(Q38176963)

30 August 2017

title

A population biological approach to understanding the maintenance and loss of the T-cell repertoire during aging (English)

1 reference

30 August 2017

3

Rustom Antia

1 reference

30 August 2017

Philip L F Johnson

1

1 reference

30 August 2017

Jörg J Goronzy

series ordinal

2

1 reference

30 August 2017

publication date

1 June 2014

1 reference

30 August 2017

1 reference

30 August 2017

volume

142

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30 August 2017

issue

2

1 reference

30 August 2017

page(s)

167-175

1 reference

Heterogeneous differentiation patterns of individual CD8+ T cells.

30 August 2017

cites work

1 reference

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Disparate individual fates compose robust CD8+ T cell immunity

31 August 2018

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Predicting the molecular complexity of sequencing libraries

31 August 2018

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Virus-specific CD4(+) memory-phenotype T cells are abundant in unexposed adults.

31 August 2018

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High-throughput sequencing of the paired human immunoglobulin heavy and light chain repertoire.

31 August 2018

1 reference

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Peripheral selection rather than thymic involution explains sudden contraction in naive CD4 T-cell diversity with age.

31 August 2018

1 reference

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Lifelong persistent viral infection alters the naive T cell pool, impairing CD8 T cell immunity in late life

31 August 2018

1 reference

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Statistical inference of the generation probability of T-cell receptors from sequence repertoires

31 August 2018

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31 August 2018

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Homeostatic maintenance of T cells and natural killer cells

31 August 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4008225

Maintenance of peripheral naive T cells is sustained by thymus output in mice but not humans.

31 August 2018

1 reference

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31 August 2018

Losing TREC with age.

1 reference

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Cytometry by time-of-flight shows combinatorial cytokine expression and virus-specific cell niches within a continuum of CD8+ T cell phenotypes

31 August 2018

1 reference

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Determinants of public T cell responses

31 August 2018

1 reference

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Quantitative impact of thymic selection on Foxp3+ and Foxp3- subsets of self-peptide/MHC class II-specific CD4+ T cells

31 August 2018

1 reference

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Nonrandom attrition of the naive CD8+ T-cell pool with aging governed by T-cell receptor:pMHC interactions

31 August 2018

1 reference

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A mechanism for TCR sharing between T cell subsets and individuals revealed by pyrosequencing.

31 August 2018

1 reference

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Evolution of the antigen-specific CD8+ TCR repertoire across the life span: evidence for clonal homogenization of the old TCR repertoire

31 August 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4008225

Overlap and effective size of the human CD8+ T cell receptor repertoire

31 August 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4008225

Homeostatic Turnover of Virus-Specific Memory CD8 T Cells Occurs Stochastically and Is Independent of CD4 T Cell Help

31 August 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4008225

High throughput sequencing reveals a complex pattern of dynamic interrelationships among human T cell subsets

31 August 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4008225

Naive T cell homeostasis: from awareness of space to a sense of place

31 August 2018

1 reference

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The yellow fever virus vaccine induces a broad and polyfunctional human memory CD8+ T cell response

31 August 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4008225

Quantifying thymic export: combining models of naive T cell proliferation and TCR excision circle dynamics gives an explicit measure of thymic output.

31 August 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4008225

Effect of ageing on CMV-specific CD8 T cells from CMV seropositive healthy donors

31 August 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4008225

Profiling the T-cell receptor beta-chain repertoire by massively parallel sequencing

31 August 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4008225

Thymic involution and immune reconstitution.

31 August 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4008225

Clonal expansions and loss of receptor diversity in the naive CD8 T cell repertoire of aged mice

31 August 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4008225

The ageing immune system: is it ever too old to become young again?

31 August 2018

1 reference

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Memory CD8 T-cell compartment grows in size with immunological experience

31 August 2018

1 reference

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Ageing and life-long maintenance of T-cell subsets in the face of latent persistent infections

31 August 2018

1 reference

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T cell subset-specific susceptibility to aging.

31 August 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4008225

Dramatic increase in naive T cell turnover is linked to loss of naive T cells from old primates

31 August 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4008225

Asymmetric T lymphocyte division in the initiation of adaptive immune responses.

31 August 2018

1 reference

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Naive and memory CD4+ T cell survival controlled by clonal abundance

31 August 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4008225

Longitudinal studies of clonally expanded CD8 T cells reveal a repertoire shrinkage predicting mortality and an increased number of dysfunctional cytomegalovirus-specific T cells in the very elderly

31 August 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4008225

Broadly targeted human cytomegalovirus-specific CD4+ and CD8+ T cells dominate the memory compartments of exposed subjects

31 August 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4008225

Post-thymic in vivo proliferation of naive CD4+ T cells constrains the TCR repertoire in healthy human adults.

31 August 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4008225

The influence of age on T cell generation and TCR diversity

31 August 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4008225

Long-term cytomegalovirus infection leads to significant changes in the composition of the CD8+ T-cell repertoire, which may be the basis for an imbalance in the cytokine production profile in elderly persons

31 August 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4008225

31 August 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4008225

Rapid turnover of effector-memory CD4(+) T cells in healthy humans

31 August 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4008225

The many important facets of T-cell repertoire diversity

31 August 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4008225

The age distribution of cancer and a multi-stage theory of carcinogenesis

31 August 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4008225

Interleukin 15 is required for proliferative renewal of virus-specific memory CD8 T cells

31 August 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4008225

Estimating the precursor frequency of naive antigen-specific CD8 T cells

31 August 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4008225

Population biology of lymphocytes: the flight for survival

31 August 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4008225

Persistence of memory CD8 T cells in MHC class I-deficient mice

31 August 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4008225

A direct estimate of the human alphabeta T cell receptor diversity

31 August 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4008225

Differential requirements for survival and proliferation of CD8 naïve or memory T cells

31 August 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4008225

Reduction of otherwise remarkably stable virus-specific cytotoxic T lymphocyte memory by heterologous viral infections.

31 August 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4008225

Lymphocyte subsets and natural killer cell activity in healthy old people and centenarians.

31 August 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4008225

Mutation and cancer: a model for human carcinogenesis

31 August 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4008225

The involution of the ageing human thymic epithelium is independent of puberty. A morphometric study

31 August 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4008225

T-cell antigen receptor genes and T-cell recognition

31 August 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4008225

Adaptive cellular interactions in the immune system: the tunable activation threshold and the significance of subthreshold responses

31 August 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4008225

31 August 2018

Measurement of Diversity

1 reference

Crossref

https://api.crossref.org/works/10.1111%2FIMM.12244

How diverse should the immune system be?

21 January 2018

1 reference

PubMed

https://pubmed.ncbi.nlm.nih.gov/24405293

inferred from PubMed ID database lookup

12 December 2020

based on heuristic

The peripheral T cell repertoire: independent homeostatic regulation of virgin and activated CD8+ T cell pools

1 reference

PubMed

https://pubmed.ncbi.nlm.nih.gov/24405293

inferred from PubMed ID database lookup

12 December 2020

based on heuristic

Kinetics of B, CD4 T, and CD8 T cells infused into humans: estimates of intravascular:extravascular ratios and total body counts

1 reference

PubMed

https://pubmed.ncbi.nlm.nih.gov/24405293

inferred from PubMed ID database lookup

12 December 2020

based on heuristic

Identifiers

DOI

10.1111/IMM.12244

1 reference

30 August 2017

0 references

1 reference