(Q38349437)

2 September 2017

Pharmacokinetic and pharmacodynamic modeling of a monoclonal antibody antagonist of glucagon receptor in male ob/ob mice (English)

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2 September 2017

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Yvonne Y Lau

1

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2 September 2017

Peiming Ma

2

1 reference

2 September 2017

Leonid Gibiansky

3

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2 September 2017

Renee Komorowski

4

1 reference

2 September 2017

Jin Wang

5

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2 September 2017

George Wang

6

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2 September 2017

Hai Yan

7

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2 September 2017

Murielle M Véniant

8

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2 September 2017

Tarundeep Kakkar

9

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2 September 2017

language of work or name

English

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publication date

23 October 2009

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2 September 2017

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2 September 2017

11

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2 September 2017

4

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2 September 2017

700-709

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https://scigraph.springernature.com/pub.10.1208/s12248-009-9150-z

2 September 2017

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cites work

Insulin signaling in alpha cells modulates glucagon secretion in vivo

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2782084

Fully human monoclonal antibodies antagonizing the glucagon receptor improve glucose homeostasis in mice and monkeys

6 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2782084

Pharmacokinetic/pharmacodynamic modelling in diabetes mellitus.

6 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2782084

The role of alpha-cell dysregulation in fasting and postprandial hyperglycemia in type 2 diabetes and therapeutic implications

6 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2782084

Glucose inhibits glucagon secretion by a direct effect on mouse pancreatic alpha cells

6 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2782084

Glucagon as a target for the treatment of Type 2 diabetes

6 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2782084

Hepatic and glucagon-like peptide-1-mediated reversal of diabetes by glucagon receptor antisense oligonucleotide inhibitors

6 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2782084

Some quantitative uses of drug antagonists

6 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2782084

Glucagon and regulation of glucose metabolism

6 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2782084

International Union of Pharmacology. XXXV. The glucagon receptor family

6 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2782084

Modeling of dose-response-time data: four examples of estimating the turnover parameters and generating kinetic functions from response profiles

6 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2782084

Banting Lecture 1997. Control of glucose uptake and release by the liver in vivo

6 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2782084

Comparison of four basic models of indirect pharmacodynamic responses

6 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2782084

Effects of the obese gene product on body weight regulation in ob/ob mice

6 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2782084

Characterization of the effects of arginine and glucose on glucagon and insulin release from the perfused rat pancreas

6 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2782084

The essential role of glucagon in the pathogenesis of diabetes mellitus

6 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2782084

Modeling the metabolic effects of terbutaline in beta2-adrenergic receptor diplotypes.

6 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2782084

Regulation of pancreatic insulin and glucagon secretion

14 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2782084

Molecular and cellular aspects of the glucagon receptor: role in diabetes and metabolism.

14 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2782084

Abnormal alpha-cell function in diabetes. Response to carbohydrate and protein ingestion

27 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2782084

Fasting hyperglycemia in non-insulin-dependent diabetes mellitus: contributions of excessive hepatic glucose production and impaired tissue glucose uptake.

23 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2782084

Predominant role of gluconeogenesis in increased hepatic glucose production in NIDDM.

23 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2782084

Approximations of the target-mediated drug disposition model and identifiability of model parameters.

23 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2782084

Reduction in glucagon receptor expression by an antisense oligonucleotide ameliorates diabetic syndrome in db/db mice

31 August 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2782084

Analytical performance of glucometers used for routine glucose self-monitoring of diabetic patients

31 August 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2782084

General pharmacokinetic model for drugs exhibiting target-mediated drug disposition

31 August 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2782084

Impact of CYP2C9 and CYP2C19 polymorphisms on tolbutamide kinetics and the insulin and glucose response in healthy volunteers

31 August 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2782084

Assessment of hepatic insulin action in obese type 2 diabetic patients

31 August 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2782084

Expression cloning and signaling properties of the rat glucagon receptor

31 August 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2782084

Minimal increases in glucagon levels enhance glucose production in man with partial hypoinsulinemia

31 August 2018

1 reference

PubMed

https://pubmed.ncbi.nlm.nih.gov/19851873

12 December 2020

inferred from PubMed ID database lookup

Mechanism-based pharmacodynamic modeling

1 reference

PubMed

https://pubmed.ncbi.nlm.nih.gov/19851873

12 December 2020

inferred from PubMed ID database lookup

Theories of drug antagonism

1 reference

PubMed

https://pubmed.ncbi.nlm.nih.gov/19851873

12 December 2020

inferred from PubMed ID database lookup

Identifiers

DOI

10.1208/S12248-009-9150-Z

1 reference

Dimensions Publication ID

2 September 2017

1025419079

0 references

Fatcat ID

release_2zr5wg4i25d23bzicxexngfvay

1 reference

Fatcat

https://api.fatcat.wiki/v0/release/2zr5wg4i25d23bzicxexngfvay

24 November 2022

mapped directly with Wikidata item

1 reference

2 September 2017

PubMed publication ID

19851873

1 reference