(Q38203467)

30 August 2017

The mutational spectrum of squamous-cell carcinoma of the head and neck: targetable genetic events and clinical impact (English)

1 reference

head and neck squamous cell carcinoma

30 August 2017

1 reference

1 reference

G Mountzios

1

1 reference

PubMed ID

24718888

30 August 2017

T Rampias

series ordinal

2

1 reference

PubMed ID

24718888

30 August 2017

A Psyrri

series ordinal

3

1 reference

30 August 2017

8 April 2014

1 reference

30 August 2017

1 reference

30 August 2017

25

1 reference

30 August 2017

10

1 reference

30 August 2017

1889-1900

1 reference

Estimates of worldwide burden of cancer in 2008: GLOBOCAN 2008

30 August 2017

1 reference

https://api.crossref.org/works/10.1093%2FANNONC%2FMDU143

Evidence for a causal association between human papillomavirus and a subset of head and neck cancers

21 January 2018

1 reference

https://api.crossref.org/works/10.1093%2FANNONC%2FMDU143

21 January 2018

1 reference

https://api.crossref.org/works/10.1093%2FANNONC%2FMDU143

Temporal trends in the incidence and survival of cancers of the upper aerodigestive tract in Ontario and the United States.

21 January 2018

1 reference

https://api.crossref.org/works/10.1093%2FANNONC%2FMDU143

Frequent mutation of the PI3K pathway in head and neck cancer defines predictive biomarkers

21 January 2018

1 reference

https://api.crossref.org/works/10.1093%2FANNONC%2FMDU143

The mutational landscape of head and neck squamous cell carcinoma

21 January 2018

1 reference

https://api.crossref.org/works/10.1093%2FANNONC%2FMDU143

Integrative genomic characterization of oral squamous cell carcinoma identifies frequent somatic drivers

21 January 2018

1 reference

https://api.crossref.org/works/10.1093%2FANNONC%2FMDU143

The Cancer Genome Atlas Pan-Cancer analysis project

21 January 2018

1 reference

https://api.crossref.org/works/10.1093%2FANNONC%2FMDU143

Pilot study using molecular profiling of patients' tumors to find potential targets and select treatments for their refractory cancers.

21 January 2018

1 reference

https://api.crossref.org/works/10.1093%2FANNONC%2FMDU143

The BATTLE trial: personalizing therapy for lung cancer

21 January 2018

1 reference

https://api.crossref.org/works/10.1093%2FANNONC%2FMDU143

Molecular subtypes in head and neck cancer exhibit distinct patterns of chromosomal gain and loss of canonical cancer genes.

21 January 2018

1 reference

https://api.crossref.org/works/10.1093%2FANNONC%2FMDU143

The molecular biology of head and neck cancer

21 January 2018

1 reference

https://api.crossref.org/works/10.1093%2FANNONC%2FMDU143

Awakening guardian angels: drugging the p53 pathway

21 January 2018

1 reference

https://api.crossref.org/works/10.1093%2FANNONC%2FMDU143

Loss of MDM2 expression in human head and neck squamous cell carcinomas and clinical significance

21 January 2018

1 reference

https://api.crossref.org/works/10.1093%2FANNONC%2FMDU143

TP53 disruptive mutations lead to head and neck cancer treatment failure through inhibition of radiation-induced senescence.

21 January 2018

1 reference

https://api.crossref.org/works/10.1093%2FANNONC%2FMDU143

The p53 tumor-suppressor gene

21 January 2018

1 reference

https://api.crossref.org/works/10.1093%2FANNONC%2FMDU143

Gain of function mutations in p53.

21 January 2018

1 reference

https://api.crossref.org/works/10.1093%2FANNONC%2FMDU143

Reassessment of the TP53 mutation database in human disease by data mining with a library of TP53 missense mutations

21 January 2018

1 reference

https://api.crossref.org/works/10.1093%2FANNONC%2FMDU143

TP53 mutations and survival in squamous-cell carcinoma of the head and neck.

21 January 2018

1 reference

https://api.crossref.org/works/10.1093%2FANNONC%2FMDU143

TP53 mutations and pathologic complete response to neoadjuvant cisplatin and fluorouracil chemotherapy in resected oral cavity squamous cell carcinoma.

21 January 2018

1 reference

https://api.crossref.org/works/10.1093%2FANNONC%2FMDU143

p53 alterations predict tumor response to neoadjuvant chemotherapy in head and neck squamous cell carcinoma: a prospective series.

21 January 2018

1 reference

https://api.crossref.org/works/10.1093%2FANNONC%2FMDU143

TP53 mutation is related to poor prognosis after radiotherapy, but not surgery, in squamous cell carcinoma of the head and neck

21 January 2018

1 reference

https://api.crossref.org/works/10.1093%2FANNONC%2FMDU143

The Ligamp TP53 Assay for Detection of Minimal Residual Disease in Head and Neck Squamous Cell Carcinoma Surgical Margins

21 January 2018

1 reference

https://api.crossref.org/works/10.1093%2FANNONC%2FMDU143

Phase II trial of intratumoral administration of ONYX-015, a replication-selective adenovirus, in patients with refractory head and neck cancer

21 January 2018

1 reference

https://api.crossref.org/works/10.1093%2FANNONC%2FMDU143

a controlled trial of intratumoral ONYX-015, a selectively-replicating adenovirus, in combination with cisplatin and 5-fluorouracil in patients with recurrent head and neck cancer

21 January 2018

1 reference

https://api.crossref.org/works/10.1093%2FANNONC%2FMDU143

Biomarkers Predict p53 Gene Therapy Efficacy in Recurrent Squamous Cell Carcinoma of the Head and Neck

21 January 2018

1 reference

https://api.crossref.org/works/10.1093%2FANNONC%2FMDU143

Head and neck cancer: response to p53-based therapeutics

21 January 2018

1 reference

https://api.crossref.org/works/10.1093%2FANNONC%2FMDU143

p16(INK4a)/CDKN2 expression and its relationship with oral squamous cell carcinoma is our current knowledge enough?

21 January 2018

1 reference

https://api.crossref.org/works/10.1093%2FANNONC%2FMDU143

Demethylation treatment restores hic1 expression and impairs aggressiveness of head and neck squamous cell carcinoma

21 January 2018

1 reference

https://api.crossref.org/works/10.1093%2FANNONC%2FMDU143

Adenovirus-mediated combined P16 gene and GM-CSF gene therapy for the treatment of established tumor and induction of antitumor immunity.

21 January 2018

1 reference

https://api.crossref.org/works/10.1093%2FANNONC%2FMDU143

Quantitative determination of nuclear and cytoplasmic epidermal growth factor receptor expression in oropharyngeal squamous cell cancer by using automated quantitative analysis

21 January 2018

1 reference

https://api.crossref.org/works/10.1093%2FANNONC%2FMDU143

Radiotherapy plus cetuximab for squamous-cell carcinoma of the head and neck

21 January 2018

1 reference

https://api.crossref.org/works/10.1093%2FANNONC%2FMDU143

Lessons learned from next-generation sequencing in head and neck cancer

21 January 2018

1 reference

https://api.crossref.org/works/10.1093%2FANNONC%2FMDU143

Genomic dissection of the epidermal growth factor receptor (EGFR)/PI3K pathway reveals frequent deletion of the EGFR phosphatase PTPRS in head and neck cancers

21 January 2018

1 reference

https://api.crossref.org/works/10.1093%2FANNONC%2FMDU143

Mutational analysis of the PTEN gene in head and neck squamous cell carcinoma.

21 January 2018

1 reference

https://api.crossref.org/works/10.1093%2FANNONC%2FMDU143

PIK3CA mutations in head and neck squamous cell carcinoma

21 January 2018

1 reference

https://api.crossref.org/works/10.1093%2FANNONC%2FMDU143

Notch1 functions as a tumor suppressor in mouse skin

21 January 2018

1 reference

https://api.crossref.org/works/10.1093%2FANNONC%2FMDU143

Biomarker-directed therapy of squamous carcinomas of the head and neck: targeting PI3K/PTEN/mTOR pathway.

21 January 2018

1 reference

https://api.crossref.org/works/10.1093%2FANNONC%2FMDU143

PIK3CA mutation H1047R is associated with response to PI3K/AKT/mTOR signaling pathway inhibitors in early-phase clinical trials

21 January 2018

1 reference

https://api.crossref.org/works/10.1093%2FANNONC%2FMDU143

Functional roles of Akt signaling in mouse skin tumorigenesis.

21 January 2018

1 reference

https://api.crossref.org/works/10.1093%2FANNONC%2FMDU143

Notch signaling: cell fate control and signal integration in development

21 January 2018

1 reference

https://api.crossref.org/works/10.1093%2FANNONC%2FMDU143

Notch signaling is a direct determinant of keratinocyte growth arrest and entry into differentiation

21 January 2018

1 reference

https://api.crossref.org/works/10.1093%2FANNONC%2FMDU143

Jagged-1 mediated activation of notch signaling induces complete maturation of human keratinocytes through NF-kappaB and PPARgamma

21 January 2018

1 reference

https://api.crossref.org/works/10.1093%2FANNONC%2FMDU143

Specific down-modulation of Notch1 signaling in cervical cancer cells is required for sustained HPV-E6/E7 expression and late steps of malignant transformation

21 January 2018

1 reference

https://api.crossref.org/works/10.1093%2FANNONC%2FMDU143

The shortest path from the surface to the nucleus: RBP-J kappa/Su(H) transcription factor

21 January 2018

1 reference

https://api.crossref.org/works/10.1093%2FANNONC%2FMDU143

A novel tumour-suppressor function for the Notch pathway in myeloid leukaemia.

21 January 2018

1 reference

https://api.crossref.org/works/10.1093%2FANNONC%2FMDU143

p63, a p53 homolog at 3q27-29, encodes multiple products with transactivating, death-inducing, and dominant-negative activities

21 January 2018

1 reference

https://api.crossref.org/works/10.1093%2FANNONC%2FMDU143

p63 Is essential for the proliferative potential of stem cells in stratified epithelia

21 January 2018

1 reference

https://api.crossref.org/works/10.1093%2FANNONC%2FMDU143

p63 is the molecular switch for initiation of an epithelial stratification program

21 January 2018

1 reference

https://api.crossref.org/works/10.1093%2FANNONC%2FMDU143

p63 is a p53 homologue required for limb and epidermal morphogenesis

21 January 2018

1 reference

https://api.crossref.org/works/10.1093%2FANNONC%2FMDU143

p63 regulates proliferation and differentiation of developmentally mature keratinocytes

21 January 2018

1 reference

https://api.crossref.org/works/10.1093%2FANNONC%2FMDU143

HES and HERP families: multiple effectors of the Notch signaling pathway

21 January 2018

1 reference

https://api.crossref.org/works/10.1093%2FANNONC%2FMDU143

Cross-regulation between Notch and p63 in keratinocyte commitment to differentiation

21 January 2018

1 reference

https://api.crossref.org/works/10.1093%2FANNONC%2FMDU143

The p53 family member genes are involved in the Notch signal pathway

21 January 2018

1 reference

https://api.crossref.org/works/10.1093%2FANNONC%2FMDU143

Promoter methylation of P16, RARbeta, E-cadherin, cyclin A1 and cytoglobin in oral cancer: quantitative evaluation using pyrosequencing

21 January 2018

1 reference

https://api.crossref.org/works/10.1093%2FANNONC%2FMDU143

High frequency of hypermethylation of p14, p15 and p16 in oral pre-cancerous lesions associated with betel-quid chewing in Sri Lanka

21 January 2018

1 reference

https://api.crossref.org/works/10.1093%2FANNONC%2FMDU143

Differential roles of p16INK4A and p14ARF genes in prognosis of oral carcinoma.

21 January 2018

1 reference

https://api.crossref.org/works/10.1093%2FANNONC%2FMDU143

Throwing the cancer switch: reciprocal roles of polycomb and trithorax proteins

21 January 2018

1 reference

https://api.crossref.org/works/10.1093%2FANNONC%2FMDU143

E6 and e7 gene silencing and transformed phenotype of human papillomavirus 16-positive oropharyngeal cancer cells

21 January 2018

1 reference

https://api.crossref.org/works/10.1093%2FANNONC%2FMDU143

Novel targets in HPV-negative head and neck cancer: overcoming resistance to EGFR inhibition

21 January 2018

1 reference

https://api.crossref.org/works/10.1093%2FANNONC%2FMDU143

Fibroblast growth factor receptors are components of autocrine signaling networks in head and neck squamous cell carcinoma cells

21 January 2018

1 reference

https://api.crossref.org/works/10.1093%2FANNONC%2FMDU143

A proangiogenic signature is revealed in FGF-mediated bevacizumab-resistant head and neck squamous cell carcinoma

21 January 2018

1 reference

https://api.crossref.org/works/10.1093%2FANNONC%2FMDU143

Promising new molecular targeted therapies in head and neck cancer

21 January 2018

1 reference

https://api.crossref.org/works/10.1093%2FANNONC%2FMDU143

Activation of the insulin-like growth factor-1 receptor alters p27 regulation by the epidermal growth factor receptor in oral squamous carcinoma cells

21 January 2018

1 reference

https://api.crossref.org/works/10.1093%2FANNONC%2FMDU143

Contrasted outcomes to gefitinib on tumoral IGF1R expression in head and neck cancer patients receiving postoperative chemoradiation (GORTEC trial 2004-02).

21 January 2018

1 reference

https://api.crossref.org/works/10.1093%2FANNONC%2FMDU143

Insulin-like growth factor 1 receptor (IGF1R) expression and survival in operable squamous-cell laryngeal cancer

21 January 2018

1 reference

https://api.crossref.org/works/10.1093%2FANNONC%2FMDU143

Association of HLA-G polymorphisms with nasopharyngeal carcinoma risk and clinical outcome

21 January 2018

1 reference

https://api.crossref.org/works/10.1093%2FANNONC%2FMDU143

Prediction of deleterious human alleles

21 January 2018

1 reference

https://api.crossref.org/works/10.1093%2FANNONC%2FMDU143

Human non-synonymous SNPs: server and survey

21 January 2018

1 reference

https://api.crossref.org/works/10.1093%2FANNONC%2FMDU143

21 January 2018

Identifiers

DOI

10.1093/ANNONC/MDU143

1 reference

30 August 2017

1 reference

PubMed ID

24718888