(Q38245652)

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:25183193%20AND%20SRC:MED&resulttype=core&format=json

15 February 2020

title

Genetically detoxified pertussis toxin (PT-9K/129G): implications for immunization and vaccines (English)

1 reference

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15 February 2020

0 references

1

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15 February 2020

4

Mariagrazia Pizza

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15 February 2020

author name string

Ugo D'Oro

series ordinal

2

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https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:25183193%20AND%20SRC:MED&resulttype=core&format=json

15 February 2020

Maria Scarselli

series ordinal

3

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15 February 2020

publication date

3 September 2014

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:25183193%20AND%20SRC:MED&resulttype=core&format=json

Expert Review of Vaccines

15 February 2020

published in

1 reference

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15 February 2020

volume

13

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15 February 2020

issue

10

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15 February 2020

page(s)

1191-1204

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https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:25183193%20AND%20SRC:MED&resulttype=core&format=json

Subunit structure of islet-activating protein, pertussis toxin, in conformity with the A-B model

15 February 2020

cites work

1 reference

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Cloning and sequencing of the pertussis toxin genes: operon structure and gene duplication

21 January 2018

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Pertussis toxin gene: nucleotide sequence and genetic organization

21 January 2018

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The ins and outs of pertussis toxin

21 January 2018

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Sequences required for expression of Bordetella pertussis virulence factors share homology with prokaryotic signal transduction proteins

21 January 2018

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Molecular characterization of an operon required for pertussis toxin secretion

21 January 2018

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Pertussis toxin export requires accessory genes located downstream from the pertussis toxin operon

21 January 2018

1 reference

https://api.crossref.org/works/10.1586%2F14760584.2014.942641

The crystal structure of pertussis toxin

21 January 2018

1 reference

https://api.crossref.org/works/10.1586%2F14760584.2014.942641

The A protomer of islet-activating protein, pertussis toxin, as an active peptide catalyzing ADP-ribosylation of a membrane protein.

21 January 2018

1 reference

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Crystal structure of the pertussis toxin-ATP complex: a molecular sensor

21 January 2018

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Subunit S1 of pertussis toxin: mapping of the regions essential for ADP-ribosyltransferase activity

21 January 2018

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Computer modelling of the NAD binding site of ADP-ribosylating toxins: active-site structure and mechanism of NAD binding.

21 January 2018

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Identification of formaldehyde-induced modifications in proteins: reactions with model peptides

21 January 2018

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Characterization of the carbohydrate binding and ADP-ribosyltransferase activities of chemically detoxified pertussis toxins

21 January 2018

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The effect of formaldehyde, hydrogen peroxide and genetic detoxification of pertussis toxin on epitope recognition by murine monoclonal antibodies

21 January 2018

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Characterization of a key neutralizing epitope on pertussis toxin recognized by monoclonal antibody 1B7.

21 January 2018

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Modifications of the catalytic and binding subunits of pertussis toxin by formaldehyde: effects on toxicity and immunogenicity

21 January 2018

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Pertussis toxin signals through the TCR to initiate cross-desensitization of the chemokine receptor CXCR4.

21 January 2018

1 reference

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Site-specific alterations in the B oligomer that affect receptor-binding activities and mitogenicity of pertussis toxin

21 January 2018

1 reference

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Hybrid genes over-express pertactin from Bordetella pertussis

21 January 2018

1 reference

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Pertussis toxin-induced cytokine differentiation and clonal expansion of T cells is mediated predominantly via costimulation

21 January 2018

1 reference

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Pertussis toxin potentiates Th1 and Th2 responses to co-injected antigen: adjuvant action is associated with enhanced regulatory cytokine production and expression of the co-stimulatory molecules B7-1, B7-2 and CD28.

21 January 2018

1 reference

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Pertussis toxin modulates the immune response to neuroantigens injected in incomplete Freund's adjuvant: induction of Th1 cells and experimental autoimmune encephalomyelitis in the presence of high frequencies of Th2 cells

21 January 2018

1 reference

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The role of the S-1 and B-oligomer components of pertussis toxin in its adjuvant properties for Th1 and Th2 cells.

21 January 2018

1 reference

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Genetically detoxified pertussis toxin induces Th1/Th17 immune response through MAPKs and IL-10-dependent mechanisms.

21 January 2018

1 reference

https://api.crossref.org/works/10.1586%2F14760584.2014.942641

Cell-surface bound pertussis toxin induces polyclonal T cell responses with high levels of interferon-gamma in the absence of interleukin-12.

21 January 2018

1 reference

https://api.crossref.org/works/10.1586%2F14760584.2014.942641

Induction of dendritic cell maturation by pertussis toxin and its B subunit differentially initiate Toll-like receptor 4-dependent signal transduction pathways

21 January 2018

1 reference

https://api.crossref.org/works/10.1586%2F14760584.2014.942641

Relative contribution of Th1 and Th17 cells in adaptive immunity to Bordetella pertussis: towards the rational design of an improved acellular pertussis vaccine.

21 January 2018

1 reference

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Protection against Bordetella pertussis in mice in the absence of detectable circulating antibody: implications for long-term immunity in children.

21 January 2018

1 reference

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TLR4 mediates vaccine-induced protective cellular immunity to Bordetella pertussis: role of IL-17-producing T cells.

21 January 2018

1 reference

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Acellular pertussis vaccines protect against disease but fail to prevent infection and transmission in a nonhuman primate model

21 January 2018

1 reference

https://api.crossref.org/works/10.1586%2F14760584.2014.942641

Nonhuman primate model of pertussis

21 January 2018

1 reference

https://api.crossref.org/works/10.1586%2F14760584.2014.942641

Airborne transmission of Bordetella pertussis

21 January 2018

1 reference

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Bordetella pertussis infection induces a mucosal IL-17 response and long-lived Th17 and Th1 immune memory cells in nonhuman primates.

21 January 2018

1 reference

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Metabolic, humoral, and cellular responses in adult volunteers immunized with the genetically inactivated pertussis toxin mutant PT-9K/129G.

21 January 2018

1 reference

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Phase I clinical trial of an acellular pertussis vaccine composed of genetically detoxified pertussis toxin combined with FHA and 69 kDa

21 January 2018

1 reference

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A Controlled Trial of Two Acellular Vaccines and One Whole-Cell Vaccine against Pertussis

21 January 2018

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Persistence of protection through 33 months of age provided by immunization in infancy with two three-component acellular pertussis vaccines. Stage II Working Group

21 January 2018

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Sustained efficacy during the first 6 years of life of 3-component acellular pertussis vaccines administered in infancy: the Italian experience

21 January 2018

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Safety and immunogenicity of tetanus diphtheria and acellular pertussis (Tdap) immunization during pregnancy in mothers and infants: a randomized clinical trial

21 January 2018

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The diphtheria and pertussis components of diphtheria-tetanus toxoids-pertussis vaccine should be genetically inactivated mutant toxins

21 January 2018

1 reference

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A phase I clinical study of a live attenuated Bordetella pertussis vaccine--BPZE1; a single centre, double-blind, placebo-controlled, dose-escalating study of BPZE1 given intranasally to healthy adult male volunteers

21 January 2018

1 reference

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Development of safer pertussis DNA vaccine expressing non-toxic C180 polypeptide of pertussis toxin S1 subunit

21 January 2018

1 reference

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Recombinant Mycobacterium bovis BCG expressing pertussis toxin subunit S1 induces protection against an intracerebral challenge with live Bordetella pertussis in mice

21 January 2018

1 reference

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The vaccine containing recombinant pertussis toxin induces early and long-lasting protection

21 January 2018

1 reference

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Pertussis vaccine: a critique

21 January 2018

1 reference

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10.1586/14760584.2014.942641

21 January 2018

Identifiers

DOI

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:25183193%20AND%20SRC:MED&resulttype=core&format=json

15 February 2020

1 reference