(Q38392343)

2 September 2017

Synthesis of novel beta-lactone inhibitors of fatty acid synthase (English)

1 reference

2 September 2017

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7

Daniel Romo

1 reference

2 September 2017

Robyn D Richardson

1

1 reference

2 September 2017

Gil Ma

2

1 reference

2 September 2017

Yatsandra Oyola

3

1 reference

2 September 2017

Manuel Zancanella

4

1 reference

2 September 2017

Lynn M Knowles

5

1 reference

2 September 2017

Piotr Cieplak

6

1 reference

2 September 2017

Jeffrey W Smith

8

1 reference

2 September 2017

language of work or name

English

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publication date

19 August 2008

1 reference

Journal of Medicinal Chemistry

2 September 2017

1 reference

2 September 2017

51

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2 September 2017

17

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2 September 2017

5285-5296

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Fatty acid synthase inhibitors: new directions for oncology

2 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3172131

Fatty acid synthase and the lipogenic phenotype in cancer pathogenesis

6 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3172131

Crystal structure of the thioesterase domain of human fatty acid synthase inhibited by Orlistat

6 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3172131

Structure and function of animal fatty acid synthase

6 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3172131

Human fatty acid synthase: structure and substrate selectivity of the thioesterase domain

6 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3172131

A fatty acid synthase blockade induces tumor cell-cycle arrest by down-regulating Skp2.

6 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3172131

Fatty acid synthase expression defines distinct molecular signatures in prostate cancer.

6 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3172131

Induction of a Common Pathway of Apoptosis by Staurosporine

6 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3172131

Novel antagonists of the thioesterase domain of human fatty acid synthase

6 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3172131

Total synthesis and comparative analysis of orlistat, valilactone, and a transposed orlistat derivative: Inhibitors of fatty acid synthase

14 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3172131

Fatty acid synthase as a tumor marker: its extracellular expression in human breast cancer

14 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3172131

A general model for selectivity in olefin cross metathesis

14 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3172131

Orlistat is a novel inhibitor of fatty acid synthase with antitumor activity

31 August 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3172131

Overexpression of fatty acid synthase is an early and common event in the development of prostate cancer.

31 August 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3172131

Practical, catalytic, asymmetric synthesis of beta-lactones via a sequential ketene dimerization/hydrogenation process: inhibitors of the thioesterase domain of fatty acid synthase

31 August 2018

1 reference

12 December 2020

Expression of fatty acid synthase (FAS) as a predictor of recurrence in stage I breast carcinoma patients

1 reference

12 December 2020

Inhibition of fatty acid synthesis delays disease progression in a xenograft model of ovarian cancer

1 reference

12 December 2020

Mode of action of orlistat

1 reference

12 December 2020

Fatty acid synthase expression in Japanese breast carcinoma patients

1 reference

12 December 2020

Ebelactone, an inhibitor of esterase, produced by actinomycetes

1 reference

12 December 2020

A Highly Diastereoselective, Tandem Mukaiyama Aldol-Lactonization Route to beta-Lactones: Application to a Concise Synthesis of the Potent Pancreatic Lipase Inhibitor, (-)-Panclicin D

1 reference

12 December 2020

Identifiers

DOI

10.1021/JM800321H

1 reference

2 September 2017

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2 September 2017

1 reference