(Q38331761)

2 September 2017

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title

Understanding the Polo Kinase machine (English)

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2 September 2017

V Archambault

1

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2 September 2017

G Lépine

series ordinal

2

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2 September 2017

D Kachaner

series ordinal

3

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2 September 2017

language of work or name

English

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publication date

26 January 2015

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2 September 2017

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2 September 2017

34

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2 September 2017

37

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2 September 2017

4799-4807

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https://scigraph.springernature.com/pub.10.1038/onc.2014.451

2 September 2017

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cites work

polo encodes a protein kinase homolog required for mitosis in Drosophila

1 reference

https://api.crossref.org/works/10.1038%2FONC.2014.451

Polo-like kinases: conservation and divergence in their functions and regulation

21 January 2018

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https://api.crossref.org/works/10.1038%2FONC.2014.451

Polo-like kinases: structural variations lead to multiple functions

21 January 2018

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https://api.crossref.org/works/10.1038%2FONC.2014.451

Mutation of the polo-box disrupts localization and mitotic functions of the mammalian polo kinase Plk.

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FONC.2014.451

Proteomic screen finds pSer/pThr-binding domain localizing Plk1 to mitotic substrates

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FONC.2014.451

The molecular basis for phosphodependent substrate targeting and regulation of Plks by the Polo-box domain

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FONC.2014.451

From Plk1 to Plk5: functional evolution of polo-like kinases

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FONC.2014.451

Bioinformatic search of plant microtubule-and cell cycle related serine-threonine protein kinases.

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FONC.2014.451

Antibody microinjection reveals an essential role for human polo-like kinase 1 (Plk1) in the functional maturation of mitotic centrosomes

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FONC.2014.451

Polo-like kinase is required for the fragmentation of pericentriolar Golgi stacks during mitosis

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FONC.2014.451

Cell cycle regulation of the activity and subcellular localization of Plk1, a human protein kinase implicated in mitotic spindle function

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FONC.2014.451

Roles of polo-like kinase 1 in the assembly of functional mitotic spindles

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FONC.2014.451

Tension-sensitive Plk1 phosphorylation on BubR1 regulates the stability of kinetochore microtubule interactions

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FONC.2014.451

Polo-like kinase 1 licenses CENP-A deposition at centromeres

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FONC.2014.451

Choice of Plk1 docking partners during mitosis and cytokinesis is controlled by the activation state of Cdk1

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FONC.2014.451

Chemical genetics reveals the requirement for Polo-like kinase 1 activity in positioning RhoA and triggering cytokinesis in human cells.

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FONC.2014.451

Polo-like kinase controls vertebrate spindle elongation and cytokinesis

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FONC.2014.451

Polo-like Kinase 1 Triggers the Initiation of Cytokinesis in Human Cells by Promoting Recruitment of the RhoGEF Ect2 to the Central Spindle

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FONC.2014.451

Use of the novel Plk1 inhibitor ZK-thiazolidinone to elucidate functions of Plk1 in early and late stages of mitosis

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FONC.2014.451

Role for Plk1 phosphorylation of Hbo1 in regulation of replication licensing

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FONC.2014.451

Bora and the kinase Aurora a cooperatively activate the kinase Plk1 and control mitotic entry

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FONC.2014.451

The dissociation of cohesin from chromosomes in prophase is regulated by Polo-like kinase

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FONC.2014.451

The initial phase of chromosome condensation requires Cdk1-mediated phosphorylation of the CAP-D3 subunit of condensin II

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FONC.2014.451

SAK/PLK4 is required for centriole duplication and flagella development

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FONC.2014.451

The Polo kinase Plk4 functions in centriole duplication

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FONC.2014.451

Polo-like kinase-2 is required for centriole duplication in mammalian cells

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FONC.2014.451

21 January 2018

The Plk3-Cdc25 circuit

1 reference

https://api.crossref.org/works/10.1038%2FONC.2014.451

Polo-like kinase 3 is required for entry into S phase

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FONC.2014.451

Silencing of the novel p53 target gene Snk/Plk2 leads to mitotic catastrophe in paclitaxel (taxol)-exposed cells

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FONC.2014.451

Replication stress, defective S-phase checkpoint and increased death in Plk2-deficient human cancer cells

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FONC.2014.451

Plk3 functionally links DNA damage to cell cycle arrest and apoptosis at least in part via the p53 pathway

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FONC.2014.451

Mammalian Polo-like kinase 3 (Plk3) is a multifunctional protein involved in stress response pathways

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FONC.2014.451

The polo-like protein kinases Fnk and Snk associate with a Ca(2+)- and integrin-binding protein and are regulated dynamically with synaptic plasticity

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FONC.2014.451

Critical role of CDK5 and Polo-like kinase 2 in homeostatic synaptic plasticity during elevated activity

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FONC.2014.451

Plk5, a polo box domain-only protein with specific roles in neuron differentiation and glioblastoma suppression

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FONC.2014.451

The novel mouse Polo-like kinase 5 responds to DNA damage and localizes in the nucleolus

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FONC.2014.451

Polo on the Rise-from Mitotic Entry to Cytokinesis with Plk1.

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FONC.2014.451

Multifaceted polo-like kinases: drug targets and antitargets for cancer therapy

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FONC.2014.451

Plk1-targeted small molecule inhibitors: molecular basis for their potency and specificity

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FONC.2014.451

Discovery and development of the Polo-like kinase inhibitor volasertib in cancer therapy

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FONC.2014.451

Functional studies on the role of the C-terminal domain of mammalian polo-like kinase

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FONC.2014.451

The crystal structure of the human polo-like kinase-1 polo box domain and its phospho-peptide complex

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FONC.2014.451

Structure and function of Polo-like kinases

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FONC.2014.451

Polo-box domain: a versatile mediator of polo-like kinase function

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FONC.2014.451

Nuclear translocation of plk1 mediated by its bipartite nuclear localization signal

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FONC.2014.451

Structural basis for the inhibition of Polo-like kinase 1

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FONC.2014.451

Sequestration of Polo kinase to microtubules by phosphopriming-independent binding to Map205 is relieved by phosphorylation at a CDK site in mitosis

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FONC.2014.451

Structure of the catalytic domain of human polo-like kinase 1

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FONC.2014.451

Identification of a consensus motif for Plk (Polo-like kinase) phosphorylation reveals Myt1 as a Plk1 substrate.

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FONC.2014.451

Polo-like kinase-activating kinases: Aurora A, Aurora B and what else?

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FONC.2014.451

Switching Polo-like kinase-1 on and off in time and space

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FONC.2014.451

Aurora-A site specificity: a study with synthetic peptide substrates

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FONC.2014.451

Phosphorylation of threonine 210 and the role of serine 137 in the regulation of mammalian polo-like kinase

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FONC.2014.451

Mitotic effects of a constitutively active mutant of the Xenopus polo-like kinase Plx1.

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FONC.2014.451

Polo-like kinase-1 is activated by aurora A to promote checkpoint recovery

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FONC.2014.451

Bora and Aurora-A continue to activate Plk1 in mitosis

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FONC.2014.451

The chromosomal passenger complex activates Polo kinase at centromeres

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FONC.2014.451

Making the Auroras glow: regulation of Aurora A and B kinase function by interacting proteins

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FONC.2014.451

The chromosomal passenger complex (CPC): from easy rider to the godfather of mitosis

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FONC.2014.451

Interdomain allosteric regulation of Polo kinase by Aurora B and Map205 is required for cytokinesis

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FONC.2014.451

Cdc28-dependent regulation of the Cdc5/Polo kinase

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FONC.2014.451

The decision to enter mitosis: feedback and redundancy in the mitotic entry network

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FONC.2014.451

Uncoupling anaphase-promoting complex/cyclosome activity from spindle assembly checkpoint control by deregulating polo-like kinase 1.

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FONC.2014.451

P21-activated kinase is required for mitotic progression and regulates Plk1.

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FONC.2014.451

Myosin phosphatase-targeting subunit 1 regulates mitosis by antagonizing polo-like kinase 1

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FONC.2014.451

A stringent requirement for Plk1 T210 phosphorylation during K-fiber assembly and chromosome congression

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FONC.2014.451

Ordered proteolysis in anaphase inactivates Plk1 to contribute to proper mitotic exit in human cells

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FONC.2014.451

Plk1-dependent phosphorylation of optineurin provides a negative feedback mechanism for mitotic progression

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FONC.2014.451

Centriole maturation requires regulated Plk1 activity during two consecutive cell cycles

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FONC.2014.451

Myosin phosphatase-targeting subunit 1 controls chromatid segregation

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FONC.2014.451

Heat shock protein 90 regulates the metaphase-anaphase transition in a polo-like kinase-dependent manner

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FONC.2014.451

Requirement of Hsp90 for centrosomal function reflects its regulation of Polo kinase stability

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FONC.2014.451

Sgt1, a co-chaperone of Hsp90 stabilizes Polo and is required for centrosome organization

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FONC.2014.451

An overview of Cdk1-controlled targets and processes

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FONC.2014.451

Cyclin-dependent kinase (CDK) phosphorylation destabilizes somatic Wee1 via multiple pathways

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FONC.2014.451

Self-regulated Plk1 recruitment to kinetochores by the Plk1-PBIP1 interaction is critical for proper chromosome segregation

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FONC.2014.451

Molecular and structural basis of polo-like kinase 1 substrate recognition: Implications in centrosomal localization

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FONC.2014.451

A microtubule-associated protein in Drosophila melanogaster: identification, characterization, and isolation of coding sequences

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FONC.2014.451

Serendipitous alkylation of a Plk1 ligand uncovers a new binding channel

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FONC.2014.451

From Crystal Packing to Molecular Recognition: Prediction and Discovery of a Binding Site on the Surface of Polo-Like Kinase 1

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FONC.2014.451

Dbf4 regulates the Cdc5 Polo-like kinase through a distinct non-canonical binding interaction

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FONC.2014.451

Cdc7p-Dbf4p regulates mitotic exit by inhibiting Polo kinase

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FONC.2014.451

The inhibition of polo kinase by matrimony maintains G2 arrest in the meiotic cell cycle

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FONC.2014.451

Matrimony ties Polo down: can this kinase get free?

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FONC.2014.451

A meiosis-specific form of the APC/C promotes the oocyte-to-embryo transition by decreasing levels of the Polo kinase inhibitor matrimony.

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FONC.2014.451

Binding of Drosophila Polo kinase to its regulator Matrimony is noncanonical and involves two separate functional domains.

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FONC.2014.451

Ubiquitylation-dependent localization of PLK1 in mitosis

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FONC.2014.451

Phosphoproteome analysis of Drosophila melanogaster embryos

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FONC.2014.451

Polo kinase links the stress pathway to cell cycle control and tip growth in fission yeast

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FONC.2014.451

Current assessment of polo-like kinases as anti-tumor drug targets.

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FONC.2014.451

A genome-wide RNAi screen identifies multiple synthetic lethal interactions with the Ras oncogene

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FONC.2014.451

Normal cells, but not cancer cells, survive severe Plk1 depletion

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FONC.2014.451

Polo-like kinase 1 is overexpressed in acute myeloid leukemia and its inhibition preferentially targets the proliferation of leukemic cells.

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FONC.2014.451

BI 6727, a Polo-like kinase inhibitor with improved pharmacokinetic profile and broad antitumor activity

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FONC.2014.451

Distinct concentration-dependent effects of the polo-like kinase 1-specific inhibitor GSK461364A, including differential effect on apoptosis

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FONC.2014.451

Inhibitors of Polo-like kinase reveal roles in spindle-pole maintenance

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FONC.2014.451

Polo-like kinase 1 directs assembly of the HsCyk-4 RhoGAP/Ect2 RhoGEF complex to initiate cleavage furrow formation

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FONC.2014.451

Targeting cancer with small molecule kinase inhibitors

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FONC.2014.451

BI 2536, a potent and selective inhibitor of polo-like kinase 1, inhibits tumor growth in vivo.

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FONC.2014.451

Polo-box domains confer target specificity to the Polo-like kinase family

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FONC.2014.451

A spindle checkpoint arrest and a cytokinesis failure by the dominant-negative polo-box domain of Plk1 in U-2 OS cells.

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FONC.2014.451

Different Plk1 functions show distinct dependencies on Polo-Box domain-mediated targeting

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FONC.2014.451

High mitotic activity of Polo-like kinase 1 is required for chromosome segregation and genomic integrity in human epithelial cells

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FONC.2014.451

Peptide-based inhibitors of Plk1 polo-box domain containing mono-anionic phosphothreonine esters and their pivaloyloxymethyl prodrugs

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FONC.2014.451

Inhibition of polo-like kinase 1 by blocking polo-box domain-dependent protein-protein interactions

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FONC.2014.451

Polo-box domain inhibitor poloxin activates the spindle assembly checkpoint and inhibits tumor growth in vivo

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FONC.2014.451

Thymoquinone blocks pSer/pThr recognition by Plk1 Polo-box domain as a phosphate mimic

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FONC.2014.451

Deficiency in chromosome congression by the inhibition of Plk1 polo box domain-dependent recognition

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FONC.2014.451

Exploring Potential Binding Modes of Small Drug-like Molecules to the Polo-Box Domain of Human Polo-like Kinase 1.

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FONC.2014.451

Independent modulation of the kinase and polo-box activities of Cdc5 protein unravels unique roles in the maintenance of genome stability

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FONC.2014.451

Targeting subcellular localization through the polo-box domain: non-ATP competitive inhibitors recapitulate a PLK1 phenotype

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FONC.2014.451

The Plk1 target Kizuna stabilizes mitotic centrosomes to ensure spindle bipolarity

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FONC.2014.451

14-3-3 proteins as signaling integration points for cell cycle control and apoptosis

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FONC.2014.451

On the Regulation and Function of Human Polo-like Kinase 1 (PLK1): Effects of Overexpression on Cell Cycle Progression

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FONC.2014.451

The small-molecule inhibitor BI 2536 reveals novel insights into mitotic roles of polo-like kinase 1

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FONC.2014.451

The Plk1-dependent phosphoproteome of the early mitotic spindle

31 March 2020

1 reference

https://api.crossref.org/works/10.1038%2FONC.2014.451

PI 3-kinase-dependent phosphorylation of Plk1-Ser99 promotes association with 14-3-3γ and is required for metaphase-anaphase transition

31 March 2020

1 reference

https://api.crossref.org/works/10.1038%2FONC.2014.451

Functions of the Hsp90 chaperone system: lifting client proteins to new heights

31 March 2020

1 reference

12 December 2020

Genetic Control of the Cell Division Cycle in Yeast: V. Genetic Analysis of cdc Mutants

1 reference

12 December 2020

polo, a mitotic mutant of Drosophila displaying abnormal spindle poles.

1 reference

12 December 2020

Cdc7p-Dbf4p becomes famous in the cell cycle.

1 reference

12 December 2020

Identifiers

DOI

10.1038/ONC.2014.451

1 reference

Dimensions Publication ID

2 September 2017

0 references

1 reference