(Q38176101)

30 August 2017

title

Targeted inhibition of the FGF19-FGFR4 pathway in hepatocellular carcinoma; translational safety considerations (English)

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30 August 2017

main subject

hepatocellular carcinoma

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Howard R Mellor

1

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30 August 2017

publication date

24 January 2014

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30 August 2017

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30 August 2017

volume

34

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30 August 2017

issue

6

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30 August 2017

page(s)

e1-9

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Fibroblast growth factor signalling: from development to cancer

30 August 2017

cites work

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Synergistic induction of mesoderm by FGF and TGF-beta and the identification of an mRNA coding for FGF in the early Xenopus embryo.

21 January 2018

1 reference

Characterization of a novel protein (FGFRL1) from human cartilage related to FGF receptors.

21 January 2018

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Fibroblast growth factors and their receptors in cancer

21 January 2018

1 reference

Liver-specific activities of FGF19 require Klotho beta

21 January 2018

1 reference

Fibroblast growth factor 19 expression correlates with tumor progression and poorer prognosis of hepatocellular carcinoma

21 January 2018

1 reference

A mouse model of hepatocellular carcinoma: ectopic expression of fibroblast growth factor 19 in skeletal muscle of transgenic mice

21 January 2018

1 reference

Targeting FGF19 inhibits tumor growth in colon cancer xenograft and FGF19 transgenic hepatocellular carcinoma models.

21 January 2018

1 reference

Targeting FGFR4 inhibits hepatocellular carcinoma in preclinical mouse models

21 January 2018

1 reference

Elevated cholesterol metabolism and bile acid synthesis in mice lacking membrane tyrosine kinase receptor FGFR4

21 January 2018

1 reference

Fibroblast growth factor 15 functions as an enterohepatic signal to regulate bile acid homeostasis

21 January 2018

1 reference

Hepatocellular carcinoma in ten children under five years of age with bile salt export pump deficiency

21 January 2018

1 reference

A new mechanism for bile acid diarrhea: defective feedback inhibition of bile acid biosynthesis

21 January 2018

1 reference

Liver functional reserve estimation: state of the art and relevance to local treatments

21 January 2018

1 reference

Specificity for fibroblast growth factors determined by heparan sulfate in a binary complex with the receptor kinase

21 January 2018

1 reference

Fibroblast growth factor receptor 4 regulates proliferation, anti-apoptosis and alpha-fetoprotein secretion during hepatocellular carcinoma progression and represents a potential target for therapeutic intervention

21 January 2018

1 reference

Cellular aspects of alpha-fetoprotein reexpression in tumors

21 January 2018

1 reference

Managing bile acid diarrhoea

21 January 2018

1 reference

Research resource: Comprehensive expression atlas of the fibroblast growth factor system in adult mouse.

21 January 2018

1 reference

Potent stimulation of fibroblast growth factor 19 expression in the human ileum by bile acids

21 January 2018

1 reference

FGF-19, a novel fibroblast growth factor with unique specificity for FGFR4

21 January 2018

1 reference

The human gallbladder secretes fibroblast growth factor 19 into bile: towards defining the role of fibroblast growth factor 19 in the enterobiliary tract.

21 January 2018

1 reference

High expression of the bile salt-homeostatic hormone fibroblast growth factor 19 in the liver of patients with extrahepatic cholestasis

21 January 2018

1 reference

FXR agonists and FGF15 reduce fecal bile acid excretion in a mouse model of bile acid malabsorption

21 January 2018

1 reference

Identification of a hormonal basis for gallbladder filling.

21 January 2018

1 reference

Tissue-specific expression of betaKlotho and fibroblast growth factor (FGF) receptor isoforms determines metabolic activity of FGF19 and FGF21

21 January 2018

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Impaired negative feedback suppression of bile acid synthesis in mice lacking betaKlotho

21 January 2018

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Transgenic mice expressing human fibroblast growth factor-19 display increased metabolic rate and decreased adiposity

21 January 2018

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Fibroblast growth factor 19 increases metabolic rate and reverses dietary and leptin-deficient diabetes.

21 January 2018

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Acetyl-CoA carboxylase 2-/- mutant mice are protected against fatty liver under high-fat, high-carbohydrate dietary and de novo lipogenic conditions.

21 January 2018

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Hepatic stearoyl-CoA desaturase-1 deficiency protects mice from carbohydrate-induced adiposity and hepatic steatosis

21 January 2018

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FGFR4 prevents hyperlipidemia and insulin resistance but underlies high-fat diet induced fatty liver

21 January 2018

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Selective activation of FGFR4 by an FGF19 variant does not improve glucose metabolism in ob/ob mice

21 January 2018

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Bile acid synthesis in humans has a rapid diurnal variation that is asynchronous with cholesterol synthesis

21 January 2018

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Mice expressing the human CYP7A1 gene in the mouse CYP7A1 knock-out background lack induction of CYP7A1 expression by cholesterol feeding and have increased hypercholesterolemia when fed a high fat diet

21 January 2018

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Regulation of cholesterol 7alpha-hydroxylase gene (CYP7A1) transcription by the liver orphan receptor (LXRalpha).

21 January 2018

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Antibody-mediated inhibition of fibroblast growth factor 19 results in increased bile acids synthesis and ileal malabsorption of bile acids in cynomolgus monkeys

21 January 2018

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Role of the bile salt export pump, BSEP, in acquired forms of cholestasis

21 January 2018

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Metabonomic profiles discriminate hepatocellular carcinoma from liver cirrhosis by ultraperformance liquid chromatography-mass spectrometry

21 January 2018

1 reference

Increased levels of typically fetal bile acid species in patients with hepatocellular carcinoma

21 January 2018

1 reference

Aberrant lipid metabolism in hepatocellular carcinoma revealed by plasma metabolomics and lipid profiling

21 January 2018

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Bile salt export pump is dysregulated with altered farnesoid X receptor isoform expression in patients with hepatocellular carcinoma

21 January 2018

1 reference

Hepatocellular carcinoma with obstructive jaundice: endoscopic and percutaneous biliary drainage

21 January 2018

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Intrahepatic bile duct recurrence of hepatocellular carcinoma without a detectable liver tumor

21 January 2018

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Hepatocellular carcinoma with bile duct tumor thrombi: correlation of magnetic resonance imaging features to histopathologic manifestations

21 January 2018

1 reference

Influence of newly synthesized cholesterol on bile acid synthesis during chronic inhibition of bile acid absorption

21 January 2018

1 reference

21 January 2018

Identifiers

DOI

10.1111/LIV.12462

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30 August 2017

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