(Q38250822)

1 September 2017

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title

Molecular characterization of common fragile sites as a strategy to discover cancer susceptibility genes (English)

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1 September 2017

Larissa Savelyeva

1

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PubMed ID

25231336

1 September 2017

Lena M Brueckner

series ordinal

2

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1 September 2017

18 September 2014

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Cellular and Molecular Life Sciences

1 September 2017

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1 September 2017

71

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1 September 2017

23

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1 September 2017

4561-4575

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https://scigraph.springernature.com/pub.10.1007/s00018-014-1723-z

1 September 2017

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cites work

Human chromosome fragility

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https://api.crossref.org/works/10.1007%2FS00018-014-1723-Z

Activation of the DNA damage checkpoint and genomic instability in human precancerous lesions

21 January 2018

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https://api.crossref.org/works/10.1007%2FS00018-014-1723-Z

An oncogene-induced DNA damage model for cancer development

21 January 2018

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https://api.crossref.org/works/10.1007%2FS00018-014-1723-Z

21 January 2018

Chromosome fragile sites

1 reference

https://api.crossref.org/works/10.1007%2FS00018-014-1723-Z

DNA polymerase alpha inhibition by aphidicolin induces gaps and breaks at common fragile sites in human chromosomes

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS00018-014-1723-Z

Multicolor FISH mapping of YAC clones in 3p14 and identification of a YAC spanning both FRA3B and the t(3;8) associated with hereditary renal cell carcinoma

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS00018-014-1723-Z

Integrated YAC contig containing the 3p14.2 hereditary renal carcinoma 3;8 translocation breakpoint and the fragile site FRA3B.

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS00018-014-1723-Z

A 350-kb cosmid contig in 3p14.2 that crosses the t(3;8) hereditary renal cell carcinoma translocation breakpoint and 17 aphidicolin-induced FRA3B breakpoints

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS00018-014-1723-Z

Preferential integration of marker DNA into the chromosomal fragile site at 3p14: an approach to cloning fragile sites

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS00018-014-1723-Z

Direct cloning of DNA sequences from the common fragile site region at chromosome band 3p14.2.

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS00018-014-1723-Z

Common fragile site FRA11G and rare fragile site FRA11B at 11q23.3 encompass distinct genomic regions.

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS00018-014-1723-Z

Cloning of genetically tagged chromosome break sequences reveals new fragile sites at 6p21 and 13q22.

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS00018-014-1723-Z

Fragile sites are preferential targets for integrations of MLV vectors in gene therapy

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS00018-014-1723-Z

Preferential sites for viral integration on mammalian genome

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS00018-014-1723-Z

FRA3B extends over a broad region and contains a spontaneous HPV16 integration site: direct evidence for the coincidence of viral integration sites and fragile sites

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS00018-014-1723-Z

Common fragile sites are preferential targets for HPV16 integrations in cervical tumors

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS00018-014-1723-Z

Preferential integration of human papillomavirus type 18 near the c-myc locus in cervical carcinoma.

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS00018-014-1723-Z

Molecular characterization of a common fragile site (FRA7H) on human chromosome 7 by the cloning of a simian virus 40 integration site.

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS00018-014-1723-Z

DNA breaks at fragile sites generate oncogenic RET/PTC rearrangements in human thyroid cells

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS00018-014-1723-Z

Initiation of the breakage-fusion-bridge mechanism through common fragile site activation in human breast cancer cells: the model of PIP gene duplication from a break at FRA7I

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS00018-014-1723-Z

SMAD5 gene expression, rearrangements, copy number, and amplification at fragile site FRA5C in human hepatocellular carcinoma

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS00018-014-1723-Z

Relationship between FRA11F and 11q13 gene amplification in oral cancer

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS00018-014-1723-Z

Infection with retroviral vectors leads to perturbed DNA replication increasing vector integrations into fragile sites

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS00018-014-1723-Z

Common fragile sites, extremely large genes, neural development and cancer

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS00018-014-1723-Z

Cell-type-specific replication initiation programs set fragility of the FRA3B fragile site

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS00018-014-1723-Z

Sequencing newly replicated DNA reveals widespread plasticity in human replication timing

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS00018-014-1723-Z

Molecular profiling of common fragile sites in human fibroblasts.

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS00018-014-1723-Z

The neurobeachin gene spans the common fragile site FRA13A.

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS00018-014-1723-Z

The FRA2C common fragile site maps to the borders of MYCN amplicons in neuroblastoma and is associated with gross chromosomal rearrangements in different cancers.

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS00018-014-1723-Z

Instability at the FRA8I common fragile site disrupts the genomic integrity of the KIAA0146, CEBPD and PRKDC genes in colorectal cancer

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS00018-014-1723-Z

Genomic rearrangements at the FRA2H common fragile site frequently involve non-homologous recombination events across LTR and L1(LINE) repeats

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS00018-014-1723-Z

Identification of the human/mouse syntenic common fragile site FRA7K/Fra12C1--relation of FRA7K and other human common fragile sites on chromosome 7 to evolutionary breakpoints

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS00018-014-1723-Z

Integration of the cytogenetic map with the draft human genome sequence

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS00018-014-1723-Z

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS00018-014-1723-Z

Fragile sites, cancer chromosome breakpoints, and oncogenes all cluster in light G bands.

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS00018-014-1723-Z

A genome-wide analysis of common fragile sites: what features determine chromosomal instability in the human genome?

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS00018-014-1723-Z

Common fragile site profiling in epithelial and erythroid cells reveals that most recurrent cancer deletions lie in fragile sites hosting large genes.

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS00018-014-1723-Z

Fish mapping of YAC clones at human chromosomal band 7q31.2: identification of YACS spanning FRA7G within the common region of LOH in breast and prostate cancer

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS00018-014-1723-Z

Common chromosomal fragile site FRA16D sequence: identification of the FOR gene spanning FRA16D and homozygous deletions and translocation breakpoints in cancer cells

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS00018-014-1723-Z

Cloning and characterization of the common fragile site FRA6F harboring a replicative senescence gene and frequently deleted in human tumors

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS00018-014-1723-Z

Evidence that instability within the FRA3B region extends four megabases

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS00018-014-1723-Z

Characterization of a conserved aphidicolin-sensitive common fragile site at human 4q22 and mouse 6C1: possible association with an inherited disease and cancer

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS00018-014-1723-Z

Breakages at common fragile sites set boundaries of amplified regions in two leukemia cell lines K562 - Molecular characterization of FRA2H and localization of a new CFS FRA2S.

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS00018-014-1723-Z

Common fragile sites: genomic hotspots of DNA damage and carcinogenesis

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS00018-014-1723-Z

Two Distinct Categories of Focal Deletions in Cancer Genomes

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS00018-014-1723-Z

RORA, a large common fragile site gene, is involved in cellular stress response

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS00018-014-1723-Z

DMD and IL1RAPL1: two large adjacent genes localized within a common fragile site (FRAXC) have reduced expression in cultured brain tumors

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS00018-014-1723-Z

Disabled-1 is a large common fragile site gene, inactivated in multiple cancers

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS00018-014-1723-Z

Molecular basis for expression of common and rare fragile sites

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS00018-014-1723-Z

FRA18C: a new aphidicolin-inducible fragile site on chromosome 18q22, possibly associated with in vivo chromosome breakage

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS00018-014-1723-Z

Stably transfected common fragile site sequences exhibit instability at ectopic sites

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS00018-014-1723-Z

Sites of genetic instability in mitosis and cancer.

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS00018-014-1723-Z

Initial sequencing and analysis of the human genome

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS00018-014-1723-Z

Oncogene-induced replication stress preferentially targets common fragile sites in preneoplastic lesions. A genome-wide study

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS00018-014-1723-Z

Cancer-specific chromosome alterations in the constitutive fragile region FRA3B.

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS00018-014-1723-Z

DNA instability at chromosomal fragile sites in cancer

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS00018-014-1723-Z

Replication fork barriers: pausing for a break or stalling for time?

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS00018-014-1723-Z

DNA structure and the Werner protein modulate human DNA polymerase delta-dependent replication dynamics within the common fragile site FRA16D.

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS00018-014-1723-Z

An AT-rich sequence in human common fragile site FRA16D causes fork stalling and chromosome breakage in S. cerevisiae

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS00018-014-1723-Z

Common fragile sites are conserved features of human and mouse chromosomes and relate to large active genes

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS00018-014-1723-Z

Allele-specific late replication and fragility of the most active common fragile site, FRA3B.

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS00018-014-1723-Z

The role of late/slow replication of the FRA16D in common fragile site induction

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS00018-014-1723-Z

Replication delay along FRA7H, a common fragile site on human chromosome 7, leads to chromosomal instability

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS00018-014-1723-Z

Replication dynamics at common fragile site FRA6E.

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS00018-014-1723-Z

Impaired replication dynamics at the FRA3B common fragile site

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS00018-014-1723-Z

Failure of origin activation in response to fork stalling leads to chromosomal instability at fragile sites

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS00018-014-1723-Z

Common fragile sites are characterized by histone hypoacetylation

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS00018-014-1723-Z

The landscape of histone modifications across 1% of the human genome in five human cell lines

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS00018-014-1723-Z

Collisions between replication and transcription complexes cause common fragile site instability at the longest human genes

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS00018-014-1723-Z

Signatures of mutation and selection in the cancer genome

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS00018-014-1723-Z

The landscape of somatic copy-number alteration across human cancers

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS00018-014-1723-Z

Studies of genomic copy number changes in human cancers reveal signatures of DNA replication stress

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS00018-014-1723-Z

PARK2 deletions occur frequently in sporadic colorectal cancer and accelerate adenoma development in Apc mutant mice.

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS00018-014-1723-Z

Testin is a tumor suppressor and prognostic marker in breast cancer

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS00018-014-1723-Z

Neurobeachin regulates neurotransmitter receptor trafficking to synapses.

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS00018-014-1723-Z

Low-frequency common fragile sites: link to neuropsychiatric disorders?

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS00018-014-1723-Z

The autism candidate gene Neurobeachin encodes a scaffolding protein implicated in membrane trafficking and signaling

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS00018-014-1723-Z

Non-random inactivation of large common fragile site genes in different cancers

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS00018-014-1723-Z

A selected group of large common fragile site genes have decreased expression in oropharyngeal squamous cell carcinomas.

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS00018-014-1723-Z

Neurobeachin (NBEA) is a target of recurrent interstitial deletions at 13q13 in patients with MGUS and multiple myeloma

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS00018-014-1723-Z

Frequent PVT1 rearrangement and novel chimeric genes PVT1-NBEA and PVT1-WWOX occur in multiple myeloma with 8q24 abnormality

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS00018-014-1723-Z

Scaffolding protein SPIDR/KIAA0146 connects the Bloom syndrome helicase with homologous recombination repair

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS00018-014-1723-Z

Five members of the CEBP transcription factor family are targeted by recurrent IGH translocations in B-cell precursor acute lymphoblastic leukemia (BCP-ALL).

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS00018-014-1723-Z

Somatic copy number changes in DPYD are associated with lower risk of recurrence in triple-negative breast cancers

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS00018-014-1723-Z

Analysis of severely affected patients with dihydropyrimidine dehydrogenase deficiency reveals large intragenic rearrangements of DPYD and a de novo interstitial deletion del(1)(p13.3p21.3).

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS00018-014-1723-Z

Changes to the dihydropyrimidine dehydrogenase gene copy number influence the susceptibility of cancers to 5-FU-based drugs: Data mining of the NCI-DTP data sets and validation with human tumour xenografts

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS00018-014-1723-Z

Report of the Committee on Chromosome Rearrangements in Neoplasia and on Fragile Sites

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS00018-014-1723-Z

The Characterization of the Common Fragile Site FRA16D and Its Involvement in Multiple Myeloma Translocations

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS00018-014-1723-Z

FRA7G extends over a broad region: coincidence of human endogenous retroviral sequences (HERV-H) and small polydispersed circular DNAs (spcDNA) and fragile sites

21 January 2018

1 reference

12 December 2020

Regulation of cancer cell proliferation by caveolin-2 down-regulation and re-expression

1 reference

12 December 2020

Determination of the specificity of aphidicolin-induced breakage of the human 3p14.2 fragile site

1 reference

12 December 2020

A role for common fragile site induction in amplification of human oncogenes

1 reference

12 December 2020

Molecular characterization of the human common fragile site FRA1H

1 reference

12 December 2020

Human papillomavirus type 16 integrations in cervical tumors frequently occur in common fragile sites.

1 reference

12 December 2020

Pathology and biology associated with the fragile FHIT gene and gene product

1 reference

12 December 2020

Persisting clone of cells with an abnormal chromosome in a woman previously irradiated

1 reference

12 December 2020

Characterization of the human common fragile site FRA2G

1 reference

12 December 2020

Chromosomal fragile site FRA16D and DNA instability in cancer

1 reference

12 December 2020

Global screening and extended nomenclature for 230 aphidicolin-inducible fragile sites, including 61 yet unreported ones

1 reference

12 December 2020

Chromosome breakage and recombination at fragile sites

1 reference

12 December 2020

Analysis of replication timing at the FRA10B and FRA16B fragile site loci

1 reference

12 December 2020

Characterization of the common fragile site FRA9E and its potential role in ovarian cancer

1 reference

12 December 2020

Molecular characterization of FRAXB and comparative common fragile site instability in cancer cells

1 reference

12 December 2020

Transcriptional profiling reveals that several common fragile-site genes are downregulated in ovarian cancer

1 reference

12 December 2020

Replication of a common fragile site, FRA3B, occurs late in S phase and is delayed further upon induction: implications for the mechanism of fragile site induction

1 reference

12 December 2020

The human genome browser at UCSC

1 reference

12 December 2020

Novel aphidicolin-inducible common fragile site FRA9G maps to 9p22.2, within the C9orf39 gene

1 reference

12 December 2020

Fragile sites are targets of diverse mutagens and carcinogens

1 reference

12 December 2020

Positions of chromosome 3p14.2 fragile sites (FRA3B) within the FHIT gene.

1 reference

12 December 2020

Genomic amplification of MET with boundaries within fragile site FRA7G and upregulation of MET pathways in esophageal adenocarcinoma

1 reference

12 December 2020

FRA1E common fragile site breaks map within a 370kilobase pair region and disrupt the dihydropyrimidine dehydrogenase gene (DPYD)

1 reference

12 December 2020

Characterization of FRA7B, a human common fragile site mapped at the 7p chromosome terminal region

1 reference

12 December 2020

WWOX, the tumour suppressor gene affected in multiple cancers.

1 reference

12 December 2020

10.1007/S00018-014-1723-Z

Identifiers

DOI

1 reference

1 September 2017

1 reference

PubMed ID

25231336