(Q30329984)

18 June 2017

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title

Rescuing the function of mutant p53. (English)

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18 June 2017

2

Fersht AR

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18 June 2017

Bullock AN

1

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18 June 2017

language of work or name

English

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publication date

1 October 2001

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18 June 2017

published in

Nature Reviews Cancer

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18 June 2017

volume

1

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18 June 2017

issue

1

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18 June 2017

page(s)

68-76

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18 June 2017

cites work

The Hallmarks of Cancer

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Emergence of genetic instability in children treated for leukemia.

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A chemical inhibitor of p53 that protects mice from the side effects of cancer therapy

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Strategies for manipulating the p53 pathway in the treatment of human cancer.

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Pharmacological rescue of mutant p53 conformation and function

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T antigen is bound to a host protein in SY40-transformed cells

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Characterization of a 54K Dalton cellular SV40 tumor antigen present in SV40-transformed cells and uninfected embryonal carcinoma cells

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p53: oncogene or anti-oncogene?

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The E6 oncoprotein encoded by human papillomavirus types 16 and 18 promotes the degradation of p53

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Regulation of p53 stability by Mdm2

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Mdm2 promotes the rapid degradation of p53

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Rescue of embryonic lethality in Mdm2-deficient mice by absence of p53

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Rescue of early embryonic lethality in mdm2-deficient mice by deletion of p53

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The loss of mdm2 induces p53-mediated apoptosis

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Surfing the p53 network

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Mutations in the p53 gene occur in diverse human tumour types

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Cell cycle inhibition by the anti-angiogenic agent TNP-470 is mediated by p53 and p21WAF1/CIP1

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Crystal structure of a p53 tumor suppressor-DNA complex: understanding tumorigenic mutations

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Flexibility: the key to p53 function?

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7 January 2021

Definition of a consensus binding site for p53

1 reference

7 January 2021

The DNA-binding domain of p53 contains the four conserved regions and the major mutation hot spots

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7 January 2021

Biochemical characterization of different conformational states of the Sf9 cell-purified p53His175 mutant protein

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7 January 2021

Allosteric regulation of the thermostability and DNA binding activity of human p53 by specific interacting proteins. CRC Cell Transformation Group

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Thermodynamic stability of wild-type and mutant p53 core domain

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Quantitative analysis of residual folding and DNA binding in mutant p53 core domain: definition of mutant states for rescue in cancer therapy

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Hot-spot mutants of p53 core domain evince characteristic local structural changes.

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7 January 2021

Structure-based rescue of common tumor-derived p53 mutants

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Genetic selection of intragenic suppressor mutations that reverse the effect of common p53 cancer mutations

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Mechanism of rescue of common p53 cancer mutations by second-site suppressor mutations

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Semirational design of active tumor suppressor p53 DNA binding domain with enhanced stability

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Cotranslation of activated mutant p53 with wild type drives the wild-type p53 protein into the mutant conformation

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7 January 2021

Crystal structure of the mouse p53 core DNA-binding domain at 2.7 A resolution

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7 January 2021

Identification of a minimal transforming domain of p53: negative dominance through abrogation of sequence-specific DNA binding

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7 January 2021

In vitro analysis of the dominant negative effect of p53 mutants

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7 January 2021

Adenovirus-mediated transfer of p53 and p16(INK4a) results in pancreatic cancer regression in vitro and in vivo

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Mutually compensatory mutations during evolution of the tetramerization domain of tumor suppressor p53 lead to impaired hetero-oligomerization

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7 January 2021

Change in oligomerization specificity of the p53 tetramerization domain by hydrophobic amino acid substitutions

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7 January 2021

Allosteric activation of latent p53 tetramers

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7 January 2021

Reciprocal Interference between the Sequence-Specific Core and Nonspecific C-Terminal DNA Binding Domains of p53: Implications for Regulation

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Conformational and molecular basis for induction of apoptosis by a p53 C-terminal peptide in human cancer cells

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7 January 2021

Small peptides activate the latent sequence-specific DNA binding function of p53.

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7 January 2021

Restoration of the growth suppression function of mutant p53 by a synthetic peptide derived from the p53 C-terminal domain

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Efficacy and safety of a specific inhibitor of the BCR-ABL tyrosine kinase in chronic myeloid leukemia

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Regulation of p53 protein function through alterations in protein-folding pathways

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p53 is associated with cellular microtubules and is transported to the nucleus by dynein

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Clinical resistance to STI-571 cancer therapy caused by BCR-ABL gene mutation or amplification

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Chalcone derivatives antagonize interactions between the human oncoprotein MDM2 and p53.

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7 January 2021

Isolation and structure elucidation of Chlorofusin, a novel p53-MDM2 antagonist from a Fusarium sp.

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Activation of p53 in cervical carcinoma cells by small molecules.

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Interactions between adenovirus proteins and the p53 pathway: the development of ONYX-015.

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Mechanism-based target identification and drug discovery in cancer research

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Small, but deadly: small-molecule inhibition of Bcl-2 homologue heterodimerization

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A subset of tumor-derived mutant forms of p53 down-regulate p63 and p73 through a direct interaction with the p53 core domain

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7 January 2021

Physical and Functional Interaction between p53 Mutants and Different Isoforms of p73

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7 January 2021

Identification of genomic DNA sequences bound by mutant p53 protein (Gly245-->Ser) in vivo

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7 January 2021

Binding of MAR-DNA elements by mutant p53: possible implications for its oncogenic functions

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7 January 2021

The function of PML in p53-dependent apoptosis

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7 January 2021

Regulation of p53 activity in nuclear bodies by a specific PML isoform

1 reference

7 January 2021

Structure of the MDM2 oncoprotein bound to the p53 tumor suppressor transactivation domain

1 reference

7 January 2021

Crystal structure of the tetramerization domain of the p53 tumor suppressor at 1.7 angstroms

1 reference

7 January 2021

Refined solution structure of the oligomerization domain of the tumour suppressor p53

1 reference

7 January 2021

Solution structure of the tetrameric minimum transforming domain of p53

1 reference

7 January 2021

Structure of the negative regulatory domain of p53 bound to S100B(betabeta)

1 reference

7 January 2021

MOLMOL: a program for display and analysis of macromolecular structures

1 reference

7 January 2021

Protein folding and association: insights from the interfacial and thermodynamic properties of hydrocarbons

1 reference

7 January 2021

Identifiers

DOI

10.1038/35094077

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Dimensions Publication ID

18 June 2017

1015264155

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1 reference