(Q38290198)

1 September 2017

title

Functionally active fusion protein of the novel composite cytokine CLC/soluble CNTF receptor (English)

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1 September 2017

Catherine Guillet

1

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1 September 2017

Eric Lelièvre

2

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1 September 2017

Hélène Plun-Favreau

3

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1 September 2017

Josy Froger

4

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1 September 2017

Marie Chabbert

5

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1 September 2017

Jacques Hermann

6

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1 September 2017

Amelie Benoit de Coignac

7

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1 September 2017

Jean-Yves Bonnefoy

8

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1 September 2017

Hugues Gascan

9

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1 September 2017

Jean-François Gauchat

10

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1 September 2017

Greg Elson

11

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1 September 2017

language of work or name

English

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publication date

1 April 2002

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1 September 2017

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1 September 2017

volume

269

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1 September 2017

issue

7

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1 September 2017

page(s)

1932-1941

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Molecular cloning, expression and regional distribution of rat ciliary neurotrophic factor

1 September 2017

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1 reference

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21 January 2018

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Ciliary neurotrophic factor enhances the survival of Purkinje cells in vitro

21 January 2018

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Ciliary neurotrophic factor prevents degeneration of motor neurons in mouse mutant progressive motor neuronopathy

21 January 2018

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Interleukin-6-type cytokine signalling through the gp130/Jak/STAT pathway

21 January 2018

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Receptor recognition by gp130 cytokines

21 January 2018

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Neuropoietic cytokines in the hematopoietic fold

21 January 2018

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Computational EST database analysis identifies a novel member of the neuropoietic cytokine family

21 January 2018

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Novel neurotrophin-1/B cell-stimulating factor-3: a cytokine of the IL-6 family

21 January 2018

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Molecular cloning and expression of an IL-6 signal transducer, gp130

21 January 2018

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The IL-6 signal transducer, gp130: an oncostatin M receptor and affinity converter for the LIF receptor

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IL-6-induced homodimerization of gp130 and associated activation of a tyrosine kinase

21 January 2018

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The receptor for ciliary neurotrophic factor

21 January 2018

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LIFR beta and gp130 as heterodimerizing signal transducers of the tripartite CNTF receptor

21 January 2018

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Proliferative responses and binding properties of hematopoietic cells transfected with low-affinity receptors for leukemia inhibitory factor, oncostatin M, and ciliary neurotrophic factor

21 January 2018

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Association and activation of Jak-Tyk kinases by CNTF-LIF-OSM-IL-6 beta receptor components

21 January 2018

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Choice of STATs and other substrates specified by modular tyrosine-based motifs in cytokine receptors

21 January 2018

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Association of transcription factor APRF and protein kinase Jak1 with the interleukin-6 signal transducer gp130.

21 January 2018

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Activation of JAK2 kinase mediated by the interleukin 6 signal transducer gp130

21 January 2018

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CLF associates with CLC to form a functional heteromeric ligand for the CNTF receptor complex

21 January 2018

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Interleukin-12: a proinflammatory cytokine with immunoregulatory functions that bridge innate resistance and antigen-specific adaptive immunity

21 January 2018

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Signaling pathways recruited by the cardiotrophin-like cytokine/cytokine-like factor-1 composite cytokine: specific requirement of the membrane-bound form of ciliary neurotrophic factor receptor alpha component

21 January 2018

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The ciliary neurotrophic factor receptor alpha component induces the secretion of and is required for functional responses to cardiotrophin-like cytokine

21 January 2018

1 reference

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Mediation of interleukin-11-dependent biological responses by a soluble form of the interleukin-11 receptor

21 January 2018

1 reference

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Novel p19 protein engages IL-12p40 to form a cytokine, IL-23, with biological activities similar as well as distinct from IL-12

21 January 2018

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The crystal structure and biological function of leukemia inhibitory factor: implications for receptor binding

21 January 2018

1 reference

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Crystal structure of a cytokine-binding region of gp130.

21 January 2018

1 reference

https://api.crossref.org/works/10.1046%2FJ.1432-1033.2002.02850.X

Structure of an extracellular gp130 cytokine receptor signaling complex

21 January 2018

1 reference

https://api.crossref.org/works/10.1046%2FJ.1432-1033.2002.02850.X

Comparative protein modelling by satisfaction of spatial restraints

21 January 2018

1 reference

https://api.crossref.org/works/10.1046%2FJ.1432-1033.2002.02850.X

Assessment of protein models with three-dimensional profiles

21 January 2018

1 reference

https://api.crossref.org/works/10.1046%2FJ.1432-1033.2002.02850.X

Receptor recognition sites of cytokines are organized as exchangeable modules. Transfer of the leukemia inhibitory factor receptor-binding site from ciliary neurotrophic factor to interleukin-6.

21 January 2018

1 reference

https://api.crossref.org/works/10.1046%2FJ.1432-1033.2002.02850.X

Binding interactions of leukemia inhibitory factor and ciliary neurotrophic factor with the different subunits of their high affinity receptors

21 January 2018

1 reference

https://api.crossref.org/works/10.1046%2FJ.1432-1033.2002.02850.X

Signaling of the cardiotrophin-1 receptor. Evidence for a third receptor component.

21 January 2018

1 reference

https://api.crossref.org/works/10.1046%2FJ.1432-1033.2002.02850.X

Functional interaction of STAT3 transcription factor with the cell cycle inhibitor p21WAF1/CIP1/SDI1.

21 January 2018

1 reference

https://api.crossref.org/works/10.1046%2FJ.1432-1033.2002.02850.X

Dual signaling role of the protein tyrosine phosphatase SHP-2 in regulating expression of acute-phase plasma proteins by interleukin-6 cytokine receptors in hepatic cells.

21 January 2018

1 reference

https://api.crossref.org/works/10.1046%2FJ.1432-1033.2002.02850.X

Gab1 acts as an adapter molecule linking the cytokine receptor gp130 to ERK mitogen-activated protein kinase

21 January 2018

1 reference

https://api.crossref.org/works/10.1046%2FJ.1432-1033.2002.02850.X

Enhanced hematopoietic activity of a human granulocyte/macrophage colony-stimulating factor-interleukin 3 fusion protein

21 January 2018

1 reference

https://api.crossref.org/works/10.1046%2FJ.1432-1033.2002.02850.X

Gene therapy with a single chain interleukin 12 fusion protein induces T cell-dependent protective immunity in a syngeneic model of murine neuroblastoma.

21 January 2018

1 reference

https://api.crossref.org/works/10.1046%2FJ.1432-1033.2002.02850.X

The designer cytokine hyper-interleukin-6 is a potent activator of STAT3-dependent gene transcription in vivo and in vitro.

21 January 2018

1 reference

https://api.crossref.org/works/10.1046%2FJ.1432-1033.2002.02850.X

Soluble interleukin-6 receptor (sIL-6R) makes IL-6R negative T cell line respond to IL-6; it inhibits TNF production.

21 January 2018

1 reference

https://api.crossref.org/works/10.1046%2FJ.1432-1033.2002.02850.X

Separate signaling mechanisms are involved in the control of STAT protein activation and gene regulation via the interleukin 6 response element by the box 3 motif of gp130

21 January 2018

1 reference

https://api.crossref.org/works/10.1046%2FJ.1432-1033.2002.02850.X

Direct isolation of human central nervous system stem cells

21 January 2018

1 reference

https://api.crossref.org/works/10.1046%2FJ.1432-1033.2002.02850.X

Stem cells in the central nervous system

21 January 2018

1 reference

https://api.crossref.org/works/10.1046%2FJ.1432-1033.2002.02850.X

A placebo-controlled trial of recombinant human ciliary neurotrophic (rhCNTF) factor in amyotrophic lateral sclerosis. rhCNTF ALS Study Group

21 January 2018

1 reference

https://api.crossref.org/works/10.1046%2FJ.1432-1033.2002.02850.X

Intrathecal delivery of CNTF using encapsulated genetically modified xenogeneic cells in amyotrophic lateral sclerosis patients

21 January 2018

1 reference

https://api.crossref.org/works/10.1046%2FJ.1432-1033.2002.02850.X

Restoration of cognitive and motor functions by ciliary neurotrophic factor in a primate model of Huntington's disease.

21 January 2018

1 reference

https://api.crossref.org/works/10.1046%2FJ.1432-1033.2002.02850.X

Control of embryonic motoneuron survival in vivo by ciliary neurotrophic factor

21 January 2018

1 reference

https://api.crossref.org/works/10.1046%2FJ.1432-1033.2002.02850.X

Arrest of motor neuron disease in wobbler mice cotreated with CNTF and BDNF

21 January 2018

1 reference

https://api.crossref.org/works/10.1046%2FJ.1432-1033.2002.02850.X

Trophic effect of ciliary neurotrophic factor on denervated skeletal muscle

21 January 2018

1 reference

https://api.crossref.org/works/10.1046%2FJ.1432-1033.2002.02850.X

Released form of CNTF receptor alpha component as a soluble mediator of CNTF responses

21 January 2018

1 reference

https://api.crossref.org/works/10.1046%2FJ.1432-1033.2002.02850.X

A bioactive designer cytokine for human hematopoietic progenitor cell expansion

21 January 2018

1 reference

https://api.crossref.org/works/10.1046%2FJ.1432-1033.2002.02850.X

A fusion protein of interleukin-11 and soluble interleukin-11 receptor acts as a superagonist on cells expressing gp130

21 January 2018

1 reference

https://api.crossref.org/works/10.1046%2FJ.1432-1033.2002.02850.X

Bioactive murine and human interleukin-12 fusion proteins which retain antitumor activity in vivo

21 January 2018

1 reference

https://api.crossref.org/works/10.1046%2FJ.1432-1033.2002.02850.X

10.1046/J.1432-1033.2002.02850.X

21 January 2018

Identifiers

DOI

1 reference

1 September 2017

1 reference