(Q38256188)

1 September 2017

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title

Specificity, polyspecificity, and heterospecificity of antibody-antigen recognition (English)

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1 September 2017

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Marc H V Van Regenmortel

series ordinal

1

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1 September 2017

publication date

1 November 2014

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Journal of Molecular Recognition

1 September 2017

published in

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1 September 2017

volume

27

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1 September 2017

issue

11

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1 September 2017

page(s)

627-639

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The known unknowns of antigen processing and presentation.

1 September 2017

cites work

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21 January 2018

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21 January 2018

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Hypermutation in antibody affinity maturation

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Molecular recognition in antibody-antigen complexes

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Natural recognition repertoire and the evolutionary emergence of the combinatorial immune system

21 January 2018

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Immunoglobulins did not arise in evolution to fight infection

21 January 2018

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A new concept of immune specificity emerges from a consideration of the self-nonself discrimination

21 January 2018

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Simplicity belies a complex system: a response to the minimal model of immunity of Langman and Cohn

21 January 2018

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Conceptual aspects of self and nonself discrimination

21 January 2018

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Mapping epitopes on the insulin molecule using monoclonal antibodies

21 January 2018

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The Remarkable Flexibility of the Human Antibody Repertoire; Isolation of Over One Thousand Different Antibodies to a Single Protein, BLyS

21 January 2018

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Degeneracy, mimicry and crossreactivity in immune recognition

21 January 2018

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An analysis of B-cell epitope discontinuity

21 January 2018

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Functional reconstruction and synthetic mimicry of a conformational epitope using CLIPS technology

21 January 2018

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Structure-activity relationships in peptide-antibody complexes: implications for epitope prediction and development of synthetic peptide vaccines.

21 January 2018

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Making sense from antisense: a review of experimental data and developing ideas on sense--antisense peptide recognition

21 January 2018

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Binding of peptides that are specified by complementary RNAs

21 January 2018

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The Proteomic Code: a molecular recognition code for proteins

21 January 2018

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Induction of human immunodeficiency virus (HIV-1) envelope specific cell-mediated immunity by a non-homologous synthetic peptide

21 January 2018

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The antigenic structure of proteins: a reappraisal.

21 January 2018

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Intrinsic and extrinsic factors in protein antigenic structure

21 January 2018

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Antibody-antigen interactions: contact analysis and binding site topography.

21 January 2018

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Antigen-binding site anatomy and somatic mutations in antibodies that recognize different types of antigens.

21 January 2018

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An analysis of the sequences of the variable regions of Bence Jones proteins and myeloma light chains and their implications for antibody complementarity

21 January 2018

1 reference

Identification of differences in the specificity-determining residues of antibodies that recognize antigens of different size: implications for the rational design of antibody repertoires.

21 January 2018

1 reference

IMGT, the international ImMunoGeneTics database.

21 January 2018

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IMGT, the international ImMunoGeneTics information system

21 January 2018

1 reference

Paratome: an online tool for systematic identification of antigen-binding regions in antibodies based on sequence or structure

21 January 2018

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Structural consensus among antibodies defines the antigen binding site

21 January 2018

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The Structural Basis of Antibody-Antigen Recognition

21 January 2018

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The indistinguishability of epitopes from protein surface is explained by the distinct binding preferences of each of the six antigen-binding loops.

21 January 2018

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Analysis of the antigen combining site: correlations between length and sequence composition of the hypervariable loops and the nature of the antigen

21 January 2018

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A new clustering of antibody CDR loop conformations

21 January 2018

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Structural analysis of B-cell epitopes in antibody:protein complexes

21 January 2018

1 reference

Computational characterization of B-cell epitopes

21 January 2018

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Use of amino acid composition to predict epitope residues of individual antibodies.

21 January 2018

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Automated identification of complementarity determining regions (CDRs) reveals peculiar characteristics of CDRs and B cell epitopes

21 January 2018

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Principles of protein-protein interactions: what are the preferred ways for proteins to interact?

21 January 2018

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Using a combined computational-experimental approach to predict antibody-specific B cell epitopes

21 January 2018

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Prediction of protein antigenic determinants from amino acid sequences

21 January 2018

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8 Predicting location of continuous epitopes in proteins from their primary structures

21 January 2018

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Benchmarking B cell epitope prediction: underperformance of existing methods

21 January 2018

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Towards a consensus on datasets and evaluation metrics for developing B-cell epitope prediction tools

21 January 2018

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Prediction of antigenic epitopes on protein surfaces by consensus scoring

21 January 2018

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Recent advances in B-cell epitope prediction methods

21 January 2018

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Prediction of conformational B-cell epitopes from 3D structures by random forests with a distance-based feature

21 January 2018

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Synthetic peptides for the immunodiagnosis of human diseases.

21 January 2018

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Prediction of linear B-cell epitopes using amino acid pair antigenicity scale.

21 January 2018

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SVMTriP: a method to predict antigenic epitopes using support vector machine to integrate tri-peptide similarity and propensity

21 January 2018

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Current status of short synthetic peptides as vaccines

21 January 2018

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Evolving concepts of specificity in immune reactions

21 January 2018

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Requirements for empirical immunogenicity trials, rather than structure-based design, for developing an effective HIV vaccine

21 January 2018

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Antigen-receptor degeneracy and immunological paradigms

21 January 2018

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From interception to incorporation: degeneracy and promiscuous recognition as precursors of a paradigm shift in immunology

21 January 2018

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Recognition and function in a degenerate immune system

21 January 2018

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Properties and function of polyreactive antibodies and polyreactive antigen-binding B cells

21 January 2018

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Antibody polyreactivity in health and disease: statu variabilis

21 January 2018

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Polyspecificity of T cell and B cell receptor recognition

21 January 2018

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The concept and operational definition of protein epitopes

21 January 2018

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The broad antibacterial activity of the natural antibody repertoire is due to polyreactive antibodies

21 January 2018

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Predominant autoantibody production by early human B cell precursors

21 January 2018

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Polyreactivity of antibody molecules

21 January 2018

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Mutation drift and repertoire shift in the maturation of the immune response

21 January 2018

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Structural insights into the evolution of an antibody combining site

21 January 2018

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The primary antibody repertoire represents a linked network of degenerate antigen specificities

21 January 2018

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Structural plasticity and the evolution of antibody affinity and specificity

21 January 2018

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Kinetic and affinity limits on antibodies produced during immune responses

21 January 2018

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Affinity dependence of the B cell response to antigen: a threshold, a ceiling, and the importance of off-rate

21 January 2018

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Multiple paths to multispecificity

21 January 2018

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Thermodynamic analysis of degenerate recognition by the NKG2D immunoreceptor: not induced fit but rigid adaptation

21 January 2018

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Antibody multispecificity mediated by conformational diversity

21 January 2018

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Structural elucidation of the mechanistic basis of degeneracy in the primary humoral response

21 January 2018

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Flexibility and molecular recognition in the immune system.

21 January 2018

1 reference

Molecular evolution of affinity and flexibility in the immune system

21 January 2018

1 reference

On the Specificity of Antibodies

21 January 2018

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Immunological specificity, unique combinations of selected natural globulins provide an alternative to the classical concept.

21 January 2018

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Analyzing proteome topology and function by automated multidimensional fluorescence microscopy

21 January 2018

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Systematic, spatial imaging of large multimolecular assemblies and the emerging principles of supramolecular order in biological systems

21 January 2018

1 reference

Induction of natural autoantibody activity following treatment of human immunoglobulin with dissociating agents

21 January 2018

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Basic research in HIV vaccinology is hampered by reductionist thinking

21 January 2018

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Somatic mutations can lead to a loss of superantigenic and polyreactive binding

21 January 2018

1 reference

Molecular characterization of virus-induced autoantibody responses.

21 January 2018

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Polyreactivity increases the apparent affinity of anti-HIV antibodies by heteroligation

21 January 2018

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Distribution and three-dimensional structure of AIDS virus envelope spikes

21 January 2018

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Few and far between: how HIV may be evading antibody avidity

21 January 2018

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Polyreactive antibodies in adaptive immune responses to viruses

21 January 2018

1 reference

Immunochemical studies of tobacco mosaic virus--II. Univalent and monogamous bivalent binding of IgG antibody

21 January 2018

1 reference

Examination of the contributions of size and avidity to the neutralization mechanisms of the anti-HIV antibodies b12 and 4E10.

21 January 2018

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Antiviral immune responses: triggers of or triggered by autoimmunity?

21 January 2018

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Theoretical considerations of the ability of monoclonal antibodies to detect antigenic differences between closely related variants, with particular reference to heterospecific reactions

21 January 2018

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Crystal structure of a four-layer aggregate of engineered TMV CP implies the importance of terminal residues for oligomer assembly

21 January 2018

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Serological studies on naturally occurring strains and chemically induced mutants of tobacco mosaic virus

21 January 2018

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Specificity and degeneracy in antigen recognition: yin and yang in the immune system

21 January 2018

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21 January 2018

Natural autoantibodies.

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Heterogeneous antigen recognition behavior of induced polyspecific antibodies

21 January 2018

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21 January 2018

Identifiers

DOI

10.1002/JMR.2394

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release_qiia3kqwfzecbimtnxszm5h4ye

1 September 2017

Fatcat ID

1 reference

Fatcat

https://api.fatcat.wiki/v0/release/qiia3kqwfzecbimtnxszm5h4ye

mapped directly with Wikidata item

24 November 2022

based on heuristic

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