(Q38293976)

1 September 2017

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title

The mechanisms and functions of spontaneous neurotransmitter release (English)

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1 September 2017

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1

Ege T Kavalali

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PubMed ID

25524119

1 September 2017

language of work or name

English

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publication date

1 January 2015

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Nature Reviews Neuroscience

1 September 2017

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1 September 2017

16

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1 September 2017

1

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1 September 2017

5-16

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https://scigraph.springernature.com/pub.10.1038/nrn3875

1 September 2017

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The SNARE protein vti1a functions in dense-core vesicle biogenesis

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Vti1a identifies a vesicle pool that preferentially recycles at rest and maintains spontaneous neurotransmission

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v-SNARE composition distinguishes synaptic vesicle pools.

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The role of non-canonical SNAREs in synaptic vesicle recycling

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The SNARE Vti1a-beta is localized to small synaptic vesicles and participates in a novel SNARE complex

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Loss of AP-3 function affects spontaneous and evoked release at hippocampal mossy fiber synapses

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Tetanus neurotoxin-insensitive vesicle-associated membrane protein localizes to a presynaptic membrane compartment in selected terminal subsets of the rat brain.

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Reelin mobilizes a VAMP7-dependent synaptic vesicle pool and selectively augments spontaneous neurotransmission

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VAMP4 directs synaptic vesicles to a pool that selectively maintains asynchronous neurotransmission

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Synaptic ribbons influence the size and frequency of miniature-like evoked postsynaptic currents

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Position of UNC-13 in the active zone regulates synaptic vesicle release probability and release kinetics

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Opposing functions of two sub-domains of the SNARE-complex in neurotransmission

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Rab3D is not required for exocrine exocytosis but for maintenance of normally sized secretory granules

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Synaptotagmin-1 functions as a Ca2+ sensor for spontaneous release

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A complexin fusion clamp regulates spontaneous neurotransmitter release and synaptic growth

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Deconstructing complexin function in activating and clamping Ca2+-triggered exocytosis by comparing knockout and knockdown phenotypes

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Doc2b is a high-affinity Ca2+ sensor for spontaneous neurotransmitter release

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Doc2 supports spontaneous synaptic transmission by a Ca(2+)-independent mechanism

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Doc2 is a Ca2+ sensor required for asynchronous neurotransmitter release.

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Ca2+-Calmodulin regulates SNARE assembly and spontaneous neurotransmitter release via v-ATPase subunit V0a1.

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Acute suppression of spontaneous neurotransmission drives synaptic potentiation

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Fast synaptic vesicle reuse slows the rate of synaptic depression in the CA1 region of hippocampus.

31 March 2020

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An isolated pool of vesicles recycles at rest and drives spontaneous neurotransmission

31 March 2020

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Synaptic vesicles recycling spontaneously and during activity belong to the same vesicle pool.

31 March 2020

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A common origin of synaptic vesicles undergoing evoked and spontaneous fusion

31 March 2020

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The same synaptic vesicles drive active and spontaneous release.

31 March 2020

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Acute dynamin inhibition dissects synaptic vesicle recycling pathways that drive spontaneous and evoked neurotransmission

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Overlapping role of dynamin isoforms in synaptic vesicle endocytosis

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Contribution of active zone subpopulation of vesicles to evoked and spontaneous release

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Visualizing presynaptic function

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A resting pool of vesicles is responsible for spontaneous vesicle fusion at the synapse

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Differential motion dynamics of synaptic vesicles undergoing spontaneous and activity-evoked endocytosis.

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Spontaneous and evoked glutamate release activates two populations of NMDA receptors with limited overlap

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Use-dependent AMPA receptor block reveals segregation of spontaneous and evoked glutamatergic neurotransmission

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Spontaneous and evoked release are independently regulated at individual active zones

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Alterations in transmission, vesicle dynamics, and transmitter release machinery at NCAM-deficient neuromuscular junctions

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31 March 2020

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Depolarization-induced suppression of spontaneous release in the avian midbrain

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Mefloquine selectively increases asynchronous acetylcholine release from motor nerve terminals

31 March 2020

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Activity-dependent suppression of miniature neurotransmission through the regulation of DNA methylation.

31 March 2020

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MeCP2-dependent transcriptional repression regulates excitatory neurotransmission.

31 March 2020

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Cholesterol and synaptic transmitter release at crayfish neuromuscular junctions

31 March 2020

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Cholesterol-dependent balance between evoked and spontaneous synaptic vesicle recycling.

31 March 2020

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A novel role for {gamma}-secretase: selective regulation of spontaneous neurotransmitter release from hippocampal neurons

31 March 2020

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Primary afferent activation of thermosensitive TRPV1 triggers asynchronous glutamate release at central neurons

31 March 2020

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Cannabinoid 1 and transient receptor potential vanilloid 1 receptors discretely modulate evoked glutamate separately from spontaneous glutamate transmission.

31 March 2020

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Coactivation of multiple tightly coupled calcium channels triggers spontaneous release of GABA

31 March 2020

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Miniature IPSCs in hippocampal granule cells are triggered by voltage-gated Ca2+ channels via microdomain coupling

31 March 2020

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Differential triggering of spontaneous glutamate release by P/Q-, N- and R-type Ca2+ channels

31 March 2020

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Spontaneous glutamate release is independent of calcium influx and tonically activated by the calcium-sensing receptor

31 March 2020

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Synaptotagmin increases the dynamic range of synapses by driving Ca²+-evoked release and by clamping a near-linear remaining Ca²+ sensor.

31 March 2020

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Synaptotagmin arrests the SNARE complex before triggering fast, efficient membrane fusion in response to Ca2+.

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Reversal of synaptic vesicle docking at central synapses.

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Quantal events shape cerebellar interneuron firing.

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31 March 2020

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31 March 2020

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Independent vesicle pools underlie different modes of release during neuronal development.

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31 March 2020

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Neurotrophin regulation of cortical dendritic growth requires activity.

31 March 2020

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Miniature neurotransmission regulates Drosophila synaptic structural maturation

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31 March 2020

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31 March 2020

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Synaptic mechanisms underlying rapid antidepressant action of ketamine

31 March 2020

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Possible contributions of a novel form of synaptic plasticity in Aplysia to reward, memory, and their dysfunctions in mammalian brain

31 March 2020

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Spontaneous transmitter release recruits postsynaptic mechanisms of long-term and intermediate-term facilitation in Aplysia.

31 March 2020

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Spontaneous transmitter release is critical for the induction of long-term and intermediate-term facilitation in Aplysia

31 March 2020

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Presynaptic miniature GABAergic currents in developing interneurons

31 March 2020

1 reference

31 March 2020

Identifiers

DOI

10.1038/NRN3875

1 reference

PubMed ID

25524119

Dimensions Publication ID

1 September 2017

0 references

1 reference

PubMed ID

25524119