(Q37331610)

English

Basal subtype and MAPK/ERK kinase (MEK)-phosphoinositide 3-kinase feedback signaling determine susceptibility of breast cancer cells to MEK inhibition

scientific article published on January 2009

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scholarly article

1 reference

Europe PubMed Central

19 August 2017

Basal subtype and MAPK/ERK kinase (MEK)-phosphoinositide 3-kinase feedback signaling determine susceptibility of breast cancer cells to MEK inhibition (English)

1 reference

Europe PubMed Central

19 August 2017

1 reference

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Zachary A Knight

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Zachary Knight

12

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15

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Sanchita Bhattacharyaa

4

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Sanchita Bhattacharya

1 reference

Europe PubMed Central

19 August 2017

Gordon B. Mills

22

object named as

Gordon B Mills

1 reference

Europe PubMed Central

19 August 2017

23

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Joe W Gray

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Europe PubMed Central

19 August 2017

3

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Laura M Heiser

1 reference

Europe PubMed Central

19 August 2017

19

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Mina J Bissell

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Europe PubMed Central

19 August 2017

16

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Paul T Spellman

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Europe PubMed Central

19 August 2017

author name string

Olga K Mirzoeva

1

1 reference

Europe PubMed Central

19 August 2017

Debopriya Das

2

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Europe PubMed Central

19 August 2017

Doris Siwak

5

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Europe PubMed Central

19 August 2017

Rina Gendelman

6

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Europe PubMed Central

19 August 2017

Nora Bayani

7

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19 August 2017

Nicholas J Wang

8

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19 August 2017

Richard M Neve

9

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Europe PubMed Central

19 August 2017

Yinghui Guan

10

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Europe PubMed Central

19 August 2017

Zhi Hu

11

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Europe PubMed Central

19 August 2017

Heidi S Feiler

13

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Europe PubMed Central

19 August 2017

Philippe Gascard

14

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19 August 2017

Kevan M Shokat

17

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19 August 2017

Andrew J Wyrobek

18

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19 August 2017

Frank McCormick

20

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19 August 2017

Wen-Lin Kuo

21

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W Michael Korn

24

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19 August 2017

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publication date

1 January 2009

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Europe PubMed Central

19 August 2017

Cancer Research

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Europe PubMed Central

19 August 2017

69

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19 August 2017

2

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Europe PubMed Central

19 August 2017

565-572

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Europe PubMed Central

19 August 2017

Individualized molecular medicine: linking functional proteomics to select therapeutics targeting the PI3K pathway for specific patients

1 reference

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Impact of basal-like breast carcinoma determination for a more specific therapy

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Phosphorylation at serines 104 and 106 by Erk1/2 MAPK is important for estrogen receptor-alpha activity

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A functional genetic approach identifies the PI3K pathway as a major determinant of trastuzumab resistance in breast cancer

1 reference

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A new mutational AKTivation in the PI3K pathway

1 reference

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EGFR associated expression profiles vary with breast tumor subtype

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Genomic and transcriptional aberrations linked to breast cancer pathophysiologies

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Genomic signatures to guide the use of chemotherapeutics.

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Scaffolding protein Grb2-associated binder 1 sustains epidermal growth factor-induced mitogenic and survival signaling by multiple positive feedback loops

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AlphaB-crystallin is a novel oncoprotein that predicts poor clinical outcome in breast cancer

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High-throughput protein expression analysis using tissue microarray technology of a large well-characterised series identifies biologically distinct classes of breast cancer confirming recent cDNA expression analyses

1 reference

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PIK3CA mutations correlate with hormone receptors, node metastasis, and ERBB2, and are mutually exclusive with PTEN loss in human breast carcinoma

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Use of reverse phase protein microarrays and reference standard development for molecular network analysis of metastatic ovarian carcinoma.

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Multicenter phase II study of the oral MEK inhibitor, CI-1040, in patients with advanced non-small-cell lung, breast, colon, and pancreatic cancer

1 reference

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High frequency of mutations of the PIK3CA gene in human cancers

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Proteomic profiling of the NCI-60 cancer cell lines using new high-density reverse-phase lysate microarrays

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Statistical significance for genomewide studies

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Gene expression patterns of breast carcinomas distinguish tumor subclasses with clinical implications

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Molecular portraits of human breast tumours

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Eukaryotic translation initiation factor 4E regulates expression of cyclin D1 at transcriptional and post-transcriptional levels

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Quantitative analysis of dose-effect relationships: the combined effects of multiple drugs or enzyme inhibitors

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Common adult stem cells in the human breast give rise to glandular and myoepithelial cell lineages: a new cell biological concept

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A chemical screen in diverse breast cancer cell lines reveals genetic enhancers and suppressors of sensitivity to PI3K isoform-selective inhibition.

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Phosphatidylinositol-3-OH kinase or RAS pathway mutations in human breast cancer cell lines

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ERK negatively regulates the epidermal growth factor-mediated interaction of Gab1 and the phosphatidylinositol 3-kinase

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Incidence of activating ras oncogene mutations associated with primary and metastatic human breast cancer

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1 reference

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12 December 2020

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Identifiers

10.1158/0008-5472.CAN-08-3389

1 reference

Europe PubMed Central

19 August 2017

1 reference

Europe PubMed Central

19 August 2017

1 reference

Europe PubMed Central

19 August 2017

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