(Q39979475)

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A chemical screen in diverse breast cancer cell lines reveals genetic enhancers and suppressors of sensitivity to PI3K isoform-selective inhibition.

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Europe PubMed Central

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https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:18498248%20AND%20SRC:MED&resulttype=core&format=json

7 January 2020

A chemical screen in diverse breast cancer cell lines reveals genetic enhancers and suppressors of sensitivity to PI3K isoform-selective inhibition (English)

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Europe PubMed Central

PMC publication ID

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:18498248%20AND%20SRC:MED&resulttype=core&format=json

7 January 2020

Zachary A Knight

3

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7 January 2020

William A Weiss

6

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7 January 2020

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David Stokoe

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7 January 2020

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Neil E Torbett

1

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7 January 2020

Antonio Luna-Moran

2

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7 January 2020

Andrew Houk

4

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7 January 2020

Mark Moasser

5

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7 January 2020

Kevan M Shokat

7

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7 January 2020

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1 October 2008

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7 January 2020

Biochemical Journal

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7 January 2020

415

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7 January 2020

1

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7 January 2020

97-110

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7 January 2020

Pharmacologic characterization of a potent inhibitor of class I phosphatidylinositide 3-kinases.

1 reference

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RAS/ERK signaling promotes site-specific ribosomal protein S6 phosphorylation via RSK and stimulates cap-dependent translation

1 reference

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22 September 2017

Ubiquitination regulates PTEN nuclear import and tumor suppression

1 reference

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22 September 2017

A collection of breast cancer cell lines for the study of functionally distinct cancer subtypes

1 reference

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22 September 2017

A pharmacological map of the PI3-K family defines a role for p110alpha in insulin signaling

1 reference

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22 September 2017

Critical role for the p110alpha phosphoinositide-3-OH kinase in growth and metabolic regulation

1 reference

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22 September 2017

Erlotinib in lung cancer - molecular and clinical predictors of outcome

1 reference

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22 September 2017

Structural bioinformatics-based design of selective, irreversible kinase inhibitors

1 reference

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22 September 2017

Sequential activation of class IB and class IA PI3K is important for the primed respiratory burst of human but not murine neutrophils

1 reference

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22 September 2017

PI 3-kinase p110beta: a new target for antithrombotic therapy

1 reference

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22 September 2017

PIK3CA mutations correlate with hormone receptors, node metastasis, and ERBB2, and are mutually exclusive with PTEN loss in human breast carcinoma

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3079392

22 September 2017

Inhibition of phosphatidylinositol-3-kinase causes cell death through a protein kinase B (PKB)-dependent mechanism and growth arrest through a PKB-independent mechanism.

1 reference

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22 September 2017

Phosphorylation and regulation of Akt/PKB by the rictor-mTOR complex

1 reference

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22 September 2017

KRAS mutations and primary resistance of lung adenocarcinomas to gefitinib or erlotinib

1 reference

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22 September 2017

Phosphatidylinositol 3-kinase mutations identified in human cancer are oncogenic

1 reference

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22 September 2017

REDD1 integrates hypoxia-mediated survival signaling downstream of phosphatidylinositol 3-kinase.

1 reference

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22 September 2017

Isoform-specific phosphoinositide 3-kinase inhibitors from an arylmorpholine scaffold

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3079392

22 September 2017

S6K1(-/-)/S6K2(-/-) mice exhibit perinatal lethality and rapamycin-sensitive 5'-terminal oligopyrimidine mRNA translation and reveal a mitogen-activated protein kinase-dependent S6 kinase pathway

1 reference

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22 September 2017

PI 3-kinase inhibition: a therapeutic target for respiratory disease

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3079392

22 September 2017

High frequency of mutations of the PIK3CA gene in human cancers

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3079392

22 September 2017

Relevance of breast cancer cell lines as models for breast tumours: an update

1 reference

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22 September 2017

Opportunities and challenges in the development of kinase inhibitor therapy for cancer

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3079392

22 September 2017

Combinatorial efficacy achieved through two-point blockade within a signaling pathway-a chemical genetic approach.

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3079392

22 September 2017

Repeated observation of breast tumor subtypes in independent gene expression data sets

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3079392

22 September 2017

A tyrosine kinase created by fusion of the PDGFRA and FIP1L1 genes as a therapeutic target of imatinib in idiopathic hypereosinophilic syndrome

1 reference

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22 September 2017

The role of genetic abnormalities of PTEN and the phosphatidylinositol 3-kinase pathway in breast and ovarian tumorigenesis, prognosis, and therapy

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3079392

22 September 2017

Synthesis and function of 3-phosphorylated inositol lipids

1 reference

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22 September 2017

5' phospholipid phosphatase SHIP-2 causes protein kinase B inactivation and cell cycle arrest in glioblastoma cells

1 reference

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22 September 2017

The PI3K-PDK1 connection: more than just a road to PKB

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3079392

22 September 2017

Roles of PLC-beta2 and -beta3 and PI3Kgamma in chemoattractant-mediated signal transduction

1 reference

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22 September 2017

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1 reference

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22 September 2017

A position 12-activated H-ras oncogene in all HS578T mammary carcinosarcoma cells but not normal mammary cells of the same patient

1 reference

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22 September 2017

The human c-Kirsten ras gene is activated by a novel mutation in codon 13 in the breast carcinoma cell line MDA-MB231.

1 reference

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Studies of the HER-2/neu proto-oncogene in human breast and ovarian cancer

1 reference

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22 September 2017

Phosphatidylinositol 3-kinase translocates to the nucleus of osteoblast-like MC3T3-E1 cells in response to insulin-like growth factor I and platelet-derived growth factor but not to the proapoptotic cytokine tumor necrosis factor alpha

1 reference

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25 September 2017

Functional analysis of PIK3CA gene mutations in human colorectal cancer

1 reference

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17 June 2018

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1 reference

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1 reference

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1 reference

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20 August 2018

PIK3CA gene is frequently mutated in breast carcinomas and hepatocellular carcinomas.

1 reference

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20 August 2018

The PIK3CA gene is mutated with high frequency in human breast cancers.

1 reference

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Mechanisms and implications of phosphoinositide 3-kinase delta in promoting neutrophil trafficking into inflamed tissue.

1 reference

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Selective role of PI3K delta in neutrophil inflammatory responses

1 reference

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20 August 2018

Regulation of breast cancer cell chemotaxis by the phosphoinositide 3-kinase p110delta.

1 reference

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20 August 2018

The PTEN/MMAC1/TEP tumor suppressor gene decreases cell growth and induces apoptosis and anoikis in breast cancer cells

1 reference

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Essential role for the p110 isoform in phosphoinositide 3-kinase activation and cell proliferation in acute myeloid leukemia

1 reference

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Reduced expression of PTEN protein and its prognostic implications in invasive ductal carcinoma of the breast

1 reference

https://pubmed.ncbi.nlm.nih.gov/18498248

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Studies on the mechanism of phosphatidylinositol 3-kinase inhibition by wortmannin and related analogs

1 reference

https://pubmed.ncbi.nlm.nih.gov/18498248

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Mutation of the PIK3CA gene in ovarian and breast cancer

1 reference

https://pubmed.ncbi.nlm.nih.gov/18498248

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Allelic loss of the PTEN region (10q23) in breast carcinomas of poor pathophenotype

1 reference

https://pubmed.ncbi.nlm.nih.gov/18498248

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Identifiers

10.1042/BJ20080639

1 reference

Europe PubMed Central

PMC publication ID

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:18498248%20AND%20SRC:MED&resulttype=core&format=json

7 January 2020

PMC publication ID

1 reference

Europe PubMed Central

PMC publication ID

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:18498248%20AND%20SRC:MED&resulttype=core&format=json

7 January 2020

PubMed publication ID

1 reference

Europe PubMed Central

PMC publication ID

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:18498248%20AND%20SRC:MED&resulttype=core&format=json

7 January 2020

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