(Q38222366)

31 August 2017

title

Therapeutic strategies for metabolic diseases: Small-molecule diacylglycerol acyltransferase (DGAT) inhibitors (English)

1 reference

31 August 2017

3

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:24954424%20AND%20SRC:MED&resulttype=core&format=json

9 June 2020

author name string

Ravi Naik

1

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:24954424%20AND%20SRC:MED&resulttype=core&format=json

9 June 2020

Brice W Obiang-Obounou

2

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:24954424%20AND%20SRC:MED&resulttype=core&format=json

9 June 2020

Yongseok Choi

4

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:24954424%20AND%20SRC:MED&resulttype=core&format=json

9 June 2020

Hyun Sun Lee

5

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:24954424%20AND%20SRC:MED&resulttype=core&format=json

9 June 2020

Kyeong Lee

6

1 reference

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9 June 2020

publication date

20 June 2014

1 reference

31 August 2017

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:24954424%20AND%20SRC:MED&resulttype=core&format=json

9 June 2020

volume

9

1 reference

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9 June 2020

issue

11

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:24954424%20AND%20SRC:MED&resulttype=core&format=json

9 June 2020

page(s)

2410-2424

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https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:24954424%20AND%20SRC:MED&resulttype=core&format=json

Childhood obesity and risk of the adult metabolic syndrome: a systematic review

9 June 2020

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A novel coenzyme A:diacylglycerol acyltransferase 1 inhibitor stimulates lipid metabolism in muscle and lowers weight in animal models of obesity.

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Beyond triglyceride synthesis: the dynamic functional roles of MGAT and DGAT enzymes in energy metabolism

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Fat in all the wrong places

21 January 2018

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Evolutionary view of acyl-CoA diacylglycerol acyltransferase (DGAT), a key enzyme in neutral lipid biosynthesis.

21 January 2018

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Cloning of DGAT2, a second mammalian diacylglycerol acyltransferase, and related family members

21 January 2018

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Coenzyme A: diacylglycerol acyltransferase 1 inhibitor ameliorates obesity, liver steatosis, and lipid metabolism abnormality in KKAy mice fed high-fat or high-carbohydrate diets.

21 January 2018

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Role of adipocyte-derived factors in enhancing insulin signaling in skeletal muscle and white adipose tissue of mice lacking Acyl CoA:diacylglycerol acyltransferase 1.

21 January 2018

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Inhibitors of diacylglycerol acyltransferase: a review of 2008 patents

21 January 2018

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Novel acyl coenzyme A (CoA): diacylglycerol acyltransferase-1 inhibitors: synthesis and biological activities of diacylethylenediamine derivatives.

21 January 2018

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Novel acyl coenzyme A: diacylglycerol acyltransferase 1 inhibitors-synthesis and biological activities of N-(substituted heteroaryl)-4-(substituted phenyl)-4-oxobutanamides

21 January 2018

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Discovery of a potent, selective, and orally efficacious pyrimidinooxazinyl bicyclooctaneacetic acid diacylglycerol acyltransferase-1 inhibitor

21 January 2018

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Validation of diacyl glycerolacyltransferase I as a novel target for the treatment of obesity and dyslipidemia using a potent and selective small molecule inhibitor

21 January 2018

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Identification and preliminary characterization of a potent, safe, and orally efficacious inhibitor of acyl-CoA:diacylglycerol acyltransferase 1.

21 January 2018

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Discovery of PF-04620110, a Potent, Selective, and Orally Bioavailable Inhibitor of DGAT-1.

21 January 2018

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Identification, optimisation and in vivo evaluation of oxadiazole DGAT-1 inhibitors for the treatment of obesity and diabetes.

21 January 2018

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Synthesis and biological evaluation of aminobenzimidazole derivatives with a phenylcyclohexyl acetic acid group as anti-obesity and anti-diabetic agents.

21 January 2018

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Identification of a gene encoding an acyl CoA:diacylglycerol acyltransferase, a key enzyme in triacylglycerol synthesis

21 January 2018

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Dissociation of obesity and impaired glucose disposal in mice overexpressing acyl coenzyme a:diacylglycerol acyltransferase 1 in white adipose tissue

21 January 2018

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Surface plasmon resonance analysis of interactions between diacylglycerol acyltransferase and its interacting molecules.

21 January 2018

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Characterization of two human genes encoding acyl coenzyme A:cholesterol acyltransferase-related enzymes

21 January 2018

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DGAT2 is a new diacylglycerol acyltransferase gene family: purification, cloning, and expression in insect cells of two polypeptides from Mortierella ramanniana with diacylglycerol acyltransferase activity

21 January 2018

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Human intestinal monoacylglycerol acyltransferase: differential features in tissue expression and activity

21 January 2018

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Identification of a gene encoding MGAT1, a monoacylglycerol acyltransferase

21 January 2018

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Membrane topology and identification of key functional amino acid residues of murine acyl-CoA:diacylglycerol acyltransferase-2.

21 January 2018

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Catalytic properties of MGAT3, a putative triacylgycerol synthase.

21 January 2018

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Acylation of acylglycerols by acyl coenzyme A:diacylglycerol acyltransferase 1 (DGAT1). Functional importance of DGAT1 in the intestinal fat absorption

21 January 2018

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The endoplasmic reticulum enzyme DGAT2 is found in mitochondria-associated membranes and has a mitochondrial targeting signal that promotes its association with mitochondria

21 January 2018

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Concerted elevation of acyl-coenzyme A:diacylglycerol acyltransferase (DGAT) activity through independent stimulation of mRNA expression of DGAT1 and DGAT2 by carbohydrate and insulin

21 January 2018

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Obesity resistance and multiple mechanisms of triglyceride synthesis in mice lacking Dgat

21 January 2018

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Lipopenia and skin barrier abnormalities in DGAT2-deficient mice

21 January 2018

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Tung tree DGAT1 and DGAT2 have nonredundant functions in triacylglycerol biosynthesis and are localized to different subdomains of the endoplasmic reticulum

21 January 2018

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Topological Orientation of Acyl-CoA:Diacylglycerol Acyltransferase-1 (DGAT1) and Identification of a Putative Active Site Histidine and the Role of the N Terminus in Dimer/Tetramer Formation

21 January 2018

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Dissociation of Hepatic Steatosis and Insulin Resistance in Mice Overexpressing DGAT in the Liver

21 January 2018

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Suppression of diacylglycerol acyltransferase-2 (DGAT2), but not DGAT1, with antisense oligonucleotides reverses diet-induced hepatic steatosis and insulin resistance

21 January 2018

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Increased very low density lipoprotein secretion and gonadal fat mass in mice overexpressing liver DGAT1.

21 January 2018

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DGAT1 overexpression in muscle by in vivo DNA electroporation increases intramyocellular lipid content

21 January 2018

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Increased lipid accumulation and insulin resistance in transgenic mice expressing DGAT2 in glycolytic (type II) muscle

21 January 2018

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Diacylglycerol acyltransferases: Potential roles as pharmacological targets

21 January 2018

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Niacin noncompetitively inhibits DGAT2 but not DGAT1 activity in HepG2 cells

21 January 2018

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Upregulation of myocellular DGAT1 augments triglyceride synthesis in skeletal muscle and protects against fat-induced insulin resistance.

21 January 2018

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Antisense oligonucleotide reduction of DGAT2 expression improves hepatic steatosis and hyperlipidemia in obese mice

21 January 2018

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Knockdown of acyl-CoA:diacylglycerol acyltransferase 2 with antisense oligonucleotide reduces VLDL TG and ApoB secretion in mice

21 January 2018

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21 January 2018

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The Monoglyceride Pathway of Fat Absorption in Man*

21 January 2018

1 reference

https://api.crossref.org/works/10.1002%2FCMDC.201402069

Seed-specific over-expression of an Arabidopsis cDNA encoding a diacylglycerol acyltransferase enhances seed oil content and seed weight

21 January 2018

1 reference

https://api.crossref.org/works/10.1002%2FCMDC.201402069

Diacylglycerol acyltransferase 1 inhibition lowers serum triglycerides in the Zucker fatty rat and the hyperlipidemic hamster.

21 January 2018

1 reference

https://api.crossref.org/works/10.1002%2FCMDC.201402069

Diacylglycerol acyltransferase: a key mediator of plant triacylglycerol synthesis.

21 January 2018

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Development and physiological regulation of intestinal lipid absorption. II. Dietary lipid absorption, complex lipid synthesis, and the intracellular packaging and secretion of chylomicrons

21 January 2018

1 reference

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Enzymes of triacylglycerol synthesis and their regulation

21 January 2018

1 reference

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A novel bifunctional wax ester synthase/acyl-CoA:diacylglycerol acyltransferase mediates wax ester and triacylglycerol biosynthesis in Acinetobacter calcoaceticus ADP1.

21 January 2018

1 reference

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Dysregulation of the endocannabinoid system in obesity

21 January 2018

1 reference

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Dysregulation of peripheral endocannabinoid levels in hyperglycemia and obesity: Effect of high fat diets

21 January 2018

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Biochemistry, pharmacology and physiology of 2-arachidonoylglycerol, an endogenous cannabinoid receptor ligand

21 January 2018

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Fate of the flavonoid quercetin in human cell lines: chemical instability and metabolism

21 January 2018

1 reference

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Separate monoacylglycerol and diacylglycerol acyltransferases function in intestinal triacylglycerol synthesis.

21 January 2018

1 reference

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Intestinal apolipoprotein B secretion is inhibited by the flavonoid quercetin: potential role of microsomal triglyceride transfer protein and diacylglycerol acyltransferase

21 January 2018

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High-content assays for evaluating cellular and hepatic diacylglycerol acyltransferase activity

21 January 2018

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Current status of the research and development of diacylglycerol O-acyltransferase 1 (DGAT1) inhibitors

21 January 2018

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Triazolo compounds useful as diacylglycerol acyltransferase1 inhibitor - WO2009126624.

21 January 2018

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Inhibitory activity of diacylglycerol acyltransferase by glabrol isolated from the roots of licorice

21 January 2018

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Identification of diacylglycerol acyltransferase inhibitors from Rosa centifolia petals

21 January 2018

1 reference

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Aphadilactones A-D, four diterpenoid dimers with DGAT inhibitory and antimalarial activities from a Meliaceae plant.

21 January 2018

1 reference

https://api.crossref.org/works/10.1002%2FCMDC.201402069

Discovery of a novel series of benzimidazole derivatives as diacylglycerol acyltransferase inhibitors.

21 January 2018

1 reference

https://api.crossref.org/works/10.1002%2FCMDC.201402069

Targeting Acyl-CoA:diacylglycerol acyltransferase 1 (DGAT1) with small molecule inhibitors for the treatment of metabolic diseases

21 January 2018

1 reference

https://api.crossref.org/works/10.1002%2FCMDC.201402069

Discovery of orally active carboxylic acid derivatives of 2-phenyl-5-trifluoromethyloxazole-4-carboxamide as potent diacylglycerol acyltransferase-1 inhibitors for the potential treatment of obesity and diabetes

21 January 2018

1 reference

https://api.crossref.org/works/10.1002%2FCMDC.201402069

Evaluation of thiazole containing biaryl analogs as diacylglycerol acyltransferase 1 (DGAT1) inhibitors.

21 January 2018

1 reference

https://api.crossref.org/works/10.1002%2FCMDC.201402069

Identification and validation of a selective small molecule inhibitor targeting the diacylglycerol acyltransferase 2 activity

21 January 2018

1 reference

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Enriching modern pharmacotherapy through synergy assessment for the combination of natural products and synthetic drugs

21 January 2018

1 reference

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Discovery and optimization of 2-phenyloxazole derivatives as diacylglycerol acyltransferase-1 inhibitors

21 January 2018

1 reference

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7 January 2021

Lead optimization of a pyridine-carboxamide series as DGAT-1 inhibitors

1 reference

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7 January 2021

Design and synthesis of potent, orally-active DGAT-1 inhibitors containing a dioxino[2,3-d]pyrimidine core

1 reference

https://api.crossref.org/works/10.1002%2FCMDC.201402069

7 January 2021

Metabolism of lipides

1 reference

https://api.crossref.org/works/10.1002%2FCMDC.201402069

7 January 2021

Diacylglycerol acyltransferase in maturing safflower seeds: its influences on the fatty acid composition of triacylglycerol and on the rate of triacylglycerol synthesis

1 reference

https://api.crossref.org/works/10.1002%2FCMDC.201402069

7 January 2021

Do long-chain acyl-CoA synthetases regulate fatty acid entry into synthetic versus degradative pathways?

1 reference

https://api.crossref.org/works/10.1002%2FCMDC.201402069

7 January 2021

The chalcone xanthohumol inhibits triglyceride and apolipoprotein B secretion in HepG2 cells

1 reference

https://api.crossref.org/works/10.1002%2FCMDC.201402069

7 January 2021

Isolation of diacyl glycerol acyl transferase (DGAT) inhibitors from Pachydictyon coriaceum

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7 January 2021

Diacylglycerol acyltransferase and monoacylglycerol acyltransferase from liver and intestine

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7 January 2021

Xanthohumols, diacylglycerol acyltransferase inhibitors, from Humulus lupulus

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7 January 2021

Roselipins, inhibitors of diacylglycerol acyltransferase, produced by Gliocladium roseum KF-1040

1 reference

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7 January 2021

In vitro potentiation of ampicillin, oxacillin, norfloxacin, ciprofloxacin, and vancomycin by sanguinarine against methicillin-resistant Staphylococcus aureus

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7 January 2021

Dietary intakes of flavonols, flavones and isoflavones by Japanese women and the inverse correlation between quercetin intake and plasma LDL cholesterol concentration

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https://api.crossref.org/works/10.1002%2FCMDC.201402069

7 January 2021

Soy isoflavones improve plasma lipids in normocholesterolemic, premenopausal women

1 reference

https://api.crossref.org/works/10.1002%2FCMDC.201402069

7 January 2021

Thiadiazoles as new inhibitors of diacylglycerol acyltransferase type 1

1 reference

https://api.crossref.org/works/10.1002%2FCMDC.201402069

7 January 2021

Synthesis and biological evaluation of isoxazole, oxazole, and oxadiazole containing heteroaryl analogs of biaryl ureas as DGAT1 inhibitors

1 reference

https://api.crossref.org/works/10.1002%2FCMDC.201402069

7 January 2021

Discovery of indolyl acrylamide derivatives as human diacylglycerol acyltransferase-2 selective inhibitors

1 reference

https://api.crossref.org/works/10.1002%2FCMDC.201402069

7 January 2021

Niacin accelerates intracellular ApoB degradation by inhibiting triacylglycerol synthesis in human hepatoblastoma (HepG2) cells

1 reference

https://api.crossref.org/works/10.1002%2FCMDC.201402069

7 January 2021

Identifiers

DOI

10.1002/CMDC.201402069

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:24954424%20AND%20SRC:MED&resulttype=core&format=json

9 June 2020

1 reference