(Q38343049)

2 September 2017

1 reference

title

Insights on the interaction of alpha-synuclein and metals in the pathophysiology of Parkinson's disease (English)

1 reference

2 September 2017

1 reference

1 reference

1

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:25648629%20AND%20SRC:MED&resulttype=core&format=json

1 June 2020

Paul Lingor

series ordinal

2

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:25648629%20AND%20SRC:MED&resulttype=core&format=json

1 June 2020

author name string

Eleonora Carboni

series ordinal

1

1 reference

2 September 2017

Paul Lingor

series ordinal

2

1 reference

2 September 2017

1 March 2015

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2 September 2017

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https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:25648629%20AND%20SRC:MED&resulttype=core&format=json

1 June 2020

volume

7

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:25648629%20AND%20SRC:MED&resulttype=core&format=json

1 June 2020

issue

3

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:25648629%20AND%20SRC:MED&resulttype=core&format=json

1 June 2020

page(s)

395-404

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https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:25648629%20AND%20SRC:MED&resulttype=core&format=json

Metalloproteomics and metal toxicology of α-synuclein

1 June 2020

cites work

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Evolutionary aspects of the synuclein super-family and sub-families based on large-scale phylogenetic and group-discrimination analysis

21 January 2018

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Red blood cells are the major source of alpha-synuclein in blood.

21 January 2018

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α-Synuclein: membrane interactions and toxicity in Parkinson's disease

21 January 2018

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alpha-Synuclein in filamentous inclusions of Lewy bodies from Parkinson's disease and dementia with lewy bodies

21 January 2018

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Increased nigral iron content and alterations in other metal ions occurring in brain in Parkinson's disease

21 January 2018

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Incidence and pathology of synucleinopathies and tauopathies related to parkinsonism

21 January 2018

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The many faces of alpha-synuclein mutations

21 January 2018

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α-Synuclein impairs oligodendrocyte progenitor maturation in multiple system atrophy

21 January 2018

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Alpha-synuclein promotes SNARE-complex assembly in vivo and in vitro

21 January 2018

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Alpha-synuclein inhibits aromatic amino acid decarboxylase activity in dopaminergic cells

21 January 2018

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Single particle characterization of iron-induced pore-forming alpha-synuclein oligomers

21 January 2018

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Granular assembly of alpha-synuclein leading to the accelerated amyloid fibril formation with shear stress

21 January 2018

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Metal-triggered structural transformations, aggregation, and fibrillation of human alpha-synuclein. A possible molecular NK between Parkinson's disease and heavy metal exposure

21 January 2018

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Accumulation of oligomer-prone α-synuclein exacerbates synaptic and neuronal degeneration in vivo

21 January 2018

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In vivo demonstration that alpha-synuclein oligomers are toxic

21 January 2018

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Staging of brain pathology related to sporadic Parkinson's disease

21 January 2018

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Parkinson's disease and alpha synuclein: is Parkinson's disease a prion-like disorder?

21 January 2018

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Lewy body-like pathology in long-term embryonic nigral transplants in Parkinson's disease

21 January 2018

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Lewy bodies in grafted neurons in subjects with Parkinson's disease suggest host-to-graft disease propagation

21 January 2018

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Exogenous α-synuclein fibrils induce Lewy body pathology leading to synaptic dysfunction and neuron death

21 January 2018

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The pathology roadmap in Parkinson disease

21 January 2018

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Targeting dysregulation of brain iron homeostasis in Parkinson's disease by iron chelators

21 January 2018

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Identification of two distinct synucleins from human brain

21 January 2018

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Structural Evidence for a Copper-Bound Carbonate Intermediate in the Peroxidase and Dismutase Activities of Superoxide Dismutase

21 January 2018

1 reference

https://api.crossref.org/works/10.1039%2FC4MT00339J

Copper handling machinery of the brain

21 January 2018

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https://api.crossref.org/works/10.1039%2FC4MT00339J

Iron dysregulation in movement disorders

21 January 2018

1 reference

https://api.crossref.org/works/10.1039%2FC4MT00339J

Manganese-induced dopaminergic neurodegeneration: insights into mechanisms and genetics shared with Parkinson's disease

21 January 2018

1 reference

https://api.crossref.org/works/10.1039%2FC4MT00339J

Metal ions and intrinsically disordered proteins and peptides: from Cu/Zn amyloid-β to general principles

21 January 2018

1 reference

https://api.crossref.org/works/10.1039%2FC4MT00339J

Copper(II)-human amylin complex protects pancreatic cells from amylin toxicity

21 January 2018

1 reference

https://api.crossref.org/works/10.1039%2FC4MT00339J

Molecular chaperones and co-chaperones in Parkinson disease

21 January 2018

1 reference

https://api.crossref.org/works/10.1039%2FC4MT00339J

Glutathione metabolism and Parkinson's disease

21 January 2018

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https://api.crossref.org/works/10.1039%2FC4MT00339J

Mitochondrial defects and oxidative stress in Alzheimer disease and Parkinson disease

21 January 2018

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Huntington's disease: underlying molecular mechanisms and emerging concepts

21 January 2018

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Friedreich ataxia: new pathways

21 January 2018

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Mechanisms of mutant SOD1 induced mitochondrial toxicity in amyotrophic lateral sclerosis

21 January 2018

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https://api.crossref.org/works/10.1039%2FC4MT00339J

Mapping metals in Parkinson's and normal brain using rapid-scanning x-ray fluorescence.

21 January 2018

1 reference

https://api.crossref.org/works/10.1039%2FC4MT00339J

Magnesium inhibits spontaneous and iron-induced aggregation of alpha-synuclein

21 January 2018

1 reference

https://api.crossref.org/works/10.1039%2FC4MT00339J

Binding of alpha-synuclein with Fe(III) and with Fe(II) and biological implications of the resultant complexes.

21 January 2018

1 reference

https://api.crossref.org/works/10.1039%2FC4MT00339J

Phosphorylation of Ser-129 is the dominant pathological modification of alpha-synuclein in familial and sporadic Lewy body disease

21 January 2018

1 reference

https://api.crossref.org/works/10.1039%2FC4MT00339J

Phosphorylation of α-Synuclein at Y125 and S129 alters its metal binding properties: implications for understanding the role of α-Synuclein in the pathogenesis of Parkinson's Disease and related disorders

21 January 2018

1 reference

https://api.crossref.org/works/10.1039%2FC4MT00339J

Single-channel electrophysiology reveals a distinct and uniform pore complex formed by α-synuclein oligomers in lipid membranes

21 January 2018

1 reference

https://api.crossref.org/works/10.1039%2FC4MT00339J

Copper and copper proteins in Parkinson's disease

21 January 2018

1 reference

https://api.crossref.org/works/10.1039%2FC4MT00339J

Copper pathology in vulnerable brain regions in Parkinson's disease

21 January 2018

1 reference

https://api.crossref.org/works/10.1039%2FC4MT00339J

Identification of the minimal copper(II)-binding alpha-synuclein sequence.

21 January 2018

1 reference

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Site-specific interactions of Cu(II) with alpha and beta-synuclein: bridging the molecular gap between metal binding and aggregation

21 January 2018

1 reference

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Structural characterization of copper(II) binding to alpha-synuclein: Insights into the bioinorganic chemistry of Parkinson's disease

21 January 2018

1 reference

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Site-specific copper-catalyzed oxidation of α-synuclein: tightening the link between metal binding and protein oxidative damage in Parkinson's disease.

21 January 2018

1 reference

https://api.crossref.org/works/10.1039%2FC4MT00339J

A novel α-synuclein missense mutation in Parkinson disease

21 January 2018

1 reference

https://api.crossref.org/works/10.1039%2FC4MT00339J

Coordination of copper to the membrane-bound form of α-synuclein

21 January 2018

1 reference

https://api.crossref.org/works/10.1039%2FC4MT00339J

The H50Q mutation enhances α-synuclein aggregation, secretion, and toxicity

21 January 2018

1 reference

https://api.crossref.org/works/10.1039%2FC4MT00339J

Copper binding regulates intracellular alpha-synuclein localisation, aggregation and toxicity

21 January 2018

1 reference

https://api.crossref.org/works/10.1039%2FC4MT00339J

Redox reactions of the α-synuclein-Cu(2+) complex and their effects on neuronal cell viability

21 January 2018

1 reference

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Dopamine and Cu+/2+ can induce oligomerization of α-synuclein in the absence of oxygen: Two types of oligomerization mechanisms for α-synuclein and related cell toxicity studies

21 January 2018

1 reference

https://api.crossref.org/works/10.1039%2FC4MT00339J

Divalent metal ions enhance DOPAL-induced oligomerization of alpha-synuclein.

21 January 2018

1 reference

https://api.crossref.org/works/10.1039%2FC4MT00339J

In vitro study of α-synuclein protofibrils by cryo-EM suggests a Cu(2+)-dependent aggregation pathway

21 January 2018

1 reference

https://api.crossref.org/works/10.1039%2FC4MT00339J

Relationship between blood levels of heavy metals and Parkinson's disease in China

21 January 2018

1 reference

https://api.crossref.org/works/10.1039%2FC4MT00339J

Oxidative stress involvement in manganese-induced alpha-synuclein oligomerization in organotypic brain slice cultures

21 January 2018

1 reference

https://api.crossref.org/works/10.1039%2FC4MT00339J

Manganese exposure induces α-synuclein aggregation in the frontal cortex of non-human primates

21 January 2018

1 reference

https://api.crossref.org/works/10.1039%2FC4MT00339J

alpha-Synuclein selectively increases manganese-induced viability loss in SK-N-MC neuroblastoma cells expressing the human dopamine transporter.

21 January 2018

1 reference

https://api.crossref.org/works/10.1039%2FC4MT00339J

alpha-Synuclein overexpression during manganese-induced apoptosis in SH-SY5Y neuroblastoma cells

21 January 2018

1 reference

https://api.crossref.org/works/10.1039%2FC4MT00339J

α-Synuclein overexpression enhances manganese-induced neurotoxicity through the NF-κB-mediated pathway

21 January 2018

1 reference

https://api.crossref.org/works/10.1039%2FC4MT00339J

Late-onset Parkinsonism in NFκB/c-Rel-deficient mice

21 January 2018

1 reference

https://api.crossref.org/works/10.1039%2FC4MT00339J

X-ray fluorescence analysis of iron and manganese distribution in primary dopaminergic neurons

21 January 2018

1 reference

https://api.crossref.org/works/10.1039%2FC4MT00339J

The Ca2+/Mn2+ ion-pump PMR1 links elevation of cytosolic Ca(2+) levels to α-synuclein toxicity in Parkinson's disease models

21 January 2018

1 reference

https://api.crossref.org/works/10.1039%2FC4MT00339J

Alpha-synuclein is part of a diverse and highly conserved interaction network that includes PARK9 and manganese toxicity

21 January 2018

1 reference

https://api.crossref.org/works/10.1039%2FC4MT00339J

Two different binding modes of α-synuclein to lipid vesicles depending on its aggregation state

21 January 2018

1 reference

https://api.crossref.org/works/10.1039%2FC4MT00339J

Lipophilic adamantyl- or deferasirox-based conjugates of desferrioxamine B have enhanced neuroprotective capacity: implications for Parkinson disease

21 January 2018

1 reference

https://api.crossref.org/works/10.1039%2FC4MT00339J

Chronic intranasal deferoxamine ameliorates motor defects and pathology in the α-synuclein rAAV Parkinson's model.

21 January 2018

1 reference

https://api.crossref.org/works/10.1039%2FC4MT00339J

Targeting chelatable iron as a therapeutic modality in Parkinson's disease

21 January 2018

1 reference

https://api.crossref.org/works/10.1039%2FC4MT00339J

GDNF and NT-4 protect midbrain dopaminergic neurons from toxic damage by iron and nitric oxide.

21 January 2018

1 reference

https://api.crossref.org/works/10.1039%2FC4MT00339J

Calcium entry and α-synuclein inclusions elevate dendritic mitochondrial oxidant stress in dopaminergic neurons

21 January 2018

1 reference

https://api.crossref.org/works/10.1039%2FC4MT00339J

Coenzyme Q10 levels correlate with the activities of complexes I and II/III in mitochondria from parkinsonian and nonparkinsonian subjects.

21 January 2018

1 reference

https://api.crossref.org/works/10.1039%2FC4MT00339J

Combination therapy with coenzyme Q10 and creatine produces additive neuroprotective effects in models of Parkinson's and Huntington's diseases

21 January 2018

1 reference

https://api.crossref.org/works/10.1039%2FC4MT00339J

Effects of coenzyme Q10 in early Parkinson disease: evidence of slowing of the functional decline

21 January 2018

1 reference

https://api.crossref.org/works/10.1039%2FC4MT00339J

A randomized clinical trial of high-dosage coenzyme Q10 in early Parkinson disease: no evidence of benefit

21 January 2018

1 reference

https://api.crossref.org/works/10.1039%2FC4MT00339J

Axon degeneration in Parkinson's disease

21 January 2018

1 reference

https://api.crossref.org/works/10.1039%2FC4MT00339J

Structural properties of pore-forming oligomers of alpha-synuclein

21 January 2018

1 reference

https://api.crossref.org/works/10.1039%2FC4MT00339J

Alpha-synuclein pore forming activity upon membrane association

21 January 2018

1 reference

https://api.crossref.org/works/10.1039%2FC4MT00339J

Cu2+Binding Modes of Recombinant α-Synuclein − Insights from EPR Spectroscopy

21 January 2018

1 reference

https://api.crossref.org/works/10.1039%2FC4MT00339J

Copper Coordination by Familial Mutants of Parkinson’s Disease-Associated α-Synuclein

21 January 2018

1 reference

https://api.crossref.org/works/10.1039%2FC4MT00339J

Alpha-synuclein oligomers and fibrils originate in two distinct conformer pools: a small angle X-ray scattering and ensemble optimisation modelling study

21 January 2018

1 reference

https://api.crossref.org/works/10.1039%2FC4MT00339J

Bioinorganic chemistry of copper coordination to alpha-synuclein: Relevance to Parkinson's disease

21 January 2018

1 reference

https://api.crossref.org/works/10.1039%2FC4MT00339J

Interaction of α-Synuclein with Divalent Metal Ions Reveals Key Differences: A Link between Structure, Binding Specificity and Fibrillation Enhancement

21 January 2018

1 reference

https://api.crossref.org/works/10.1039%2FC4MT00339J

21 January 2018

Identifiers

DOI

10.1039/C4MT00339J

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:25648629%20AND%20SRC:MED&resulttype=core&format=json

1 June 2020

1 reference