(Q38384145)

2 September 2017

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title

Regulation of antiviral T cell responses by type I interferons (English)

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2 September 2017

Ulrich Kalinke

2

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Annette Oxenius

series ordinal

3

object named as

Annette Oxenius

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2 September 2017

Josh Crouse

1

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2 September 2017

publication date

20 March 2015

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Nature Reviews Immunology

2 September 2017

published in

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2 September 2017

volume

15

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2 September 2017

issue

4

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2 September 2017

page(s)

231-242

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Virus interference. I. The interferon

2 September 2017

cites work

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Interferons, interferon-like cytokines, and their receptors

31 March 2020

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A variant upstream of IFNL3 (IL28B) creating a new interferon gene IFNL4 is associated with impaired clearance of hepatitis C virus

31 March 2020

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Modulation of human plasmacytoid DC function by IFN-lambda1 (IL-29)

31 March 2020

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Induction of type I IFNs by intracellular DNA-sensing pathways

31 March 2020

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OAS proteins and cGAS: unifying concepts in sensing and responding to cytosolic nucleic acids

31 March 2020

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Virus-induced interferon alpha production by a dendritic cell subset in the absence of feedback signaling in vivo

31 March 2020

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Plasmacytoid dendritic cells: recent progress and open questions

31 March 2020

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Plasmacytoid dendritic cells contribute to systemic but not local antiviral responses to HSV infections

31 March 2020

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Plasmacytoid dendritic cell ablation impacts early interferon responses and antiviral NK and CD8(+) T cell accrual

31 March 2020

1 reference

Interferon-alpha and granulocyte-macrophage colony-stimulating factor differentiate peripheral blood monocytes into potent antigen-presenting cells

31 March 2020

1 reference

Type I interferon as a powerful adjuvant for monocyte-derived dendritic cell development and activity in vitro and in Hu-PBL-SCID mice.

31 March 2020

1 reference

Viruses evade the immune system through type I interferon-mediated STAT2-dependent, but STAT1-independent, signaling

31 March 2020

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Expression of CCR-7, MIP-3beta , and Th-1 chemokines in type I IFN-induced monocyte-derived dendritic cells: importance for the rapid acquisition of potent migratory and functional activities

31 March 2020

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Dendritic cells adhere to and transmigrate across lymphatic endothelium in response to IFN-α

31 March 2020

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Low levels of interferon-alpha induce CD86 (B7.2) expression and accelerates dendritic cell maturation from human peripheral blood mononuclear cells

31 March 2020

1 reference

Induction of dendritic cell differentiation by IFN-alpha in systemic lupus erythematosus.

31 March 2020

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Natural adjuvants: endogenous activators of dendritic cells

31 March 2020

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Type I interferons produced by dendritic cells promote their phenotypic and functional activation

31 March 2020

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Dendritic cells require a systemic type I interferon response to mature and induce CD4+ Th1 immunity with poly IC as adjuvant

31 March 2020

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Type I IFN drives a distinctive dendritic cell maturation phenotype that allows continued class II MHC synthesis and antigen processing

31 March 2020

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Cross-presentation by dendritic cells

31 March 2020

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Antigen cross-presentation by dendritic cell subsets: one general or all sergeants?

31 March 2020

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Cross-priming of CD8+ T cells stimulated by virus-induced type I interferon

31 March 2020

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IFN-α enhances cross-presentation in human dendritic cells by modulating antigen survival, endocytic routing, and processing.

31 March 2020

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The small GTPase Rac2 controls phagosomal alkalinization and antigen crosspresentation selectively in CD8(+) dendritic cells

31 March 2020

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Structural Linkage between Ligand Discrimination and Receptor Activation by Type I Interferons

31 March 2020

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Differential activity of type I interferon subtypes for dendritic cell differentiation

31 March 2020

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Intranasal Poly-IC treatment exacerbates tuberculosis in mice through the pulmonary recruitment of a pathogen-permissive monocyte/macrophage population

31 March 2020

1 reference

TPL-2-ERK1/2 signaling promotes host resistance against intracellular bacterial infection by negative regulation of type I IFN production

31 March 2020

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Persistent LCMV infection is controlled by blockade of type I interferon signaling

31 March 2020

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Blockade of chronic type I interferon signaling to control persistent LCMV infection

31 March 2020

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Emergence of distinct multiarmed immunoregulatory antigen-presenting cells during persistent viral infection

31 March 2020

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IL-15 is expressed by dendritic cells in response to type I IFN, double-stranded RNA, or lipopolysaccharide and promotes dendritic cell activation

31 March 2020

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Potent and selective stimulation of memory-phenotype CD8+ T cells in vivo by IL-15.

31 March 2020

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Coordinated and distinct roles for IFN-alpha beta, IL-12, and IL-15 regulation of NK cell responses to viral infection

31 March 2020

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Dendritic cells prime natural killer cells by trans-presenting interleukin 15

31 March 2020

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IL-15Ralpha recycles and presents IL-15 In trans to neighboring cells

31 March 2020

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Critical role for STAT4 activation by type 1 interferons in the interferon-gamma response to viral infection

31 March 2020

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Expanding roles for CD4⁺ T cells in immunity to viruses.

31 March 2020

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Homeostasis of naive and memory T cells

31 March 2020

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Interferon-alpha/beta inhibition of interleukin 12 and interferon-gamma production in vitro and endogenously during viral infection

31 March 2020

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Type I interferons and IL-12: convergence and cross-regulation among mediators of cellular immunity

31 March 2020

2 references

31 March 2020

12 December 2020

Interferon Induces Natural Killer Cell Blastogenesis In Vivo

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Enhanced NK cell activity in mice injected with interferon and interferon inducers

31 March 2020

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Distinct requirements for IFNs and STAT1 in NK cell function

31 March 2020

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Control of human viral infections by natural killer cells

31 March 2020

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T-bet is rapidly induced by interferon-gamma in lymphoid and myeloid cells

31 March 2020

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Natural killer cells regulate diverse T cell responses.

31 March 2020

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NK cells regulating T cell responses: mechanisms and outcome

31 March 2020

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Regulation of activated CD4+ T cells by NK cells via the Qa-1-NKG2A inhibitory pathway.

31 March 2020

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Absence of mouse 2B4 promotes NK cell-mediated killing of activated CD8+ T cells, leading to prolonged viral persistence and altered pathogenesis

31 March 2020

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Type I interferon protects antiviral CD8+ T cells from NK cell cytotoxicity.

31 March 2020

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Activated, but not resting, T cells can be recognized and killed by syngeneic NK cells

31 March 2020

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Antigen-activated human T lymphocytes express cell-surface NKG2D ligands via an ATM/ATR-dependent mechanism and become susceptible to autologous NK- cell lysis

31 March 2020

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Cutting edge: CD8+ T cell priming in the absence of NK cells leads to enhanced memory responses

31 March 2020

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Type I interferons protect T cells against NK cell attack mediated by the activating receptor NCR1.

31 March 2020

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Up-regulation of a death receptor renders antiviral T cells susceptible to NK cell-mediated deletion.

31 March 2020

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Interferon-inducible antiviral effectors

31 March 2020

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Enforced viral replication activates adaptive immunity and is essential for the control of a cytopathic virus

31 March 2020

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Viral persistence alters CD8 T-cell immunodominance and tissue distribution and results in distinct stages of functional impairment

31 March 2020

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Antigen amount dictates CD8+ T-cell exhaustion during chronic viral infection irrespective of the type of antigen presenting cell

31 March 2020

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High antigen levels are the cause of T cell exhaustion during chronic viral infection

31 March 2020

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Antigen load and viral sequence diversification determine the functional profile of HIV-1-specific CD8+ T cells

31 March 2020

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Complex modulation of cell type-specific signaling in response to type I interferons

31 March 2020

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Stats: multifaceted regulators of transcription

31 March 2020

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Mechanisms of type-I- and type-II-interferon-mediated signalling

31 March 2020

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Cutting edge: role of STAT1, STAT3, and STAT5 in IFN-alpha beta responses in T lymphocytes

31 March 2020

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Stat1 and Stat2 but not Stat3 arbitrate contradictory growth signals elicited by alpha/beta interferon in T lymphocytes.

31 March 2020

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Loss of interferon-induced Stat1 phosphorylation in activated T cells

31 March 2020

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Type I IFNs provide a third signal to CD8 T cells to stimulate clonal expansion and differentiation

31 March 2020

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Type 1 interferons and the virus-host relationship: a lesson in détente .

31 March 2020

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Modulation of STAT1 protein levels: a mechanism shaping CD8 T-cell responses in vivo

31 March 2020

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Signal 3 determines tolerance versus full activation of naive CD8 T cells: dissociating proliferation and development of effector function

31 March 2020

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CD8 T Cell Clonal Expansion and Development of Effector Function Require Prolonged Exposure to Antigen, Costimulation, and Signal 3 Cytokine

31 March 2020

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Effects of IFN-α as a signal-3 cytokine on human naïve and antigen-experienced CD8(+) T cells

31 March 2020

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IFN-α exerts opposing effects on activation-induced and IL-7-induced proliferation of T cells that may impair homeostatic maintenance of CD4+ T cell numbers in treated HIV infection

31 March 2020

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Interferon-beta mediates stromal cell rescue of T cells from apoptosis.

31 March 2020

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Type I interferons keep activated T cells alive

31 March 2020

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Type I interferons act directly on CD8 T cells to allow clonal expansion and memory formation in response to viral infection

31 March 2020

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CD8 T cells specific for lymphocytic choriomeningitis virus require type I IFN receptor for clonal expansion

31 March 2020

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Innate inflammatory signals induced by various pathogens differentially dictate the IFN-I dependence of CD8 T cells for clonal expansion and memory formation.

31 March 2020

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Cutting Edge: The direct action of type I IFN on CD4 T cells is critical for sustaining clonal expansion in response to a viral but not a bacterial infection

31 March 2020

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Signal 3 cytokines as modulators of primary immune responses during infections: the interplay of type I IFN and IL-12 in CD8 T cell responses.

31 March 2020

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Type-I IFN drives the differentiation of short-lived effector CD8+ T cells in vivo.

31 March 2020

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Concomitant type I IFN receptor-triggering of T cells and of DC is required to promote maximal modified vaccinia virus Ankara-induced T-cell expansion

31 March 2020

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Signal 3 requirement for memory CD8+ T-cell activation is determined by the infectious pathogen.

31 March 2020

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Direct Stimulation of T Cells by Type I IFN Enhances the CD8+ T Cell Response during Cross-Priming

31 March 2020

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Type I interferon is required to mount an adaptive response to immunostimulatory DNA

31 March 2020

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IL-12 and type I interferon prolong the division of activated CD8 T cells by maintaining high-affinity IL-2 signaling in vivo

31 March 2020

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Programming for CD8 T cell memory development requires IL-12 or type I IFN

31 March 2020

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Interferon alpha/beta-mediated inhibition and promotion of interferon gamma: STAT1 resolves a paradox

31 March 2020

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Regulating type 1 IFN effects in CD8 T cells during viral infections: changing STAT4 and STAT1 expression for function

31 March 2020

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Gene regulation and chromatin remodeling by IL-12 and type I IFN in programming for CD8 T cell effector function and memory

31 March 2020

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Effector T-cell differentiation during viral and bacterial infections: Role of direct IL-12 signals for cell fate decision of CD8(+) T cells

31 March 2020

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Type I IFN substitutes for T cell help during viral infections

31 March 2020

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Prolonged interleukin-2Ralpha expression on virus-specific CD8+ T cells favors terminal-effector differentiation in vivo.

31 March 2020

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Interleukin-2 and inflammation induce distinct transcriptional programs that promote the differentiation of effector cytolytic T cells

31 March 2020

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Cutting edge: IL-12 and type I IFN differentially program CD8 T cells for programmed death 1 re-expression levels and tumor control

31 March 2020

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Cytokines of the γ(c) family control CD4+ T cell differentiation and function

31 March 2020

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Interferon alpha increases the frequency of interferon gamma-producing human CD4+ T cells

31 March 2020

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Sustained IL-12 signaling is required for Th1 development

31 March 2020

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IFN-alpha is not sufficient to drive Th1 development due to lack of stable T-bet expression

31 March 2020

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IL-12, but not IFN-alpha, promotes STAT4 activation and Th1 development in murine CD4+ T cells expressing a chimeric murine/human Stat2 gene

31 March 2020

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Generation of T follicular helper cells is mediated by interleukin-21 but independent of T helper 1, 2, or 17 cell lineages

31 March 2020

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Functional STAT3 deficiency compromises the generation of human T follicular helper cells.

31 March 2020

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Transcription factor STAT3 and type I interferons are corepressive insulators for differentiation of follicular helper and T helper 1 cells

31 March 2020

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Molecular mechanisms that control the expression and activity of Bcl-6 in TH1 cells to regulate flexibility with a TFH-like gene profile

31 March 2020

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Follicular helper CD4 T cells (TFH)

31 March 2020

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Type I IFN induces binding of STAT1 to Bcl6: divergent roles of STAT family transcription factors in the T follicular helper cell genetic program

31 March 2020

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Type I interferons directly inhibit regulatory T cells to allow optimal antiviral T cell responses during acute LCMV infection

31 March 2020

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Type I interferons directly regulate lymphocyte recirculation and cause transient blood lymphopenia

31 March 2020

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CD69 acts downstream of interferon-alpha/beta to inhibit S1P1 and lymphocyte egress from lymphoid organs

31 March 2020

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Hypertrophy of infected Peyer's patches arises from global, interferon-receptor, and CD69-independent shutdown of lymphocyte egress

31 March 2020

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IFN-alpha2 induces leukocyte integrin redistribution, increased adhesion, and migration.

31 March 2020

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Down-modulation of responses to type I IFN upon T cell activation

31 March 2020

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Type I interferon-mediated stimulation of T cells by CpG DNA

31 March 2020

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Transcriptionally active Stat1 is required for the antiproliferative effects of both interferon alpha and interferon gamma

31 March 2020

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Antiproliferative action of interferon-α requires components of T-cell-receptor signalling

31 March 2020

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IFN-α directly promotes programmed cell death-1 transcription and limits the duration of T cell-mediated immunity

31 March 2020

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Regulation of TNF-related apoptosis-inducing ligand on primary CD4+ T cells by HIV-1: role of type I IFN-producing plasmacytoid dendritic cells

31 March 2020

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Interferon alpha augments activation-induced T cell death by upregulation of Fas (CD95/APO-1) and Fas ligand expression

31 March 2020

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Type I interferon upregulates Bak and contributes to T cell loss during human immunodeficiency virus (HIV) infection

31 March 2020

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IFN-alpha 2b reduces IL-2 production and IL-2 receptor function in primary CD4+ T cells

31 March 2020

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Analysis of apoptosis of memory T cells and dendritic cells during the early stages of viral infection or exposure to toll-like receptor agonists

31 March 2020

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Attrition of bystander CD8 T cells during virus-induced T-cell and interferon responses

31 March 2020

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IFN-induced attrition of CD8 T cells in the presence or absence of cognate antigen during the early stages of viral infections.

31 March 2020

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Selective Depletion of Nonspecific T Cells During the Early Stage of Immune Responses to Infection

31 March 2020

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IFN-alpha beta and self-MHC divert CD8 T cells into a distinct differentiation pathway characterized by rapid acquisition of effector functions

31 March 2020

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Virus-induced transient immune suppression and the inhibition of T cell proliferation by type I interferon

31 March 2020

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Out-of-sequence signal 3 as a mechanism for virus-induced immune suppression of CD8 T cell responses

31 March 2020

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Suppressor of cytokine signaling (SOCS) 1 inhibits type I interferon (IFN) signaling via the interferon alpha receptor (IFNAR1)-associated tyrosine kinase Tyk2

31 March 2020

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Type I interferon production in HIV-infected patients

31 March 2020

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Type I interferon responses in rhesus macaques prevent SIV infection and slow disease progression

31 March 2020

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Type I interferon is a therapeutic target for virus-induced lethal vascular damage

31 March 2020

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Timing and magnitude of type I interferon responses by distinct sensors impact CD8 T cell exhaustion and chronic viral infection

31 March 2020

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Negative regulation of type I IFN expression by OASL1 permits chronic viral infection and CD8⁺ T-cell exhaustion.

31 March 2020

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Continuous recruitment of naive T cells contributes to heterogeneity of antiviral CD8 T cells during persistent infection.

31 March 2020

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Type I interferon suppresses de novo virus-specific CD4 Th1 immunity during an established persistent viral infection

31 March 2020

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Bystander chronic infection negatively impacts development of CD8(+) T cell memory.

31 March 2020

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Interferon-alpha activates multiple STAT proteins and upregulates proliferation-associated IL-2Ralpha, c-myc, and pim-1 genes in human T cells

31 March 2020

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12 December 2020

The role of Stat4 in species-specific regulation of Th cell development by type I IFNs.

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12 December 2020

IFN-alpha2a induces IP-10/CXCL10 and MIG/CXCL9 production in monocyte-derived dendritic cells and enhances their capacity to attract and stimulate CD8+ effector T cells

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12 December 2020

Type I IFNs enhance the terminal differentiation of dendritic cells

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12 December 2020

Differential role of "Signal 3" inflammatory cytokines in regulating CD8 T cell expansion and differentiation in vivo.

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12 December 2020

IFN-gamma modulates the early development of Th1 and Th2 responses in a murine model of cutaneous leishmaniasis

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12 December 2020

Resolution of immune activation defines nonpathogenic SIV infection

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12 December 2020

Effect of interferon and interferon inducers on the NK sensitivity of normal mouse thymocytes

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12 December 2020

Identifiers

DOI

10.1038/NRI3806

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2 September 2017

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