(Q38305294)

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Strategies for studies of neurotoxic mechanisms involving deficient transport of L-glutamate: antisense knockout in rat brain in vivo and changes in the neurotransmitter metabolism following inhibition of glutamate transport in guinea pig brain slic

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3 November 2019

Strategies for studies of neurotoxic mechanisms involving deficient transport of L-glutamate: antisense knockout in rat brain in vivo and changes in the neurotransmitter metabolism following inhibition of glutamate transport in guinea pig brain slices (English)

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3 November 2019

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neurotransmitter

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Caroline D. Rae

1

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3 November 2019

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M L Lawrance

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3 November 2019

L S Dias

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3 November 2019

T Provis

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3 November 2019

W A Bubb

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3 November 2019

V J Balcar

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1 November 2000

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3 November 2019

Brain Research Bulletin

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3 November 2019

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3 November 2019

373-381

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3 November 2019

Glutamate toxicity in neuron-enriched and neuron-astrocyte co-cultures: effect of the glutamate uptake inhibitor L-trans-pyrrolidine-2,4-dicarboxylate.

1 reference

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7 January 2021

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Excitatory amino acid transporter 5, a retinal glutamate transporter coupled to a chloride conductance

1 reference

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7 January 2021

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Functional comparisons of three glutamate transporter subtypes cloned from human motor cortex

1 reference

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7 January 2021

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Cerebral metabolism of acetate and glucose studied by 13C-n.m.r. spectroscopy. A technique for investigating metabolic compartmentation in the brain

1 reference

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7 January 2021

based on heuristic

inferred from DOI database lookup

Na(+)-dependent high-affinity uptake of L-glutamate in cultured fibroblasts

1 reference

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7 January 2021

based on heuristic

inferred from DOI database lookup

High affinity uptake of L-glutamate and L-aspartate by glial cells

1 reference

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7 January 2021

based on heuristic

inferred from DOI database lookup

The structural specificity of the high affinity uptake of L-glutamate and L-aspartate by rat brain slices.

1 reference

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7 January 2021

based on heuristic

inferred from DOI database lookup

Stereospecificity of the inhibition of L-glutamate and L-aspartate high affinity uptake in rat brain slices by threo-3-hydroxyaspartate.

1 reference

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7 January 2021

based on heuristic

inferred from DOI database lookup

Heterogeneity of high affinity uptake of L-glutamate and L-aspartate in the mammalian central nervous system

1 reference

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7 January 2021

based on heuristic

inferred from DOI database lookup

Effects of L-trans-pyrrolidine-2,4-dicarboxylate and L-threo-3-hydroxyaspartate on the binding of [3H]L-aspartate, [3H]alpha-amino-3-hydroxy-5-methyl-4-isoxazolepropionate (AMPA), [3H]DL-(E)-2-amino-4-propyl-5-phosphono-3-pentenoate (CGP 39653), [3H

1 reference

https://api.crossref.org/works/10.1016%2FS0361-9230%2800%2900372-5

7 January 2021

based on heuristic

inferred from DOI database lookup

Differences between substrate specificities of l-glutamate uptake by neurons and glia, studied in cell lines and primary cultures.

1 reference

https://api.crossref.org/works/10.1016%2FS0361-9230%2800%2900372-5

7 January 2021

based on heuristic

inferred from DOI database lookup

Amino acid neurotransmitter candidates: sodium-dependent high-affinity uptake by unique synaptosomal fractions.

1 reference

https://api.crossref.org/works/10.1016%2FS0361-9230%2800%2900372-5

7 January 2021

based on heuristic

inferred from DOI database lookup

Forty years of amino acid transmission in the brain

1 reference

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7 January 2021

based on heuristic

inferred from DOI database lookup

The glutamate transport inhibitor L-trans-pyrrolidine-2,4-dicarboxylate indirectly evokes NMDA receptor mediated neurotoxicity in rat cortical cultures.

1 reference

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7 January 2021

based on heuristic

inferred from DOI database lookup

Glutamine--a major substrate for nerve endings.

1 reference

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7 January 2021

based on heuristic

inferred from DOI database lookup

A conformationally constrained competitive inhibitor of the sodium-dependent glutamate transporter in forebrain synaptosomes: L-anti-endo-3,4-methanopyrrolidine dicarboxylate.

1 reference

https://api.crossref.org/works/10.1016%2FS0361-9230%2800%2900372-5

7 January 2021

based on heuristic

inferred from DOI database lookup

Conformationally defined neurotransmitter analogs. Selective inhibition of glutamate uptake by one pyrrolidine-2,4-dicarboxylate diastereomer

1 reference

https://api.crossref.org/works/10.1016%2FS0361-9230%2800%2900372-5

7 January 2021

based on heuristic

inferred from DOI database lookup

Transmitter timecourse in the synaptic cleft: its role in central synaptic function

1 reference

https://api.crossref.org/works/10.1016%2FS0361-9230%2800%2900372-5

7 January 2021

based on heuristic

inferred from DOI database lookup

Structural selectivity and molecular nature of L-glutamate transport in cultured human fibroblasts.

1 reference

https://api.crossref.org/works/10.1016%2FS0361-9230%2800%2900372-5

7 January 2021

based on heuristic

inferred from DOI database lookup

Synaptically released glutamate does not overwhelm transporters on hippocampal astrocytes during high-frequency stimulation

1 reference

https://api.crossref.org/works/10.1016%2FS0361-9230%2800%2900372-5

7 January 2021

based on heuristic

inferred from DOI database lookup

Excitotoxic mechanisms in the pathogenesis of dementia

1 reference

https://api.crossref.org/works/10.1016%2FS0361-9230%2800%2900372-5

7 January 2021

based on heuristic

inferred from DOI database lookup

An excitatory amino-acid transporter with properties of a ligand-gated chloride channel

1 reference

https://api.crossref.org/works/10.1016%2FS0361-9230%2800%2900372-5

7 January 2021

based on heuristic

inferred from DOI database lookup

Glutamate: A Neurotransmitter in Mammalian Brain

1 reference

https://api.crossref.org/works/10.1016%2FS0361-9230%2800%2900372-5

7 January 2021

based on heuristic

inferred from DOI database lookup

Cellular distribution and kinetic properties of high-affinity glutamate transporters

1 reference

https://api.crossref.org/works/10.1016%2FS0361-9230%2800%2900372-5

7 January 2021

based on heuristic

inferred from DOI database lookup

Glutamate translocation of the neuronal glutamate transporter EAAC1 occurs within milliseconds

1 reference

https://api.crossref.org/works/10.1016%2FS0361-9230%2800%2900372-5

7 January 2021

based on heuristic

inferred from DOI database lookup

ALS-linked Cu/Zn-SOD mutation impairs cerebral synaptic glucose and glutamate transport and exacerbates ischemic brain injury

1 reference

https://api.crossref.org/works/10.1016%2FS0361-9230%2800%2900372-5

7 January 2021

based on heuristic

inferred from DOI database lookup

Glutamate as a CNS transmitter. I. Evaluation of glucose and glutamine as precursors for the synthesis of preferentially released glutamate

1 reference

https://api.crossref.org/works/10.1016%2FS0361-9230%2800%2900372-5

7 January 2021

based on heuristic

inferred from DOI database lookup

Amyloid beta peptide (25-35) inhibits Na+-dependent glutamate uptake in rat hippocampal astrocyte cultures

1 reference

https://api.crossref.org/works/10.1016%2FS0361-9230%2800%2900372-5

7 January 2021

based on heuristic

inferred from DOI database lookup

Uptake of the neurotransmitter candidate glutamate by glia.

1 reference

https://api.crossref.org/works/10.1016%2FS0361-9230%2800%2900372-5

7 January 2021

based on heuristic

inferred from DOI database lookup

The uptake inhibitor L-trans-PDC enhances responses to glutamate but fails to alter the kinetics of excitatory synaptic currents in the hippocampus

1 reference

https://api.crossref.org/works/10.1016%2FS0361-9230%2800%2900372-5

7 January 2021

based on heuristic

inferred from DOI database lookup

Primary structure and functional characterization of a high-affinity glutamate transporter

1 reference

https://api.crossref.org/works/10.1016%2FS0361-9230%2800%2900372-5

7 January 2021

based on heuristic

inferred from DOI database lookup

Optical detection of synaptically induced glutamate transport in hippocampal slices.

1 reference

https://api.crossref.org/works/10.1016%2FS0361-9230%2800%2900372-5

7 January 2021

based on heuristic

inferred from DOI database lookup

Compilation and analysis of sequences upstream from the translational start site in eukaryotic mRNAs

1 reference

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7 January 2021

based on heuristic

inferred from DOI database lookup

Adiabatic Pulses for Wideband Inversion and Broadband Decoupling

1 reference

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7 January 2021

based on heuristic

inferred from DOI database lookup

The number of glutamate transporter subtype molecules at glutamatergic synapses: chemical and stereological quantification in young adult rat brain

1 reference

https://api.crossref.org/works/10.1016%2FS0361-9230%2800%2900372-5

7 January 2021

based on heuristic

inferred from DOI database lookup

Differential expression of two glial glutamate transporters in the rat brain: quantitative and immunocytochemical observations

1 reference

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7 January 2021

based on heuristic

inferred from DOI database lookup

The Na(+)-dependent binding of [3H]L-aspartate in thaw-mounted sections of rat forebrain.

1 reference

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7 January 2021

based on heuristic

inferred from DOI database lookup

Quantitative autoradiography of Na+-dependent [3H]L-aspartate binding to L-glutamate transporters in rat brain: structure-activity studies using L-trans-pyrrolidine-2,4-dicarboxylate (L-t-PDC) and 2-(carboxycyclopropyl)-glycine (CCG)

1 reference

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7 January 2021

based on heuristic

inferred from DOI database lookup

Aberrant RNA processing in a neurodegenerative disease: the cause for absent EAAT2, a glutamate transporter, in amyotrophic lateral sclerosis

1 reference

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7 January 2021

based on heuristic

inferred from DOI database lookup

Unique high affinity uptake systems for glycine, glutamic and aspartic acids in central nervous tissue of the rat.

1 reference

https://api.crossref.org/works/10.1016%2FS0361-9230%2800%2900372-5

7 January 2021

based on heuristic

inferred from DOI database lookup

Deficient glutamate transport is associated with neurodegeneration in Alzheimer's disease

1 reference

https://api.crossref.org/works/10.1016%2FS0361-9230%2800%2900372-5

7 January 2021

based on heuristic

inferred from DOI database lookup

Neuronal expression of the glutamate transporter GLT-1 in hippocampal microcultures.

1 reference

https://api.crossref.org/works/10.1016%2FS0361-9230%2800%2900372-5

7 January 2021

based on heuristic

inferred from DOI database lookup

The glial glutamate transporter in hyperammonemia and hepatic encephalopathy: relation to energy metabolism and glutamatergic neurotransmission.

1 reference

https://api.crossref.org/works/10.1016%2FS0361-9230%2800%2900372-5

7 January 2021

based on heuristic

inferred from DOI database lookup

Altered glutamatergic transmission in neurological disorders: from high extracellular glutamate to excessive synaptic efficacy

1 reference

https://api.crossref.org/works/10.1016%2FS0361-9230%2800%2900372-5

7 January 2021

based on heuristic

inferred from DOI database lookup

Glutamate transporter EAAC-1-deficient mice develop dicarboxylic aminoaciduria and behavioral abnormalities but no neurodegeneration

1 reference

https://api.crossref.org/works/10.1016%2FS0361-9230%2800%2900372-5

7 January 2021

based on heuristic

inferred from DOI database lookup

Cloning and expression of a rat brain L-glutamate transporter

1 reference

https://api.crossref.org/works/10.1016%2FS0361-9230%2800%2900372-5

7 January 2021

based on heuristic

inferred from DOI database lookup

Transient expression of the glial glutamate transporters GLAST and GLT in hippocampal neurons in primary culture

1 reference

https://api.crossref.org/works/10.1016%2FS0361-9230%2800%2900372-5

7 January 2021

based on heuristic

inferred from DOI database lookup

Glial glutamate transporter GLT-1 down-regulation precedes delayed neuronal death in gerbil hippocampus following transient global cerebral ischemia

1 reference

https://api.crossref.org/works/10.1016%2FS0361-9230%2800%2900372-5

7 January 2021

based on heuristic

inferred from DOI database lookup

The family of sodium-dependent glutamate transporters: a focus on the GLT-1/EAAT2 subtype

1 reference

https://api.crossref.org/works/10.1016%2FS0361-9230%2800%2900372-5

7 January 2021

based on heuristic

inferred from DOI database lookup

Heterogeneity and functional properties of subtypes of sodium-dependent glutamate transporters in the mammalian central nervous system.

1 reference

https://api.crossref.org/works/10.1016%2FS0361-9230%2800%2900372-5

7 January 2021

based on heuristic

inferred from DOI database lookup

Knockout of glutamate transporters reveals a major role for astroglial transport in excitotoxicity and clearance of glutamate

1 reference

https://api.crossref.org/works/10.1016%2FS0361-9230%2800%2900372-5

7 January 2021

based on heuristic

inferred from DOI database lookup

Chronic inhibition of glutamate uptake produces a model of slow neurotoxicity

1 reference

https://api.crossref.org/works/10.1016%2FS0361-9230%2800%2900372-5

7 January 2021

based on heuristic

inferred from DOI database lookup

Localization of neuronal and glial glutamate transporters

1 reference

https://api.crossref.org/works/10.1016%2FS0361-9230%2800%2900372-5

7 January 2021

based on heuristic

inferred from DOI database lookup

Decreased glutamate transport by the brain and spinal cord in amyotrophic lateral sclerosis

1 reference

https://api.crossref.org/works/10.1016%2FS0361-9230%2800%2900372-5

7 January 2021

based on heuristic

inferred from DOI database lookup

Abnormal excitatory amino acid metabolism in amyotrophic lateral sclerosis

1 reference

https://api.crossref.org/works/10.1016%2FS0361-9230%2800%2900372-5

7 January 2021

based on heuristic

inferred from DOI database lookup

Selective loss of glial glutamate transporter GLT-1 in amyotrophic lateral sclerosis

1 reference

https://api.crossref.org/works/10.1016%2FS0361-9230%2800%2900372-5

7 January 2021

based on heuristic

inferred from DOI database lookup

Transient inhibition of glutamate uptake in vivo induces neurodegeneration when energy metabolism is impaired.

1 reference

https://api.crossref.org/works/10.1016%2FS0361-9230%2800%2900372-5

7 January 2021

based on heuristic

inferred from DOI database lookup

Molecular mechanisms of calcium-dependent excitotoxicity

1 reference

https://api.crossref.org/works/10.1016%2FS0361-9230%2800%2900372-5

7 January 2021

based on heuristic

inferred from DOI database lookup

Transport and Metabolism of Glutamate and Gaba in Neurons and Glial Cells

1 reference

https://api.crossref.org/works/10.1016%2FS0361-9230%2800%2900372-5

7 January 2021

based on heuristic

inferred from DOI database lookup

Uptake and metabolism of glutamate in astrocytes cultured from dissociated mouse brain hemispheres

1 reference

https://api.crossref.org/works/10.1016%2FS0361-9230%2800%2900372-5

7 January 2021

based on heuristic

inferred from DOI database lookup

Quinolinic acid: an endogenous metabolite that produces axon-sparing lesions in rat brain

1 reference

https://api.crossref.org/works/10.1016%2FS0361-9230%2800%2900372-5

7 January 2021

based on heuristic

inferred from DOI database lookup

Variant forms of neuronal glutamate transporter sites in Alzheimer's disease cerebral cortex.

1 reference

https://api.crossref.org/works/10.1016%2FS0361-9230%2800%2900372-5

7 January 2021

based on heuristic

inferred from DOI database lookup

DL-threo-beta-benzyloxyaspartate, a potent blocker of excitatory amino acid transporters

1 reference

https://api.crossref.org/works/10.1016%2FS0361-9230%2800%2900372-5

7 January 2021

based on heuristic

inferred from DOI database lookup

Mitochondrial heterogeneity in the brain at the cellular level

1 reference

https://api.crossref.org/works/10.1016%2FS0361-9230%2800%2900372-5

7 January 2021

based on heuristic

inferred from DOI database lookup

Structure, expression, and functional analysis of a Na(+)-dependent glutamate/aspartate transporter from rat brain

1 reference

https://api.crossref.org/works/10.1016%2FS0361-9230%2800%2900372-5

7 January 2021

based on heuristic

inferred from DOI database lookup

Epilepsy and exacerbation of brain injury in mice lacking the glutamate transporter GLT-1

1 reference

https://api.crossref.org/works/10.1016%2FS0361-9230%2800%2900372-5

7 January 2021

based on heuristic

inferred from DOI database lookup

On the relationship between extracellular glutamate, hyperexcitation and neurodegeneration, in vivo

1 reference

https://api.crossref.org/works/10.1016%2FS0361-9230%2800%2900372-5

7 January 2021

based on heuristic

inferred from DOI database lookup

Amyotrophic lateral sclerosis-linked glutamate transporter mutant has impaired glutamate clearance capacity

1 reference

https://api.crossref.org/works/10.1016%2FS0361-9230%2800%2900372-5

7 January 2021

based on heuristic

inferred from DOI database lookup

SOD1 mutants linked to amyotrophic lateral sclerosis selectively inactivate a glial glutamate transporter.

1 reference

https://api.crossref.org/works/10.1016%2FS0361-9230%2800%2900372-5

7 January 2021

based on heuristic

inferred from DOI database lookup

Molecular pharmacology and physiology of glutamate transporters in the central nervous system.

1 reference

https://api.crossref.org/works/10.1016%2FS0361-9230%2800%2900372-5

7 January 2021

based on heuristic

inferred from DOI database lookup

The competitive transport inhibitor L-trans-pyrrolidine-2, 4-dicarboxylate triggers excitotoxicity in rat cortical neuron-astrocyte co-cultures via glutamate release rather than uptake inhibition.

1 reference

https://api.crossref.org/works/10.1016%2FS0361-9230%2800%2900372-5

7 January 2021

based on heuristic

inferred from DOI database lookup

Motor discoordination and increased susceptibility to cerebellar injury in GLAST mutant mice

1 reference

https://api.crossref.org/works/10.1016%2FS0361-9230%2800%2900372-5

7 January 2021

based on heuristic

inferred from DOI database lookup

Gradient selection in inverse heteronuclear correlation spectroscopy

1 reference

https://api.crossref.org/works/10.1016%2FS0361-9230%2800%2900372-5

7 January 2021

based on heuristic

inferred from DOI database lookup

Ligand recognition sites on P2X receptors studied by quantitative autoradiography of [3H]alpha,beta-methylene-ATP binding in rat brain

1 reference

https://api.crossref.org/works/10.1016%2FS0361-9230%2800%2900372-5

7 January 2021

based on heuristic

inferred from DOI database lookup

Astrocyte metabolism of [15N]glutamine: implications for the glutamine-glutamate cycle

1 reference

https://api.crossref.org/works/10.1016%2FS0361-9230%2800%2900372-5

7 January 2021

based on heuristic

inferred from DOI database lookup

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