(Q38312527)

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Mutations in the catalytic domain of prohormone convertase 2 result in decreased binding to 7B2 and loss of inhibition with 7B2 C-terminal peptide.

scientific article published on May 2000

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scholarly article

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https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:10799554%20AND%20SRC:MED&resulttype=core&format=json

6 November 2019

Mutations in the catalytic domain of prohormone convertase 2 result in decreased binding to 7B2 and loss of inhibition with 7B2 C-terminal peptide (English)

1 reference

Europe PubMed Central

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:10799554%20AND%20SRC:MED&resulttype=core&format=json

6 November 2019

2

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6 November 2019

author name string

E V Apletalina

1

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6 November 2019

I Lindberg

3

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6 November 2019

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1 May 2000

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6 November 2019

Journal of Biological Chemistry

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6 November 2019

275

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6 November 2019

14667-14677

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6 November 2019

19

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6 November 2019

Proteolytic processing mechanisms in the biosynthesis of neuroendocrine peptides: the subtilisin-like proprotein convertases.

1 reference

https://api.crossref.org/works/10.1074%2FJBC.275.19.14667

21 January 2018

Eukaryotic protein processing: endoproteolysis of precursor proteins

1 reference

https://api.crossref.org/works/10.1074%2FJBC.275.19.14667

21 January 2018

Proteolytic processing in the secretory pathway

1 reference

https://api.crossref.org/works/10.1074%2FJBC.275.19.14667

21 January 2018

Differences in pH optima and calcium requirements for maturation of the prohormone convertases PC2 and PC3 indicates different intracellular locations for these events.

1 reference

https://api.crossref.org/works/10.1074%2FJBC.275.19.14667

21 January 2018

Differences in the autocatalytic cleavage of pro-PC2 and pro-PC3 can be attributed to sequences within the propeptide and Asp310 of pro-PC2.

1 reference

https://api.crossref.org/works/10.1074%2FJBC.275.19.14667

21 January 2018

The proteolytic maturation of prohormone convertase 2 (PC2) is a pH-driven process.

1 reference

https://api.crossref.org/works/10.1074%2FJBC.275.19.14667

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.275.19.14667

21 January 2018

Proprotein convertase PC1/3-related peptides are potent slow tight-binding inhibitors of murine PC1/3 and Hfurin

1 reference

https://api.crossref.org/works/10.1074%2FJBC.275.19.14667

21 January 2018

Subtilases: the superfamily of subtilisin-like serine proteases

1 reference

https://api.crossref.org/works/10.1074%2FJBC.275.19.14667

21 January 2018

Processing of prodynorphin by the prohormone convertase PC1 results in high molecular weight intermediate forms. Cleavage at a single arginine residue

1 reference

https://api.crossref.org/works/10.1074%2FJBC.275.19.14667

21 January 2018

Role of prohormone convertases in the tissue-specific processing of proglucagon

1 reference

https://api.crossref.org/works/10.1074%2FJBC.275.19.14667

21 January 2018

Prodynorphin processing by proprotein convertase 2. Cleavage at single basic residues and enhanced processing in the presence of carboxypeptidase activity

1 reference

https://api.crossref.org/works/10.1074%2FJBC.275.19.14667

21 January 2018

Specificity of prohormone convertase 2 on proenkephalin and proenkephalin-related substrates.

1 reference

https://api.crossref.org/works/10.1074%2FJBC.275.19.14667

21 January 2018

In vitro cleavage of internally quenched fluorogenic human proparathyroid hormone and proparathyroid-related peptide substrates by furin. Generation of a potent inhibitor

1 reference

https://api.crossref.org/works/10.1074%2FJBC.275.19.14667

21 January 2018

PC1 and PC2 are proprotein convertases capable of cleaving proopiomelanocortin at distinct pairs of basic residues

1 reference

https://api.crossref.org/works/10.1074%2FJBC.275.19.14667

21 January 2018

Differential processing of proglucagon by the subtilisin-like prohormone convertases PC2 and PC3 to generate either glucagon or glucagon-like peptide

1 reference

https://api.crossref.org/works/10.1074%2FJBC.275.19.14667

21 January 2018

Role of the prohormone convertase PC3 in the processing of proglucagon to glucagon-like peptide 1.

1 reference

https://api.crossref.org/works/10.1074%2FJBC.275.19.14667

21 January 2018

Evidence that PC2 is the endogenous pro-neurotensin convertase in rMTC 6-23 cells and that PC1- and PC2-transfected PC12 cells differentially process pro-neurotensin

1 reference

https://api.crossref.org/works/10.1074%2FJBC.275.19.14667

21 January 2018

Cellular localization and role of prohormone convertases in the processing of pro-melanin concentrating hormone in mammals

1 reference

https://api.crossref.org/works/10.1074%2FJBC.275.19.14667

21 January 2018

7B2 facilitates the maturation of proPC2 in neuroendocrine cells and is required for the expression of enzymatic activity

1 reference

https://api.crossref.org/works/10.1074%2FJBC.275.19.14667

21 January 2018

7B2 is a specific intracellular binding protein of the prohormone convertase PC2

1 reference

https://api.crossref.org/works/10.1074%2FJBC.275.19.14667

21 January 2018

Mechanism of the facilitation of PC2 maturation by 7B2: involvement in ProPC2 transport and activation but not folding

1 reference

https://api.crossref.org/works/10.1074%2FJBC.275.19.14667

21 January 2018

Neuroendocrine protein 7B2 is essential for proteolytic conversion and activation of proprotein convertase 2 in vivo.

1 reference

https://api.crossref.org/works/10.1074%2FJBC.275.19.14667

21 January 2018

Protein 7B2 is essential for the targeting and activation of PC2 into the regulated secretory pathway of rMTC 6-23 cells

1 reference

https://api.crossref.org/works/10.1074%2FJBC.275.19.14667

21 January 2018

The neuroendocrine protein 7B2 is required for peptide hormone processing in vivo and provides a novel mechanism for pituitary Cushing's disease

1 reference

https://api.crossref.org/works/10.1074%2FJBC.275.19.14667

21 January 2018

Enzymatic characterization of immunopurified prohormone convertase 2: potent inhibition by a 7B2 peptide fragment

1 reference

https://api.crossref.org/works/10.1074%2FJBC.275.19.14667

21 January 2018

Internal cleavage of the inhibitory 7B2 carboxyl-terminal peptide by PC2: a potential mechanism for its inactivation

1 reference

https://api.crossref.org/works/10.1074%2FJBC.275.19.14667

21 January 2018

The role of the 7B2 CT peptide in the inhibition of prohormone convertase 2 in endocrine cell lines

1 reference

https://api.crossref.org/works/10.1074%2FJBC.275.19.14667

21 January 2018

The neuroendocrine polypeptide 7B2 is an endogenous inhibitor of prohormone convertase PC2

1 reference

https://api.crossref.org/works/10.1074%2FJBC.275.19.14667

21 January 2018

A 36-residue peptide contains all of the information required for 7B2-mediated activation of prohormone convertase 2.

1 reference

https://api.crossref.org/works/10.1074%2FJBC.275.19.14667

21 January 2018

Structural elements of PC2 required for interaction with its helper protein 7B2.

1 reference

https://api.crossref.org/works/10.1074%2FJBC.275.19.14667

21 January 2018

Structure-function studies on the biosynthesis and bioactivity of the precursor convertase PC2 and the formation of the PC2/7B2 complex

1 reference

https://api.crossref.org/works/10.1074%2FJBC.275.19.14667

21 January 2018

Residues unique to the pro-hormone convertase PC2 modulate its autoactivation, binding to 7B2 and enzymatic activity

1 reference

https://api.crossref.org/works/10.1074%2FJBC.275.19.14667

21 January 2018

Homology modelling of the catalytic domain of human furin. A model for the eukaryotic subtilisin-like proprotein convertases.

1 reference

https://api.crossref.org/works/10.1074%2FJBC.275.19.14667

21 January 2018

Identification of inhibitors of prohormone convertases 1 and 2 using a peptide combinatorial library

1 reference

https://api.crossref.org/works/10.1074%2FJBC.275.19.14667

21 January 2018

Distribution of immunoreactive peptide B in the rat brain.

1 reference

https://api.crossref.org/works/10.1074%2FJBC.275.19.14667

21 January 2018

Prohormone convertase 1 is necessary for the formation of cholecystokinin 8 in Rin5F and STC-1 cells

1 reference

https://api.crossref.org/works/10.1074%2FJBC.275.19.14667

21 January 2018

7B2 is a neuroendocrine chaperone that transiently interacts with prohormone convertase PC2 in the secretory pathway

1 reference

https://api.crossref.org/works/10.1074%2FJBC.275.19.14667

21 January 2018

Posttranslational maturation of the prohormone convertase SPC3 in vitro.

1 reference

https://api.crossref.org/works/10.1074%2FJBC.275.19.14667

21 January 2018

Fluorescent peptidyl substrates as an aid in studying the substrate specificity of human prohormone convertase PC1 and human furin and designing a potent irreversible inhibitor

1 reference

https://api.crossref.org/works/10.1074%2FJBC.275.19.14667

21 January 2018

Role of PC2 in proenkephalin processing: antisense and overexpression studies.

1 reference

https://api.crossref.org/works/10.1074%2FJBC.275.19.14667

21 January 2018

Molecular modeling of the substrate specificity of prohormone convertases SPC2 and SPC3

1 reference

https://api.crossref.org/works/10.1074%2FJBC.275.19.14667

21 January 2018

Identification of the region within the neuroendocrine polypeptide 7B2 responsible for the inhibition of prohormone convertase PC2

1 reference

https://api.crossref.org/works/10.1074%2FJBC.275.19.14667

21 January 2018

Structure-function analysis of the 7B2 CT peptide

1 reference

https://api.crossref.org/works/10.1074%2FJBC.275.19.14667

21 January 2018

Purification and enzymatic characterization of recombinant prohormone convertase 2: stabilization of activity by 21 kDa 7B2

1 reference

https://api.crossref.org/works/10.1074%2FJBC.275.19.14667

21 January 2018

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