(Q38204270)

31 August 2017

title

The organization of the sphingosine 1-phosphate signaling system (English)

1 reference

31 August 2017

Hugh Rosen

1

1 reference

31 August 2017

M Germana Sanna

series ordinal

2

1 reference

31 August 2017

Pedro J Gonzalez-Cabrera

series ordinal

3

1 reference

31 August 2017

Edward Roberts

series ordinal

4

1 reference

31 August 2017

publication date

1 January 2014

1 reference

Current Topics in Microbiology and Immunology

31 August 2017

published in

1 reference

31 August 2017

volume

378

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31 August 2017

page(s)

1-21

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Sphingosine-1-phosphate receptors and the development of the vascular system

31 August 2017

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Sphingosine-1-phosphate lyase deficiency produces a pro-inflammatory response while impairing neutrophil trafficking.

31 March 2020

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GRK2-dependent S1PR1 desensitization is required for lymphocytes to overcome their attraction to blood.

31 March 2020

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31 March 2020

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31 March 2020

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31 March 2020

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31 March 2020

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31 March 2020

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31 March 2020

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Actions of a picomolar short-acting S1P₁ agonist in S1P₁-eGFP knock-in mice

31 March 2020

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Sphingosine 1-phosphate receptor 1 (S1P(1)) upregulation and amelioration of experimental autoimmune encephalomyelitis by an S1P(1) antagonist

31 March 2020

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Regulation of limb development by the sphingosine 1-phosphate receptor S1p1/EDG-1 occurs via the hypoxia/VEGF axis.

31 March 2020

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FTY720 (fingolimod) efficacy in an animal model of multiple sclerosis requires astrocyte sphingosine 1-phosphate receptor 1 (S1P1) modulation

31 March 2020

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Sphingosine-1-phosphate and lymphocyte egress from lymphoid organs

31 March 2020

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Identification of Leu276 of the S1P1 receptor and Phe263 of the S1P3 receptor in interaction with receptor specific agonists by molecular modeling, site-directed mutagenesis, and affinity studies.

31 March 2020

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Relapse and disability outcomes in patients with multiple sclerosis treated with fingolimod: subgroup analyses of the double-blind, randomised, placebo-controlled FREEDOMS study

31 March 2020

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A lipid binding domain in sphingosine kinase 2

31 March 2020

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Essential requirement for sphingosine kinase 2 in a sphingolipid apoptosis pathway activated by FTY720 analogues

31 March 2020

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Structure of the Adenosine A2A Receptor in Complex with ZM241385 and the Xanthines XAC and Caffeine

31 March 2020

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Immune cell regulation and cardiovascular effects of sphingosine 1-phosphate receptor agonists in rodents are mediated via distinct receptor subtypes.

31 March 2020

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Identification of residues responsible for ligand recognition and regioisomeric selectivity of lysophosphatidic acid receptors expressed in mammalian cells

31 March 2020

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Identification of the hydrophobic ligand binding pocket of the S1P1 receptor

31 March 2020

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The sphingosine-1-phosphate transporter Spns2 expressed on endothelial cells regulates lymphocyte trafficking in mice

31 March 2020

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lazaro encodes a lipid phosphate phosphohydrolase that regulates phosphatidylinositol turnover during Drosophila phototransduction.

31 March 2020

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Mapping pathways downstream of sphingosine 1-phosphate subtype 1 by differential chemical perturbation and proteomics

31 March 2020

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Full pharmacological efficacy of a novel S1P1 agonist that does not require S1P-like headgroup interactions

31 March 2020

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S1P(1) receptor modulation with cyclical recovery from lymphopenia ameliorates mouse model of multiple sclerosis

31 March 2020

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Lymph node cortical sinus organization and relationship to lymphocyte egress dynamics and antigen exposure.

31 March 2020

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Discovery, design and synthesis of the first reported potent and selective sphingosine-1-phosphate 4 (S1P4) receptor antagonists

31 March 2020

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Discovery, design and synthesis of novel potent and selective sphingosine-1-phosphate 4 receptor (S1P₄-R) agonists

31 March 2020

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https://api.crossref.org/works/10.1007%2F978-3-319-05879-5_1

Discovery, design and synthesis of a selective S1P(3) receptor allosteric agonist

31 March 2020

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https://api.crossref.org/works/10.1007%2F978-3-319-05879-5_1

Crystal structure of a lipid G protein-coupled receptor

31 March 2020

1 reference

https://api.crossref.org/works/10.1007%2F978-3-319-05879-5_1

Endocannabinoid tone versus constitutive activity of cannabinoid receptors

31 March 2020

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https://api.crossref.org/works/10.1007%2F978-3-319-05879-5_1

Murine lipid phosphate phosphohydrolase-3 acts as a cell-associated integrin ligand

31 March 2020

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Sphingosine 1-phosphate analogue recognition and selectivity at S1P4 within the endothelial differentiation gene family of receptors.

31 March 2020

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S1P1-selective in vivo-active agonists from high-throughput screening: off-the-shelf chemical probes of receptor interactions, signaling, and fate

31 March 2020

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Novel selective allosteric and bitopic ligands for the S1P(3) receptor.

31 March 2020

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Oral fingolimod (FTY720) for relapsing multiple sclerosis

31 March 2020

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https://api.crossref.org/works/10.1007%2F978-3-319-05879-5_1

A placebo-controlled trial of oral fingolimod in relapsing multiple sclerosis

31 March 2020

1 reference

https://api.crossref.org/works/10.1007%2F978-3-319-05879-5_1

Comparison of fingolimod with interferon beta-1a in relapsing-remitting multiple sclerosis: a randomised extension of the TRANSFORMS study.

31 March 2020

1 reference

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Edg-1, the G protein-coupled receptor for sphingosine-1-phosphate, is essential for vascular maturation

31 March 2020

1 reference

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Cyclical modulation of sphingosine-1-phosphate receptor 1 surface expression during lymphocyte recirculation and relationship to lymphoid organ transit

31 March 2020

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Sphingosine-1-phosphate signaling and its role in disease

31 March 2020

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Molecular cloning and characterization of a lipid phosphohydrolase that degrades sphingosine-1- phosphate and induces cell death

31 March 2020

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https://api.crossref.org/works/10.1007%2F978-3-319-05879-5_1

Alteration of lymphocyte trafficking by sphingosine-1-phosphate receptor agonists

31 March 2020

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https://api.crossref.org/works/10.1007%2F978-3-319-05879-5_1

Local not systemic modulation of dendritic cell S1P receptors in lung blunts virus-specific immune responses to influenza

31 March 2020

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A critical role for the sphingosine analog AAL-R in dampening the cytokine response during influenza virus infection

31 March 2020

1 reference

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Modulation of chemokines and allergic airway inflammation by selective local sphingosine-1-phosphate receptor 1 agonism in lungs

31 March 2020

1 reference

https://api.crossref.org/works/10.1007%2F978-3-319-05879-5_1

Lymphocyte egress from thymus and peripheral lymphoid organs is dependent on S1P receptor 1

31 March 2020

1 reference

https://api.crossref.org/works/10.1007%2F978-3-319-05879-5_1

FTY720-phosphate is dephosphorylated by lipid phosphate phosphatase 3.

31 March 2020

1 reference

https://api.crossref.org/works/10.1007%2F978-3-319-05879-5_1

Sphingosine 1-phosphate receptor signaling regulates proper embryonic vascular patterning.

31 March 2020

1 reference

https://api.crossref.org/works/10.1007%2F978-3-319-05879-5_1

The transporter Spns2 is required for secretion of lymph but not plasma sphingosine-1-phosphate

31 March 2020

1 reference

https://api.crossref.org/works/10.1007%2F978-3-319-05879-5_1

Essential role for sphingosine kinases in neural and vascular development

31 March 2020

1 reference

https://api.crossref.org/works/10.1007%2F978-3-319-05879-5_1

Persistent signaling induced by FTY720-phosphate is mediated by internalized S1P1 receptors.

31 March 2020

1 reference

https://api.crossref.org/works/10.1007%2F978-3-319-05879-5_1

Mutations in the novel membrane protein spinster interfere with programmed cell death and cause neural degeneration in Drosophila melanogaster

31 March 2020

1 reference

https://api.crossref.org/works/10.1007%2F978-3-319-05879-5_1

Pulmonary phosphatidic acid phosphatase and lipid phosphate phosphohydrolase

31 March 2020

1 reference

https://api.crossref.org/works/10.1007%2F978-3-319-05879-5_1

Dissecting influenza virus pathogenesis uncovers a novel chemical approach to combat the infection

31 March 2020

1 reference

https://api.crossref.org/works/10.1007%2F978-3-319-05879-5_1

Immunosuppressive and anti-angiogenic sphingosine 1-phosphate receptor-1 agonists induce ubiquitinylation and proteasomal degradation of the receptor

31 March 2020

1 reference

https://api.crossref.org/works/10.1007%2F978-3-319-05879-5_1

Engagement of S1P₁-degradative mechanisms leads to vascular leak in mice

31 March 2020

1 reference

https://api.crossref.org/works/10.1007%2F978-3-319-05879-5_1

The spinster homolog, two of hearts, is required for sphingosine 1-phosphate signaling in zebrafish.

31 March 2020

1 reference

https://api.crossref.org/works/10.1007%2F978-3-319-05879-5_1

Regulation of sphingosine-1-phosphate lyase gene expression by members of the GATA family of transcription factors.

31 March 2020

1 reference

https://api.crossref.org/works/10.1007%2F978-3-319-05879-5_1

Promotion of lymphocyte egress into blood and lymph by distinct sources of sphingosine-1-phosphate

31 March 2020

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https://api.crossref.org/works/10.1007%2F978-3-319-05879-5_1

Identification of Edg1 receptor residues that recognize sphingosine 1-phosphate.

31 March 2020

1 reference

https://api.crossref.org/works/10.1007%2F978-3-319-05879-5_1

S1P1 receptor signaling overrides retention mediated by G alpha i-coupled receptors to promote T cell egress

31 March 2020

1 reference

https://api.crossref.org/works/10.1007%2F978-3-319-05879-5_1

Lymphatic endothelial cell sphingosine kinase activity is required for lymphocyte egress and lymphatic patterning

31 March 2020

1 reference

https://api.crossref.org/works/10.1007%2F978-3-319-05879-5_1

The selective sphingosine 1-phosphate receptor 1 agonist ponesimod protects against lymphocyte-mediated tissue inflammation.

31 March 2020

1 reference

https://api.crossref.org/works/10.1007%2F978-3-319-05879-5_1

Crystal structure of the human beta2 adrenergic G-protein-coupled receptor

31 March 2020

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Structure of a nanobody-stabilized active state of the β(2) adrenoceptor

31 March 2020

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Crystal structure of the β2 adrenergic receptor-Gs protein complex

31 March 2020

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Desensitization by progressive up-titration prevents first-dose effects on the heart: guinea pig study with ponesimod, a selective S1P1 receptor modulator

31 March 2020

1 reference

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Effects of ponesimod, a selective S1P1 receptor modulator, on the pharmacokinetics of a hormonal combination contraceptive

31 March 2020

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Sphingosine 1-phosphate receptor agonists: a patent review (2010-2012)

31 March 2020

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Spinster is required for autophagic lysosome reformation and mTOR reactivation following starvation

31 March 2020

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Egress: a receptor-regulated step in lymphocyte trafficking

31 March 2020

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Tipping the gatekeeper: S1P regulation of endothelial barrier function

31 March 2020

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Modulating tone: the overture of S1P receptor immunotherapeutics

31 March 2020

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Sphingosine 1-phosphate receptor signaling

31 March 2020

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Sphingosine-1-phosphate and its receptors: structure, signaling, and influence

31 March 2020

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GPCR engineering yields high-resolution structural insights into beta2-adrenergic receptor function

31 March 2020

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Structure and function of an irreversible agonist-β(2) adrenoceptor complex

31 March 2020

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Sphingosine 1-phosphate (S1P) receptor subtypes S1P1 and S1P3, respectively, regulate lymphocyte recirculation and heart rate

31 March 2020

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Enhancement of capillary leakage and restoration of lymphocyte egress by a chiral S1P1 antagonist in vivo.

31 March 2020

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Molecular basis for lysophosphatidic acid receptor antagonist selectivity

31 March 2020

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Real-time differential labeling of blood, interstitium, and lymphatic and single-field analysis of vasculature dynamics in vivo

31 March 2020

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A sphingosine 1-phosphate receptor 2 selective allosteric agonist.

31 March 2020

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Ligand-binding pocket shape differences between sphingosine 1-phosphate (S1P) receptors S1P1 and S1P3 determine efficiency of chemical probe identification by ultrahigh-throughput screening

31 March 2020

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Lymphocyte sequestration through S1P lyase inhibition and disruption of S1P gradients

31 March 2020

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Siponimod for patients with relapsing-remitting multiple sclerosis (BOLD): an adaptive, dose-ranging, randomised, phase 2 study

31 March 2020

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Sphingosine 1-phosphate (S1P) receptor agonists mediate pro-fibrotic responses in normal human lung fibroblasts via S1P2 and S1P3 receptors and Smad-independent signaling

31 March 2020

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The outs and the ins of sphingosine-1-phosphate in immunity

31 March 2020

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Endothelial cells are central orchestrators of cytokine amplification during influenza virus infection

31 March 2020

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Cell-surface residence of sphingosine 1-phosphate receptor 1 on lymphocytes determines lymphocyte egress kinetics

31 March 2020

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High-density lipoproteins and their constituent, sphingosine-1-phosphate, directly protect the heart against ischemia/reperfusion injury in vivo via the S1P3 lysophospholipid receptor

31 March 2020

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Lipid phosphate phosphohydrolase type 1 (LPP1) degrades extracellular lysophosphatidic acid in vivo

31 March 2020

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SAR analysis of innovative selective small molecule antagonists of sphingosine-1-phosphate 4 (S1P₄) receptor

31 March 2020

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Discovery, synthesis and SAR analysis of novel selective small molecule S1P4-R agonists based on a (2Z,5Z)-5-((pyrrol-3-yl)methylene)-3-alkyl-2-(alkylimino)thiazolidin-4-one chemotype

31 March 2020

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Modulators of the Sphingosine 1-phosphate receptor 1.

31 March 2020

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Treatment with a sphingosine analog does not alter the outcome of a persistent virus infection

31 March 2020

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Suppression of cytokine storm with a sphingosine analog provides protection against pathogenic influenza virus

31 March 2020

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Quelling the storm: utilization of sphingosine-1-phosphate receptor signaling to ameliorate influenza virus-induced cytokine storm

31 March 2020

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A single amino acid determines lysophospholipid specificity of the S1P1 (EDG1) and LPA1 (EDG2) phospholipid growth factor receptors

31 March 2020

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The structural basis for agonist and partial agonist action on a β(1)-adrenergic receptor

31 March 2020

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https://api.crossref.org/works/10.1007%2F978-3-319-05879-5_1

Anti-lipid phosphate phosphohydrolase-3 (LPP3) antibody inhibits bFGF- and VEGF-induced capillary morphogenesis of endothelial cells

31 March 2020

1 reference

https://api.crossref.org/works/10.1007%2F978-3-319-05879-5_1

Sphingosine 1-phosphate type 1 receptor agonism inhibits transendothelial migration of medullary T cells to lymphatic sinuses

31 March 2020

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https://api.crossref.org/works/10.1007%2F978-3-319-05879-5_1

Structure of an agonist-bound human A2A adenosine receptor

31 March 2020

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https://api.crossref.org/works/10.1007%2F978-3-319-05879-5_1

Therapeutic use of a selective S1P1 receptor modulator ponesimod in autoimmune diabetes

31 March 2020

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https://api.crossref.org/works/10.1007%2F978-3-319-05879-5_1

Identification of the first mammalian sphingosine phosphate lyase gene and its functional expression in yeast

31 March 2020

1 reference

https://api.crossref.org/works/10.1007%2F978-3-319-05879-5_1

10.1007/978-3-319-05879-5_1

31 March 2020

Identifiers

DOI

1 reference

31 August 2017

1 reference