(Q38209177)

31 August 2017

title

Apelin receptor: its responsiveness to stretch mechanisms and its potential for cardiovascular therapy (English)

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31 August 2017

Maria Cecilia Scimia

1

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31 August 2017

Benjamin E Blass

series ordinal

2

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31 August 2017

Walter J Koch

series ordinal

3

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31 August 2017

publication date

5 May 2014

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Expert Review of Cardiovascular Therapy

31 August 2017

published in

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31 August 2017

volume

12

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31 August 2017

issue

6

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31 August 2017

page(s)

733-741

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A human gene that shows identity with the gene encoding the angiotensin receptor is located on chromosome 11

31 August 2017

cites work

1 reference

https://api.crossref.org/works/10.1586%2F14779072.2014.911661

Immunocytochemical localization of the endogenous vasoactive peptide apelin to human vascular and endocardial endothelial cells

21 January 2018

1 reference

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Low stringency hybridization study of the dopamine D4 receptor revealed D4-like mRNA distribution of the orphan seven-transmembrane receptor, APJ, in human brain.

21 January 2018

1 reference

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Pharmacological and immunohistochemical characterization of the APJ receptor and its endogenous ligand apelin

21 January 2018

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Isolation and characterization of a novel endogenous peptide ligand for the human APJ receptor

21 January 2018

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[Pyr1]apelin-13 identified as the predominant apelin isoform in the human heart: vasoactive mechanisms and inotropic action in disease.

21 January 2018

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[(125)I]-(Pyr(1))Apelin-13 is a novel radioligand for localizing the APJ orphan receptor in human and rat tissues with evidence for a vasoconstrictor role in man

21 January 2018

1 reference

https://api.crossref.org/works/10.1586%2F14779072.2014.911661

Apelin, the novel endogenous ligand of the orphan receptor APJ, regulates cardiac contractility

21 January 2018

1 reference

https://api.crossref.org/works/10.1586%2F14779072.2014.911661

The endogenous peptide apelin potently improves cardiac contractility and reduces cardiac loading in vivo

21 January 2018

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https://api.crossref.org/works/10.1586%2F14779072.2014.911661

G protein-coupled receptor APJ and its ligand apelin act downstream of Cripto to specify embryonic stem cells toward the cardiac lineage through extracellular signal-regulated kinase/p70S6 kinase signaling pathway

21 January 2018

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Endogenous regulation of cardiovascular function by apelin-APJ.

21 January 2018

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Apelin-APJ signaling is a critical regulator of endothelial MEF2 activation in cardiovascular development

21 January 2018

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APJ acts as a dual receptor in cardiac hypertrophy

21 January 2018

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Physiological role of a novel neuropeptide, apelin, and its receptor in the rat brain.

21 January 2018

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Reciprocal regulation of plasma apelin and vasopressin by osmotic stimuli

21 January 2018

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Abnormal fluid homeostasis in apelin receptor knockout mice

21 January 2018

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Molecular properties of apelin: tissue distribution and receptor binding

21 January 2018

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The effects of centrally administered apelin-13 on food intake, water intake and pituitary hormone release in rats

21 January 2018

1 reference

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Stimulus-specific neuroendocrine responses to osmotic challenges in apelin receptor knockout mice

21 January 2018

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Apelin, a newly identified adipokine up-regulated by insulin and obesity

21 January 2018

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Apelin stimulates glucose utilization in normal and obese insulin-resistant mice

21 January 2018

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Apelin and APJ regulation in adipose tissue and skeletal muscle of type 2 diabetic mice and humans

21 January 2018

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Apelin, a novel adipokine over-produced in obesity: friend or foe?

21 January 2018

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Changes and relations of circulating visfatin, apelin, and resistin levels in normal, impaired glucose tolerance, and type 2 diabetic subjects.

21 January 2018

1 reference

https://api.crossref.org/works/10.1586%2F14779072.2014.911661

Altered glucose homeostasis is associated with increased serum apelin levels in type 2 diabetes mellitus

21 January 2018

1 reference

https://api.crossref.org/works/10.1586%2F14779072.2014.911661

Apelin levels are increased in morbidly obese subjects with type 2 diabetes mellitus.

21 January 2018

1 reference

https://api.crossref.org/works/10.1586%2F14779072.2014.911661

Cellular localization of apelin and its receptor in the anterior pituitary: evidence for a direct stimulatory action of apelin on ACTH release

21 January 2018

1 reference

https://api.crossref.org/works/10.1586%2F14779072.2014.911661

The effects of apelin on hypothalamic-pituitary-adrenal axis neuroendocrine function are mediated through corticotrophin-releasing factor- and vasopressin-dependent mechanisms

21 January 2018

1 reference

https://api.crossref.org/works/10.1586%2F14779072.2014.911661

Functional dissociation of apelin receptor signaling and endocytosis: implications for the effects of apelin on arterial blood pressure

21 January 2018

1 reference

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Mitochondrial deficiency and cardiac sudden death in mice lacking the MEF2A transcription factor

21 January 2018

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Control of mouse cardiac morphogenesis and myogenesis by transcription factor MEF2C

21 January 2018

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Vascular system defects and impaired cell chemokinesis as a result of Galpha13 deficiency

21 January 2018

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Essential role for Galpha13 in endothelial cells during embryonic development

21 January 2018

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The biochemistry of the renin-angiotensin system and its role in hypertension

21 January 2018

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Monoclonal antibodies reveal receptor specificity among G-protein-coupled receptor kinases

21 January 2018

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https://api.crossref.org/works/10.1586%2F14779072.2014.911661

Functional antagonism of different G protein-coupled receptor kinases for beta-arrestin-mediated angiotensin II receptor signaling

21 January 2018

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https://api.crossref.org/works/10.1586%2F14779072.2014.911661

Dynamin and beta-arrestin reveal distinct mechanisms for G protein-coupled receptor internalization

21 January 2018

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Differential affinities of visual arrestin, beta arrestin1, and beta arrestin2 for G protein-coupled receptors delineate two major classes of receptors

21 January 2018

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Beta-arrestin 2: a receptor-regulated MAPK scaffold for the activation of JNK3

21 January 2018

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Activation and targeting of extracellular signal-regulated kinases by beta-arrestin scaffolds

21 January 2018

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beta-arrestin-dependent endocytosis of proteinase-activated receptor 2 is required for intracellular targeting of activated ERK1/2

21 January 2018

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Transactivation: a novel signaling pathway from angiotensin II to tyrosine kinase receptors

21 January 2018

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Independent beta-arrestin 2 and G protein-mediated pathways for angiotensin II activation of extracellular signal-regulated kinases 1 and 2.

21 January 2018

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The Role of a Conserved Region of the Second Intracellular Loop in AT1 Angiotensin Receptor Activation and Signaling

21 January 2018

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https://api.crossref.org/works/10.1586%2F14779072.2014.911661

Cardiac-specific overexpression of AT1 receptor mutant lacking G alpha q/G alpha i coupling causes hypertrophy and bradycardia in transgenic mice.

21 January 2018

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beta-Arrestin-biased agonism of the angiotensin receptor induced by mechanical stress

21 January 2018

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Side-chain substitutions within angiotensin II reveal different requirements for signaling, internalization, and phosphorylation of type 1A angiotensin receptors.

21 January 2018

1 reference

https://api.crossref.org/works/10.1586%2F14779072.2014.911661

Differential extracellular signal-regulated kinases 1 and 2 activation by the angiotensin type 1 receptor supports distinct phenotypes of cardiac myocytes.

21 January 2018

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https://api.crossref.org/works/10.1586%2F14779072.2014.911661

Beta-arrestin- but not G protein-mediated signaling by the "decoy" receptor CXCR7

21 January 2018

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Beta-arrestin-biased ligands at seven-transmembrane receptors

21 January 2018

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Selectively engaging β-arrestins at the angiotensin II type 1 receptor reduces blood pressure and increases cardiac performance.

21 January 2018

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https://api.crossref.org/works/10.1586%2F14779072.2014.911661

Acute myocardial and vascular responses to specific angiotensin II antagonism in the spontaneously hypertensive rat.

21 January 2018

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https://api.crossref.org/works/10.1586%2F14779072.2014.911661

Cardiorenal actions of TRV120027, a novel ß-arrestin-biased ligand at the angiotensin II type I receptor, in healthy and heart failure canines: a novel therapeutic strategy for acute heart failure

21 January 2018

1 reference

https://api.crossref.org/works/10.1586%2F14779072.2014.911661

Myocyte redistribution of GRK2 and GRK5 in hypertensive, heart-failure-prone rats

21 January 2018

1 reference

https://api.crossref.org/works/10.1586%2F14779072.2014.911661

Nuclear effects of G-protein receptor kinase 5 on histone deacetylase 5-regulated gene transcription in heart failure

21 January 2018

1 reference

https://api.crossref.org/works/10.1586%2F14779072.2014.911661

Uncovering G protein-coupled receptor kinase-5 as a histone deacetylase kinase in the nucleus of cardiomyocytes

21 January 2018

1 reference

https://api.crossref.org/works/10.1586%2F14779072.2014.911661

Differential functional expression of human myocardial G protein receptor kinases in left ventricular cardiac diseases

21 January 2018

1 reference

https://api.crossref.org/works/10.1586%2F14779072.2014.911661

Determining the absolute requirement of G protein-coupled receptor kinase 5 for pathological cardiac hypertrophy: short communication

21 January 2018

1 reference

https://api.crossref.org/works/10.1586%2F14779072.2014.911661

Nuclear translocation of cardiac G protein-Coupled Receptor kinase 5 downstream of select Gq-activating hypertrophic ligands is a calmodulin-dependent process

21 January 2018

1 reference

https://api.crossref.org/works/10.1586%2F14779072.2014.911661

Comparison of carvedilol and metoprolol on clinical outcomes in patients with chronic heart failure in the Carvedilol Or Metoprolol European Trial (COMET): randomised controlled trial

21 January 2018

1 reference

https://api.crossref.org/works/10.1586%2F14779072.2014.911661

Beta-blockers in heart failure: are pharmacological differences clinically important?

21 January 2018

1 reference

https://api.crossref.org/works/10.1586%2F14779072.2014.911661

Effect of beta blockers, particularly carvedilol, on reducing the risk of events after acute myocardial infarction

21 January 2018

1 reference

https://api.crossref.org/works/10.1586%2F14779072.2014.911661

Beta-arrestin-mediated beta1-adrenergic receptor transactivation of the EGFR confers cardioprotection.

21 January 2018

1 reference

https://api.crossref.org/works/10.1586%2F14779072.2014.911661

Role of beta-adrenergic receptor signaling and desensitization in heart failure: new concepts and prospects for treatment

21 January 2018

1 reference

https://api.crossref.org/works/10.1586%2F14779072.2014.911661

Beta-arrestin-mediated signaling in the heart

21 January 2018

1 reference

https://api.crossref.org/works/10.1586%2F14779072.2014.911661

beta-Arrestin-dependent activation of Ca(2+)/calmodulin kinase II after beta(1)-adrenergic receptor stimulation

21 January 2018

1 reference

https://api.crossref.org/works/10.1586%2F14779072.2014.911661

10.1586/14779072.2014.911661

21 January 2018

Identifiers

DOI

1 reference

31 August 2017

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