is increased in the bronchial mucosa of stable chronic obstructive pulmonary disease patients.

31 March 2020

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Expression of the T helper 17-associated cytokines IL-17A and IL-17F in asthma and COPD.

31 March 2020

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CD8 positive T cells express IL-17 in patients with chronic obstructive pulmonary disease

31 March 2020

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The expression of Foxp3 and ROR gamma t in lung tissues from normal smokers and chronic obstructive pulmonary disease patients.

31 March 2020

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Cigarette smoke induction of osteopontin (SPP1) mediates T(H)17 inflammation in human and experimental emphysema

31 March 2020

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Interleukin-17-mediated immunopathogenesis in experimental hypersensitivity pneumonitis

31 March 2020

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Bleomycin and IL-1beta-mediated pulmonary fibrosis is IL-17A dependent

31 March 2020

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Blocking IL-17A promotes the resolution of pulmonary inflammation and fibrosis via TGF-beta1-dependent and -independent mechanisms

31 March 2020

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31 March 2020

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31 March 2020

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31 March 2020

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31 March 2020

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31 March 2020

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Digoxin and its derivatives suppress TH17 cell differentiation by antagonizing RORγt activity

31 March 2020

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Suppression of TH17 differentiation and autoimmunity by a synthetic ROR ligand

31 March 2020

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Ursolic acid suppresses interleukin-17 (IL-17) production by selectively antagonizing the function of RORgamma t protein

31 March 2020

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31 March 2020

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World Bispecific Antibody Summit, September 27-28, 2011, Boston, MA.

31 March 2020

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Interleukin-17 and its receptor

31 March 2020

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Structure and signalling in the IL-17 receptor family

31 March 2020

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IL-17RA and IL-17RC receptors are essential for IL-17A-induced ELR+ CXC chemokine expression in synoviocytes and are overexpressed in rheumatoid blood

31 March 2020

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Brief report: inhibition of interleukin-6 function corrects Th17/Treg cell imbalance in patients with rheumatoid arthritis

31 March 2020

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Effects of AIN457, a Fully Human Antibody to Interleukin-17A, on Psoriasis, Rheumatoid Arthritis, and Uveitis

31 March 2020

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LY2439821, a humanized anti-interleukin-17 monoclonal antibody, in the treatment of patients with rheumatoid arthritis: A phase I randomized, double-blind, placebo-controlled, proof-of-concept study

31 March 2020

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Brodalumab, an Anti–Interleukin-17–Receptor Antibody for Psoriasis

31 March 2020

1 reference

Are Th17 cells in the gut pathogenic or protective?

31 March 2020

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Interleukin-17: an emerging role in lung inflammation

31 March 2020

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Anti–Interleukin-17 Monoclonal Antibody Ixekizumab in Chronic Plaque Psoriasis

31 March 2020

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Interleukin-17 in fashion, at last: ten years after its description, its cellular source has been identified

31 March 2020

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Interleukin 17, a T-cell-derived cytokine, promotes tumorigenicity of human cervical tumors in nude mice.

31 March 2020

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12 December 2020

Secukinumab, a human anti-IL-17A monoclonal antibody, for moderate to severe Crohn's disease: unexpected results of a randomised, double-blind placebo-controlled trial

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12 December 2020

IL-17 stimulates granulopoiesis in mice: use of an alternate, novel gene therapy-derived method for in vivo evaluation of cytokines

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12 December 2020

CTLA-8, cloned from an activated T cell, bearing AU-rich messenger RNA instability sequences, and homologous to a herpesvirus saimiri gene

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Human IL-17: a novel cytokine derived from T cells

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Interleukin 17: an example for gene therapy as a tool to study cytokine mediated regulation of hematopoiesis

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A CC' loop decoy peptide blocks the interaction between Act1 and IL-17RA to attenuate IL-17- and IL-25-induced inflammation.

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12 December 2020

Enhancing effect of IL-17 on IL-1-induced IL-6 and leukemia inhibitory factor production by rheumatoid arthritis synoviocytes and its regulation by Th2 cytokines.

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12 December 2020

IL-17: prototype member of an emerging cytokine family

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12 December 2020

Th17-polarized immune response in a murine model of hypersensitivity pneumonitis and lung fibrosis

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12 December 2020

Identifiers

DOI

10.1038/NRD3794

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27 August 2017

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