(Q39523668)

12 September 2017

title

Autophagy suppression promotes apoptotic cell death in response to inhibition of the PI3K-mTOR pathway in pancreatic adenocarcinoma (English)

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12 September 2017

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ChEBI release 2020-05-28

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Jayanta Debnath

4

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author name string

Olga K Mirzoeva

1

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12 September 2017

Byron Hann

2

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12 September 2017

Yun K Hom

3

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12 September 2017

Dana Aftab

5

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12 September 2017

Kevan Shokat

6

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12 September 2017

W Michael Korn

7

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12 September 2017

publication date

16 June 2011

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Journal of Molecular Medicine

12 September 2017

published in

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12 September 2017

volume

89

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12 September 2017

issue

9

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12 September 2017

page(s)

877-889

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https://scigraph.springernature.com/pub.10.1007/s00109-011-0774-y

12 September 2017

exact match

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cites work

Targeting RAS signalling pathways in cancer therapy

1 reference

https://api.crossref.org/works/10.1007%2FS00109-011-0774-Y

Oncogenic K-ras drives cell cycle progression and phenotypic conversion of primary pancreatic duct epithelial cells

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS00109-011-0774-Y

Finding and drugging the vulnerabilities of RAS-dependent cancers

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS00109-011-0774-Y

The PI 3-kinase/Akt signaling pathway is activated due to aberrant Pten expression and targets transcription factors NF-kappaB and c-Myc in pancreatic cancer cells

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS00109-011-0774-Y

Frequent activation of AKT2 kinase in human pancreatic carcinomas

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS00109-011-0774-Y

Activated Akt and Erk expression and survival after surgery in pancreatic carcinoma.

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS00109-011-0774-Y

Multicenter phase II study of the oral MEK inhibitor, CI-1040, in patients with advanced non-small-cell lung, breast, colon, and pancreatic cancer

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS00109-011-0774-Y

Active-site inhibitors of mTOR target rapamycin-resistant outputs of mTORC1 and mTORC2

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS00109-011-0774-Y

Ku-0063794 is a specific inhibitor of the mammalian target of rapamycin (mTOR)

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS00109-011-0774-Y

Biochemical, cellular, and in vivo activity of novel ATP-competitive and selective inhibitors of the mammalian target of rapamycin

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS00109-011-0774-Y

A dual PI3 kinase/mTOR inhibitor reveals emergent efficacy in glioma

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS00109-011-0774-Y

Activity of a novel, dual PI3-kinase/mTor inhibitor NVP-BEZ235 against primary human pancreatic cancers grown as orthotopic xenografts.

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS00109-011-0774-Y

A pharmacological map of the PI3-K family defines a role for p110alpha in insulin signaling

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS00109-011-0774-Y

Analysis of genomic DNA alterations and mRNA expression patterns in a panel of human pancreatic cancer cell lines

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS00109-011-0774-Y

Basal subtype and MAPK/ERK kinase (MEK)-phosphoinositide 3-kinase feedback signaling determine susceptibility of breast cancer cells to MEK inhibition

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS00109-011-0774-Y

Induction of autophagy during extracellular matrix detachment promotes cell survival

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS00109-011-0774-Y

Regulation of translational effectors by amino acid and mammalian target of rapamycin signaling pathways. Possible involvement of autophagy in cultured hepatoma cells

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS00109-011-0774-Y

Electron microscopic and biochemical study of the effects of rapamycin on glycogen autophagy in the newborn rat liver

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS00109-011-0774-Y

LC3, a mammalian homologue of yeast Apg8p, is localized in autophagosome membranes after processing

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS00109-011-0774-Y

Role of autophagy in temozolomide-induced cytotoxicity for malignant glioma cells

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS00109-011-0774-Y

Autophagy, cytoplasm-to-vacuole targeting pathway, and pexophagy in yeast and mammalian cells.

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS00109-011-0774-Y

Life and death partners: apoptosis, autophagy and the cross-talk between them

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS00109-011-0774-Y

Phosphorylation and functional inactivation of TSC2 by Erk implications for tuberous sclerosis and cancer pathogenesis

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS00109-011-0774-Y

Oncogenic MAPK signaling stimulates mTORC1 activity by promoting RSK-mediated raptor phosphorylation

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS00109-011-0774-Y

Pharmacologic characterization of a potent inhibitor of class I phosphatidylinositide 3-kinases.

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS00109-011-0774-Y

NF-kappaB activation represses tumor necrosis factor-alpha-induced autophagy

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS00109-011-0774-Y

Inhibition of macroautophagy triggers apoptosis

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS00109-011-0774-Y

FOXO transcription factors at the interface between longevity and tumor suppression

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS00109-011-0774-Y

Coordinate activation of autophagy and the proteasome pathway by FoxO transcription factor.

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS00109-011-0774-Y

Akt inhibition promotes autophagy and sensitizes PTEN-null tumors to lysosomotropic agents

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS00109-011-0774-Y

Differential induction of apoptosis in HER2 and EGFR addicted cancers following PI3K inhibition.

21 January 2018

1 reference

PubMed

https://pubmed.ncbi.nlm.nih.gov/21678117

inferred from PubMed ID database lookup

12 December 2020

based on heuristic

Eating oneself and uninvited guests: autophagy-related pathways in cellular defense

1 reference

PubMed

https://pubmed.ncbi.nlm.nih.gov/21678117

inferred from PubMed ID database lookup

12 December 2020

based on heuristic

Specific apoptosis induction by the dual PI3K/mTor inhibitor NVP-BEZ235 in HER2 amplified and PIK3CA mutant breast cancer cells

1 reference

PubMed

https://pubmed.ncbi.nlm.nih.gov/21678117

inferred from PubMed ID database lookup

12 December 2020

based on heuristic

Identifiers

DOI

10.1007/S00109-011-0774-Y

1 reference

12 September 2017

1 reference