(Q36777355)

16 August 2017

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title

Mutant p53: an oncogenic transcription factor (English)

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16 August 2017

Strano S

1

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16 August 2017

Dell'Orso S

2

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16 August 2017

Di Agostino S

3

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16 August 2017

Fontemaggi G

4

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16 August 2017

Sacchi A

5

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16 August 2017

Blandino G

6

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16 August 2017

language of work or name

English

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publication date

1 April 2007

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16 August 2017

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16 August 2017

26

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16 August 2017

2212-2219

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16 August 2017

15

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https://scigraph.springernature.com/pub.10.1038/sj.onc.1210296

16 August 2017

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cites work

Cloning and chromosomal mapping of the human p53-related KET gene to chromosome 3q27 and its murine homolog Ket to mouse chromosome 16.

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1210296

Induction of p57(KIP2) expression by p73beta.

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1210296

Post-translational modification of p53 in tumorigenesis

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1210296

Ubiquitination, phosphorylation and acetylation: the molecular basis for p53 regulation

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1210296

ChIP-chip: considerations for the design, analysis, and application of genome-wide chromatin immunoprecipitation experiments

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1210296

Rescuing the function of mutant p53.

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1210296

The effects of wild-type p53 tumor suppressor activity and mutant p53 gain-of-function on cell growth

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1210296

Crystal structure of a p53 tumor suppressor-DNA complex: understanding tumorigenic mutations

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1210296

DNA damage-dependent acetylation of p73 dictates the selective activation of apoptotic target genes.

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1210296

Gain of function of mutant p53: the mutant p53/NF-Y protein complex reveals an aberrant transcriptional mechanism of cell cycle regulation

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1210296

Gain of function mutations in p53.

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1210296

The p53-deficient mouse: a model for basic and applied cancer studies

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1210296

Identification of direct p73 target genes combining DNA microarray and chromatin immunoprecipitation analyses.

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1210296

Activation of c-myc gene expression by tumor-derived p53 mutants requires a discrete C-terminal domain

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1210296

A subset of tumor-derived mutant forms of p53 down-regulate p63 and p73 through a direct interaction with the p53 core domain

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1210296

Mutant p53 proteins bind DNA in a DNA structure-selective mode

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1210296

An oncogenic form of p53 confers a dominant, gain-of-function phenotype that disrupts spindle checkpoint control

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1210296

Mdm2 promotes the rapid degradation of p53

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1210296

The p53MH algorithm and its application in detecting p53-responsive genes

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1210296

p53 mutations in human cancers

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1210296

Covalent and noncovalent modifiers of the p53 protein

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1210296

Tumor spectrum analysis in p53-mutant mice

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1210296

The emerging p53 gene family

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1210296

Monoallelically expressed gene related to p53 at 1p36, a region frequently deleted in neuroblastoma and other human cancers

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1210296

DeltaNp73 can modulate the expression of various genes in a p53-independent fashion

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1210296

Identification of genomic DNA sequences bound by mutant p53 protein (Gly245-->Ser) in vivo.

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1210296

Regulation of p53 stability by Mdm2

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1210296

T antigen is bound to a host protein in SY40-transformed cells

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1210296

Gain of function of a p53 hot spot mutation in a mouse model of Li-Fraumeni syndrome.

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1210296

S100A2 gene is a direct transcriptional target of p53 homologues during keratinocyte differentiation.

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1210296

Activation of the insulin-like growth factor II transcription by aflatoxin B1 induced p53 mutant 249 is caused by activation of transcription complexes; implications for a gain-of-function during the formation of hepatocellular carcinoma

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1210296

Mutant p53 protein expression interferes with p53-independent apoptotic pathways.

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1210296

Characterization of a 54K Dalton cellular SV40 tumor antigen present in SV40-transformed cells and uninfected embryonal carcinoma cells

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1210296

Intrinsic tumour suppression

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1210296

Transcriptional activation of the human epidermal growth factor receptor promoter by human p53.

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1210296

A common polymorphism acts as an intragenic modifier of mutant p53 behaviour

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1210296

p53 protein stability in tumour cells is not determined by mutation but is dependent on Mdm2 binding.

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1210296

p63 is a p53 homologue required for limb and epidermal morphogenesis

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1210296

Mutant p53 induces the GEF-H1 oncogene, a guanine nucleotide exchange factor-H1 for RhoA, resulting in accelerated cell proliferation in tumor cells

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1210296

Two distinct mechanisms alter p53 in breast cancer: mutation and nuclear exclusion

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1210296

Mutations in the p53 gene occur in diverse human tumour types

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1210296

Comparison of the effect of mutant and wild-type p53 on global gene expression

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1210296

The IARC TP53 database: new online mutation analysis and recommendations to users

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1210296

Molecular cloning of a cDNA specific for the murine p53 cellular tumor antigen

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1210296

Cloning and functional analysis of human p51, which structurally and functionally resembles p53

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1210296

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1210296

Tumor-derived p53 mutants induce NF-kappaB2 gene expression

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1210296

Modulation of gene expression by tumor-derived p53 mutants

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1210296

A novel protein with strong homology to the tumor suppressor p53.

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1210296

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1210296

Inactivation of retinoblastoma (RB) tumor suppressor by oncogenic isoforms of the p53 family member p73.

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1210296

Physical interaction with human tumor-derived p53 mutants inhibits p63 activities.

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1210296

Profiling of gene expression changes caused by p53 gain-of-function mutant alleles in prostate cancer cells

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1210296

A new human p53 homologue

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1210296

Specific interaction of mutant p53 with regions of matrix attachment region DNA elements (MARs) with a high potential for base-unpairing

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1210296

ChIP-chip comes of age for genome-wide functional analysis

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1210296

Live or let die: the cell's response to p53

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1210296

Regulation of p53 responses by post-translational modifications

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1210296

p63 is essential for regenerative proliferation in limb, craniofacial and epithelial development

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1210296

P63 and P73: P53 mimics, menaces and more

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1210296

p73-deficient mice have neurological, pheromonal and inflammatory defects but lack spontaneous tumours

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1210296

Physical and Functional Interaction between p53 Mutants and Different Isoforms of p73

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1210296

Specific P53 mutations are associated with de novo resistance to doxorubicin in breast cancer patients

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1210296

7 January 2021

Mutant p53 gain of function: differential effects of different p53 mutants on resistance of cultured cells to chemotherapy

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1210296

7 January 2021

ENCODE and ChIP-chip in the genome era.

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1210296

7 January 2021

Analysis of JNK, Mdm2 and p14(ARF) contribution to the regulation of mutant p53 stability

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1210296

7 January 2021

Modulation of cellular and viral promoters by mutant human p53 proteins found in tumor cells

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1210296

7 January 2021

p73 function is inhibited by tumor-derived p53 mutants in mammalian cells.

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1210296

7 January 2021

Different tumor-derived p53 mutants exhibit distinct biological activities

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1210296

7 January 2021

Chemosensitivity linked to p73 function

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1210296

7 January 2021

Mutant p53 gain of function in two mouse models of Li-Fraumeni syndrome

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1210296

7 January 2021

Transactivation of the EGR1 gene contributes to mutant p53 gain of function

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1210296

7 January 2021

Repression of the MSP/MST-1 gene contributes to the antiapoptotic gain of function of mutant p53

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1210296

7 January 2021

Identifiers

DOI

10.1038/SJ.ONC.1210296

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Dimensions Publication ID

16 August 2017

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1 reference