(Q38198086)

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:24654603%20AND%20SRC:MED&resulttype=core&format=json

11 March 2020

review article

1 reference

title

Therapeutic potential of tyrosine kinase 2 in autoimmunity (English)

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:24654603%20AND%20SRC:MED&resulttype=core&format=json

11 March 2020

8

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:24654603%20AND%20SRC:MED&resulttype=core&format=json

11 March 2020

author name string

Yan Liang

1

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:24654603%20AND%20SRC:MED&resulttype=core&format=json

11 March 2020

Yan Zhu

2

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:24654603%20AND%20SRC:MED&resulttype=core&format=json

11 March 2020

Yi Xia

3

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:24654603%20AND%20SRC:MED&resulttype=core&format=json

11 March 2020

Hui Peng

4

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:24654603%20AND%20SRC:MED&resulttype=core&format=json

11 March 2020

Xiao-Ke Yang

5

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:24654603%20AND%20SRC:MED&resulttype=core&format=json

11 March 2020

Yan-Yan Liu

6

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:24654603%20AND%20SRC:MED&resulttype=core&format=json

11 March 2020

Wang-Dong Xu

7

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:24654603%20AND%20SRC:MED&resulttype=core&format=json

11 March 2020

Dong-Qing Ye

9

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:24654603%20AND%20SRC:MED&resulttype=core&format=json

11 March 2020

language of work or name

English

0 references

publication date

21 March 2014

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:24654603%20AND%20SRC:MED&resulttype=core&format=json

Expert Opinion on Therapeutic Targets

11 March 2020

published in

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:24654603%20AND%20SRC:MED&resulttype=core&format=json

11 March 2020

volume

18

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:24654603%20AND%20SRC:MED&resulttype=core&format=json

11 March 2020

issue

5

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:24654603%20AND%20SRC:MED&resulttype=core&format=json

11 March 2020

page(s)

571-580

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:24654603%20AND%20SRC:MED&resulttype=core&format=json

A natural mutation in the Tyk2 pseudokinase domain underlies altered susceptibility of B10.Q/J mice to infection and autoimmunity

11 March 2020

cites work

1 reference

https://api.crossref.org/works/10.1517%2F14728222.2014.892925

An unusual insertion in Jak2 is crucial for kinase activity and differentially affects cytokine responses

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14728222.2014.892925

Janus kinases in immune cell signaling

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14728222.2014.892925

Interferon-induced nuclear signalling by Jak protein tyrosine kinases

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14728222.2014.892925

The JAK-STAT signaling pathway: input and output integration

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14728222.2014.892925

Activation of Tyk2 and Stat3 is required for the apoptotic actions of interferon-beta in primary pro-B cells

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14728222.2014.892925

Involvement of tyrosine kinase-2 in both the IL-12/Th1 and IL-23/Th17 axes in vivo.

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14728222.2014.892925

Partial impairment of cytokine responses in Tyk2-deficient mice

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14728222.2014.892925

Novel functions of tyrosine kinase 2 in the antiviral defense against murine cytomegalovirus

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14728222.2014.892925

Octamer-binding factor 6 (Oct-6/Pou3f1) is induced by interferon and contributes to dsRNA-mediated transcriptional responses

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14728222.2014.892925

Central role for type I interferons and Tyk2 in lipopolysaccharide-induced endotoxin shock

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14728222.2014.892925

Selective contribution of Tyk2 to cell activation by lipopolysaccharide.

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14728222.2014.892925

Transcriptome analysis reveals a major impact of JAK protein tyrosine kinase 2 (Tyk2) on the expression of interferon-responsive and metabolic genes

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14728222.2014.892925

Protein tyrosine phosphatase 1B negatively regulates macrophage development through CSF-1 signaling

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14728222.2014.892925

RRR-alpha-tocopherol decreases the expression of the major scavenger receptor, CD36, in human macrophages via inhibition of tyrosine kinase (Tyk2).

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14728222.2014.892925

From macrophage interleukin-13 receptor to foam cell formation: mechanisms for αMβ2 integrin interference

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14728222.2014.892925

IL-4 and IL-13 employ discrete signaling pathways for target gene expression in alternatively activated monocytes/macrophages

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14728222.2014.892925

Tyrosine kinase 2 and interferon regulatory factor 5 polymorphisms are associated with discoid and subacute cutaneous lupus erythematosus

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14728222.2014.892925

Tyk2-signaling plays an important role in host defense against Escherichia coli through IL-23-induced IL-17 production by gammadelta T cells

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14728222.2014.892925

Protective role of naturally occurring interleukin-17A-producing γδ T cells in the lung at the early stage of systemic candidiasis in mice

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14728222.2014.892925

Dengue virus type 2 antagonizes IFN-alpha but not IFN-gamma antiviral effect via down-regulating Tyk2-STAT signaling in the human dendritic cell

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14728222.2014.892925

Defective IL-10 signaling in hyper-IgE syndrome results in impaired generation of tolerogenic dendritic cells and induced regulatory T cells.

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14728222.2014.892925

Tumor-induced suppressor of cytokine signaling 3 inhibits toll-like receptor 3 signaling in dendritic cells via binding to tyrosine kinase 2.

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14728222.2014.892925

IFN-γ activated JAK1 shifts CD40-induced cytokine profiles in human antigen-presenting cells toward high IL-12p70 and low IL-10 production.

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14728222.2014.892925

An important role of Tyk2 in APC function of dendritic cells for priming CD8+ T cells producing IFN-gamma.

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14728222.2014.892925

NK cells in central nervous system disorders

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14728222.2014.892925

Natural killer (NK) cells in antibacterial innate immunity: angels or devils?

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14728222.2014.892925

JAK1 and Tyk2 activation by the homologous polycythemia vera JAK2 V617F mutation: cross-talk with IGF1 receptor.

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14728222.2014.892925

Cutting edge: tyk2 is required for the induction and nuclear translocation of Daxx which regulates IFN-alpha-induced suppression of B lymphocyte formation.

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14728222.2014.892925

Limitin, an interferon-like cytokine, transduces inhibitory signals on B-cell growth through activation of Tyk2, but not Stat1, followed by induction and nuclear translocation of Daxx.

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14728222.2014.892925

Daxx: death or survival protein?

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14728222.2014.892925

Aberrant CD40-induced NF-κB activation in human lupus B lymphocytes

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14728222.2014.892925

Tyrosine kinase 2 interacts with the proapoptotic protein Siva-1 and augments its apoptotic functions

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14728222.2014.892925

Analysis of the mitochondrial proteome in multiple sclerosis cortex

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14728222.2014.892925

Tyk2 tyrosine kinase expression is required for the maintenance of mitochondrial respiration in primary pro-B lymphocytes

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14728222.2014.892925

A proteomic investigation of B lymphocytes in an autistic family: a pilot study of exposure to natural rubber latex (NRL) may lead to autism

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14728222.2014.892925

Enhanced Th2 cell-mediated allergic inflammation in Tyk2-deficient mice

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14728222.2014.892925

Hapten-induced contact hypersensitivity is enhanced in Tyk2-deficient mice

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14728222.2014.892925

Tyk2 negatively regulates adaptive Th1 immunity by mediating IL-10 signaling and promoting IFN-gamma-dependent IL-10 reactivation

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14728222.2014.892925

Tyrosine kinase 2 variant influences T lymphocyte polarization and multiple sclerosis susceptibility

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14728222.2014.892925

Tyrosine kinase 2 plays critical roles in the pathogenic CD4 T cell responses for the development of experimental autoimmune encephalomyelitis

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14728222.2014.892925

The kinase inhibitory region of SOCS-1 is sufficient to inhibit T-helper 17 and other immune functions in experimental allergic encephalomyelitis

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14728222.2014.892925

Noncanonical K27-linked polyubiquitination of TIEG1 regulates Foxp3 expression and tumor growth.

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14728222.2014.892925

PD-L1 regulates the development, maintenance, and function of induced regulatory T cells

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14728222.2014.892925

Mesenchymal stem cells from periapical lesions modulate differentiation and functional properties of monocyte-derived dendritic cells.

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14728222.2014.892925

Induction of antitumor immunity ex vivo using dendritic cells transduced with fowl pox vector expressing MUC1, CEA, and a triad of costimulatory molecules (rF-PANVAC).

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14728222.2014.892925

Tyk2 deficiency protects joints against destruction in anti-type II collagen antibody-induced arthritis in mice.

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14728222.2014.892925

Gene expression in IFNß signalling pathway differs between monocytes, CD4 and CD8 T cells from MS patients

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14728222.2014.892925

A restricted role for TYK2 catalytic activity in human cytokine responses revealed by novel TYK2-selective inhibitors

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14728222.2014.892925

Tyk2 is essential for IFN-alpha-induced gene expression in mast cells

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14728222.2014.892925

Organ-specific and differential requirement of TYK2 and IFNAR1 for LPS-induced iNOS expression in vivo

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14728222.2014.892925

STAT1-deficient mice are resistant to cecal ligation and puncture-induced septic shock

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14728222.2014.892925

Replication of recently identified systemic lupus erythematosus genetic associations: a case-control study

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14728222.2014.892925

Evidence for genetic association and interaction between the TYK2 and IRF5 genes in systemic lupus erythematosus

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14728222.2014.892925

Lack of association between tyrosine kinase 2 (TYK2) gene polymorphisms and susceptibility to SLE in a Japanese population

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14728222.2014.892925

Polymorphisms in the tyrosine kinase 2 and interferon regulatory factor 5 genes are associated with systemic lupus erythematosus

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14728222.2014.892925

Lack of association of TYK2 gene polymorphisms in Chinese patients with systemic lupus erythematosus.

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14728222.2014.892925

Association of NCF2, IKZF1, IRF8, IFIH1, and TYK2 with systemic lupus erythematosus

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14728222.2014.892925

A rare variant of the TYK2 gene is confirmed to be associated with multiple sclerosis

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14728222.2014.892925

Genome-wide association study identifies new multiple sclerosis susceptibility loci on chromosomes 12 and 20.

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14728222.2014.892925

Replication analysis identifies TYK2 as a multiple sclerosis susceptibility factor

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14728222.2014.892925

Exome sequencing identifies a novel multiple sclerosis susceptibility variant in the TYK2 gene

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14728222.2014.892925

The influence of non-HLA gene polymorphisms and interactions on disease risk in a Western Australian multiple sclerosis cohort

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14728222.2014.892925

Lack of replication of genetic predictors for the rheumatoid arthritis response to anti-TNF treatments: a prospective case-only study

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14728222.2014.892925

Strong evidence of a combination polymorphism of the tyrosine kinase 2 gene and the signal transducer and activator of transcription 3 gene as a DNA-based biomarker for susceptibility to Crohn's disease in the Japanese population

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14728222.2014.892925

The imprinted DLK1-MEG3 gene region on chromosome 14q32.2 alters susceptibility to type 1 diabetes

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14728222.2014.892925

Oleanolic acid suppresses resistin induction in adipocytes by modulating Tyk-STAT signaling

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14728222.2014.892925

Interferon-alpha-dependent activation of Tyk2 requires phosphorylation of positive regulatory tyrosines by another kinase

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14728222.2014.892925

Deficient SOCS3 and SHP-1 expression in psoriatic T cells

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14728222.2014.892925

PTP1B is a negative regulator of interleukin 4-induced STAT6 signaling

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14728222.2014.892925

CD45 is a JAK phosphatase and negatively regulates cytokine receptor signalling

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14728222.2014.892925

TYK2 kinase activity is required for functional type I interferon responses in vivo

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14728222.2014.892925

Cross-inhibition of interferon-induced signals by GM-CSF through a block in Stat1 activation

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14728222.2014.892925

A dual role for the kinase-like domain of the tyrosine kinase Tyk2 in interferon-alpha signaling

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14728222.2014.892925

Two rare disease-associated Tyk2 variants are catalytically impaired but signaling competent.

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14728222.2014.892925

Structural and thermodynamic characterization of the TYK2 and JAK3 kinase domains in complex with CP-690550 and CMP-6

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14728222.2014.892925

A new regulatory switch in a JAK protein kinase

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14728222.2014.892925

Enabling structure-based drug design of Tyk2 through co-crystallization with a stabilizing aminoindazole inhibitor

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14728222.2014.892925

Association of a haplotype in the promoter region of the interferon regulatory factor 5 gene with rheumatoid arthritis

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14728222.2014.892925

10.1517/14728222.2014.892925

21 January 2018

Identifiers

DOI

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:24654603%20AND%20SRC:MED&resulttype=core&format=json

11 March 2020

1 reference