(Q38336253)

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A phase II study of SB939, a novel pan-histone deacetylase inhibitor, in patients with translocation-associated recurrent/metastatic sarcomas-NCIC-CTG IND 200†.

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Europe PubMed Central

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2 September 2017

A phase II study of SB939, a novel pan-histone deacetylase inhibitor, in patients with translocation-associated recurrent/metastatic sarcomas-NCIC-CTG IND 200†. (English)

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Europe PubMed Central

PubMed publication ID

2 September 2017

3-[2-butyl-1-[2-(diethylamino)ethyl]-5-benzimidazolyl]-N-hydroxy-2-propenamide

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ChEBI release 2020-05-28

author name string

Q S-C Chu

1

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Europe PubMed Central

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2 September 2017

T O Nielsen

2

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2 September 2017

T Alcindor

3

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Europe PubMed Central

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2 September 2017

A Gupta

4

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2 September 2017

M Endo

5

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Europe PubMed Central

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2 September 2017

A Goytain

6

1 reference

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2 September 2017

H Xu

7

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Europe PubMed Central

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2 September 2017

S Verma

8

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2 September 2017

R Tozer

9

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Europe PubMed Central

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2 September 2017

M Knowling

10

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Europe PubMed Central

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2 September 2017

V B Bramwell

11

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Europe PubMed Central

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2 September 2017

J Powers

12

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2 September 2017

L K Seymour

13

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2 September 2017

E A Eisenhauer

14

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2 September 2017

publication date

28 January 2015

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2 September 2017

Annals of Oncology

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2 September 2017

26

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2 September 2017

5

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2 September 2017

973-981

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2 September 2017

Molecular pathology of sarcomas

1 reference

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21 January 2018

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Stat3 dimerization regulated by reversible acetylation of a single lysine residue

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Histone deacetylase inhibitors differentially stabilize acetylated p53 and induce cell cycle arrest or apoptosis in prostate cancer cells.

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SIR2 is required for polycomb silencing and is associated with an E(Z) histone methyltransferase complex

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Transcriptional repression mediated by the human polycomb-group protein EED involves histone deacetylation

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Significant growth suppression of synovial sarcomas by the histone deacetylase inhibitor FK228 in vitro and in vivo

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Histone deacetylase inhibitors reverse SS18-SSX-mediated polycomb silencing of the tumor suppressor early growth response 1 in synovial sarcoma

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EGR1 reactivation by histone deacetylase inhibitors promotes synovial sarcoma cell death through the PTEN tumor suppressor

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21 January 2018

EWS/FLI mediates transcriptional repression via NKX2.2 during oncogenic transformation in Ewing's sarcoma

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21 January 2018

Valproate inhibition of histone deacetylase 2 affects differentiation and decreases proliferation of endometrial stromal sarcoma cells

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SAHA induces caspase-independent, autophagic cell death of endometrial stromal sarcoma cells by influencing the mTOR pathway

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Histone deacetylase inhibitors induce growth arrest, apoptosis, and differentiation in clear cell sarcoma models

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HDAC2 regulates chromatin plasticity and enhances DNA vulnerability

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Phase I trial of vorinostat and doxorubicin in solid tumours: histone deacetylase 2 expression as a predictive marker.

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Phase I clinical, pharmacokinetic and pharmacodynamic study of SB939, an oral histone deacetylase (HDAC) inhibitor, in patients with advanced solid tumours

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21 January 2018

Pharmacodynamic evaluation of the target efficacy of SB939, an oral HDAC inhibitor with selectivity for tumor tissue

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21 January 2018

New response evaluation criteria in solid tumours: revised RECIST guideline (version 1.1)

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21 January 2018

Pf1, a novel PHD zinc finger protein that links the TLE corepressor to the mSin3A-histone deacetylase complex

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21 January 2018

Histone deacetylase inhibitors induce cell death and enhance the apoptosis-inducing activity of TRAIL in Ewing's sarcoma cells

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21 January 2018

Chromosome instability accounts for reverse metastatic outcomes of pediatric and adult synovial sarcomas.

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ULK-Atg13-FIP200 complexes mediate mTOR signaling to the autophagy machinery

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Identifiers

10.1093/ANNONC/MDV033

1 reference

Europe PubMed Central

PubMed publication ID

2 September 2017

PubMed publication ID

1 reference

Europe PubMed Central

PubMed publication ID

2 September 2017

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