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G protein-coupled receptors: functional and mechanistic insights through altered gene expression

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2 September 2017

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Europe PubMed Central

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G protein-coupled receptors: functional and mechanistic insights through altered gene expression (English)

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Europe PubMed Central

2 September 2017

G protein-coupled receptor

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Kobilka BK

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Europe PubMed Central

2 September 2017

Rohrer DK

1

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Europe PubMed Central

2 September 2017

1 January 1998

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stated in

Europe PubMed Central

2 September 2017

Physiological Reviews

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stated in

Europe PubMed Central

2 September 2017

78

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Europe PubMed Central

2 September 2017

1

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Europe PubMed Central

2 September 2017

35-52

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Europe PubMed Central

2 September 2017

Magnetic resonance microscopy of mouse embryos

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27 May 2022

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Constitutive and conditional suppression of exogenous and endogenous genes by anti-sense RNA.

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Antisense technology reveals the alpha2A adrenoceptor to be the subtype mediating the hypnotic response to the highly selective agonist, dexmedetomidine, in the locus coeruleus of the rat.

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11 October 2022

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Gene modification via "plug and socket" gene targeting

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Tissue-specific targeting of retroviral vectors through ligand-receptor interactions

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A targeted mutation of the D3 dopamine receptor gene is associated with hyperactivity in mice

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Use of double-replacement gene targeting to replace the murine alpha-lactalbumin gene with its human counterpart in embryonic stem cells and mice.

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Genetic alteration of alpha 2C-adrenoceptor expression in mice: influence on locomotor, hypothermic, and neurochemical effects of dexmedetomidine, a subtype-nonselective alpha 2-adrenoceptor agonist.

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Infusion of antisense oligodeoxynucleotides to the oxytocin receptor in the ventromedial hypothalamus reduces estrogen-induced sexual receptivity and oxytocin receptor binding in the female rat.

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Decrease in exploratory behavior in naturally occurring cholecystokinin (CCK)-A receptor gene knockout rats.

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The 5' flanking region of the serotonin 2 receptor gene directs brain specific expression in transgenic animals

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Reporter gene expression in cones in transgenic mice carrying bovine rhodopsin promoter/lacZ transgenes

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Physiological effects of inverse agonists in transgenic mice with myocardial overexpression of the beta 2-adrenoceptor

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Ecdysone-inducible gene expression in mammalian cells and transgenic mice.

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Interaction of endothelin-3 with endothelin-B receptor is essential for development of epidermal melanocytes and enteric neurons

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Transgenesis in nonmurine species

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Opiate receptor knockout mice define mu receptor roles in endogenous nociceptive responses and morphine-induced analgesia

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Impairment of hippocampal mossy fiber LTD in mice lacking mGluR2.

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A rhodopsin gene mutation responsible for autosomal dominant retinitis pigmentosa results in a protein that is defective in localization to the photoreceptor outer segment

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A system for tissue-specific gene targeting: transgenic mice susceptible to subgroup A avian leukosis virus-based retroviral vectors

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Enhanced myocardial function in transgenic mice overexpressing the beta 2-adrenergic receptor

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Impaired locomotor activity and exploratory behavior in mice lacking histamine H1 receptors

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A decrease in angiotensin receptor binding in rat brain nuclei by antisense oligonucleotides to the angiotensin AT1 receptor.

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V1 vasopressin receptor antisense oligodeoxynucleotide into septum reduces vasopressin binding, social discrimination abilities, and anxiety-related behavior in rats.

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Specific regulation of gene expression by antisense, sense and antigene nucleic acids

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Dopamine D1 receptor mutant mice are deficient in striatal expression of dynorphin and in dopamine-mediated behavioral responses

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Reduction in muscarinic receptors by antisense oligodeoxynucleotide

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Targeted disruption of a B2 bradykinin receptor gene in mice eliminates bradykinin action in smooth muscle and neurons.

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Double replacement: strategy for efficient introduction of subtle mutations into the murine Col1a-1 gene by homologous recombination in embryonic stem cells

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Targeted gene replacement.

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Strain-dependent epithelial defects in mice lacking the EGF receptor

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Evidence against a role for metabotropic glutamate receptors in mossy fiber LTP: the use of mutant mice and pharmacological antagonists

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Cardiac function in mice overexpressing the beta-adrenergic receptor kinase or a beta ARK inhibitor

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Diversity and selectivity of receptor-G protein interaction

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Elimination of cocaine-induced hyperactivity and dopamine-mediated neurophysiological effects in dopamine D1 receptor mutant mice

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Adenoviruses as gene-delivery vehicles

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Specific atrial overexpression of G protein coupled human beta 1 adrenoceptors in transgenic mice

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The molecular biology of the FSH receptor.

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Reversal of left-right asymmetry: a situs inversus mutation.

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Genetic mapping of two DNA markers, D16Ros1 and D16Ros2, flanking the mutation site in the chakragati mouse, a transgenic insertional mutant

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Attenuation of gastrin-induced gastric acid secretion by antisense oligonucleotide to the CCKB/gastrin receptor

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Altered striatal function in a mutant mouse lacking D1A dopamine receptors

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Essential role of beta-adrenergic receptor kinase 1 in cardiac development and function

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Effects of phosphorothioated neuropeptide Y Y1-receptor antisense oligodeoxynucleotide in conscious rats and in human vessels

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Echocardiographic assessment of left ventricular mass and systolic function in mice

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Orphan seven transmembrane domain receptors: reversing pharmacology

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Eating disorder and epilepsy in mice lacking 5-HT2c serotonin receptors

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Chimeric mice carrying 'regional' targeted deletion of the angiotensin type 1A receptor gene. Evidence against the role for local angiotensin in the in vivo feedback regulation of renin synthesis in juxtaglomerular cells

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Apoptosis: final common pathway of photoreceptor death in rd, rds, and rhodopsin mutant mice

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Doppler echocardiography of normal and abnormal embryonic mouse heart

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Targeted disruption of the tyrosine hydroxylase locus results in severe catecholamine depletion and perinatal lethality in mice

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Role of the thrombin receptor in development and evidence for a second receptor.

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Targeted and natural (piebald-lethal) mutations of endothelin-B receptor gene produce megacolon associated with spotted coat color in mice

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A proposed new nomenclature for 5-HT receptors.

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Regulation of blood pressure by the type 1A angiotensin II receptor gene

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Retinopathy induced in mice by targeted disruption of the rhodopsin gene

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Targeted disruption of the tyrosine hydroxylase gene reveals that catecholamines are required for mouse fetal development

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Antisense inhibition of AT1 receptor mRNA and angiotensinogen mRNA in the brain of spontaneously hypertensive rats reduces hypertension of neurogenic origin

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Structure and function of ASP, the human homolog of the mouse agouti gene

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Ectopic expression of the agouti gene in transgenic mice causes obesity, features of type II diabetes, and yellow fur

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11 October 2022

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Transgenesis in the rat and larger mammals

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11 October 2022

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Dopamine D3 receptor antisense influences dopamine synthesis in rat brain

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11 October 2022

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Chronic infusion of a CRH1 receptor antisense oligodeoxynucleotide into the central nucleus of the amygdala reduced anxiety-related behavior in socially defeated rats

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Deletion and replacement of the mouse adult beta-globin genes by a "plug and socket" repeated targeting strategy

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Antisense phosphorothioate oligodeoxynucleotides: introductory concepts and possible molecular mechanisms of toxicity

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11 October 2022

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Parkinsonian-like locomotor impairment in mice lacking dopamine D2 receptors

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11 October 2022

https://opencitations.net/index/coci/api/v1/references/10.1152/PHYSREV.1998.78.1.35

Myocardial expression of a constitutively active alpha 1B-adrenergic receptor in transgenic mice induces cardiac hypertrophy

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11 October 2022

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Inducible gene targeting in mice

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DNA antisense therapy for asthma in an animal model

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Inducible site-directed recombination in mouse embryonic stem cells

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Temporal control of gene expression in transgenic mice by a tetracycline-responsive promoter.

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Apoptotic photoreceptor cell death in mouse models of retinitis pigmentosa

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11 October 2022

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Antisense to NPY-Y1 demonstrates that Y1 receptors in the hypothalamus underlie NPY hypothermia and feeding in rats

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Targeted disruption of the mouse beta1-adrenergic receptor gene: developmental and cardiovascular effects

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Motor deficit and impairment of synaptic plasticity in mice lacking mGluR1.

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Antisense and ribozyme constructs in transgenic animals

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The family of G-protein-coupled receptors.

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A mouse model of human familial hypocalciuric hypercalcemia and neonatal severe hyperparathyroidism.

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Noradrenaline is essential for mouse fetal development

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Doxycycline-mediated quantitative and tissue-specific control of gene expression in transgenic mice

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11 October 2022

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Germ-line transformation of mice

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11 October 2022

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Sensitivity to leptin and susceptibility to seizures of mice lacking neuropeptide Y

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11 October 2022

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Asymmetric elevation of striatal dopamine D2 receptors in the chakragati mouse: neurobehavioral dysfunction in a transgenic insertional mutant

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Thyroid expression of an A2 adenosine receptor transgene induces thyroid hyperplasia and hyperthyroidism

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Somatic mutations in the thyrotropin receptor gene cause hyperfunctioning thyroid adenomas

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Genetic control of blood pressure and the angiotensinogen locus

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Elevated alcohol consumption in null mutant mice lacking 5-HT1B serotonin receptors.

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Central hypotensive effects of the alpha2a-adrenergic receptor subtype.

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Neurogenic amplification of immune complex inflammation

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Cardiovascular regulation in mice lacking alpha2-adrenergic receptor subtypes b and c.

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An antisense oligodeoxynucleotide to mu-opioid receptors inhibits mu-opioid receptor agonist-induced analgesia in rats

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Enhanced aggressive behavior in mice lacking 5-HT1B receptor.

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11 October 2022

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Cellular responses to psychomotor stimulant and neuroleptic drugs are abnormal in mice lacking the D1 dopamine receptor

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11 October 2022

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Constitutive activation of phototransduction by K296E opsin is not a cause of photoreceptor degeneration

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11 October 2022

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Antisense knockouts: molecular scalpels for the dissection of signal transduction

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Single-copy transgenic mice with chosen-site integration

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Subregion- and cell type-restricted gene knockout in mouse brain

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11 October 2022

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The human D1A dopamine receptor gene promoter directs expression of a reporter gene to the central nervous system in transgenic mice.

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11 October 2022

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Angiotensin II type 1a receptor-deficient mice with hypotension and hyperreninemia

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11 October 2022

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Altered cAMP levels in retinas from transgenic mice expressing a rhodopsin mutant

1 reference

11 October 2022

https://opencitations.net/index/coci/api/v1/references/10.1152/PHYSREV.1998.78.1.35

Efficient insertion of genes into the mouse germ line via retroviral vectors

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11 October 2022

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In vivo echocardiographic detection of enhanced left ventricular function in gene-targeted mice with phospholamban deficiency

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11 October 2022

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Specific deficit of the ON response in visual transmission by targeted disruption of the mGluR6 gene.

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11 October 2022

https://opencitations.net/index/coci/api/v1/references/10.1152/PHYSREV.1998.78.1.35

Expression of transduced genes in mice generated by infecting blastocysts with avian leukosis virus-based retroviral vectors

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11 October 2022

https://opencitations.net/index/coci/api/v1/references/10.1152/PHYSREV.1998.78.1.35

Salt-sensitive hypertension in bradykinin B2 receptor knockout mice

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11 October 2022

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Chronic control of high blood pressure in the spontaneously hypertensive rat by delivery of angiotensin type 1 receptor antisense

1 reference

11 October 2022

https://opencitations.net/index/coci/api/v1/references/10.1152/PHYSREV.1998.78.1.35

Elevated blood pressure and craniofacial abnormalities in mice deficient in endothelin-1

1 reference

11 October 2022

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Intracerebroventricular administration of angiotensin type 1 (AT1) receptor antisense oligonucleotides attenuate thirst in the rat.

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11 October 2022

https://opencitations.net/index/coci/api/v1/references/10.1152/PHYSREV.1998.78.1.35

Comparative hemodynamic, left ventricular functional, and antiadrenergic effects of chronic treatment with metoprolol versus carvedilol in the failing heart

1 reference

11 October 2022

https://opencitations.net/index/coci/api/v1/references/10.1152/PHYSREV.1998.78.1.35

Alphaviruses as vectors for gene delivery

1 reference

11 October 2022

https://opencitations.net/index/coci/api/v1/references/10.1152/PHYSREV.1998.78.1.35

Transgenic mice with a rhodopsin mutation (Pro23His): a mouse model of autosomal dominant retinitis pigmentosa

1 reference

11 October 2022

https://opencitations.net/index/coci/api/v1/references/10.1152/PHYSREV.1998.78.1.35

Intracerebroventricular treatment with an antisense oligodeoxynucleotide to kappa-opioid receptors inhibited kappa-agonist-induced analgesia in rats

1 reference

11 October 2022

https://opencitations.net/index/coci/api/v1/references/10.1152/PHYSREV.1998.78.1.35

Cellular interactions implicated in the mechanism of photoreceptor degeneration in transgenic mice expressing a mutant rhodopsin gene

1 reference

11 October 2022

https://opencitations.net/index/coci/api/v1/references/10.1152/PHYSREV.1998.78.1.35

Progress in antisense oligonucleotide therapeutics

1 reference

11 October 2022

https://opencitations.net/index/coci/api/v1/references/10.1152/PHYSREV.1998.78.1.35

Approaching the multifaceted nature of energy metabolism: inactivation of the cytosolic creatine kinases via homologous recombination in mouse embryonic stem cells

1 reference

11 October 2022

https://opencitations.net/index/coci/api/v1/references/10.1152/PHYSREV.1998.78.1.35

Creatine kinase (CK) in skeletal muscle energy metabolism: a study of mouse mutants with graded reduction in muscle CK expression

1 reference

11 October 2022

https://opencitations.net/index/coci/api/v1/references/10.1152/PHYSREV.1998.78.1.35

Hyperlocomotion and indifference to cocaine and amphetamine in mice lacking the dopamine transporter

1 reference

11 October 2022

https://opencitations.net/index/coci/api/v1/references/10.1152/PHYSREV.1998.78.1.35

Simulation of human autosomal dominant retinitis pigmentosa in transgenic mice expressing a mutated murine opsin gene

1 reference

11 October 2022

https://opencitations.net/index/coci/api/v1/references/10.1152/PHYSREV.1998.78.1.35

Adenovirus-mediated gene transfer of dopamine D2 receptor cDNA into rat striatum

1 reference

11 October 2022

https://opencitations.net/index/coci/api/v1/references/10.1152/PHYSREV.1998.78.1.35

Structural elements of G alpha subunits that interact with G beta gamma, receptors, and effectors

1 reference

11 October 2022

https://opencitations.net/index/coci/api/v1/references/10.1152/PHYSREV.1998.78.1.35

Impaired cerebellar synaptic plasticity and motor performance in mice lacking the mGluR4 subtype of metabotropic glutamate receptor

1 reference

11 October 2022

https://opencitations.net/index/coci/api/v1/references/10.1152/PHYSREV.1998.78.1.35

Alteration of catecholamine phenotype in transgenic mice influences expression of adrenergic receptor subtypes

1 reference

11 October 2022

https://opencitations.net/index/coci/api/v1/references/10.1152/PHYSREV.1998.78.1.35

Overexpression of an Agouti cDNA in the skin of transgenic mice recapitulates dominant coat color phenotypes of spontaneous mutants

1 reference

11 October 2022

https://opencitations.net/index/coci/api/v1/references/10.1152/PHYSREV.1998.78.1.35

Overexpression of Gs alpha protein in the hearts of transgenic mice

1 reference

11 October 2022

https://opencitations.net/index/coci/api/v1/references/10.1152/PHYSREV.1998.78.1.35

Antisense oligodeoxynucleotide reduces brain dopamine D2 receptors: behavioral correlates

1 reference

11 October 2022

https://opencitations.net/index/coci/api/v1/references/10.1152/PHYSREV.1998.78.1.35

Behavioural and cardiovascular effects of disrupting the angiotensin II type-2 receptor in mice

1 reference

11 October 2022

https://opencitations.net/index/coci/api/v1/references/10.1152/PHYSREV.1998.78.1.35

Antisense oligodeoxynucleotide to the CCKB receptor produces naltrindole- and [Leu5]enkephalin antiserum-sensitive enhancement of morphine antinociception

1 reference

11 October 2022

https://opencitations.net/index/coci/api/v1/references/10.1152/PHYSREV.1998.78.1.35

Targeted disruption of the melanocortin-4 receptor results in obesity in mice

1 reference

11 October 2022

https://opencitations.net/index/coci/api/v1/references/10.1152/PHYSREV.1998.78.1.35

General anosmia caused by a targeted disruption of the mouse olfactory cyclic nucleotide-gated cation channel

1 reference

11 October 2022

https://opencitations.net/index/coci/api/v1/references/10.1152/PHYSREV.1998.78.1.35

Reduced hippocampal long-term potentiation and context-specific deficit in associative learning in mGluR1 mutant mice.

1 reference

11 October 2022

https://opencitations.net/index/coci/api/v1/references/10.1152/PHYSREV.1998.78.1.35

Dopamine-deficient mice are severely hypoactive, adipsic, and aphagic

1 reference

11 October 2022

https://opencitations.net/index/coci/api/v1/references/10.1152/PHYSREV.1998.78.1.35

The essential role of hippocampal CA1 NMDA receptor-dependent synaptic plasticity in spatial memory

1 reference

11 October 2022

https://opencitations.net/index/coci/api/v1/references/10.1152/PHYSREV.1998.78.1.35

Loss of morphine-induced analgesia, reward effect and withdrawal symptoms in mice lacking the mu-opioid-receptor gene

1 reference

11 October 2022

https://opencitations.net/index/coci/api/v1/references/10.1152/PHYSREV.1998.78.1.35

Targeted disruption of the beta 3-adrenergic receptor gene.

1 reference

11 October 2022

https://opencitations.net/index/coci/api/v1/references/10.1152/PHYSREV.1998.78.1.35

Modulation of anxiety and neuropeptide Y-Y1 receptors by antisense oligodeoxynucleotides.

1 reference

11 October 2022

https://opencitations.net/index/coci/api/v1/references/10.1152/PHYSREV.1998.78.1.35

Site-directed point mutations in embryonic stem cells: a gene-targeting tag-and-exchange strategy

1 reference

11 October 2022

https://opencitations.net/index/coci/api/v1/references/10.1152/PHYSREV.1998.78.1.35

Viral vectors in gene therapy

1 reference

11 October 2022

https://opencitations.net/index/coci/api/v1/references/10.1152/PHYSREV.1998.78.1.35

Effects on blood pressure and exploratory behaviour of mice lacking angiotensin II type-2 receptor

1 reference

11 October 2022

https://opencitations.net/index/coci/api/v1/references/10.1152/PHYSREV.1998.78.1.35

NMDA-Receptor-Independent Long-Term Potentiation

1 reference

11 October 2022

https://opencitations.net/index/coci/api/v1/references/10.1152/PHYSREV.1998.78.1.35

Antisense oligodeoxynucleotide to a delta-opioid receptor selectively blocks the spinal antinociception induced by delta-, but not mu- or kappa-opioid receptor agonists in the mouse

1 reference

11 October 2022

https://opencitations.net/index/coci/api/v1/references/10.1152/PHYSREV.1998.78.1.35

Myocardial signaling defects and impaired cardiac function of a human beta 2-adrenergic receptor polymorphism expressed in transgenic mice

1 reference

11 October 2022

https://opencitations.net/index/coci/api/v1/references/10.1152/PHYSREV.1998.78.1.35

Medical therapy can improve the biological properties of the chronically failing heart. A new era in the treatment of heart failure

1 reference

11 October 2022

https://opencitations.net/index/coci/api/v1/references/10.1152/PHYSREV.1998.78.1.35

Identifiers

DOI

10.1152/PHYSREV.1998.78.1.35

0 references

PubMed ID

9457168

1 reference

stated in

Europe PubMed Central

PubMed ID

9457168

retrieved

2 September 2017

(Q38340269)

G protein-coupled receptors: functional and mechanistic insights through altered gene expression

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