(Q38382440)

2 September 2017

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title

Genomic instability: Crossing pathways at the origin of structural and numerical chromosome changes (English)

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2 September 2017

Antonella Russo

1

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Daniela Cimini

object named as

Daniela Cimini

3

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Sofia Pavanello

object named as

Sofia Pavanello

7

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Giorgio Valle

object named as

Giorgio Valle

8

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author name string

Francesca Pacchierotti

2

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2 September 2017

Neil J Ganem

4

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2 September 2017

Anna Genescà

5

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2 September 2017

Adayapalam T Natarajan

6

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2 September 2017

Francesca Degrassi

9

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2 September 2017

publication date

18 March 2015

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Environmental and Molecular Mutagenesis

2 September 2017

published in

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2 September 2017

volume

56

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2 September 2017

issue

7

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2 September 2017

page(s)

563-580

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Death without caspases, caspases without death

2 September 2017

cites work

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Tetraploid state induces p53-dependent arrest of nontransformed mammalian cells in G1.

21 January 2018

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Mismatch repair in correction of replication errors and processing of DNA damage

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Replication stress induces genome-wide copy number changes in human cells that resemble polymorphic and pathogenic variants

21 January 2018

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Hydroxyurea induces de novo copy number variants in human cells

21 January 2018

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De novo CNV formation in mouse embryonic stem cells occurs in the absence of Xrcc4-dependent nonhomologous end joining

21 January 2018

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Copy number variants are produced in response to low-dose ionizing radiation in cultured cells

21 January 2018

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Telomere dysfunction promotes non-reciprocal translocations and epithelial cancers in mice

21 January 2018

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Divergence of sperm and leukocyte age-dependent telomere dynamics: implications for male-driven evolution of telomere length in humans

21 January 2018

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Chromosomal instability substantiates poor prognosis in patients with diffuse large B-cell lymphoma.

21 January 2018

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DNA-damage response during mitosis induces whole-chromosome missegregation

21 January 2018

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The mitotic origin of chromosomal instability

21 January 2018

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Topoisomerase II inactivation prevents the completion of DNA replication in budding yeast

21 January 2018

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Cancer cell micronucleus: an update on clinical and diagnostic applications

21 January 2018

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Telomere shortening and tumor formation by mouse cells lacking telomerase RNA

21 January 2018

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Meta-analysis of telomere length in 19,713 subjects reveals high heritability, stronger maternal inheritance and a paternal age effect

21 January 2018

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Making a long story short: noncoding RNAs and chromosome change

21 January 2018

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Apoptosis and increased generation of reactive oxygen species in Down's syndrome neurons in vitro.

21 January 2018

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Properties and rates of germline mutations in humans

21 January 2018

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Parental somatic mosaicism is underrecognized and influences recurrence risk of genomic disorders

21 January 2018

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Replication stress-induced genome instability: the dark side of replication maintenance by homologous recombination

21 January 2018

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Effects of Cytochalasins on Mammalian Cells

21 January 2018

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Meiotic recombination in human oocytes.

21 January 2018

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Modifiers of epigenetic reprogramming show paternal effects in the mouse.

21 January 2018

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Merotelic kinetochore orientation is a major mechanism of aneuploidy in mitotic mammalian tissue cells

21 January 2018

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DNA breaks and chromosome pulverization from errors in mitosis

21 January 2018

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Human cancer cells commonly acquire DNA damage during mitotic arrest

21 January 2018

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The causes and consequences of polyploidy in normal development and cancer

21 January 2018

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Telomere-driven tetraploidization occurs in human cells undergoing crisis and promotes transformation of mouse cells

21 January 2018

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Common fragile sites: mechanisms of instability revisited.

21 January 2018

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Spatial and temporal diversity in genomic instability processes defines lung cancer evolution

21 January 2018

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Distinct profiles of critically short telomeres are a key determinant of different chromosome aberrations in immortalized human cells: whole-genome evidence from multiple cell lines.

21 January 2018

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The shortest telomeres drive karyotype evolution in transformed cells

21 January 2018

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Tolerance of whole-genome doubling propagates chromosomal instability and accelerates cancer genome evolution.

21 January 2018

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Inactivation of Dnmt3b in mouse embryonic fibroblasts results in DNA hypomethylation, chromosomal instability, and spontaneous immortalization.

21 January 2018

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Aneuploidy as a mechanism for stress-induced liver adaptation.

21 January 2018

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Replication stress induces tumor-like microdeletions in FHIT/FRA3B

21 January 2018

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Delayed paternal age of reproduction in humans is associated with longer telomeres across two generations of descendants

21 January 2018

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The HUMN and HUMNxL international collaboration projects on human micronucleus assays in lymphocytes and buccal cells--past, present and future

21 January 2018

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Cytokinesis failure generating tetraploids promotes tumorigenesis in p53-null cells

21 January 2018

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Linking abnormal mitosis to the acquisition of DNA damage

21 January 2018

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Tetraploidy, aneuploidy and cancer

21 January 2018

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A mechanism linking extra centrosomes to chromosomal instability

21 January 2018

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Cytokinesis failure triggers hippo tumor suppressor pathway activation.

21 January 2018

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Chromosome instability, chromosome transcriptome, and clonal evolution of tumor cell populations

21 January 2018

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Induced dicentric chromosome formation promotes genomic rearrangements and tumorigenesis.

21 January 2018

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Induction of Tumors in Mice by Genomic Hypomethylation

21 January 2018

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Chromosomal aneuploidy affects the global proteome equilibrium of colorectal cancer cells.

21 January 2018

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Generation of trisomies in cancer cells by multipolar mitosis and incomplete cytokinesis

21 January 2018

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The coordinate release of cytochrome c during apoptosis is rapid, complete and kinetically invariant

21 January 2018

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Paternal age effect mutations and selfish spermatogonial selection: causes and consequences for human disease

21 January 2018

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Mitotic repression of the transcriptional machinery.

21 January 2018

1 reference

Male-driven de novo mutations in haploid germ cells

21 January 2018

1 reference

Centromere-localized breaks indicate the generation of DNA damage by the mitotic spindle.

21 January 2018

1 reference

ATM activation by oxidative stress

21 January 2018

1 reference

Hallmarks of Cancer: The Next Generation

21 January 2018

1 reference

Discovery and genotyping of genome structural polymorphism by sequencing on a population scale

21 January 2018

1 reference

Catastrophic nuclear envelope collapse in cancer cell micronuclei.

21 January 2018

1 reference

A telomere-dependent DNA damage checkpoint induced by prolonged mitotic arrest

21 January 2018

1 reference

The Shortest Telomere, Not Average Telomere Length, Is Critical for Cell Viability and Chromosome Stability

21 January 2018

1 reference

21 January 2018

1 reference

Resolution of anaphase bridges in cancer cells

21 January 2018

1 reference

Losing balance: the origin and impact of aneuploidy in cancer

21 January 2018

1 reference

Common chromosome fragile sites in human and murine epithelial cells and FHIT/FRA3B loss-induced global genome instability

21 January 2018

1 reference

DNA lesions induced by replication stress trigger mitotic aberration and tetraploidy development

21 January 2018

1 reference

Chromosome segregation errors as a cause of DNA damage and structural chromosome aberrations

21 January 2018

1 reference

Laser micro-irradiation of mitochondria: is there an amplified mitochondrial death signal in neural cells?

21 January 2018

1 reference

Chromothripsis in congenital disorders and cancer: similarities and differences

21 January 2018

1 reference

Rate of de novo mutations and the importance of father's age to disease risk

21 January 2018

1 reference

PEMer: a computational framework with simulation-based error models for inferring genomic structural variants from massive paired-end sequencing data

21 January 2018

1 reference

Repeated cleavage failure does not establish centrosome amplification in untransformed human cells

21 January 2018

1 reference

Abnormal mitosis triggers p53-dependent cell cycle arrest in human tetraploid cells.

21 January 2018

1 reference

The actin cytoskeleton in spindle assembly and positioning

21 January 2018

1 reference

DbVar and DGVa: public archives for genomic structural variation

21 January 2018

1 reference

Caspase 3/caspase-activated DNase promote cell differentiation by inducing DNA strand breaks

21 January 2018

1 reference

Shortened telomeres join to DNA breaks interfering with their correct repair.

21 January 2018

1 reference

Common fragile site profiling in epithelial and erythroid cells reveals that most recurrent cancer deletions lie in fragile sites hosting large genes.

21 January 2018

1 reference

The ATM-p53 pathway suppresses aneuploidy-induced tumorigenesis

21 January 2018

1 reference

Mechanisms for recurrent and complex human genomic rearrangements

21 January 2018

1 reference

The origins and processing of ultra fine anaphase DNA bridges.

21 January 2018

1 reference

DNA amplification by breakage/fusion/bridge cycles initiated by spontaneous telomere loss in a human cancer cell line.

21 January 2018

1 reference

21 January 2018

The hallmarks of aging

1 reference

Probing meiotic recombination and aneuploidy of single sperm cells by whole-genome sequencing

21 January 2018

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53BP1 nuclear bodies form around DNA lesions generated by mitotic transmission of chromosomes under replication stress

21 January 2018

1 reference

Genomic disorders ten years on.

21 January 2018

1 reference

Genetics. Genome mosaicism--one human, multiple genomes

21 January 2018

1 reference

Characterization of aneuploid populations with trisomy 7 and 20 derived from diploid human colonic epithelial cells

21 January 2018

1 reference

How unfinished business from S-phase affects mitosis and beyond

21 January 2018

1 reference

Understanding nucleotide excision repair and its roles in cancer and ageing.

21 January 2018

1 reference

Dormant origins, the licensing checkpoint, and the response to replicative stresses

21 January 2018

1 reference

Computational methods for discovering structural variation with next-generation sequencing

21 January 2018

1 reference

Terminal phase of cytokinesis in D-98s cells

21 January 2018

1 reference

Altered cohesin gene dosage affects Mammalian meiotic chromosome structure and behavior.

21 January 2018

1 reference

Telomere loss as a mechanism for chromosome instability in human cancer

21 January 2018

1 reference

ERCC1 and MUS81-EME1 promote sister chromatid separation by processing late replication intermediates at common fragile sites during mitosis

21 January 2018

1 reference

The strength of combined cytogenetic and mate-pair sequencing techniques illustrated by a germline chromothripsis rearrangement involving FOXP2.

21 January 2018

1 reference

Prolonged mitotic arrest triggers partial activation of apoptosis, resulting in DNA damage and p53 induction

21 January 2018

1 reference

The role of microhomology in genomic structural variation

21 January 2018

1 reference

Observation and prediction of recurrent human translocations mediated by NAHR between nonhomologous chromosomes

21 January 2018

1 reference

The complex basis underlying common fragile site instability in cancer

21 January 2018

1 reference

Progressive telomere dysfunction causes cytokinesis failure and leads to the accumulation of polyploid cells

21 January 2018

1 reference

Spontaneous and induced aneuploidy, considerations which may influence chromosome malsegregation.

21 January 2018

1 reference

Aneuploidy confers quantitative proteome changes and phenotypic variation in budding yeast

21 January 2018

1 reference

Sustained mitotic block elicits DNA breaks: one-step alteration of ploidy and chromosome integrity in mammalian cells.

21 January 2018

1 reference

Characterizing complex structural variation in germline and somatic genomes

21 January 2018

1 reference

Genome-wide mapping and assembly of structural variant breakpoints in the mouse genome

21 January 2018

1 reference

Daddy issues: paternal effects on phenotype

21 January 2018

1 reference

Indirect mitotic nondisjunction in Vicia faba and Chinese hamster cells

21 January 2018

1 reference

Human condensin function is essential for centromeric chromatin assembly and proper sister kinetochore orientation.

21 January 2018

1 reference

Aneuploidy and isochromosome formation in drug-resistant Candida albicans

21 January 2018

1 reference

Acquisition of aneuploidy provides increased fitness during the evolution of antifungal drug resistance

21 January 2018

1 reference

When, where and how the bridge breaks: anaphase bridge breakage plays a crucial role in gene amplification and HSR generation

21 January 2018

1 reference

Multipolar spindle pole coalescence is a major source of kinetochore mis-attachment and chromosome mis-segregation in cancer cells

21 January 2018

1 reference

Telomere dysfunction drives chromosomal instability in human mammary epithelial cells.

21 January 2018

1 reference

A paternal environmental legacy: evidence for epigenetic inheritance through the male germ line.

21 January 2018

1 reference

Aurora B-mediated abscission checkpoint protects against tetraploidization

21 January 2018

1 reference

Structural and numerical chromosome changes in colon cancer develop through telomere-mediated anaphase bridges, not through mitotic multipolarity

21 January 2018

1 reference

Global analysis of genome, transcriptome and proteome reveals the response to aneuploidy in human cells.

21 January 2018

1 reference

Telomere fusions in early human breast carcinoma

21 January 2018

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DNA lesions sequestered in micronuclei induce a local defective-damage response.

21 January 2018

1 reference

Genetic activities in micronuclei: is the DNA entrapped in micronuclei lost for the cell?

21 January 2018

1 reference

An integrated map of genetic variation from 1,092 human genomes

21 January 2018

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Examining the link between chromosomal instability and aneuploidy in human cells

21 January 2018

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Proliferation of aneuploid human cells is limited by a p53-dependent mechanism.

21 January 2018

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Chromosome missegregation in human cells arises through specific types of kinetochore-microtubule attachment errors

21 January 2018

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Mechanisms of chromosomal instability.

21 January 2018

1 reference

Telomere loss provokes multiple pathways to apoptosis and produces genomic instability in Drosophila melanogaster

21 January 2018

1 reference

Effects of aneuploidy on cellular physiology and cell division in haploid yeast

21 January 2018

1 reference

The number of dysfunctional telomeres in a cell: one amplifies; more than one translocate.

21 January 2018

1 reference

Prolonged prometaphase blocks daughter cell proliferation despite normal completion of mitosis

21 January 2018

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Chromosome transfer induced aneuploidy results in complex dysregulation of the cellular transcriptome in immortalized and cancer cells

21 January 2018

1 reference

Discovery of recurrent structural variants in nasopharyngeal carcinoma

21 January 2018

1 reference

Aneuploidy and copy number variation in early human development

21 January 2018

1 reference

21 January 2018

1 reference

The adverse outcome pathway concept: a pragmatic tool in toxicology.

21 January 2018

1 reference

The human cleavage stage embryo is a cradle of chromosomal rearrangements

21 January 2018

1 reference

Meiotic recombination hotspots of fission yeast are directed to loci that express non-coding RNA.

21 January 2018

1 reference

CREST maps somatic structural variation in cancer genomes with base-pair resolution.

21 January 2018

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Expression of genes regulating chromosome segregation, the cell cycle and apoptosis during human preimplantation development.

21 January 2018

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Spontaneous slow replication fork progression elicits mitosis alterations in homologous recombination-deficient mammalian cells.

21 January 2018

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Aneuploidy affects proliferation and spontaneous immortalization in mammalian cells

21 January 2018

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Genome analyses substantiate male mutation bias in many species

21 January 2018

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MUS81 promotes common fragile site expression.

21 January 2018

1 reference

Pan-cancer patterns of somatic copy number alteration

21 January 2018

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Causes and consequences of replication stress

21 January 2018

1 reference

Chronic pro-oxidative state and mitochondrial dysfunctions are more pronounced in fibroblasts from Down syndrome foeti with congenital heart defects

21 January 2018

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Nuclear envelope defects impede a proper response to micronuclear DNA lesions

21 January 2018

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Two autosomal dominant neuropathies result from reciprocal DNA duplication/deletion of a region on chromosome 17

21 January 2018

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7 January 2021

Causes and consequences of aneuploidy in cancer.

1 reference

7 January 2021

Mitotic indirect non-disjunction in phytohemagglutinin stimulated human lymphocytes

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7 January 2021

Chromothripsis: how does such a catastrophic event impact human reproduction?

1 reference

7 January 2021

Chromosome aberrations in mouse bone marrow cells following treatment in vivo with vinblastine and Colcemid

1 reference

7 January 2021

Formation of anucleate and multinucleate cells in normal and SV 40 transformed WI-38 by cytochalasin B

1 reference

7 January 2021

Identifiers

DOI

10.1002/EM.21945

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2 September 2017

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