(Q38309128)

2 September 2017

1 reference

title

Therapeutic uses of furin and its inhibitors: a patent review (English)

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2 September 2017

Frédéric Couture

1

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2 September 2017

Anna Kwiatkowska

series ordinal

2

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2 September 2017

Yves L Dory

series ordinal

3

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2 September 2017

Robert Day

series ordinal

4

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2 September 2017

language of work or name

English

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publication date

7 January 2015

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Expert Opinion on Therapeutic Patents

2 September 2017

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2 September 2017

25

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2 September 2017

4

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2 September 2017

379-396

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The biology and therapeutic targeting of the proprotein convertases

2 September 2017

1 reference

https://api.crossref.org/works/10.1517%2F13543776.2014.1000303

Proprotein convertases in health and disease

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F13543776.2014.1000303

PACS-1 defines a novel gene family of cytosolic sorting proteins required for trans-Golgi network localization

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F13543776.2014.1000303

Interaction of furin in immature secretory granules from neuroendocrine cells with the AP-1 adaptor complex is modulated by casein kinase II phosphorylation

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F13543776.2014.1000303

A role for PACE4 in osteoarthritis pain: evidence from human genetic association and null mutant phenotype

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F13543776.2014.1000303

Proprotein convertases: lessons from knockouts

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F13543776.2014.1000303

Knock-out mouse models of proprotein convertases: unique functions or redundancy?

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F13543776.2014.1000303

Limited redundancy of the proprotein convertase furin in mouse liver

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F13543776.2014.1000303

On the cutting edge of proprotein convertase pharmacology: from molecular concepts to clinical applications

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F13543776.2014.1000303

Curbing activation: proprotein convertases in homeostasis and pathology

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F13543776.2014.1000303

Furin at the cutting edge: from protein traffic to embryogenesis and disease

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F13543776.2014.1000303

Proprotein convertases in tumor progression and malignancy: novel targets in cancer therapy

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F13543776.2014.1000303

Proprotein convertases: "master switches" in the regulation of tumor growth and progression

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F13543776.2014.1000303

Comparative analysis of expression of the proprotein convertases furin, PACE4, PC1 and PC2 in human lung tumours

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F13543776.2014.1000303

Pro-protein convertase gene expression in human breast cancer.

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F13543776.2014.1000303

Elevated furin expression in aggressive human head and neck tumors and tumor cell lines

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F13543776.2014.1000303

Molecular Validation of PACE4 as a Target in Prostate Cancer

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F13543776.2014.1000303

Proteolytic processing of vascular endothelial growth factor-D is essential for its capacity to promote the growth and spread of cancer

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F13543776.2014.1000303

Increased furin activity enhances the malignant phenotype of human head and neck cancer cells

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F13543776.2014.1000303

Protective role of systemic furin in immune response-induced arthritis.

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F13543776.2014.1000303

Evidence that furin is an authentic transforming growth factor-beta1-converting enzyme

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F13543776.2014.1000303

Anti-inflammatory and pro-inflammatory roles of TGF-beta, IL-10, and IL-22 in immunity and autoimmunity

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F13543776.2014.1000303

TGF-beta signaling and the fibrotic response

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F13543776.2014.1000303

Role of interleukin-1 and tumor necrosis factor alpha in matrix degradation of human osteoarthritic cartilage.

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F13543776.2014.1000303

T-cell-expressed proprotein convertase furin is essential for maintenance of peripheral immune tolerance

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F13543776.2014.1000303

Inhibition of furin-mediated cleavage activation of HIV-1 glycoprotein gp160

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F13543776.2014.1000303

Epidemiology and pathogenesis of influenza

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F13543776.2014.1000303

Cutting back on pro-protein convertases: the latest approaches to pharmacological inhibition

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F13543776.2014.1000303

alpha1-Antitrypsin Portland, a bioengineered serpin highly selective for furin: application as an antipathogenic agent

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F13543776.2014.1000303

Modulating furin activity with designed mini-PDX peptides: synthesis and in vitro kinetic evaluation

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F13543776.2014.1000303

Reversal of acute and chronic synovial inflammation by anti-transforming growth factor beta

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F13543776.2014.1000303

Transforming growth factor beta 1 suppresses acute and chronic arthritis in experimental animals

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F13543776.2014.1000303

BRI3 inhibits amyloid precursor protein processing in a mechanistically distinct manner from its homologue dementia gene BRI2

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F13543776.2014.1000303

Polyarginines are potent furin inhibitors

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F13543776.2014.1000303

Inhibition of furin by polyarginine-containing peptides: nanomolar inhibition by nona-D-arginine

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F13543776.2014.1000303

The furin inhibitor hexa-D-arginine blocks the activation of Pseudomonas aeruginosa exotoxin A in vivo

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F13543776.2014.1000303

Protection against anthrax toxemia by hexa-D-arginine in vitro and in vivo

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F13543776.2014.1000303

Polyarginine inhibits gp160 processing by furin and suppresses productive human immunodeficiency virus type 1 infection

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F13543776.2014.1000303

Nona-D-arginine therapy for Pseudomonas aeruginosa keratitis

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F13543776.2014.1000303

Nona-D-arginine amide for prophylaxis and treatment of experimental Pseudomonas aeruginosa keratitis

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F13543776.2014.1000303

Nona-D-arginine amide suppresses corneal cytokines in Pseudomonas aeruginosa keratitis

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F13543776.2014.1000303

SKI-1 and Furin generate multiple RGMa fragments that regulate axonal growth.

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F13543776.2014.1000303

Processing of viral glycoproteins by the subtilisin-like endoprotease furin and its inhibition by specific peptidylchloroalkylketones

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F13543776.2014.1000303

The crystal structure of the proprotein processing proteinase furin explains its stringent specificity

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F13543776.2014.1000303

Proprotein convertase models based on the crystal structures of furin and kexin: explanation of their specificity

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F13543776.2014.1000303

Selective and potent furin inhibitors protect cells from anthrax without significant toxicity

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F13543776.2014.1000303

Highly potent inhibitors of proprotein convertase furin as potential drugs for treatment of infectious diseases

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F13543776.2014.1000303

Human papillomavirus and cervical cancer

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F13543776.2014.1000303

Proprotein convertase inhibition results in decreased skin cell proliferation, tumorigenesis, and metastasis

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F13543776.2014.1000303

Design, synthesis, and structure-activity relationship studies of a potent PACE4 inhibitor

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F13543776.2014.1000303

Potent inhibitors of furin and furin-like proprotein convertases containing decarboxylated P1 arginine mimetics

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F13543776.2014.1000303

X-ray Structures of Human Furin in Complex with Competitive Inhibitors

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F13543776.2014.1000303

Optimization of furin inhibitors to protect against the activation of influenza hemagglutinin H5 and Shiga toxin.

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F13543776.2014.1000303

Tumour microenvironment: TGFbeta: the molecular Jekyll and Hyde of cancer

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F13543776.2014.1000303

TGF-beta directly targets cytotoxic T cell functions during tumor evasion of immune surveillance

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F13543776.2014.1000303

Phase I trial of "bi-shRNAi(furin)/GMCSF DNA/autologous tumor cell" vaccine (FANG) in advanced cancer

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F13543776.2014.1000303

Enhancing the proteolytic maturation of human immunodeficiency virus type 1 envelope glycoproteins

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F13543776.2014.1000303

Partial maturation: an immune-evasion strategy of dengue virus?

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F13543776.2014.1000303

Reverse genetics demonstrates that proteolytic processing of the Ebola virus glycoprotein is not essential for replication in cell culture

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F13543776.2014.1000303

Pathway for polyarginine entry into mammalian cells

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F13543776.2014.1000303

Inhibition of proteolytic activation of influenza virus hemagglutinin by specific peptidyl chloroalkyl ketones

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F13543776.2014.1000303

The future of peptide-based drugs

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F13543776.2014.1000303

The Multi-Leu peptide inhibitor discriminates between PACE4 and furin and exhibits antiproliferative effects on prostate cancer cells

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F13543776.2014.1000303

Inhibitory potency and specificity of subtilase-like pro-protein convertase (SPC) prodomains

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F13543776.2014.1000303

Proprotein convertases promote processing of VEGF-D, a critical step for binding the angiogenic receptor VEGFR-2

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F13543776.2014.1000303

10.1517/13543776.2014.1000303

21 January 2018

Identifiers

DOI

1 reference

2 September 2017

1 reference