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Druggable sensors of the unfolded protein response
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scholarly article
1 reference
stated in
Europe PubMed Central
PMCID
4664160
retrieved
1 September 2017
review article
1 reference
stated in
Europe PubMed Central
title
Druggable sensors of the unfolded protein response
(English)
1 reference
stated in
Europe PubMed Central
PMCID
4664160
retrieved
1 September 2017
author
Dustin J. Maly
series ordinal
1
1 reference
stated in
Europe PubMed Central
PMCID
4664160
reference URL
https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:25325700%20AND%20SRC:MED&resulttype=core&format=json
retrieved
6 June 2020
author name string
Feroz R Papa
series ordinal
2
1 reference
stated in
Europe PubMed Central
PMCID
4664160
reference URL
https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:25325700%20AND%20SRC:MED&resulttype=core&format=json
retrieved
6 June 2020
publication date
1 November 2014
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Europe PubMed Central
PMCID
4664160
retrieved
1 September 2017
published in
Nature Chemical Biology
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stated in
Europe PubMed Central
PMCID
4664160
reference URL
https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:25325700%20AND%20SRC:MED&resulttype=core&format=json
retrieved
6 June 2020
volume
10
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stated in
Europe PubMed Central
PMCID
4664160
reference URL
https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:25325700%20AND%20SRC:MED&resulttype=core&format=json
retrieved
6 June 2020
issue
11
1 reference
stated in
Europe PubMed Central
PMCID
4664160
reference URL
https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:25325700%20AND%20SRC:MED&resulttype=core&format=json
retrieved
6 June 2020
page(s)
892-901
1 reference
stated in
Europe PubMed Central
PMCID
4664160
reference URL
https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:25325700%20AND%20SRC:MED&resulttype=core&format=json
retrieved
6 June 2020
exact match
https://scigraph.springernature.com/pub.10.1038/nchembio.1664
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ASK1 is essential for endoplasmic reticulum stress-induced neuronal cell death triggered by expanded polyglutamine repeats
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Targeted disruption of the Chop gene delays endoplasmic reticulum stress-mediated diabetes
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IRE1 couples endoplasmic reticulum load to secretory capacity by processing the XBP-1 mRNA
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XBP1 mRNA is induced by ATF6 and spliced by IRE1 in response to ER stress to produce a highly active transcription factor
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Overexpression of glucose-regulated protein 94 (Grp94) in esophageal adenocarcinomas of a rat surgical model and humans
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https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4664160
retrieved
6 September 2017
ER stress induces cleavage of membrane-bound ATF6 by the same proteases that process SREBPs
1 reference
stated in
PubMed Central
reference URL
https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4664160
retrieved
6 September 2017
Gadd153 sensitizes cells to endoplasmic reticulum stress by down-regulating Bcl2 and perturbing the cellular redox state
1 reference
stated in
PubMed Central
reference URL
https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4664160
retrieved
6 September 2017
EIF2AK3, encoding translation initiation factor 2-alpha kinase 3, is mutated in patients with Wolcott-Rallison syndrome
1 reference
stated in
PubMed Central
reference URL
https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4664160
retrieved
6 September 2017
Perk is essential for translational regulation and cell survival during the unfolded protein response
1 reference
stated in
PubMed Central
reference URL
https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4664160
retrieved
6 September 2017
Dynamic interaction of BiP and ER stress transducers in the unfolded-protein response
1 reference
stated in
PubMed Central
reference URL
https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4664160
retrieved
6 September 2017
Functional and genomic analyses reveal an essential coordination between the unfolded protein response and ER-associated degradation
1 reference
stated in
PubMed Central
reference URL
https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4664160
retrieved
6 September 2017
Coupling of stress in the ER to activation of JNK protein kinases by transmembrane protein kinase IRE1
1 reference
stated in
PubMed Central
reference URL
https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4664160
retrieved
6 September 2017
Protein translation and folding are coupled by an endoplasmic-reticulum-resident kinase
1 reference
stated in
PubMed Central
reference URL
https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4664160
retrieved
6 September 2017
Cloning of mammalian Ire1 reveals diversity in the ER stress responses
1 reference
stated in
PubMed Central
reference URL
https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4664160
retrieved
6 September 2017
A stress response pathway from the endoplasmic reticulum to the nucleus requires a novel bifunctional protein kinase/endoribonuclease (Ire1p) in mammalian cells
1 reference
stated in
PubMed Central
reference URL
https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4664160
retrieved
6 September 2017
Expression of heat shock proteins in Alzheimer's disease
1 reference
stated in
PubMed Central
reference URL
https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4664160
retrieved
6 September 2017
Cytoprotection by pre-emptive conditional phosphorylation of translation initiation factor 2
1 reference
stated in
PubMed Central
reference URL
https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4664160
retrieved
6 September 2017
IRE1alpha kinase activation modes control alternate endoribonuclease outputs to determine divergent cell fates.
1 reference
stated in
PubMed Central
reference URL
https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4664160
retrieved
14 September 2017
Induction of the unfolded protein response in familial amyotrophic lateral sclerosis and association of protein-disulfide isomerase with superoxide dismutase 1.
1 reference
stated in
PubMed Central
reference URL
https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4664160
retrieved
14 September 2017
Parkinsonian mimetics induce aspects of unfolded protein response in death of dopaminergic neurons
1 reference
stated in
PubMed Central
reference URL
https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4664160
retrieved
14 September 2017
Induction of glucose-regulated protein 78 by chronic hypoxia in human gastric tumor cells through a protein kinase C-epsilon/ERK/AP-1 signaling cascade
1 reference
stated in
PubMed Central
reference URL
https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4664160
retrieved
28 September 2017
Xbp1s-negative tumor B cells and pre-plasmablasts mediate therapeutic proteasome inhibitor resistance in multiple myeloma
1 reference
stated in
PubMed Central
reference URL
https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4664160
retrieved
23 June 2018
Coxsackievirus B3 infection activates the unfolded protein response and induces apoptosis through downregulation of p58IPK and activation of CHOP and SREBP1.
1 reference
stated in
PubMed Central
reference URL
https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4664160
retrieved
23 June 2018
Characterization of a novel PERK kinase inhibitor with antitumor and antiangiogenic activity
1 reference
stated in
PubMed Central
reference URL
https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4664160
retrieved
31 August 2018
A kinase inhibitor activates the IRE1alpha RNase to confer cytoprotection against ER stress
1 reference
stated in
PubMed Central
reference URL
https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4664160
retrieved
31 August 2018
A transgenic mouse model for monitoring endoplasmic reticulum stress
1 reference
stated in
PubMed Central
reference URL
https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4664160
retrieved
31 August 2018
Bypassing a Kinase Activity with an ATP-Competitive Drug
1 reference
stated in
PubMed Central
reference URL
https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4664160
retrieved
31 August 2018
Ligand-independent dimerization activates the stress response kinases IRE1 and PERK in the lumen of the endoplasmic reticulum.
1 reference
stated in
PubMed Central
reference URL
https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4664160
retrieved
31 August 2018
Differentiation induction enhances bortezomib efficacy and overcomes drug resistance in multiple myeloma
1 reference
stated in
PubMed
reference URL
https://pubmed.ncbi.nlm.nih.gov/25325700
retrieved
12 December 2020
based on heuristic
inferred from PubMed ID database lookup
Overexpression of the glucose-regulated stress gene GRP78 in malignant but not benign human breast lesions
1 reference
stated in
PubMed
reference URL
https://pubmed.ncbi.nlm.nih.gov/25325700
retrieved
12 December 2020
based on heuristic
inferred from PubMed ID database lookup
Endoplasmic reticulum stress features are prominent in Alzheimer disease but not in prion diseases in vivo
1 reference
stated in
PubMed
reference URL
https://pubmed.ncbi.nlm.nih.gov/25325700
retrieved
12 December 2020
based on heuristic
inferred from PubMed ID database lookup
Transcriptional induction of mammalian ER quality control proteins is mediated by single or combined action of ATF6alpha and XBP1
1 reference
stated in
PubMed
reference URL
https://pubmed.ncbi.nlm.nih.gov/25325700
retrieved
12 December 2020
based on heuristic
inferred from PubMed ID database lookup
Identifiers
DOI
10.1038/NCHEMBIO.1664
1 reference
stated in
Europe PubMed Central
PMCID
4664160
reference URL
https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:25325700%20AND%20SRC:MED&resulttype=core&format=json
retrieved
6 June 2020
PMCID
4664160
1 reference
stated in
Europe PubMed Central
PMCID
4664160
reference URL
https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:25325700%20AND%20SRC:MED&resulttype=core&format=json
retrieved
6 June 2020
PubMed ID
25325700
1 reference
stated in
Europe PubMed Central
PMCID
4664160
reference URL
https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:25325700%20AND%20SRC:MED&resulttype=core&format=json
retrieved
6 June 2020
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