(Q38296637)

1 September 2017

title

Lysine 114 of antithrombin is of crucial importance for the affinity and kinetics of heparin pentasaccharide binding (English)

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1 September 2017

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Arocas V

1

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1 September 2017

Bock SC

2

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1 September 2017

Raja S

3

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1 September 2017

Olson ST

4

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1 September 2017

Bjork I

5

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1 September 2017

language of work or name

English

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publication date

20 September 2001

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Journal of Biological Chemistry

1 September 2017

number of pages

9

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based on heuristic

inferred from page(s)

published in

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1 September 2017

volume

276

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1 September 2017

issue

47

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1 September 2017

page(s)

43809-43817

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Complete antithrombin deficiency in mice results in embryonic lethality

1 September 2017

cites work

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https://api.crossref.org/works/10.1074%2FJBC.M105294200

Formation of the covalent serpin-proteinase complex involves translocation of the proteinase by more than 70 A and full insertion of the reactive center loop into beta-sheet A.

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M105294200

Partitioning of serpin-proteinase reactions between stable inhibition and substrate cleavage is regulated by the rate of serpin reactive center loop insertion into beta-sheet A.

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M105294200

Structure of a serpin-protease complex shows inhibition by deformation

21 January 2018

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https://api.crossref.org/works/10.1074%2FJBC.M105294200

Further characterization of the antithrombin-binding sequence in heparin

21 January 2018

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https://api.crossref.org/works/10.1074%2FJBC.M105294200

Characterization of specific receptors for vasopressin in the pituitary gland

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M105294200

The anticoagulant activation of antithrombin by heparin

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M105294200

Antithrombin III Toyama: replacement of arginine-47 by cysteine in hereditary abnormal antithrombin III that lacks heparin-binding ability

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M105294200

Lysine-heparin interactions in antithrombin. Properties of K125M and K290M,K294M,K297M variants

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M105294200

Requirement of lysine residues outside of the proposed pentasaccharide binding region for high affinity heparin binding and activation of human antithrombin III.

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M105294200

Lysine residue 114 in human antithrombin III is required for heparin pentasaccharide-mediated activation.

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M105294200

The role of Arg46 and Arg47 of antithrombin in heparin binding.

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M105294200

Elimination of glycosylation heterogeneity affecting heparin affinity of recombinant human antithrombin III by expression of a beta-like variant in baculovirus-infected insect cells

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M105294200

The oligosaccharide side chain on Asn-135 of alpha-antithrombin, absent in beta-antithrombin, decreases the heparin affinity of the inhibitor by affecting the heparin-induced conformational change

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M105294200

Transmission of conformational change from the heparin binding site to the reactive center of antithrombin

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M105294200

Carbohydrate isoforms of antithrombin variant N135Q with different heparin affinities

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M105294200

Kinetic characterization of heparin-catalyzed and uncatalyzed inhibition of blood coagulation proteinases by antithrombin.

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M105294200

Cleavage of Structural Proteins during the Assembly of the Head of Bacteriophage T4

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M105294200

Tricine-sodium dodecyl sulfate-polyacrylamide gel electrophoresis for the separation of proteins in the range from 1 to 100 kDa

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M105294200

The Size and Shape of Human and Bovine Antithrombin III

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M105294200

Mechanism of heparin activation of antithrombin. Role of individual residues of the pentasaccharide activating sequence in the recognition of native and activated states of antithrombin.

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M105294200

Decreased affinity of recombinant antithrombin for heparin due to increased glycosylation

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M105294200

Antithrombin-heparin affinity reduced by fucosylation of carbohydrate at asparagine 155.

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M105294200

Effect of individual carbohydrate chains of recombinant antithrombin on heparin affinity and on the generation of glycoforms differing in heparin affinity

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M105294200

Partial glycosylation of antithrombin III asparagine-135 is caused by the serine in the third position of its N-glycosylation consensus sequence and is responsible for production of the beta-antithrombin III isoform with enhanced heparin affinity

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M105294200

Mechanism of heparin activation of antithrombin: evidence for an induced-fit model of allosteric activation involving two interaction subsites

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M105294200

Alpha 1-proteinase inhibitor variant T345R. Influence of P14 residue on substrate and inhibitory pathways

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M105294200

The 2.6 A structure of antithrombin indicates a conformational change at the heparin binding site

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M105294200

21 January 2018

Identifiers

DOI

10.1074/JBC.M105294200

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1 September 2017

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