(Q38219840)

31 August 2017

title

Role of ezrin in osteosarcoma metastasis (English)

1 reference

31 August 2017

Ling Ren

1

1 reference

31 August 2017

Chand Khanna

series ordinal

2

1 reference

31 August 2017

language of work or name

English

0 references

publication date

1 January 2014

1 reference

Advances in Experimental Medicine and Biology

31 August 2017

published in

1 reference

31 August 2017

volume

804

1 reference

31 August 2017

page(s)

181-201

1 reference

Metastasis: recent discoveries and novel treatment strategies

31 August 2017

cites work

1 reference

https://api.crossref.org/works/10.1007%2F978-3-319-04843-7_10

Postrelapse survival in osteosarcoma of the extremities: prognostic factors for long-term survival

31 March 2020

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Treatment of metastatic osteosarcoma at diagnosis: a Pediatric Oncology Group Study

31 March 2020

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Pattern of disease recurrence and prognostic factors in patients with osteosarcoma treated with contemporary chemotherapy

31 March 2020

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https://api.crossref.org/works/10.1007%2F978-3-319-04843-7_10

Osteosarcoma: basic science and clinical implications

31 March 2020

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https://api.crossref.org/works/10.1007%2F978-3-319-04843-7_10

Normal development of mice and unimpaired cell adhesion/cell motility/actin-based cytoskeleton without compensatory up-regulation of ezrin or radixin in moesin gene knockout

31 March 2020

1 reference

https://api.crossref.org/works/10.1007%2F978-3-319-04843-7_10

Radixin deficiency causes conjugated hyperbilirubinemia with loss of Mrp2 from bile canalicular membranes

31 March 2020

1 reference

https://api.crossref.org/works/10.1007%2F978-3-319-04843-7_10

Radixin deficiency causes deafness associated with progressive degeneration of cochlear stereocilia

31 March 2020

1 reference

https://api.crossref.org/works/10.1007%2F978-3-319-04843-7_10

Ezrin is essential for epithelial organization and villus morphogenesis in the developing intestine

31 March 2020

1 reference

https://api.crossref.org/works/10.1007%2F978-3-319-04843-7_10

Small is beautiful: what flies tell us about ERM protein function in development

31 March 2020

1 reference

https://api.crossref.org/works/10.1007%2F978-3-319-04843-7_10

Lumen morphogenesis in C. elegans requires the membrane-cytoskeleton linker erm-1.

31 March 2020

1 reference

https://api.crossref.org/works/10.1007%2F978-3-319-04843-7_10

MOESIN crosslinks actin and cell membrane in Drosophila oocytes and is required for OSKAR anchoring

31 March 2020

1 reference

https://api.crossref.org/works/10.1007%2F978-3-319-04843-7_10

Dmoesin controls actin-based cell shape and polarity during Drosophila melanogaster oogenesis

31 March 2020

1 reference

https://api.crossref.org/works/10.1007%2F978-3-319-04843-7_10

Slik Sterile-20 kinase regulates Moesin activity to promote epithelial integrity during tissue growth

31 March 2020

1 reference

https://api.crossref.org/works/10.1007%2F978-3-319-04843-7_10

Spatial control of actin organization at adherens junctions by a synaptotagmin-like protein Btsz

31 March 2020

1 reference

https://api.crossref.org/works/10.1007%2F978-3-319-04843-7_10

Tyrosine phosphorylation and cellular redistribution of ezrin in MDCK cells treated with pervanadate

31 March 2020

1 reference

https://api.crossref.org/works/10.1007%2F978-3-319-04843-7_10

Single-molecule detection of phosphorylation-induced plasticity changes during ezrin activation.

31 March 2020

1 reference

https://api.crossref.org/works/10.1007%2F978-3-319-04843-7_10

Structural basis of the membrane-targeting and unmasking mechanisms of the radixin FERM domain

31 March 2020

1 reference

https://api.crossref.org/works/10.1007%2F978-3-319-04843-7_10

Phosphoinositide binding and phosphorylation act sequentially in the activation mechanism of ezrin

31 March 2020

1 reference

https://api.crossref.org/works/10.1007%2F978-3-319-04843-7_10

Ezrin is a downstream effector of trafficking PKC-integrin complexes involved in the control of cell motility

31 March 2020

1 reference

https://api.crossref.org/works/10.1007%2F978-3-319-04843-7_10

Protein kinase C-theta phosphorylation of moesin in the actin-binding sequence

31 March 2020

1 reference

https://api.crossref.org/works/10.1007%2F978-3-319-04843-7_10

Atypical protein kinase C (iota) activates ezrin in the apical domain of intestinal epithelial cells

31 March 2020

1 reference

https://api.crossref.org/works/10.1007%2F978-3-319-04843-7_10

Rho-kinase phosphorylates COOH-terminal threonines of ezrin/radixin/moesin (ERM) proteins and regulates their head-to-tail association

31 March 2020

1 reference

https://api.crossref.org/works/10.1007%2F978-3-319-04843-7_10

G protein-coupled receptor kinase 2-mediated phosphorylation of ezrin is required for G protein-coupled receptor-dependent reorganization of the actin cytoskeleton

31 March 2020

1 reference

https://api.crossref.org/works/10.1007%2F978-3-319-04843-7_10

Phosphorylation of ERM proteins at filopodia induced by Cdc42

31 March 2020

1 reference

https://api.crossref.org/works/10.1007%2F978-3-319-04843-7_10

The Nck-interacting kinase phosphorylates ERM proteins for formation of lamellipodium by growth factors

31 March 2020

1 reference

https://api.crossref.org/works/10.1007%2F978-3-319-04843-7_10

Rac1 mediates collapse of microvilli on chemokine-activated T lymphocytes

31 March 2020

1 reference

https://api.crossref.org/works/10.1007%2F978-3-319-04843-7_10

Constitutively active ezrin increases membrane tension, slows migration, and impedes endothelial transmigration of lymphocytes in vivo in mice

31 March 2020

1 reference

https://api.crossref.org/works/10.1007%2F978-3-319-04843-7_10

Unopposed phosphatase action initiates ezrin dysfunction: a potential mechanism for anoxic injury

31 March 2020

1 reference

https://api.crossref.org/works/10.1007%2F978-3-319-04843-7_10

ERM (ezrin/radixin/moesin)-based molecular mechanism of microvillar breakdown at an early stage of apoptosis

31 March 2020

1 reference

https://api.crossref.org/works/10.1007%2F978-3-319-04843-7_10

ERM family members as molecular linkers between the cell surface glycoprotein CD44 and actin-based cytoskeletons

31 March 2020

1 reference

https://api.crossref.org/works/10.1007%2F978-3-319-04843-7_10

Identification and functional analysis of the ezrin-binding site in the hyaluronan receptor, CD44.

31 March 2020

1 reference

https://api.crossref.org/works/10.1007%2F978-3-319-04843-7_10

A novel PKC-regulated mechanism controls CD44 ezrin association and directional cell motility

31 March 2020

1 reference

https://api.crossref.org/works/10.1007%2F978-3-319-04843-7_10

Ezrin/radixin/moesin (ERM) proteins bind to a positively charged amino acid cluster in the juxta-membrane cytoplasmic domain of CD44, CD43, and ICAM-2

31 March 2020

1 reference

https://api.crossref.org/works/10.1007%2F978-3-319-04843-7_10

Association of ezrin with intercellular adhesion molecule-1 and -2 (ICAM-1 and ICAM-2). Regulation by phosphatidylinositol 4, 5-bisphosphate

31 March 2020

1 reference

https://api.crossref.org/works/10.1007%2F978-3-319-04843-7_10

Dynamic interaction of VCAM-1 and ICAM-1 with moesin and ezrin in a novel endothelial docking structure for adherent leukocytes.

31 March 2020

1 reference

https://api.crossref.org/works/10.1007%2F978-3-319-04843-7_10

A novel serine-rich motif in the intercellular adhesion molecule 3 is critical for its ezrin/radixin/moesin-directed subcellular targeting

31 March 2020

1 reference

https://api.crossref.org/works/10.1007%2F978-3-319-04843-7_10

Identification and Relevance of the CD95-binding Domain in the N-terminal Region of Ezrin

31 March 2020

1 reference

https://api.crossref.org/works/10.1007%2F978-3-319-04843-7_10

P-glycoprotein binds to ezrin at amino acid residues 149-242 in the FERM domain and plays a key role in the multidrug resistance of human osteosarcoma.

31 March 2020

1 reference

https://api.crossref.org/works/10.1007%2F978-3-319-04843-7_10

The carboxyl-terminal region of EBP50 binds to a site in the amino-terminal domain of ezrin that is masked in the dormant molecule

31 March 2020

1 reference

https://api.crossref.org/works/10.1007%2F978-3-319-04843-7_10

NHERF family and NHE3 regulation

31 March 2020

1 reference

https://api.crossref.org/works/10.1007%2F978-3-319-04843-7_10

ERM proteins in epithelial cell organization and functions

31 March 2020

1 reference

https://api.crossref.org/works/10.1007%2F978-3-319-04843-7_10

Ezrin is a cyclic AMP-dependent protein kinase anchoring protein

31 March 2020

1 reference

https://api.crossref.org/works/10.1007%2F978-3-319-04843-7_10

The role of NHERF and E3KARP in the cAMP-mediated inhibition of NHE3.

31 March 2020

1 reference

https://api.crossref.org/works/10.1007%2F978-3-319-04843-7_10

NHERF associations with sodium-hydrogen exchanger isoform 3 (NHE3) and ezrin are essential for cAMP-mediated phosphorylation and inhibition of NHE3

31 March 2020

1 reference

https://api.crossref.org/works/10.1007%2F978-3-319-04843-7_10

E3KARP mediates the association of ezrin and protein kinase A with the cystic fibrosis transmembrane conductance regulator in airway cells

31 March 2020

1 reference

https://api.crossref.org/works/10.1007%2F978-3-319-04843-7_10

CD95/phosphorylated ezrin association underlies HIV-1 GP120/IL-2-induced susceptibility to CD95(APO-1/Fas)-mediated apoptosis of human resting CD4+T lymphocytes

31 March 2020

1 reference

https://api.crossref.org/works/10.1007%2F978-3-319-04843-7_10

The NHE3 juxtamembrane cytoplasmic domain directly binds ezrin: dual role in NHE3 trafficking and mobility in the brush border

31 March 2020

1 reference

https://api.crossref.org/works/10.1007%2F978-3-319-04843-7_10

Ezrin directly interacts with the alpha1b-adrenergic receptor and plays a role in receptor recycling

31 March 2020

1 reference

https://api.crossref.org/works/10.1007%2F978-3-319-04843-7_10

Characterization of protein kinase A-mediated phosphorylation of ezrin in gastric parietal cell activation

31 March 2020

1 reference

https://api.crossref.org/works/10.1007%2F978-3-319-04843-7_10

Activation of ERM proteins in vivo by Rho involves phosphatidyl-inositol 4-phosphate 5-kinase and not ROCK kinases

31 March 2020

1 reference

https://api.crossref.org/works/10.1007%2F978-3-319-04843-7_10

Association of the myosin-binding subunit of myosin phosphatase and moesin: dual regulation of moesin phosphorylation by Rho-associated kinase and myosin phosphatase

31 March 2020

1 reference

https://api.crossref.org/works/10.1007%2F978-3-319-04843-7_10

RhoA-dependent phosphorylation and relocalization of ERM proteins into apical membrane/actin protrusions in fibroblasts

31 March 2020

1 reference

https://api.crossref.org/works/10.1007%2F978-3-319-04843-7_10

Rho regulates association of both the ERM family and vinculin with the plasma membrane in MDCK cells

31 March 2020

1 reference

https://api.crossref.org/works/10.1007%2F978-3-319-04843-7_10

Direct interaction of the Rho GDP dissociation inhibitor with ezrin/radixin/moesin initiates the activation of the Rho small G protein

31 March 2020

1 reference

https://api.crossref.org/works/10.1007%2F978-3-319-04843-7_10

Actin microdomains on endothelial cells: association with CD44, ERM proteins, and signaling molecules during quiescence and wound healing

31 March 2020

1 reference

https://api.crossref.org/works/10.1007%2F978-3-319-04843-7_10

Activated ERM protein plays a critical role in drug resistance of MOLT4 cells induced by CCL25

31 March 2020

1 reference

https://api.crossref.org/works/10.1007%2F978-3-319-04843-7_10

Activation of ERM-family proteins via RhoA-ROCK signaling increases intestinal P-gp expression and leads to attenuation of oral morphine analgesia

31 March 2020

1 reference

https://api.crossref.org/works/10.1007%2F978-3-319-04843-7_10

Nuclear ERM (ezrin, radixin, moesin) proteins: regulation by cell density and nuclear import

31 March 2020

1 reference

https://api.crossref.org/works/10.1007%2F978-3-319-04843-7_10

Abnormal ezrin localization is associated with clinicopathological features in invasive breast carcinomas

31 March 2020

1 reference

https://api.crossref.org/works/10.1007%2F978-3-319-04843-7_10

ERM/Rho protein expression in ductal breast cancer: a 15 year follow-up.

31 March 2020

1 reference

https://api.crossref.org/works/10.1007%2F978-3-319-04843-7_10

Phosphorylated ezrin is located in the nucleus of the osteosarcoma cell

31 March 2020

1 reference

https://api.crossref.org/works/10.1007%2F978-3-319-04843-7_10

Clinical implications of Ezrin and CD44 co‑expression in breast cancer

31 March 2020

1 reference

https://api.crossref.org/works/10.1007%2F978-3-319-04843-7_10

Increase in ezrin expression from benign to malignant breast tumours.

31 March 2020

1 reference

https://api.crossref.org/works/10.1007%2F978-3-319-04843-7_10

Ezrin promotes ovarian carcinoma cell invasion and its retained expression predicts poor prognosis in ovarian carcinoma.

31 March 2020

1 reference

https://api.crossref.org/works/10.1007%2F978-3-319-04843-7_10

Ezrin immunoreactivity in relation to survival in serous ovarian carcinoma patients

31 March 2020

1 reference

https://api.crossref.org/works/10.1007%2F978-3-319-04843-7_10

Pleiotropic function of ezrin in human metastatic melanomas.

31 March 2020

1 reference

https://api.crossref.org/works/10.1007%2F978-3-319-04843-7_10

Ezrin in primary cutaneous melanoma

31 March 2020

1 reference

https://api.crossref.org/works/10.1007%2F978-3-319-04843-7_10

Differential tissue and subcellular expressionof ERM proteins in normal and malignant tissues: cytoplasmic ezrin expression has prognostic significance for head and neck squamous cell carcinoma

31 March 2020

1 reference

https://api.crossref.org/works/10.1007%2F978-3-319-04843-7_10

Cytoplasmic ezrin and moesin correlate with poor survival in head and neck squamous cell carcinoma

31 March 2020

1 reference

https://api.crossref.org/works/10.1007%2F978-3-319-04843-7_10

Value of ezrin, maspin and nm23-H1 protein expressions in predicting outcome of patients with head and neck squamous-cell carcinoma treated with radical radiotherapy

31 March 2020

1 reference

https://api.crossref.org/works/10.1007%2F978-3-319-04843-7_10

Expression and clinical significance of ezrin in non--small-cell lung cancer.

31 March 2020

1 reference

https://api.crossref.org/works/10.1007%2F978-3-319-04843-7_10

Overexpression of ezrin inactivates NF2 tumor suppressor in glioblastoma

31 March 2020

1 reference

https://api.crossref.org/works/10.1007%2F978-3-319-04843-7_10

Expression and functional significance of ezrin in human brain astrocytoma

31 March 2020

1 reference

https://api.crossref.org/works/10.1007%2F978-3-319-04843-7_10

Ezrin expression in rectal cancer predicts time to development of local recurrence

31 March 2020

1 reference

https://api.crossref.org/works/10.1007%2F978-3-319-04843-7_10

Preoperative radiotherapy modulates ezrin expression and its value as a predictive marker in patients with rectal cancer

31 March 2020

1 reference

https://api.crossref.org/works/10.1007%2F978-3-319-04843-7_10

Intense cytoplasmic ezrin immunoreactivity predicts poor survival in colorectal cancer

31 March 2020

1 reference

https://api.crossref.org/works/10.1007%2F978-3-319-04843-7_10

Ezrin expression as a prognostic marker in colorectal adenocarcinoma

31 March 2020

1 reference

https://api.crossref.org/works/10.1007%2F978-3-319-04843-7_10

Ezrin is associated with gastric cancer progression and prognosis

31 March 2020

1 reference

https://api.crossref.org/works/10.1007%2F978-3-319-04843-7_10

Prognostic impact of immunohistochemical expression of ezrin in highly malignant soft tissue sarcomas

31 March 2020

1 reference

https://api.crossref.org/works/10.1007%2F978-3-319-04843-7_10

Ezrin expression predicts local recurrence and development of metastases in soft tissue sarcomas

31 March 2020

1 reference

https://api.crossref.org/works/10.1007%2F978-3-319-04843-7_10

Ezrin and alpha-smooth muscle actin are immunohistochemical prognostic markers in conventional osteosarcomas

31 March 2020

1 reference

https://api.crossref.org/works/10.1007%2F978-3-319-04843-7_10

Ezrin expression predicts survival in stage IIB osteosarcomas

31 March 2020

1 reference

https://api.crossref.org/works/10.1007%2F978-3-319-04843-7_10

The Prognostic Role of Ezrin Immunoexpression in Osteosarcoma: A Meta-Analysis of Published Data

31 March 2020

1 reference

https://api.crossref.org/works/10.1007%2F978-3-319-04843-7_10

Immunoexpression of Ezrin and CD44 in patients with osteosarcoma

31 March 2020

1 reference

https://api.crossref.org/works/10.1007%2F978-3-319-04843-7_10

In Vitro and in Vivo Characterization of Molecular Interactions between Calmodulin, Ezrin/Radixin/Moesin, and L-selectin

31 March 2020

1 reference

https://api.crossref.org/works/10.1007%2F978-3-319-04843-7_10

Potent phagocytic activity discriminates metastatic and primary human malignant melanomas: a key role of ezrin

31 March 2020

1 reference

https://api.crossref.org/works/10.1007%2F978-3-319-04843-7_10

Cannibalism of live lymphocytes by human metastatic but not primary melanoma cells

31 March 2020

1 reference

https://api.crossref.org/works/10.1007%2F978-3-319-04843-7_10

Molecular profiling of tumor progression in head and neck cancer

31 March 2020

1 reference

https://api.crossref.org/works/10.1007%2F978-3-319-04843-7_10

Expression of the cytoskeleton linker protein ezrin in human cancers

31 March 2020

1 reference

https://api.crossref.org/works/10.1007%2F978-3-319-04843-7_10

The membrane-cytoskeleton linker ezrin is necessary for osteosarcoma metastasis

31 March 2020

1 reference

https://api.crossref.org/works/10.1007%2F978-3-319-04843-7_10

Expression profiling identifies the cytoskeletal organizer ezrin and the developmental homeoprotein Six-1 as key metastatic regulators

31 March 2020

1 reference

https://api.crossref.org/works/10.1007%2F978-3-319-04843-7_10

The homeoprotein six1 transcriptionally activates multiple protumorigenic genes but requires ezrin to promote metastasis.

31 March 2020

1 reference

https://api.crossref.org/works/10.1007%2F978-3-319-04843-7_10

Ezrin mediates growth and survival in Ewing’s sarcoma through the AKT/mTOR, but not the MAPK, signaling pathway

31 March 2020

1 reference

https://api.crossref.org/works/10.1007%2F978-3-319-04843-7_10

The prognostic value of elevated ezrin in patients with osteosarcoma

31 March 2020

1 reference

https://api.crossref.org/works/10.1007%2F978-3-319-04843-7_10

Co-operative effect of c-Src and ezrin in deregulation of cell-cell contacts and scattering of mammary carcinoma cells

31 March 2020

1 reference

https://api.crossref.org/works/10.1007%2F978-3-319-04843-7_10

Phosphorylated ezrin is associated with EBV latent membrane protein 1 in nasopharyngeal carcinoma and induces cell migration

31 March 2020

1 reference

https://api.crossref.org/works/10.1007%2F978-3-319-04843-7_10

Effects of transplantation sites on tumour growth, pulmonary metastasis and ezrin expression of canine osteosarcoma cell lines in nude mice

31 March 2020

1 reference

https://api.crossref.org/works/10.1007%2F978-3-319-04843-7_10

The actin-cytoskeleton linker protein ezrin is regulated during osteosarcoma metastasis by PKC.

31 March 2020

1 reference

https://api.crossref.org/works/10.1007%2F978-3-319-04843-7_10

Protein kinase C regulates ezrin-radixin-moesin phosphorylation in canine osteosarcoma cells

31 March 2020

1 reference

https://api.crossref.org/works/10.1007%2F978-3-319-04843-7_10

Apoptosis resistance and PKC signaling: distinguishing features of high and low metastatic cells

31 March 2020

1 reference

https://api.crossref.org/works/10.1007%2F978-3-319-04843-7_10

Hypoxia-induced treatment failure in advanced squamous cell carcinoma of the uterine cervix is primarily due to hypoxia-induced radiation resistance rather than hypoxia-induced metastasis

31 March 2020

1 reference

https://api.crossref.org/works/10.1007%2F978-3-319-04843-7_10

Contribution of nitric oxide-mediated apoptosis to cancer metastasis inefficiency

31 March 2020

1 reference

https://api.crossref.org/works/10.1007%2F978-3-319-04843-7_10

Endostatin overexpression inhibits lymphangiogenesis and lymph node metastasis in mice

31 March 2020

1 reference

https://api.crossref.org/works/10.1007%2F978-3-319-04843-7_10

Glucose transporters: expression, regulation and cancer.

31 March 2020

1 reference

https://api.crossref.org/works/10.1007%2F978-3-319-04843-7_10

Revisiting the seed and soil in cancer metastasis

31 March 2020

1 reference

https://api.crossref.org/works/10.1007%2F978-3-319-04843-7_10

Dysregulation of ezrin phosphorylation prevents metastasis and alters cellular metabolism in osteosarcoma

31 March 2020

1 reference

https://api.crossref.org/works/10.1007%2F978-3-319-04843-7_10

The ezrin metastatic phenotype is associated with the initiation of protein translation

31 March 2020

1 reference

https://api.crossref.org/works/10.1007%2F978-3-319-04843-7_10

Small molecule inhibitors of ezrin inhibit the invasive phenotype of osteosarcoma cells.

31 March 2020

1 reference

https://api.crossref.org/works/10.1007%2F978-3-319-04843-7_10

Rapamycin inhibits ezrin-mediated metastatic behavior in a murine model of osteosarcoma

31 March 2020

1 reference

https://api.crossref.org/works/10.1007%2F978-3-319-04843-7_10

mTOR inhibitors (rapamycin and its derivatives) and nitrogen containing bisphosphonates: bi-functional compounds for the treatment of bone tumours

31 March 2020

1 reference

https://api.crossref.org/works/10.1007%2F978-3-319-04843-7_10

Ezrin, a plasma membrane-microfilament linker, signals cell survival through the phosphatidylinositol 3-kinase/Akt pathway

31 March 2020

1 reference

https://api.crossref.org/works/10.1007%2F978-3-319-04843-7_10

10.1007/978-3-319-04843-7_10

31 March 2020

Identifiers

DOI

1 reference

31 August 2017

1 reference