(Q38356866)

English

Insight into the functional consequences of inherited variants of the hMYH adenine glycosylase associated with colorectal cancer: complementation assays with hMYH variants and pre-steady-state kinetics of the corresponding mutated E.coli enzymes

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scholarly article

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Europe PubMed Central

PubMed publication ID

2 September 2017

Insight into the functional consequences of inherited variants of the hMYH adenine glycosylase associated with colorectal cancer: complementation assays with hMYH variants and pre-steady-state kinetics of the corresponding mutated E.coli enzymes (English)

1 reference

Europe PubMed Central

PubMed publication ID

2 September 2017

Escherichia coli

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colorectal cancer

1 reference

based on heuristic

inferred from title

colorectal carcinoma

1 reference

based on heuristic

inferred from title

author name string

Nikolas H Chmiel

1

1 reference

Europe PubMed Central

PubMed publication ID

2 September 2017

Alison L Livingston

2

1 reference

Europe PubMed Central

PubMed publication ID

2 September 2017

Sheila S David

3

1 reference

Europe PubMed Central

PubMed publication ID

2 September 2017

language of work or name

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publication date

1 March 2003

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Europe PubMed Central

PubMed publication ID

2 September 2017

Journal of Molecular Biology

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Europe PubMed Central

PubMed publication ID

2 September 2017

327

1 reference

Europe PubMed Central

PubMed publication ID

2 September 2017

2

1 reference

Europe PubMed Central

PubMed publication ID

2 September 2017

431-443

1 reference

Europe PubMed Central

PubMed publication ID

2 September 2017

Lessons from hereditary colorectal cancer

1 reference

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7 January 2021

Mismatch repair and the hereditary non-polyposis colorectal cancer syndrome (HNPCC)

1 reference

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7 January 2021

Deficient DNA mismatch repair: a common etiologic factor for colon cancer

1 reference

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7 January 2021

Biology of the adenomatous polyposis coli tumor suppressor

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7 January 2021

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7 January 2021

A role for the Adenomatous Polyposis Coli protein in chromosome segregation

1 reference

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7 January 2021

Mutations in the APC tumour suppressor gene cause chromosomal instability

1 reference

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7 January 2021

Antioncogenes and human cancer

1 reference

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7 January 2021

APC mutations in sporadic colorectal tumors: A mutational "hotspot" and interdependence of the "two hits"

1 reference

https://api.crossref.org/works/10.1016%2FS0022-2836%2803%2900124-4

7 January 2021

Inherited variants of MYH associated with somatic G:C-->T:A mutations in colorectal tumors

1 reference

https://api.crossref.org/works/10.1016%2FS0022-2836%2803%2900124-4

7 January 2021

Mutagenesis by 8-oxoguanine: an enemy within

1 reference

https://api.crossref.org/works/10.1016%2FS0022-2836%2803%2900124-4

7 January 2021

Genetic effects of oxidative DNA damage: comparative mutagenesis of 7,8-dihydro-8-oxoguanine and 7,8-dihydro-8-oxoadenine in Escherichia coli

1 reference

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7 January 2021

Insertion of specific bases during DNA synthesis past the oxidation-damaged base 8-oxodG

1 reference

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7 January 2021

Chemistry of Glycosylases and Endonucleases Involved in Base-Excision Repair

1 reference

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7 January 2021

MutT protein specifically hydrolyses a potent mutagenic substrate for DNA synthesis

1 reference

https://api.crossref.org/works/10.1016%2FS0022-2836%2803%2900124-4

7 January 2021

Functional cooperation of MutT, MutM and MutY proteins in preventing mutations caused by spontaneous oxidation of guanine nucleotide in Escherichia coli.

1 reference

https://api.crossref.org/works/10.1016%2FS0022-2836%2803%2900124-4

7 January 2021

Recent progress in the biology, chemistry and structural biology of DNA glycosylases

1 reference

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7 January 2021

Differential DNA recognition and glycosylase activity of the native human MutY homolog (hMYH) and recombinant hMYH expressed in bacteria

1 reference

https://api.crossref.org/works/10.1016%2FS0022-2836%2803%2900124-4

7 January 2021

Identification of human MutY homolog (hMYH) as a repair enzyme for 2-hydroxyadenine in DNA and detection of multiple forms of hMYH located in nuclei and mitochondria

1 reference

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7 January 2021

Differential subcellular localization of human MutY homolog (hMYH) and the functional activity of adenine:8-oxoguanine DNA glycosylase

1 reference

https://api.crossref.org/works/10.1016%2FS0022-2836%2803%2900124-4

7 January 2021

Adenine excisional repair function of MYH protein on the adenine:8-hydroxyguanine base pair in double-stranded DNA.

1 reference

https://api.crossref.org/works/10.1016%2FS0022-2836%2803%2900124-4

7 January 2021

Single-turnover and pre-steady-state kinetics of the reaction of the adenine glycosylase MutY with mismatch-containing DNA substrates

1 reference

https://api.crossref.org/works/10.1016%2FS0022-2836%2803%2900124-4

7 January 2021

Cloning, overexpression, and biochemical characterization of the catalytic domain of MutY

1 reference

https://api.crossref.org/works/10.1016%2FS0022-2836%2803%2900124-4

7 January 2021

MutY catalytic core, mutant and bound adenine structures define specificity for DNA repair enzyme superfamily

1 reference

https://api.crossref.org/works/10.1016%2FS0022-2836%2803%2900124-4

7 January 2021

The C-terminal domain of the adenine-DNA glycosylase MutY confers specificity for 8-oxoguanine.adenine mispairs and may have evolved from MutT, an 8-oxo-dGTPase

1 reference

https://api.crossref.org/works/10.1016%2FS0022-2836%2803%2900124-4

7 January 2021

Structural similarities between MutT and the C-terminal domain of MutY

1 reference

https://api.crossref.org/works/10.1016%2FS0022-2836%2803%2900124-4

7 January 2021

Efficient recognition of substrates and substrate analogs by the adenine glycosylase MutY requires the C-terminal domain

1 reference

https://api.crossref.org/works/10.1016%2FS0022-2836%2803%2900124-4

7 January 2021

Molecular genetics and structural biology of human MutT homolog, MTH1.

1 reference

https://api.crossref.org/works/10.1016%2FS0022-2836%2803%2900124-4

7 January 2021

Evidence that MutY and MutM combine to prevent mutations by an oxidatively damaged form of guanine in DNA

1 reference

https://api.crossref.org/works/10.1016%2FS0022-2836%2803%2900124-4

7 January 2021

Site-directed mutagenesis of the cysteine ligands to the [4Fe-4S] cluster of Escherichia coli MutY

1 reference

https://api.crossref.org/works/10.1016%2FS0022-2836%2803%2900124-4

7 January 2021

Interaction of rifamycin with bacterial RNA polymerase

1 reference

https://api.crossref.org/works/10.1016%2FS0022-2836%2803%2900124-4

7 January 2021

Formation of a Schiff base intermediate is not required for the adenine glycosylase activity of Escherichia coli MutY

1 reference

https://api.crossref.org/works/10.1016%2FS0022-2836%2803%2900124-4

7 January 2021

A single engineered point mutation in the adenine glycosylase MutY confers bifunctional glycosylase/AP lyase activity

1 reference

https://api.crossref.org/works/10.1016%2FS0022-2836%2803%2900124-4

7 January 2021

Positively charged residues within the iron-sulfur cluster loop of E. coli MutY participate in damage recognition and removal

1 reference

https://api.crossref.org/works/10.1016%2FS0022-2836%2803%2900124-4

7 January 2021

Noncysteinyl coordination to the [4Fe-4S]2+ cluster of the DNA repair adenine glycosylase MutY introduced via site-directed mutagenesis. Structural characterization of an unusual histidinyl-coordinated cluster

1 reference

https://api.crossref.org/works/10.1016%2FS0022-2836%2803%2900124-4

7 January 2021

Substrate recognition by Escherichia coli MutY using substrate analogs

1 reference

https://api.crossref.org/works/10.1016%2FS0022-2836%2803%2900124-4

7 January 2021

Substrate specificity of Escherichia coli MutY protein.

1 reference

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7 January 2021

Specific binding of a designed pyrrolidine abasic site analog to multiple DNA glycosylases

1 reference

https://api.crossref.org/works/10.1016%2FS0022-2836%2803%2900124-4

7 January 2021

Gel retardation.

1 reference

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7 January 2021

Crystal structure of a human alkylbase-DNA repair enzyme complexed to DNA: mechanisms for nucleotide flipping and base excision

1 reference

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7 January 2021

Molecular basis for discriminating between normal and damaged bases by the human alkyladenine glycosylase, AAG

1 reference

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7 January 2021

Potential double-flipping mechanism by E. coli MutY.

1 reference

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7 January 2021

The MutT proteins or "Nudix" hydrolases, a family of versatile, widely distributed, "housecleaning" enzymes

1 reference

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7 January 2021

Solution structure of the quaternary MutT-M2+-AMPCPP-M2+ complex and mechanism of its pyrophosphohydrolase action

1 reference

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7 January 2021

NMR Studies of the Conformations and Location of Nucleotides Bound to the Escherichia coli MutT Enzyme

1 reference

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A mammalian DNA repair enzyme that excises oxidatively damaged guanines maps to a locus frequently lost in lung cancer

1 reference

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7 January 2021

Somatic mutations and single nucleotide polymorphisms of base excision repair genes involved in the repair of 8-hydroxyguanine in damaged DNA.

1 reference

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7 January 2021

The GO system protects organisms from the mutagenic effect of the spontaneous lesion 8-hydroxyguanine (7,8-dihydro-8-oxoguanine)

1 reference

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7 January 2021

Identifiers

10.1016/S0022-2836(03)00124-4

1 reference

Europe PubMed Central

PubMed publication ID

2 September 2017

PubMed publication ID

1 reference

Europe PubMed Central

PubMed publication ID

2 September 2017

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