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Vulnerabilities of mutant SWI/SNF complexes in cancer.
scientific article published on September 2014
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Europe PubMed Central
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4159614
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https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:25203320%20AND%20SRC:MED&resulttype=core&format=json
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16 February 2020
review article
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title
Vulnerabilities of mutant SWI/SNF complexes in cancer
(English)
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Europe PubMed Central
PMC publication ID
4159614
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https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:25203320%20AND%20SRC:MED&resulttype=core&format=json
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16 February 2020
author
Charles W Roberts
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3
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Europe PubMed Central
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4159614
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16 February 2020
author name string
Katherine C Helming
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1
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Europe PubMed Central
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4159614
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16 February 2020
Xiaofeng Wang
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2
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4159614
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16 February 2020
publication date
1 September 2014
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16 February 2020
published in
Cancer Cell
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Europe PubMed Central
PMC publication ID
4159614
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https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:25203320%20AND%20SRC:MED&resulttype=core&format=json
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16 February 2020
volume
26
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Europe PubMed Central
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4159614
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https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:25203320%20AND%20SRC:MED&resulttype=core&format=json
retrieved
16 February 2020
issue
3
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Europe PubMed Central
PMC publication ID
4159614
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16 February 2020
page(s)
309-317
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4159614
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16 February 2020
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Selective inhibition of BET bromodomains
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Reexpression of hSNF5 in malignant rhabdoid tumor cell lines causes cell cycle arrest through a p21(CIP1/WAF1)-dependent mechanism
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Mammalian SWI/SNF--a subunit BAF250/ARID1 is an E3 ubiquitin ligase that targets histone H2B.
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Oncogenesis caused by loss of the SNF5 tumor suppressor is dependent on activity of BRG1, the ATPase of the SWI/SNF chromatin remodeling complex.
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An embryonic stem cell chromatin remodeling complex, esBAF, is an essential component of the core pluripotency transcriptional network.
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ES cell pluripotency and germ-layer formation require the SWI/SNF chromatin remodeling component BAF250a
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SWI/SNF mediates polycomb eviction and epigenetic reprogramming of the INK4b-ARF-INK4a locus
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Regulation of dendritic development by neuron-specific chromatin remodeling complexes
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An essential switch in subunit composition of a chromatin remodeling complex during neural development
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Rad4-Rad23 interaction with SWI/SNF links ATP-dependent chromatin remodeling with nucleotide excision repair
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Mammalian SWI/SNF complexes facilitate DNA double-strand break repair by promoting gamma-H2AX induction
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The SWI/SNF chromatin-remodeling complex subunit SNF5 is essential for hepatocyte differentiation
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6 September 2017
Baf60c is essential for function of BAF chromatin remodelling complexes in heart development
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6 September 2017
SWI/SNF unwraps, slides, and rewraps the nucleosome
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6 September 2017
The SWI/SNF chromatin-remodeling factor stimulates repair by human excision nuclease in the mononucleosome core particle
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6 September 2017
Reciprocal regulation of CD4/CD8 expression by SWI/SNF-like BAF complexes
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6 September 2017
Compensation of BRG-1 function by Brm: insight into the role of the core SWI-SNF subunits in retinoblastoma tumor suppressor signaling
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6 September 2017
Disruption of Ini1 leads to peri-implantation lethality and tumorigenesis in mice
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6 September 2017
The murine SNF5/INI1 chromatin remodeling factor is essential for embryonic development and tumor suppression
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PubMed Central
reference URL
https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4159614
retrieved
6 September 2017
Expression of chromatin remodeling factors during neural differentiation
1 reference
stated in
PubMed Central
reference URL
https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4159614
retrieved
6 September 2017
Haploinsufficiency of Snf5 (integrase interactor 1) predisposes to malignant rhabdoid tumors in mice
1 reference
stated in
PubMed Central
reference URL
https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4159614
retrieved
6 September 2017
BRG1, a component of the SWI-SNF complex, is mutated in multiple human tumor cell lines
1 reference
stated in
PubMed Central
reference URL
https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4159614
retrieved
6 September 2017
Functional selectivity of recombinant mammalian SWI/SNF subunits
1 reference
stated in
PubMed Central
reference URL
https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4159614
retrieved
6 September 2017
Gain-of-function mutations in the tumor suppressor gene p53.
1 reference
stated in
PubMed Central
reference URL
https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4159614
retrieved
6 September 2017
c-MYC interacts with INI1/hSNF5 and requires the SWI/SNF complex for transactivation function
1 reference
stated in
PubMed Central
reference URL
https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4159614
retrieved
6 September 2017
Reconstitution of a core chromatin remodeling complex from SWI/SNF subunits
1 reference
stated in
PubMed Central
reference URL
https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4159614
retrieved
6 September 2017
Germ-line and acquired mutations of INI1 in atypical teratoid and rhabdoid tumors
1 reference
stated in
PubMed Central
reference URL
https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4159614
retrieved
6 September 2017
Altered control of cellular proliferation in the absence of mammalian brahma (SNF2alpha).
1 reference
stated in
PubMed Central
reference URL
https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4159614
retrieved
6 September 2017
Truncating mutations of hSNF5/INI1 in aggressive paediatric cancer
1 reference
stated in
PubMed Central
reference URL
https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4159614
retrieved
6 September 2017
RB and hbrm cooperate to repress the activation functions of E2F1
1 reference
stated in
PubMed Central
reference URL
https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4159614
retrieved
6 September 2017
Purification and biochemical heterogeneity of the mammalian SWI-SNF complex
1 reference
stated in
PubMed Central
reference URL
https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4159614
retrieved
6 September 2017
The retinoblastoma protein and BRG1 form a complex and cooperate to induce cell cycle arrest
1 reference
stated in
PubMed Central
reference URL
https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4159614
retrieved
6 September 2017
Dosage-dependent modifiers of polycomb and antennapedia mutations in Drosophila
1 reference
stated in
PubMed Central
reference URL
https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4159614
retrieved
6 September 2017
The activity of mammalian brm/SNF2alpha is dependent on a high-mobility-group protein I/Y-like DNA binding domain
1 reference
stated in
PubMed Central
reference URL
https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4159614
retrieved
14 September 2017
Involvement of SMARCA2/BRM in the SWI/SNF chromatin-remodeling complex in schizophrenia
1 reference
stated in
PubMed Central
reference URL
https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4159614
retrieved
14 September 2017
The SWI/SNF ATPase Brm is a gatekeeper of proliferative control in prostate cancer
1 reference
stated in
PubMed Central
reference URL
https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4159614
retrieved
14 September 2017
The expression of the SWI/SNF ATPase subunits BRG1 and BRM in normal human tissues.
1 reference
stated in
PubMed Central
reference URL
https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4159614
retrieved
14 September 2017
Loss of the INI1 tumor suppressor does not impair the expression of multiple BRG1-dependent genes or the assembly of SWI/SNF enzymes
1 reference
stated in
PubMed Central
reference URL
https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4159614
retrieved
14 September 2017
P16INK4a is required for hSNF5 chromatin remodeler-induced cellular senescence in malignant rhabdoid tumor cells
1 reference
stated in
PubMed Central
reference URL
https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4159614
retrieved
14 September 2017
Transcriptional specificity of human SWI/SNF BRG1 and BRM chromatin remodeling complexes
1 reference
stated in
PubMed Central
reference URL
https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4159614
retrieved
14 September 2017
Targeted disruption of the EZH2-EED complex inhibits EZH2-dependent cancer
1 reference
stated in
PubMed Central
reference URL
https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4159614
retrieved
23 June 2018
Mutational landscape of basal cell carcinomas by whole-exome sequencing.
1 reference
stated in
PubMed Central
reference URL
https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4159614
retrieved
23 June 2018
A unifying model for the selective regulation of inducible transcription by CpG islands and nucleosome remodeling
1 reference
stated in
PubMed Central
reference URL
https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4159614
retrieved
23 June 2018
Understanding the words of chromatin regulation
1 reference
stated in
PubMed Central
reference URL
https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4159614
retrieved
23 June 2018
Antagonistic roles for BRM and BRG1 SWI/SNF complexes in differentiation
1 reference
stated in
PubMed Central
reference URL
https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4159614
retrieved
23 June 2018
Hotspot mutation of Brahma in non-melanoma skin cancer.
1 reference
stated in
PubMed Central
reference URL
https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4159614
retrieved
23 June 2018
The c-myc gene is a direct target of mammalian SWI/SNF-related complexes during differentiation-associated cell cycle arrest
1 reference
stated in
PubMed Central
reference URL
https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4159614
retrieved
23 June 2018
SWI/SNF complex prevents lineage reversion and induces temporal patterning in neural stem cells
1 reference
stated in
PubMed Central
reference URL
https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4159614
retrieved
31 August 2018
Molecular pathways: SWI/SNF (BAF) complexes are frequently mutated in cancer--mechanisms and potential therapeutic insights.
1 reference
stated in
PubMed Central
reference URL
https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4159614
retrieved
31 August 2018
INI1 induces interferon signaling and spindle checkpoint in rhabdoid tumors.
1 reference
stated in
PubMed Central
reference URL
https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4159614
retrieved
31 August 2018
Characterization of mammary tumors from Brg1 heterozygous mice.
1 reference
stated in
PubMed Central
reference URL
https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4159614
retrieved
31 August 2018
The reversible epigenetic silencing of BRM: implications for clinical targeted therapy.
1 reference
stated in
PubMed Central
reference URL
https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4159614
retrieved
31 August 2018
Chromatin remodeling factors and BRM/BRG1 expression as prognostic indicators in non-small cell lung cancer.
1 reference
stated in
PubMed Central
reference URL
https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4159614
retrieved
31 August 2018
Expression of genes encoding chromatin regulatory factors in developing rhesus monkey oocytes and preimplantation stage embryos: possible roles in genome activation
1 reference
stated in
PubMed Central
reference URL
https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4159614
retrieved
31 August 2018
Re-expression of hSNF5/INI1/BAF47 in pediatric tumor cells leads to G1 arrest associated with induction of p16ink4a and activation of RB.
1 reference
stated in
PubMed Central
reference URL
https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4159614
retrieved
31 August 2018
Highly penetrant, rapid tumorigenesis through conditional inversion of the tumor suppressor gene Snf5
1 reference
stated in
PubMed
reference URL
https://pubmed.ncbi.nlm.nih.gov/25203320
retrieved
12 December 2020
based on heuristic
inferred from PubMed ID database lookup
Loss of BRG1/BRM in human lung cancer cell lines and primary lung cancers: correlation with poor prognosis
1 reference
stated in
PubMed
reference URL
https://pubmed.ncbi.nlm.nih.gov/25203320
retrieved
12 December 2020
based on heuristic
inferred from PubMed ID database lookup
SnapShot: Chromatin remodeling: SWI/SNF
1 reference
stated in
PubMed
reference URL
https://pubmed.ncbi.nlm.nih.gov/25203320
retrieved
12 December 2020
based on heuristic
inferred from PubMed ID database lookup
Identifiers
DOI
10.1016/J.CCR.2014.07.018
1 reference
stated in
Europe PubMed Central
PMC publication ID
4159614
reference URL
https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:25203320%20AND%20SRC:MED&resulttype=core&format=json
retrieved
16 February 2020
PMC publication ID
4159614
1 reference
stated in
Europe PubMed Central
PMC publication ID
4159614
reference URL
https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:25203320%20AND%20SRC:MED&resulttype=core&format=json
retrieved
16 February 2020
PubMed publication ID
25203320
1 reference
stated in
Europe PubMed Central
PMC publication ID
4159614
reference URL
https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:25203320%20AND%20SRC:MED&resulttype=core&format=json
retrieved
16 February 2020
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